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Disease on EC 3.2.2.15 - DNA-deoxyinosine glycosylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
DNA damage responses in neural cells: Focus on the telomere.
Anemia, Hypochromic
Advanced loop-mediated isothermal amplification method for sensitive and specific detection of Tomato chlorosis virus using a uracil DNA glycosylase to control carry-over contamination.
Bloom Syndrome
Immunological alteration of the Bloom's syndrome uracil DNA glycosylase in Epstein-Barr virus-transformed human lymphoblastoid cells.
Immunological lesions in human uracil DNA glycosylase: association with Bloom syndrome.
Monoclonal antibodies detect conformational abnormality of uracil DNA glycosylase in Bloom's syndrome cells.
Purification and properties of the uracil DNA glycosylase from Bloom's syndrome.
Regulation of hypoxanthine DNA glycosylase in normal human and Bloom's syndrome fibroblasts.
Cardiovascular Diseases
Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases.
Chickenpox
Identification and characterization of the simian varicella virus uracil DNA glycosylase.
The simian varicella virus uracil DNA glycosylase and dUTPase genes are expressed in vivo, but are non-essential for replication in cell culture.
Colorectal Neoplasms
Analysis of uracil DNA glycosylase in human colorectal cancer.
Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil.
Ecthyma, Contagious
Characterization of GM-CSF-inhibitory factor and Uracil DNA glycosylase encoding genes from camel pseudocowpoxvirus.
Esophageal Neoplasms
The efficacy of uracil DNA glycosylase pretreatment in amplicon-based massively parallel sequencing with DNA extracted from archived formalin-fixed paraffin-embedded esophageal cancer tissues.
Genetic Diseases, Inborn
Purification and properties of the uracil DNA glycosylase from Bloom's syndrome.
Glioblastoma
Mutation of the uracil DNA glycosylase gene detected in glioblastoma.
Hepatitis B
Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA.
Herpes Simplex
Association between the herpes simplex virus-1 DNA polymerase and uracil DNA glycosylase.
Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system.
Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.
Reconstitution of uracil DNA glycosylase initiated base excision repair in herpes simplex virus-1.
Infarction, Middle Cerebral Artery
Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia.
Infections
A poxvirus-encoded uracil DNA glycosylase is essential for virus viability.
Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages.
Evidence for a cytopathogenicity determinant in HIV-1 Vpr.
X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells.
Lung Diseases
O(6)-methylguanine-DNA methyltransferase and uracil DNA glycosylase in human broncho-alveolar lavage cells and peripheral blood mononuclear cells from tobacco smokers and non-smokers.
Lung Neoplasms
[Expression of DNA excision repair enzymes and lung cancer prognosis]
Lymphoma, B-Cell
Mimicking damaged DNA with a small molecule inhibitor of human UNG2.
Neoplasms
Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination.
Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil.
Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.
Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU.
The dumbbell probe mediated triple cascade signal amplification strategy for sensitive and specific detection of uracil DNA glycosylase activity.
Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase.
Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed.
Neurodegenerative Diseases
DNA damage responses in neural cells: Focus on the telomere.
Plasmacytoma
Mammalian mitochondrial endonuclease activities specific for ultraviolet-irradiated DNA.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Frequently ABL kinase domain G:C?A:T mutation and uracil DNA glycosylase abnormal expression in TKI-resistant acute lymphoblastic leukemia of Chinese population].
Prostatic Neoplasms
Small interfering RNA-directed knockdown of uracil DNA glycosylase induces apoptosis and sensitizes human prostate cancer cells to genotoxic stress.
Stroke
DNA damage responses in neural cells: Focus on the telomere.
Tauopathies
Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis.
Tuberculosis
Substrate specificities and functional characterization of a thermo-tolerant uracil DNA glycosylase (UdgB) from Mycobacterium tuberculosis.
Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening.
Tumor Virus Infections
A poxvirus-encoded uracil DNA glycosylase is essential for virus viability.
Vaccinia
A poxvirus-encoded uracil DNA glycosylase is essential for virus viability.
Construction of a vaccinia virus deficient in the essential DNA repair enzyme uracil DNA glycosylase by a complementing cell line.
Crystallization and preliminary X-ray diffraction analysis of three recombinant mutants of Vaccinia virus uracil DNA glycosylase.
Dominant host range selection of vaccinia recombinants by rescue of an essential gene.
Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice.
Evaluation of the role of the vaccinia virus uracil DNA glycosylase and A20 proteins as intrinsic components of the DNA polymerase holoenzyme.
Highly efficient induction of protective immunity by a vaccinia virus vector defective in late gene expression.
Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase.
The vaccinia virus-encoded uracil DNA glycosylase has an essential role in viral DNA replication.
Vaccinia virus uracil DNA glycosylase has an essential role in DNA synthesis that is independent of its glycosylase activity: catalytic site mutations reduce virulence but not virus replication in cultured cells.
Vaccinia virus uracil DNA glycosylase interacts with the A20 protein to form a heterodimeric processivity factor for the viral DNA polymerase.