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Disease on EC 3.2.2.23 - DNA-formamidopyrimidine glycosylase

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DISEASE
TITLE OF PUBLICATION
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Adenocarcinoma
Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer.
Adenocarcinoma of Lung
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
NEIL3 may act as a potential prognostic biomarker for lung adenocarcinoma.
Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer.
Adenoma
Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.
Rapid recognition of aberrant dHPLC elution profiles using the Transgenomic Navigator software.
Agammaglobulinemia
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
Alzheimer Disease
Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease.
Loss of NEIL1 causes defects in olfactory function in mice.
Asthma
DNA damage and glutathione level in children with asthma bronchiale: Effect of antiasthmatic therapy.
Astrocytoma
Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients.
Atherosclerosis
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Carcinogenesis
Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker.
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.
NEIL3 contributes toward the carcinogenesis of liver cancer and regulates PI3K/Akt/mTOR signaling.
Carcinoma
Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma.
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species.
NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity in suppressing mutations.
Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer.
Carcinoma, Hepatocellular
Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1.
NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice.
NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis.
Phase I studies of peptide vaccine cocktails derived from GPC3, WDRPUH and NEIL3 for advanced hepatocellular carcinoma.
Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3.
The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo.
Carcinoma, Non-Small-Cell Lung
A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma.
Carcinoma, Squamous Cell
Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma.
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
Cholangiocarcinoma
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma.
Cholangitis, Sclerosing
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma.
Cockayne Syndrome
Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase.
Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli formamidopyrimidine DNA glycosylase.
Defective repair of 5-hydroxy-2'-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III.
Oxidatively damaged DNA repair defect in cockayne syndrome and its complementation by heterologous repair proteins.
Colonic Neoplasms
Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells.
The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage.
Colorectal Neoplasms
Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.
Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer.
Common Variable Immunodeficiency
NEIL1 is a candidate gene associated with common variable immunodeficiency in a patient with a chromosome 15q24 deletion.
Diabetes Mellitus, Type 2
Identification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight.
Prevalence of the DNA repair enzyme-NEIL1 - gene mutation in patients with type 2 diabetes in the Turkish population.
Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects.
dna-formamidopyrimidine glycosylase deficiency
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.
Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice.
Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice.
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.
Dyslipidemias
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Esophageal Neoplasms
An NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy.
Genetic variations in DNA repair gene NEIL1 associated with radiation pneumonitis risk in lung cancer patients.
Fanconi Anemia
Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair.
Fanconi's anaemia cells have normal steady-state levels and repair of oxidative DNA base modifications sensitive to Fpg protein.
TRAIP is a master regulator of DNA interstrand crosslink repair.
Fatty Liver
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Glioblastoma
Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population.
Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients.
Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells.
NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks.
Glioma
Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer.
glutathione synthase deficiency
Oxidative DNA damage in cultured fibroblasts from patients with hereditary glutathione synthetase deficiency.
Heart Failure
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Hepatitis C
Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1.
HIV Infections
The base excision repair pathway is required for efficient lentivirus integration.
Hyperinsulinism
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Hypersensitivity
The Fanconi anemia pathway promotes DNA glycosylase-dependent excision of interstrand DNA crosslinks.
Infections
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
Ischemic Stroke
Ginsenoside Rd Attenuates DNA Damage by Increasing Expression of DNA Glycosylase Endonuclease VIII-like Proteins after Focal Cerebral Ischemia.
NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress.
Leukemia
DNA damage induced by photosensitizers in cellular and cell-free systems.
Oxidative DNA damage induced by potassium bromate under cell-free conditions and in mammalian cells.
Liver Diseases
Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1.
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Liver Neoplasms
NEIL3 contributes toward the carcinogenesis of liver cancer and regulates PI3K/Akt/mTOR signaling.
Lung Injury
Regulation of the angiotensin II-p22phox-reactive oxygen species signaling pathway, apoptosis and 8-oxoguanine-DNA glycosylase 1 retrieval in hyperoxia-induced lung injury and fibrosis in rats.
Lung Neoplasms
A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma.
Genetic variations in DNA repair gene NEIL1 associated with radiation pneumonitis risk in lung cancer patients.
Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer.
OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study.
Lymphatic Metastasis
Deficiency of NEIL3 Enhances the Chemotherapy Resistance of Prostate Cancer.
Lymphoma
Evaluation of mutagenic effects of hyperbaric oxygen (HBO) in vitro. II. Induction of oxidative DNA damage and mutations in the mouse lymphoma assay.
Genotoxicity of tungsten carbide-cobalt (WC-Co) nanoparticles in vitro: mechanisms-of-action studies.
Mesothelioma
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Mesothelioma, Malignant
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Metabolic Syndrome
Human polymorphic variants of the NEIL1 DNA glycosylase.
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Myocardial Infarction
Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study.
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Neoplasm Metastasis
Deficiency of NEIL3 Enhances the Chemotherapy Resistance of Prostate Cancer.
Neoplasms
A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma.
Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma.
Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma.
Expression patterns of Neil3 during embryonic brain development and neoplasia.
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing.
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin.
Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells.
NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity in suppressing mutations.
NEIL3 contributes toward the carcinogenesis of liver cancer and regulates PI3K/Akt/mTOR signaling.
NEIL3 may act as a potential prognostic biomarker for lung adenocarcinoma.
Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer.
Oxidative DNA damage induced by metabolites of chloramphenicol, an antibiotic drug.
PARP1 Co-Regulates EP300-BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair.
Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate.
Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer.
Nephritis
Genetic cause of immune dysregulation - one gene or two?
Nephrotic Syndrome
Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome.
Neuroblastoma
Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases.
Neuroinflammatory Diseases
NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress.
Obesity
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.
Obesity, Morbid
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Photosensitivity Disorders
Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization.
The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes.
Polycystic Ovary Syndrome
DNA damage, DNA susceptibility to oxidation and glutathione level in women with polycystic ovary syndrome.
Prion Diseases
Neil3 induced neurogenesis protects against prion disease during the clinical phase.
Prostatic Neoplasms
Deficiency of NEIL3 Enhances the Chemotherapy Resistance of Prostate Cancer.
Distinct Genomic Alterations in Prostate Tumors Derived from African American Men.
Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair.
Radiation Pneumonitis
Genetic variations in DNA repair gene NEIL1 associated with radiation pneumonitis risk in lung cancer patients.
Squamous Cell Carcinoma of Head and Neck
Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma.
Starvation
Contribution of E. coli AlkA, TagA glycosylases and UvrABC-excinuclease in MMS mutagenesis.
Effect of mutY and mutM/fpg-1 mutations on starvation-associated mutation in Escherichia coli: implications for the role of 7,8-dihydro-8-oxoguanine.
Mutation frequency decline in MMS-treated Escherichia coli K-12 mutS strains.
Prediction of DtxR regulon: identification of binding sites and operons controlled by Diphtheria toxin repressor in Corynebacterium diphtheriae.
Stomach Neoplasms
Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.
Three novel NEIL1 promoter polymorphisms in gastric cancer patients.
Stroke
Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice.
Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery.
Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice.
Tuberculosis
Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats.
Vitiligo
Increased oxidative DNA damage in mononuclear leukocytes in vitiligo.
Werner Syndrome
Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases.
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1.
Xeroderma Pigmentosum
Effect of the multifunctional proteins RPA, YB-1, and XPC repair factor on AP site cleavage by DNA glycosylase NEIL1.
Interaction of selenium compounds with zinc finger proteins involved in DNA repair.
Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms.
The human oxidative DNA glycosylase NEIL1 excises psoralen-induced interstrand DNA cross-links in a three-stranded DNA structure.