Reference on EC 3.4.11.14 - cytosol alanyl aminopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Starnes, W.L.; Szechinski, J.; Behal, F.J.
Human-liver alanine aminopeptidase. A kinin-converting enzyme sensitive to beta-lactam antibiotics
Eur. J. Biochem.
124
363-370
1982
Homo sapiens
Yamamoto, Y.; Li, Y.H.; Huang, K.; Ohkubo, I.; Nishi, K.
Isolation and characterization of an alanyl aminopeptidase from rat liver cytosol as a puromycin-sensitive enkephalin-degrading aminopeptidase
Biol. Chem.
379
711-719
1998
Rattus norvegicus
Garner, C.W.; Behal, F.J.
Hydrophobic binding sites of human liver alanine aminopeptidase
Arch. Biochem. Biophys.
182
667-673
1977
Homo sapiens
Little, G.H.; Starnes, W.L.; Behal, F.J.
Human liver aminopeptidase
Methods Enzymol.
45
495-503
1976
Homo sapiens
Garner, C.W.; Behal, F.J.
Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups
Biochemistry
14
5084-5088
1975
Homo sapiens
Garner, C.W.; Behal, F.J.
Human liver alanine aminopeptidase. Inhibition by amino acids
Biochemistry
14
3208-3212
1975
Homo sapiens
Starnes, W.L.; Behal, F.J.
A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein
Biochemistry
13
3221-3227
1974
Homo sapiens
Garner, C.W.; Behal, F.J.
Human liver aminopeptidase. Role of metal ions in mechanism of action
Biochemistry
13
3227-3233
1974
Homo sapiens
Kao, Y.J.; Starnes, W.L.; Behal, F.J.
Human kidney alanine aminopeptidase: physical and kinetic properties of a sialic acid containing glycoprotein
Biochemistry
17
2990-2994
1978
Homo sapiens
Fricke, B.; Aurich, H.
Periplasmic aminopeptidases in Acinetobacter calcoaceticus and Pseudomonas aeruginosa
J. Basic Microbiol.
33
291-299
1993
Acinetobacter calcoaceticus, Pseudomonas aeruginosa, Acinetobacter calcoaceticus 69-V
Jensch, T.; Fricke, B.
Localization of alanyl aminopeptidase and leucyl aminopeptidase in cells of Pseudomonas aeruginosa by application of different methods for periplasm release
J. Basic Microbiol.
37
115-128
1997
Pseudomonas aeruginosa
Larrinaga, G.; Callado, L.F.; Agirregoitia, N.; Varona, A.; Gil, J.
Subcellular distribution of membrane-bound aminopeptidases in the human and rat brain
Neurosci. Lett.
383
136-140
2005
Homo sapiens, Rattus norvegicus
Larrinaga, G.; Gil, J.; Meana, J.J.; Ruiz, F.; Callado, L.F.; Irazusta, J.
Aminopeptidase activity in the postmortem brain of human heroin addicts
Neurochem. Int.
46
213-219
2005
Homo sapiens
Hui, M.; Hui, K.S.
Neuron-specific aminopeptidase and puromycin-sensitive aminopeptidase in rat brain development
Neurochem. Res.
28
855-860
2003
Rattus norvegicus
Sanchez-Moran, E.; Jones, G.H.; Franklin, F.C.; Santos, J.L.
A puromycin-sensitive aminopeptidase is essential for meiosis in Arabidopsis thaliana
Plant Cell
16
2895-2909
2004
Arabidopsis thaliana
Varona, A.; Blanco, L.; Lopez, J.I.; Gil, J.; Agirregoitia, E.; Irazusta, J.; Larrinaga, G.
Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma
Am. J. Physiol. Renal Physiol.
292
F780-F788
2007
Homo sapiens
Ewing, M.A.; Wang, J.; Sheeley, S.A.; Sweedler, J.V.
Detecting D-amino acid-containing neuropeptides using selective enzymatic digestion
Anal. Chem.
80
2874-2880
2008
Sus scrofa
Sengupta, S.; Horowitz, P.M.; Karsten, S.L.; Jackson, G.R.; Geschwind, D.H.; Fu, Y.; Berry, R.W.; Binder, L.I.
Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro
Biochemistry
45
15111-15119
2006
Homo sapiens
Zambotti-Villela, L.; Yamasaki, S.C.; Villarroel, J.S.; Alponti, R.F.; Silveira, P.F.
Aspartyl, arginyl and alanyl aminopeptidase activities in the hippocampus and hypothalamus of streptozotocin-induced diabetic rats
Brain Res.
1170
112-118
2007
Rattus norvegicus
Lyczak, R.; Zweier, L.; Group, T.; Murrow, M.A.; Snyder, C.; Kulovitz, L.; Beatty, A.; Smith, K.; Bowerman, B.
The puromycin-sensitive aminopeptidase PAM-1 is required for meiotic exit and anteroposterior polarity in the one-cell Caenorhabditis elegans embryo
Development
133
4281-4292
2006
Caenorhabditis elegans
Bhutani, N.; Venkatraman, P.; Goldberg, A.L.
Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation
EMBO J.
26
1385-1396
2007
Homo sapiens
Banegas, I.; Barrero, F.; Duran, R.; Morales, B.; Luna, J.D.; Prieto, I.; Ramirez, M.; Alba, F.; Vives, F.
Plasma aminopeptidase activities in Parkinsons disease
Horm. Metab. Res.
38
758-760
2006
Homo sapiens
Bank, U.; Tadje, J.; Taeger, M.; Wolke, C.; Bukowska, A.; Ittenson, A.; Reinhold, D.; Helmuth, M.; Ansorge, S.; Shakespeare, A.; Vieth, M.; Malfertheiner, P.; Naumann, M.; Lendeckel, U.
Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice
Int. J. Mol. Med.
20
483-492
2007
Mus musculus
Segarra, A.B.; Wangensteen, R.; Ramirez, M.; Banegas, I.; Hermoso, F.; Vargas, F.; Vives, F.; Duran, R.; Alba, F.; de Gasparo, M.; Prieto, I.
Atrial angiotensinase activity in hypothyroid, euthyroid, and hyperthyroid rats
J. Cardiovasc. Pharmacol.
48
117-120
2006
Rattus norvegicus
Wherry, E.J.; Golovina, T.N.; Morrison, S.E.; Sinnathamby, G.; McElhaugh, M.J.; Shockey, D.C.; Eisenlohr, L.C.
Re-evaluating the generation of a "proteasome-independent" MHC class I-restricted CD8 T cell epitope
J. Immunol.
176
2249-2261
2006
Mus musculus
Towne, C.F.; York, I.A.; Neijssen, J.; Karow, M.L.; Murphy, A.J.; Valenzuela, D.M.; Yancopoulos, G.D.; Neefjes, J.J.; Rock, K.L.
Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections
J. Immunol.
180
1704-1712
2008
Mus musculus
Hui, K.S.
Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration
Neurochem. Res.
32
2062-2071
2007
Mus musculus, Rattus norvegicus
Karsten, S.L.; Sang, T.K.; Gehman, L.T.; Chatterjee, S.; Liu, J.; Lawless, G.M.; Sengupta, S.; Berry, R.W.; Pomakian, J.; Oh, H.S.; Schulz, C.; Hui, K.S.; Wiedau-Pazos, M.; Vinters, H.V.; Binder, L.I.; Geschwind, D.H.; Jackson, G.R.
A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration
Neuron
51
549-560
2006
Homo sapiens
Cicin-Sain, L.; Simaga, S.; Froebe, A.; Abramic, M.
Central aminopeptidase and serotonin system activities: possible relationship
Neuropeptides
42
435-440
2008
Rattus norvegicus
Lee, S.H.; Kim, H.G.
Cobalt chloride-induced downregulation of puromycin-sensitive aminopeptidase suppresses the migration and invasion of PC-3 cells
J. Microbiol. Biotechnol.
19
530-536
2009
Homo sapiens
Yanagi, K.; Tanaka, T.; Kato, K.; Sadik, G.; Morihara, T.; Kudo, T.; Takeda, M.
Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau
Psychogeriatrics
9
157-166
2009
Homo sapiens
Chen, S.H.; Cao, M.J.; Huang, J.Z.; Wu, G.P.
Identification of a puromycin-sensitive aminopeptidase from zebrafish (Danio rerio)
Comp. Biochem. Physiol. B
159
10-17
2011
Danio rerio
Menzies, F.M.; Hourez, R.; Imarisio, S.; Raspe, M.; Sadiq, O.; Chandraratna, D.; OKane, C.; Rock, K.L.; Reits, E.; Goldberg, A.L.; Rubinsztein, D.C.
Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy
Hum. Mol. Genet.
19
4573-4586
2010
Homo sapiens
Kudo, L.C.; Parfenova, L.; Ren, G.; Vi, N.; Hui, M.; Ma, Z.; Lau, K.; Gray, M.; Bardag-Gorce, F.; Wiedau-Pazos, M.; Hui, K.S.; Karsten, S.L.
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice
Hum. Mol. Genet.
20
1820-1833
2011
Homo sapiens
Ren, G.; Ma, Z.; Hui, M.; Kudo, L.C.; Hui, K.S.; Karsten, S.L.
Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis
Mol. Neurodegener.
6
29
2011
Homo sapiens
Kruppa, A.J.; Ott, S.; Chandraratna, D.S.; Irving, J.A.; Page, R.M.; Speretta, E.; Seto, T.; Camargo, L.M.; Marciniak, S.J.; Lomas, D.A.; Crowther, D.C.
Suppression of Abeta toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity
Biochim. Biophys. Acta
1832
2115-2126
2013
Drosophila melanogaster
Huber, R.J.; Catalano, A.; ODay, D.H.
Cyclin-dependent kinase 5 is a calmodulin-binding protein that associates with puromycin-sensitive aminopeptidase in the nucleus of Dictyostelium
Biochim. Biophys. Acta
1833
11-20
2013
Dictyostelium discoideum
ODay, D.; Catalano, A.; Poloz, Y.
A tale of three proteins: The nucleolar calmodulin-binding protein nucleomorphin and its binding partners calcium-binding protein 4A and puromycin-sensitive aminopeptidase
Calcium Signal.
2012
119-130
2012
Dictyostelium discoideum
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