Disease on EC 3.4.11.22 - aminopeptidase I
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Abortion, Spontaneous
ERAP, KIR and HLA-C gene interaction in susceptibility to recurrent spontaneous abortion in the Polish population.
Achlorhydria
Observations on the etiologic relationship of achylia gastrica to pernicious anemia. XII. Failure of thymus aminopolypeptidase to act as intrinsic factor.
aminopeptidase i deficiency
Aminopeptidase yscII of yeast. Isolation of mutants and their biochemical and genetic analysis.
aminopeptidase i deficiency
In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.
aminopeptidase i deficiency
Isolation and characterization of Schizosaccharomyces pombe mutants lacking aminopeptidase activity.
aminopeptidase i deficiency
Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses.
aminopeptidase i deficiency
Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses.
aminopeptidase i deficiency
The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation.
Anemia, Pernicious
Observations on the etiologic relationship of achylia gastrica to pernicious anemia. XII. Failure of thymus aminopolypeptidase to act as intrinsic factor.
Arthritis
ERAP1 rs30187 single nucleotide polymorphism does not confer disease susceptibility in North Indian children with enthesitis-related arthritis.
Arthritis
Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis.
Arthritis, Juvenile
Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis.
Arthritis, Psoriatic
ERAP1 and ERAP2 Gene Variations Influence the Risk of Psoriatic Arthritis in Romanian Population.
Arthritis, Psoriatic
Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis.
Arthritis, Psoriatic
The association of HLA-C and ERAP1 polymorphisms in early and late onset psoriasis and psoriatic arthritis patients of Hungary.
Arthritis, Rheumatoid
ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations.
Autoimmune Diseases
Autoimmune Disease-Associated Variants of Extracellular Endoplasmic Reticulum Aminopeptidase 1 Induce Altered Innate Immune Responses by Human Immune Cells.
Autoimmune Diseases
Autoimmune risk variants in ERAP2 are associated with gene-expression levels in thymus.
Autoimmune Diseases
Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme.
Autoimmune Diseases
Discovery and Optimization of a Series of Benzofuran Selective ERAP1 Inhibitors: Biochemical and In Silico Studies.
Autoimmune Diseases
Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.
Autoimmune Diseases
Endoplasmic reticulum aminopeptidase 1 function and its pathogenic role in regulating innate and adaptive immunity in cancer and major histocompatibility complex class I-associated autoimmune diseases.
Autoimmune Diseases
Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response.
Autoimmune Diseases
ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population.
Autoimmune Diseases
ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses.
Autoimmune Diseases
Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection.
Autoimmune Diseases
Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations.
Autoimmune Diseases
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1.
Autoimmune Diseases
Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.
Autoimmune Diseases
Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.
Autoimmune Diseases
Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.
Autoimmune Diseases
Peptide Trimming for MHC Class I Presentation by Endoplasmic Reticulum Aminopeptidases.
Autoimmune Diseases
The gene expression of two endoplasmic reticulum aminopeptidase 1 isoforms is regulated by distinct posttranscriptional mechanisms.
Autoimmune Diseases
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
Autoimmune Diseases
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Bacterial Infections
A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.
Biliary Atresia
Association of X-prolyl aminopeptidase 1 rs17095355 polymorphism with biliary atresia in Thai children.
Birdshot Chorioretinopathy
Allele-specific Alterations in the Peptidome Underlie the Joint Association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy.
Birdshot Chorioretinopathy
Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen.
Birdshot Chorioretinopathy
The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.
Birdshot Chorioretinopathy
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Blister
[Determination of leucine-aminopeptidase in the serum and blister fluid of some patients with skin diseases]
Blister
[Leucine-aminopeptidase activity in blood serum & blister content. I. Studies on persons with a normal skin.]
Breast Neoplasms
EpCAM associates with endoplasmic reticulum aminopeptidase 2 (ERAP2) in breast cancer cells.
Carcinogenesis
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of ?TrCP.
Carcinogenesis
Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma.
Carcinoma
Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma.
Carcinoma
Differences in genetic variation in antigen-processing machinery components and association with cervical carcinoma risk in two Indonesian populations.
Carcinoma
Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.
Carcinoma
Genetic variation of antigen processing machinery components and association with cervical carcinoma.
Carcinoma
Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.
Carcinoma
Post-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women.
Carcinoma
Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma.
Carcinoma
[Expression and significance of differentially expressed protein endoplasmic reticulum aminopeptidase 1 in ovarian carcinoma with lymph node metastasis.]
Carcinoma
[Serum content and urinary elimination of leucine-aminopeptidase in women with carcinoma of the uterine cervix.]
Carcinoma, Endometrioid
Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125.
Carcinoma, Endometrioid
Possible involvement of adipocyte-derived leucine aminopeptidase via angiotensin II in endometrial carcinoma.
Carcinoma, Non-Small-Cell Lung
Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers.
Carcinoma, Non-Small-Cell Lung
Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival.
Carcinoma, Non-Small-Cell Lung
[A study on the relationship between endoplasmic reticulum aminopeptidase2 genetic polymorphisms and non-small cell lung cancer in Yunnan Han population].
Carcinoma, Squamous Cell
Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.
Carcinoma, Squamous Cell
Post-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women.
Cervical Intraepithelial Neoplasia
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.
Cervical Intraepithelial Neoplasia
Post-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women.
Choriocarcinoma
Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells.
Choriocarcinoma
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells.
Choriocarcinoma
The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma.
Colorectal Neoplasms
Induction of protective antitumor immunity through attenuation of ERAAP function.
Communicable Diseases
Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations.
Communicable Diseases
Polymorphisms in ERAP1 and ERAP2 are shared by Caninae and segregate within and between random- and pure-breeds of dogs.
COVID-19
Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms.
Crohn Disease
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
Cystic Fibrosis
Analysis of fetal intestinal enzymes in amniotic fluid for the prenatal diagnosis of cystic fibrosis.
Dermatitis, Atopic
Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro.
Dermatitis, Atopic
Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence.
Diabetes Mellitus, Type 1
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
Eclampsia
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.
Endometrial Neoplasms
Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system.
Endometrial Neoplasms
Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125.
Endometrial Neoplasms
Possible involvement of adipocyte-derived leucine aminopeptidase via angiotensin II in endometrial carcinoma.
Essential Hypertension
Association of single nucleotide polymorphisms in the 3'UTR of ERAP1 gene with essential hypertension in the Northeastern Han Chinese.
Essential Hypertension
Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1.
Essential Hypertension
The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.
Food Hypersensitivity
Colonoscopic allergen provocation (COLAP): a new diagnostic approach for gastrointestinal food allergy.
Food Hypersensitivity
Evaluation of colonoscopic allergen provocation as a diagnostic tool in dogs with proven food hypersensitivity reactions.
HELLP Syndrome
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.
Hepatitis
[On the diagnostic and physiopathological significance of the changes in serum polypeptidase activity in epidemic hepatitis]
Hepatitis C
ERAP1 allotypes impact the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection.
Hepatitis C
Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection.
HIV Infections
Bestatin-mediated inhibition of leucine aminopeptidase may hinder HIV infection.
HIV Infections
Endoplasmic reticulum aminopeptidase 2 (ERAP2) haplotypes play a role in modulating susceptibility to HIV infection.
Hypersensitivity
Evaluation of colonoscopic allergen provocation as a diagnostic tool in dogs with proven food hypersensitivity reactions.
Hypertension
Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women.
Hypertension
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.
Hypertension
Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1.
Hypertension
Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses.
Immune System Diseases
Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.
Infections
Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
Infections
ERAP1 allotypes impact the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection.
Infections
Evaluation of three disk tests for identification of enterococci, leuconostocs, and pediococci.
Infections
Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection.
Infections
Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.
Infections
Impact of Natural Occurring ERAP1 Single Nucleotide Polymorphisms within miRNA-Binding Sites on HCMV Infection.
Infections
New sensitive markers for the detection of experimental ascending pyelonephritis.
Infections
The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation.
Inflammatory Bowel Diseases
Association between single nucleotide polymorphisms in prospective genes and susceptibility to ankylosing spondylitis and inflammatory bowel disease in a single centre in Turkey.
Inflammatory Bowel Diseases
ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population.
Inflammatory Bowel Diseases
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
Influenza, Human
p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1.
Liver Cirrhosis
Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection.
Liver Diseases
[The diagnostic significance of the alkalimetric determination of serum polypeptidase in liver diseases and other diseases.]
Lung Neoplasms
Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers.
Lung Neoplasms
Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival.
Lung Neoplasms
[A study on the relationship between endoplasmic reticulum aminopeptidase2 genetic polymorphisms and non-small cell lung cancer in Yunnan Han population].
Lymphatic Metastasis
Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis.
Lymphatic Metastasis
[Expression and significance of differentially expressed protein endoplasmic reticulum aminopeptidase 1 in ovarian carcinoma with lymph node metastasis.]
Lymphoma
Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing.
Lymphoma, T-Cell
Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing.
Malaria
Ankylosing Spondylitis: A Trade Off of HLA-B27, ERAP, and Pathogen Interconnections? Focus on Sardinia.
Malaria
IgG antibody response against Plasmodium falciparum aminopeptidase 1 antigen in Gabonese children living in Makokou and Franceville.
Melanoma
Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1).
Melanoma
ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope.
Melanoma
The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.
Multiple Sclerosis
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
Neoplasm Metastasis
Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.
Neoplasm Metastasis
Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis.
Neoplasm Metastasis
[Expression and significance of differentially expressed protein endoplasmic reticulum aminopeptidase 1 in ovarian carcinoma with lymph node metastasis.]
Neoplasms
A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.
Neoplasms
Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system.
Neoplasms
Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues.
Neoplasms
Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma.
Neoplasms
Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes.
Neoplasms
Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
Neoplasms
Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumor necrosis factor receptor 1 (TNFR1) and regulation by cytokines.
Neoplasms
Discovery and Optimization of a Series of Benzofuran Selective ERAP1 Inhibitors: Biochemical and In Silico Studies.
Neoplasms
Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma.
Neoplasms
Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer.
Neoplasms
Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1).
Neoplasms
Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.
Neoplasms
Endoplasmic Reticulum Aminopeptidase 1 beyond Antigenic Peptide-Processing Enzyme in the Endoplasmic Reticulum.
Neoplasms
Endoplasmic reticulum aminopeptidase 1 function and its pathogenic role in regulating innate and adaptive immunity in cancer and major histocompatibility complex class I-associated autoimmune diseases.
Neoplasms
Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.
Neoplasms
Endoplasmic Reticulum Aminopeptidase 2, a common immunological link to adverse pregnancy outcomes and cancer clearance?
Neoplasms
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.
Neoplasms
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of ?TrCP.
Neoplasms
ERAP1 Regulates Natural Killer Cell Function by Controlling the Engagement of Inhibitory Receptors.
Neoplasms
ERAP1-dependent antigen cross-presentation determines efficacy of adoptive T cell therapy in mice.
Neoplasms
Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125.
Neoplasms
Expression of Endoplasmic Reticulum Aminopeptidases in EBV-B Cell Lines from Healthy Donors and in Leukemia/Lymphoma, Carcinoma, and Melanoma Cell Lines.
Neoplasms
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells.
Neoplasms
Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection.
Neoplasms
HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8+ T-cell Tumor Infiltration in OPSCC.
Neoplasms
Induction of protective antitumor immunity through attenuation of ERAAP function.
Neoplasms
Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations.
Neoplasms
Interaction between ERAP Alleles and HLA Class I Types Support a Role of Antigen Presentation in Hodgkin Lymphoma Development.
Neoplasms
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1.
Neoplasms
Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing.
Neoplasms
Peptide Trimming for MHC Class I Presentation by Endoplasmic Reticulum Aminopeptidases.
Neoplasms
Polymorphisms in ERAP1 and ERAP2 are shared by Caninae and segregate within and between random- and pure-breeds of dogs.
Neoplasms
Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.
Neoplasms
Post-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women.
Neoplasms
Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.
Neoplasms
Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.
Neoplasms
Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms.
Neoplasms
Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma.
Neoplasms
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation.
Neoplasms
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Neoplasms
Visualization of Endoplasmic Reticulum Aminopeptidase 1 under Different Redox Conditions with a Two-Photon Fluorescent Probe.
Neoplasms
[Dynamics of the changes in cytosol aminopeptidase, aminopeptidase I (microsomal) and gamma-glutamyltransferase activities during brachytherapy of cancer of the uterine cervix and corpus]
Neoplasms
[Expression and significance of differentially expressed protein endoplasmic reticulum aminopeptidase 1 in ovarian carcinoma with lymph node metastasis.]
Neoplasms
[Tumor markers in the cytodiagnosis of thyroid nodules. Detection of dipeptidyl aminopeptidase IV (DAP IV) activity]
Nephrotic Syndrome
[Determination of enzyme activity in childhood. III. Serum leucine-aminopeptidase in the nephrotic syndrome.]
Ovarian Neoplasms
Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer.
Ovarian Neoplasms
[Expression and significance of differentially expressed protein endoplasmic reticulum aminopeptidase 1 in ovarian carcinoma with lymph node metastasis.]
Persistent Infection
The ERAP gene is associated with HCV chronic infection in a Chinese Han population.
Pre-Eclampsia
A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk.
Pre-Eclampsia
Association study of polymorphisms of endoplasmic reticulum aminopeptidase 1 gene with preeclampsia in Chinese populations.
Pre-Eclampsia
Association Study of Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 and 2 Genes in Iranian Women with Preeclampsia.
Pre-Eclampsia
Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study.
Pre-Eclampsia
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.
Psoriasis
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
Psoriasis
Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
Psoriasis
Association of ERAP1 gene polymorphisms with the susceptibility to psoriasis vulgaris: A case-control study.
Psoriasis
Associations between ERAP1 Gene Polymorphisms and Psoriasis Susceptibility: A Meta-Analysis of Case-Control Studies.
Psoriasis
Associations of ERAP1 coding variants and domain specific interaction with HLA-C?06 in the early onset psoriasis patients of India.
Psoriasis
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Psoriasis
Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms and psoriasis susceptibility: A systematic review and meta-analysis.
Psoriasis
Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation.
Psoriasis
Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics.
Psoriasis
ERAP1 and ERAP2 Gene Variations Influence the Risk of Psoriatic Arthritis in Romanian Population.
Psoriasis
ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland.
Psoriasis
Evaluation of Psoriasis Genetic Risk Based on Five Susceptibility Markers in a Population from Northern Poland.
Psoriasis
Gene-gene interactions between HLA-C, ERAP1, TNFAIP3 and TRAF3IP2 to the risk of psoriasis in Chinese Han.
Psoriasis
Genetic Association with ERAP1 in Psoriasis Is Confined to Disease Onset after Puberty and Not Dependent on HLA-C*06.
Psoriasis
Genetics of Psoriasis: Evidence for Epistatic Interaction between Skin Barrier Abnormalities and Immune Deviation.
Psoriasis
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
Psoriasis
Genotype-Phenotype Correlations in a Prospective Cohort Study of Paediatric Plaque Psoriasis: Lack of Correlation Between HLA-C*06 and Family History of Psoriasis.
Psoriasis
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review.
Psoriasis
Paediatric Onset Psoriasis is Associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06.
Psoriasis
Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.
Psoriasis
Sequencing-based approach identified three new susceptibility loci for psoriasis.
Psoriasis
The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset.
Psoriasis
The association of HLA-C and ERAP1 polymorphisms in early and late onset psoriasis and psoriatic arthritis patients of Hungary.
Psoriasis
The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.
Psoriasis
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
Psoriasis
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Psoriasis
Tissue-Resident Memory CD8+ T Cells From Skin Differentiate Psoriatic Arthritis From Psoriasis.
Psoriasis
TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis.
Psoriasis
[CAPILLARY VISUALIZATION IN THE PAPILLARY BODY, ESPECIALLY IN PSORIASIS VULGARIS, BY MEANS OF THE LEUCINE-AMINOPEPTIDASE REACTION.]
Pyelonephritis
New sensitive markers for the detection of experimental ascending pyelonephritis.
Rheumatic Diseases
Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties.
Rheumatic Diseases
Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation.
Rheumatic Diseases
Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics.
Skin Diseases
ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland.
Skin Diseases
[Determination of leucine-aminopeptidase in the serum and blister fluid of some patients with skin diseases]
Spondylarthropathies
Spondyloarthropathies: HLA-B27 and ERAP1 contribute to ankylosing spondylitis via aberrant peptide processing and presentation.
Spondylitis
Investigating the genetic association between ERAP1 and ankylosing spondylitis.
Spondylitis
Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis.
Spondylitis, Ankylosing
A common functional variant of endoplasmic reticulum aminopeptidase 2 (ERAP2) that reduces major histocompatibility complex class I expression is not associated with ankylosing spondylitis.
Spondylitis, Ankylosing
A polymorphism in ERAP1 is associated with susceptibility to ankylosing spondylitis in a Turkish population.
Spondylitis, Ankylosing
Association analysis of ERAP1 gene single nucleotide polymorphism in susceptibility to ankylosing spondylitis in Iranian population.
Spondylitis, Ankylosing
Association between ERAP1 gene polymorphisms and ankylosing spondylitis susceptibility in Han population.
Spondylitis, Ankylosing
Association between single nucleotide polymorphisms in prospective genes and susceptibility to ankylosing spondylitis and inflammatory bowel disease in a single centre in Turkey.
Spondylitis, Ankylosing
Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.
Spondylitis, Ankylosing
Association of ankylosing spondylitis with HLA-B27 and ERAP1: pathogenic role of antigenic peptide.
Spondylitis, Ankylosing
Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: the rs27044 variant is associated with HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis.
Spondylitis, Ankylosing
Association of ERAP1 Allelic Variants with Risk of Ankylosing Spondylitis.
Spondylitis, Ankylosing
Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population.
Spondylitis, Ankylosing
Association of ERAP1, IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis.
Spondylitis, Ankylosing
Association of HLA-B27 and ERAP1 with ankylosing spondylitis susceptibility in Beijing Han Chinese.
Spondylitis, Ankylosing
Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population.
Spondylitis, Ankylosing
Association of polymorphisms in ERAP1 and risk of ankylosing spondylitis in a Chinese population.
Spondylitis, Ankylosing
Association of rs27044 and rs30187 polymorphisms in endoplasmic reticulum aminopeptidase 1 gene and ankylosing spondylitis susceptibility: A meta-analysis.
Spondylitis, Ankylosing
Association of the genetic variants in the endoplasmic reticulum aminopeptidase 2 gene with ankylosing spondylitis susceptibility.
Spondylitis, Ankylosing
Association study of ankylosing spondylitis and polymorphisms in ERAP1 gene in Zhejiang Han Chinese population.
Spondylitis, Ankylosing
Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
Spondylitis, Ankylosing
Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: An updated meta-analysis.
Spondylitis, Ankylosing
Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: A meta-analysis of East Asian Population.
Spondylitis, Ankylosing
Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.
Spondylitis, Ankylosing
Beyond the TNF-? Inhibitors: New and Emerging Targeted Therapies for Patients with Axial Spondyloarthritis and their Relation to Pathophysiology.
Spondylitis, Ankylosing
Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis.
Spondylitis, Ankylosing
Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands.
Spondylitis, Ankylosing
Corrigendum: Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
Spondylitis, Ankylosing
Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.
Spondylitis, Ankylosing
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Spondylitis, Ankylosing
Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis.
Spondylitis, Ankylosing
Dominant Role of the ERAP1 Polymorphism R528K in Shaping the HLA-B27 Peptidome Through Differential Processing Determined by Multiple Peptide Residues.
Spondylitis, Ankylosing
Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene.
Spondylitis, Ankylosing
Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis.
Spondylitis, Ankylosing
Endoplasmic reticulum aminopeptidase 1 and interleukin-23 receptor in ankylosing spondylitis.
Spondylitis, Ankylosing
Endoplasmic reticulum aminopeptidase 2 gene single nucleotide polymorphisms in association with susceptibility to ankylosing spondylitis in an Iranian population.
Spondylitis, Ankylosing
Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential.
Spondylitis, Ankylosing
ERAP1 allotypes impact the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection.
Spondylitis, Ankylosing
ERAP1 and ERAP2 Gene Variations Influence the Risk of Psoriatic Arthritis in Romanian Population.
Spondylitis, Ankylosing
ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population.
Spondylitis, Ankylosing
ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations.
Spondylitis, Ankylosing
ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis.
Spondylitis, Ankylosing
ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis.
Spondylitis, Ankylosing
ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role.
Spondylitis, Ankylosing
ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population.
Spondylitis, Ankylosing
ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface.
Spondylitis, Ankylosing
ERAP1 rs30187 single nucleotide polymorphism does not confer disease susceptibility in North Indian children with enthesitis-related arthritis.
Spondylitis, Ankylosing
ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases.
Spondylitis, Ankylosing
ERAP1 variants are associated with ankylosing spondylitis in East Asian population: a new Chinese case-control study and meta-analysis of published series.
Spondylitis, Ankylosing
ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients.
Spondylitis, Ankylosing
Evaluation of ERAP1 Gene Single Nucleotide Polymorphism in Impressing the Inflammatory Cytokine Profile of Ankylosing Spondylitis Patients.
Spondylitis, Ankylosing
Evaluation of ERAP1 gene single nucleotide polymorphisms in immunomodulation of pro-inflammatory and anti-inflammatory cytokines profile in ankylosing spondylitis.
Spondylitis, Ankylosing
Expression of MHC class I dimers and ERAP1 in an ankylosing spondylitis patient cohort.
Spondylitis, Ankylosing
Functional interaction of the ankylosing spondylitis associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo.
Spondylitis, Ankylosing
Functional Interaction of the Ankylosing Spondylitis Associated Endoplasmic Reticulum Aminopeptidase 2 with the HLA-B*27 Peptidome in Human Cells.
Spondylitis, Ankylosing
Functional variants of ERAP1 gene are associated with HLA-B27 positive spondyloarthritis.
Spondylitis, Ankylosing
Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.
Spondylitis, Ankylosing
Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients.
Spondylitis, Ankylosing
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
Spondylitis, Ankylosing
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
Spondylitis, Ankylosing
Investigating the genetic association between ERAP1 and ankylosing spondylitis.
Spondylitis, Ankylosing
Investigating the genetic association between ERAP1 and spondyloarthritis.
Spondylitis, Ankylosing
KIR3DL1 interaction with HLA-B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking.
Spondylitis, Ankylosing
Lack of Associations between Endoplasmic Reticulum Aminopeptidase 2 Gene Polymorphisms and Ankylosing Spondylitis: A Meta-analysis with Trial Sequential Analysis.
Spondylitis, Ankylosing
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.
Spondylitis, Ankylosing
Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.
Spondylitis, Ankylosing
Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to endoplasmic reticulum aminopeptidase 1 (ERAP1).
Spondylitis, Ankylosing
Protective effect of an ERAP1 haplotype in ankylosing spondylitis: investigating non-MHC genes in HLA-B27-positive individuals.
Spondylitis, Ankylosing
Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis.
Spondylitis, Ankylosing
Reply to Robinson and Brown: It is the combination of ERAP1 allotypes that identifies individuals with Ankylosing Spondylitis.
Spondylitis, Ankylosing
Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome.
Spondylitis, Ankylosing
Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms.
Spondylitis, Ankylosing
Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.
Spondylitis, Ankylosing
Spondyloarthropathies: HLA-B27 and ERAP1 contribute to ankylosing spondylitis via aberrant peptide processing and presentation.
Spondylitis, Ankylosing
Susceptibility to ankylosing spondylitis: evidence for the role of ERAP1, TGFb1 and TLR9 gene polymorphisms.
Spondylitis, Ankylosing
Susceptibility to ERAP1 gene single nucleotide polymorphism modulates the inflammatory cytokine setting in ankylosing spondylitis.
Spondylitis, Ankylosing
The association between seven ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis involving 8,530 cases and 12,449 controls.
Spondylitis, Ankylosing
The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.
Spondylitis, Ankylosing
The influence of ERAP1 gene variants on clinical phenotype in ankylosing spondylitis.
Spondylitis, Ankylosing
The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies.
Spondylitis, Ankylosing
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
Spondylitis, Ankylosing
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Squamous Cell Carcinoma of Head and Neck
Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.
Starvation
Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway.
Starvation
Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
Thrombophilia
Behçet disease (BD) and BD-like clinical phenotypes: NF-kB pathway in mucosal ulcerating diseases.
Thyroid Nodule
[Tumor markers in the cytodiagnosis of thyroid nodules. Detection of dipeptidyl aminopeptidase IV (DAP IV) activity]
Toxoplasmosis, Congenital
Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.
Trophoblastic Neoplasms
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells.
Trophoblastic Tumor, Placental Site
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells.
Tuberculosis
Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese.
Tuberculosis, Bovine
ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis.
Urinary Bladder Neoplasms
Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration.
Uterine Cervical Neoplasms
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.
Uterine Cervical Neoplasms
Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population.
Uterine Cervical Neoplasms
[Dynamics of the changes in cytosol aminopeptidase, aminopeptidase I (microsomal) and gamma-glutamyltransferase activities during brachytherapy of cancer of the uterine cervix and corpus]
Uveitis
Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.
Vasculitis
Behçet disease (BD) and BD-like clinical phenotypes: NF-kB pathway in mucosal ulcerating diseases.
Virus Diseases
Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.
Virus Diseases
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.
Virus Diseases
ERAP1 allotypes impact the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection.
Virus Diseases
Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection.
Virus Diseases
Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1.
Virus Diseases
Peptide Trimming for MHC Class I Presentation by Endoplasmic Reticulum Aminopeptidases.
Virus Diseases
Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese.
Virus Diseases
Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.
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