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Disease on EC 3.2.1.24 - alpha-mannosidase

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DISEASE
TITLE OF PUBLICATION
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Adenocarcinoma
Dual effect of 1-deoxymannojirimycin on the mannose uptake and on the N-glycan processing of the human colon cancer cell line HT-29.
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Swainsonine is a useful tool to monitor the intracellular traffic of N-linked glycoproteins as a function of the state of enterocytic differentiation of HT-29 cells.
alpha 1-Antitrypsin Deficiency
Altered alpha-mannosidase isoenzymes in the liver in hepatic cirrhosis.
alpha-mannosidase deficiency
Alpha-mannosidase activity in goats fed with Sida carpinifolia.
Alpha-mannosidosis.
Bilateral patellar dislocation associated with alpha-mannosidase deficiency.
Cell antigens recognized by rabbit antibodies specific for oligomannosyl determinants.
Characterization of alpha-mannosidase in feline mannosidosis.
Cloning and heterologous expression of glycosidase genes from Saccharomyces cerevisiae.
Enzyme replacement therapy for alpha-mannosidosis: 12 months follow-up of a single centre, randomised, multiple dose study.
Excretion of mannose-rich complex carbohydrates by a patient with alpha-mannosidase deficiency (mannosidosis).
Glycopeptide storage in skin fibroblasts cultured from a patient with alpha-mannosidase deficiency.
Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals.
Hereditary neurovisceral mannosidosis associated with alpha-mannosidase deficiency in a family of Persian cats.
Mannosidosis in three brothers--a review of the literature.
Mannosidosis. New clinical presentation, enzyme studied, and carbohydrate analysis.
Multiple suture synostosis, macrocephaly, and intracranial hypertension in a child with alpha-D-mannosidase deficiency. Case report.
Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment.
Retrovirus vector-mediated correction and cross-correction of lysosomal alpha-mannosidase deficiency in human and feline fibroblasts.
The substrate specificity of bovine and feline lysosomal alpha-D-mannosidases in relation to alpha-mannosidosis.
[Mannosidosis. Study of two families and prenatal diagnosis]
alpha-Mannosidosis
A human lysosomal alpha(1----6)-mannosidase active on the branched trimannosyl core of complex glycans.
A human lysosomal alpha-mannosidase specific for the core of complex glycans.
A multi-species comparative structural bioinformatics analysis of inherited mutations in alpha-D-mannosidase reveals strong genotype-phenotype correlation.
Alpha-mannosidase activity in goats fed with Sida carpinifolia.
Alpha-mannosidosis - a review of genetic, clinical findings and options of treatment.
Alpha-mannosidosis in the guinea pig: a new animal model for lysosomal storage disorders.
alpha-Mannosidosis in the guinea pig: cloning of the lysosomal alpha-mannosidase cDNA and identification of a missense mutation causing alpha-mannosidosis.
Alpha-mannosidosis.
Alpha-mannosidosis: correlation between phenotype, genotype and mutant MAN2B1 subcellular localisation.
alpha-Mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings.
Behavioural characterisation of the alpha-mannosidosis guinea pig.
Bilateral patellar dislocation associated with alpha-mannosidase deficiency.
Biological properties of D- and L-1-deoxyazasugars.
Cell antigens recognized by rabbit antibodies specific for oligomannosyl determinants.
Characterization of a novel alpha-mannosidosis-causing mutation and its use in leukocyte genotyping after bone marrow transplantation.
Characterization of alpha-mannosidase in feline mannosidosis.
Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice.
Clinical Improvement of Alpha-mannosidosis Cat Following a Single Cisterna Magna Infusion of AAV1.
Cloning and heterologous expression of glycosidase genes from Saccharomyces cerevisiae.
Cognitive profile and activities of daily living: 35 patients with alpha-mannosidosis.
Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosis.
Developmental analysis of CNS pathology in the lysosomal storage disease alpha-mannosidosis.
Diagnosis of alpha-mannosidosis by measuring alpha-mannosidase in plasma.
Direct transfer in vitro of alpha-D-mannosidase activity from normal lymphocytes to fibroblasts of a patient with alpha-mannosidosis.
Disease progression of alpha-mannosidosis and impact on patients and carers - A UK natural history survey.
Early biochemical effects of velmanase alfa in a 7-month-old infant with alpha-mannosidosis.
Early onset alpha-mannosidosis with slow progression in three Hispanic males.
Efficacy and safety of Velmanase alfa in the treatment of patients with alpha-mannosidosis: results from the core and extension phase analysis of a phase III multicentre, double-blind, randomised, placebo-controlled trial.
Efficacy of enzyme replacement therapy in alpha-mannosidosis mice: a preclinical animal study.
Enzyme replacement therapy for alpha-mannosidosis: 12 months follow-up of a single centre, randomised, multiple dose study.
Enzyme replacement therapy in alpha-mannosidosis guinea-pigs.
Enzyme replacement therapy with velmanase alfa (human recombinant alpha-mannosidase): Novel global treatment response model and outcomes in patients with alpha-mannosidosis.
Excretion of mannose-rich complex carbohydrates by a patient with alpha-mannosidase deficiency (mannosidosis).
First-trimester diagnosis of an unusual case of alpha-mannosidosis.
Funtional characterization of four novel MAN2B1 mutations causing juvenile onset alpha-mannosidosis.
Genomic structure of the human lysosomal alpha-mannosidase gene (MANB).
Glycopeptide storage in skin fibroblasts cultured from a patient with alpha-mannosidase deficiency.
Haemopoietic chimaerism: a complication in heterozygote detection tests for inherited defects in cattle.
Hereditary neurovisceral mannosidosis associated with alpha-mannosidase deficiency in a family of Persian cats.
Histopathology, electrodiagnostic testing, and magnetic resonance imaging show significant peripheral and central nervous system myelin abnormalities in the cat model of alpha-mannosidosis.
Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNA.
Identification and characterization of five novel MAN2B1 mutations in Italian patients with alpha-mannosidosis.
Identification of 83 novel alpha-mannosidosis-associated sequence variants: Functional analysis of MAN2B1 missense mutations.
Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.
Intellectual functioning in alpha-mannosidosis.
Late-onset retinal dystrophy in alpha-mannosidosis.
Lectin histochemistry of the central nervous system in a case of feline alpha-mannosidosis.
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Lysosomal alpha-mannosidase and alpha-mannosidosis.
Magnetic resonance spectroscopy of the occipital cortex and the cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats.
Mannosidosis in three brothers--a review of the literature.
Mannosidosis. New clinical presentation, enzyme studied, and carbohydrate analysis.
Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosis.
Morphopathological features in tissues of alpha-mannosidosis guinea pigs at different gestational ages.
Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment.
Natural history of alpha mannosidosis a longitudinal study.
Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis.
Over-expression of human lysosomal alpha-mannosidase in mouse embryonic stem cells.
Purification and characterization of recombinant human lysosomal alpha-mannosidase.
Purification of bovine lysosomal alpha-mannosidase, characterization of its gene and determination of two mutations that cause alpha-mannosidosis.
Purification of feline lysosomal alpha-mannosidase, determination of its cDNA sequence and identification of a mutation causing alpha-mannosidosis in Persian cats.
Recognition of alpha-mannosidosis in paediatric and adult patients: Presentation of a diagnostic algorithm from an international working group.
Retrovirus vector-mediated correction and cross-correction of lysosomal alpha-mannosidase deficiency in human and feline fibroblasts.
Reversal of peripheral and central neural storage and ataxia after recombinant enzyme replacement therapy in alpha-mannosidosis mice.
Sisters with alpha-mannosidosis and systemic lupus erythematosus.
Spectrum of mutations in alpha-mannosidosis.
Substrate specificities of rat kidney lysosomal and cytosolic alpha-D-mannosidases and effects of swainsonine suggest a role of the cytosolic enzyme in glycoprotein catabolism.
Survival and engraftment of mouse embryonic stem cell-derived implants in the guinea pig brain.
Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis.
The SPARKLE registry: protocol for an international prospective cohort study in patients with alpha-mannosidosis.
The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation.
The substrate specificity of bovine and feline lysosomal alpha-D-mannosidases in relation to alpha-mannosidosis.
The substrate-specificity of human lysosomal alpha-D-mannosidase in relation to genetic alpha-mannosidosis.
Two novel mutations in the gene for human alpha-mannosidase that cause alpha-mannosidosis.
Ultra-orphan lysosomal storage diseases: A cross-sectional quantitative analysis of the natural history of alpha-mannosidosis.
Use of the Bruininks-Oseretsky test of motor proficiency (BOT-2) to assess efficacy of velmanase alfa as enzyme therapy for alpha-mannosidosis.
[Adult leukoencephalopathy caused by alpha-mannosidosis deficiency]
[Mannosidosis. Study of two families and prenatal diagnosis]
Alzheimer Disease
Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies.
Amyotrophic Lateral Sclerosis
Alpha-D-mannosidase properties in serum of patients with amyotrophic lateral sclerosis.
Anaphylaxis
A case of anaphylaxis due to alpha-mannosidase from Auricularia.
Anemia
A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus.
Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding alpha-mannosidase II.
Anemia, Dyserythropoietic, Congenital
A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus.
HEMPAS disease: genetic defect of glycosylation.
HEMPAS. Hereditary erythroblastic multinuclearity with positive acidified serum lysis test.
Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding alpha-mannosidase II.
Arteritis
Coronavirus interactions with the cellular autophagy machinery.
Arthritis, Rheumatoid
Activity of lysosomal exoglycosidases in serum and synovial fluid in patients with chronic Lyme and rheumatoid arthritis.
Ataxia
Mannosidosis: two brothers with different degrees of disease severity.
Autoimmune Diseases
Genetic remodeling of protein glycosylation in vivo induces autoimmune disease.
Innate immune response triggers lupus-like autoimmune disease.
Blister
Reversible cellular damage by dimethyl sulfoxide reflected by release of marker enzymes for intracellular fractions.
Breast Neoplasms
Beta-galactosidase and alpha-mannosidase inhibit formation of multicellular nodules in breast cancer cell cultures.
Reduced mannosidase MAN1A1 expression leads to aberrant N-glycosylation and impaired survival in breast cancer.
Bronchitis
Coronavirus interactions with the cellular autophagy machinery.
Candidiasis
Enhanced enzymatic activity of Candida species responsible for oral candidiasis in renal transplant recipients.
Increased sensitivity of mannanemia detection tests by joint detection of alpha- and beta-linked oligomannosides during experimental and human systemic candidiasis.
Carcinoma
?-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.
Golgi Alpha-Mannosidase II as a Novel Biomarker Predicts Prognosis in Clear Cell Renal Cell Carcinoma.
Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.
Inhibition of alpha-mannosidase Man2c1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis.
The histochemistry of glycosidases in human benign and malignant breast tissue.
Carcinoma, Hepatocellular
Activities of serum enzymes in patients with viral hepatitis B, posthepatitic cirrhosis and hepatocellular carcinoma.
Comparative study of high-mannose-type oligosaccharides in membrane glycoproteins of rat hepatocytes and different rat hepatoma cell lines.
Further studies on the role of glycosylation in thyroxine-binding globulin secretion by human hepatoma (HEP G2) cells.
Glycosidases in normal and regenerating chicken liver, hepatoma Mc-29, Rous sarcoma, in turkey poult liver and hemocytoblastomes, provoked by the leukosis virus strain Mc-31.
Serum and host liver activities of glycosidases and sialyltransferases in animals bearing transplantable tumors.
The soluble form of rat liver alpha-mannosidase is immunologically related to the endoplasmic reticulum membrane alpha-mannosidase.
[The influence of tumor growth on natural cytotoxicity and activity of some lysosomal enzymes of human effector cells and the C3HA mouse splenocytes]
[Value of serum glycosidase spectrum in the diagnosis of hepatocellular carcinoma]
Carcinoma, Renal Cell
Golgi Alpha-Mannosidase II as a Novel Biomarker Predicts Prognosis in Clear Cell Renal Cell Carcinoma.
Carcinoma, Squamous Cell
Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1.
Cataract
Fine mapping of the keratoconus with cataract locus on chromosome 15q and candidate gene analysis.
Variation in glycosidase activity in soluble fractions in ICR/f rat lenses with the progression of cataract formation.
Cholesteatoma
Catabolism of glycoconjugates in chronic otitis media with cholesteatoma.
Chondrosarcoma
Incorporation of mannose 6-phosphate receptors into liposomes. Receptor topography and binding of alpha-mannosidase.
Monoclonal antibodies as probes for determining the microheterogeneity of the link proteins of cartilage proteoglycan.
Choriocarcinoma
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.
Colonic Neoplasms
Lysosomal exoglycosidases in serum and urine of patients with colon adenocarcinoma.
The N-glycan processing in HT-29 cells is a function of their state of enterocytic differentiation. Evidence for an atypical traffic associated with change in polypeptide stability in undifferentiated HT-29 cells.
Cone Dystrophy
Progressive cone dystrophy associated with low alpha-L-fucosidase activity in serum and leukocytes.
Congenital Disorders of Glycosylation
beta-hexosaminidase, alpha-D-mannosidase, and beta-mannosidase expression in serum from patients with carbohydrate-deficient glycoprotein syndrome type I.
Coronavirus Infections
Coronavirus interactions with the cellular autophagy machinery.
COVID-19
Coronavirus interactions with the cellular autophagy machinery.
Craniosynostoses
Multiple suture synostosis, macrocephaly, and intracranial hypertension in a child with alpha-D-mannosidase deficiency. Case report.
Cystic Fibrosis
Acid hydrolases in sera and plasma from patients with cystic fibrosis.
Cobalamin R binder as a possible model molecule for glycoprotein study in cystic fibrosis.
Cystic fibrosis: decreased thermostability of alpha-mannosidase in crude extracellular fluids of patients and carriers.
Detection of cystic fibrosis homozygotes and heterozygotes with plasma.
Diagnosis of cystic fibrosis homozygotes and heterozygotes from plasma and fibroblast cultures. A three-generation family study.
Intracellular and extracellular alpha-D-mannosidase activity of cultured skin fibroblasts: relationship to cystic fibrosis.
Plasma and submandibular saliva lysosomal enzymes in cystic fibrosis.
Serum lysosomal hydrolases in cystic fibrosis.
Studies in meconium in cystic fibrosis: the activities of alpha-D-mannosidase, beta-glucuronidase, beta-D-fucosidase, acid and alkaline phosphatase.
Thermostability of alpha-mannosidase in plasma from cystic fibrosis patients and carriers.
Dementia
Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies.
Loss of endoplasmic reticulum-associated enzymes in affected brain regions in Huntington's disease and Alzheimer-type dementia.
Dermatitis
[Outline of the pathology of the Langerhans cell system]
Dermatitis, Contact
[Outline of the pathology of the Langerhans cell system]
Dermatitis, Exfoliative
A lysosomal storage disorder of the epidermis characterized by a deficiency of alpha-mannosidase and an accumulation of mannose-rich materials.
Diabetes Mellitus
Alterations in the activity of several glycohydrolases in red blood cell membrane from type 2 diabetes mellitus patients.
Decreased serum beta-D-mannosidase activity in diabetic patients, in comparison with other glycosidases.
Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.
Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy.
Diabetes Mellitus, Type 1
Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy.
Diabetes Mellitus, Type 2
Alterations in the activity of several glycohydrolases in red blood cell membrane from type 2 diabetes mellitus patients.
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.
Diabetic Nephropathies
Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy.
Dystonic Disorders
Elevated beta-N-acetylhexosaminidase activity in focal dystonia fibroblasts.
Encephalitis, Japanese
Effects on alpha-mannosidase on the active site of Japanese encephalitis viral receptor.
Exostoses
[Primary study on glycan structure in pathopoiesis mechanism of recurrent respiratory papillomatosis]
Fabry Disease
Production in yeast of alpha-galactosidase A, a lysosomal enzyme applicable to enzyme replacement therapy for Fabry disease.
Fructose Intolerance
Plasma lysosomal enzyme activities in congenital disorders of glycosylation, galactosemia and fructosemia.
Fucosidosis
Alpha-L-fucosidase and alpha-D-mannosidase activity in the white blood cells in the disease and carrier state of fucosidosis.
Galactosemias
Plasma lysosomal enzyme activities in congenital disorders of glycosylation, galactosemia and fructosemia.
Gaucher Disease
Elevation of serum beta-hexosaminidase and alpha-D-mannosidase in type 2 Gaucher disease: a clinical and biochemical study.
Genetic Diseases, Inborn
Bilateral patellar dislocation associated with alpha-mannosidase deficiency.
Cemented total hip arthroplasty in a patient with alpha-mannosidosis: a case report.
Gingivitis
Glycosidase activities in gingival crevicular fluid in subjects with adult periodontitis or gingivitis.
Glioblastoma
Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells.
Glioma
Activity of lysosomal exoglycosidases in human gliomas.
Graves Disease
Serum lysosomal acid hydrolase activities in Graves' disease.
Gray Platelet Syndrome
Grey platelet syndrome: studies on platelet alpha-granules, lysosomes and defective response to thrombin.
Hemochromatosis
[A study of lysosomal enzyme activities in serum and leukocytes in chronic hepatic disease (author's transl)]
Hepatitis
Activities of serum enzymes in patients with viral hepatitis B, posthepatitic cirrhosis and hepatocellular carcinoma.
Coronavirus interactions with the cellular autophagy machinery.
Hepatitis, Chronic
Activities of serum enzymes in patients with viral hepatitis B, posthepatitic cirrhosis and hepatocellular carcinoma.
Herpes Simplex
Coronavirus interactions with the cellular autophagy machinery.
Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1.
Removal of N-linked carbohydrates decreases the infectivity of herpes simplex virus type 1.
Herpes Zoster
Essential role of the nonreducing terminal alpha-mannosyl residues of the N-linked carbohydrate chain of bovine zona pellucida glycoproteins in sperm-egg binding.
Evidence for the presence of high-mannose/hybrid oligosaccharide chain(s) on the mouse ZP2 and ZP3.
Human sperm plasma membranes possess alpha-D-mannosidase activity but no galactosyltransferase activity.
Inhibition of the mouse sperm surface alpha-D-mannosidase inhibits sperm-egg binding in vitro.
Mannose-binding molecules of rat spermatozoa and sperm-egg interaction.
Novel alpha-D-mannosidase of rat sperm plasma membranes: characterization and potential role in sperm-egg interactions.
Histiocytosis
Congenital histiocytosis. A heterogeneous group of diseases, one presenting as so-called congenital self-healing histiocytosis.
Histiocytosis, Langerhans-Cell
alpha-D-mannosidase activity in histiocytosis X.
Congenital histiocytosis. A heterogeneous group of diseases, one presenting as so-called congenital self-healing histiocytosis.
[Outline of the pathology of the Langerhans cell system]
Huntington Disease
Loss of endoplasmic reticulum-associated enzymes in affected brain regions in Huntington's disease and Alzheimer-type dementia.
Hutchinson's Melanotic Freckle
Enzyme histochemistry of human melanomas and pigmented naevi with special reference to alpha-D-mannosidase activity.
Hyperthyroidism
Graves' disease-associated changes in the serum lysosomal glycosidases activity and the glycosaminoglycan content.
Serum lysosomal acid hydrolase activities in Graves' disease.
Infections
Elevated levels of activities of beta-hexosaminidase and alpha-mannosidase in human immunodeficiency virus-infected patients.
Isolation and characterization of a class II alpha-mannosidase cDNA from lepidopteran insect cells.
Processing of N-linked oligosaccharides on the measles virus glycoproteins: importance for antigenicity and for production of infectious virus particles.
Unusual clinical and ultrastructural features in a boy with biochemically typical mannosidosis.
[Study of lysosomal enzymes in chick embryo fibroblasts infected with microorganisms of family Halprowiaceae (Chlamydiaceae)]
Influenza in Birds
Structure of the N- and O-glycans of the A-chain of human plasma alpha 2HS-glycoprotein as deduced from the chemical compositions of the derivatives prepared by stepwise degradation with exoglycosidases.
Influenza, Human
Inhibition of mouse liver sialidase by plant flavonoids.
The role of carbohydrate in determining the immunochemical properties of the hemagglutinin of influenza A virus.
Use of HDEL-tagged Trichoderma reesei mannosyl oligosaccharide 1,2-alpha-D-mannosidase for N-glycan engineering in Pichia pastoris.
[Role of carbohydrates in the manifestation of the hemagglutinating and neuraminidase activities of the influenza virus]
Intellectual Disability
A new variant of mannosidosis with increased residual enzymatic activity and mild clinical manifestation.
Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence.
Mannosidosis: two brothers with different degrees of disease severity.
Mutations in the Alpha 1,2-Mannosidase Gene, MAN1B1, Cause Autosomal-Recessive Intellectual Disability.
Intracranial Hypertension
Multiple suture synostosis, macrocephaly, and intracranial hypertension in a child with alpha-D-mannosidase deficiency. Case report.
Keratitis, Herpetic
[Use of tear enzyme assay to predict recurrent herpetic keratitis in children]
Keratoconus
Fine mapping of the keratoconus with cataract locus on chromosome 15q and candidate gene analysis.
Kwashiorkor
Lysosomal enzymuria in protein energy malnutrition.
Leiomyoma
Transethnic and race-stratified genome-wide association study of fibroid characteristics in African American and European American women.
Lentigo
Enzyme histochemistry of human melanomas and pigmented naevi with special reference to alpha-D-mannosidase activity.
Leukemia
Biochemical activities of lysosomal acid hydrolases in leukemic cells.
Serum and host liver activities of glycosidases and sialyltransferases in animals bearing transplantable tumors.
Leukemia, Hairy Cell
Biochemical activities of lysosomal acid hydrolases in leukemic cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Acid alpha-D-mannosidase of human leukocytes in the norm and during chronic myeloid leukemia]
Leukemia, T-Cell
Biochemical activities of lysosomal acid hydrolases in leukemic cells.
Leukoencephalopathies
[Adult leukoencephalopathy caused by alpha-mannosidosis deficiency]
Liver Cirrhosis
Altered alpha-mannosidase isoenzymes in the liver in hepatic cirrhosis.
Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.
Serum alpha-mannosidase in patients with alcoholic liver disease.
Liver Cirrhosis, Alcoholic
Altered alpha-mannosidase isoenzymes in the liver in hepatic cirrhosis.
Influence of ethanol on the human serum level of beta-hexosaminidase.
[A study of lysosomal enzyme activities in serum and leukocytes in chronic hepatic disease (author's transl)]
Liver Diseases
[A study of lysosomal enzyme activities in serum and leukocytes in chronic hepatic disease (author's transl)]
[Value of serum glycosidase spectrum in the diagnosis of hepatocellular carcinoma]
Liver Diseases, Alcoholic
Serum alpha-mannosidase in patients with alcoholic liver disease.
Lupus Erythematosus, Systemic
Studies on the activity of selected lysosomal exoglycosidases in patients with systemic lupus erythematosus.
Lyme Disease
Activity of lysosomal exoglycosidases in the serum of patients with chronic Lyme arthritis.
Lymphoproliferative Disorders
Acidic alpha-D-mannosidase in phenotypically different leukemic lymphoid cells.
Lysosomal Storage Diseases
Characterization of human liver alpha-D-mannosidase purified by affinity chromatography.
Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice.
Cognitive profile and activities of daily living: 35 patients with alpha-mannosidosis.
Developmental analysis of CNS pathology in the lysosomal storage disease alpha-mannosidosis.
Diagnosis of alpha-mannosidosis by measuring alpha-mannosidase in plasma.
Direct enzyme transfer from lymphocytes corrects a lysosomal storage disease.
Enzyme replacement therapy for alpha-mannosidosis: 12 months follow-up of a single centre, randomised, multiple dose study.
Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNA.
Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.
Late-onset retinal dystrophy in alpha-mannosidosis.
Magnetic resonance spectroscopy of the occipital cortex and the cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats.
Multiple suture synostosis, macrocephaly, and intracranial hypertension in a child with alpha-D-mannosidase deficiency. Case report.
Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis.
Neutral alpha-mannosidase activity in human serum.
Survival and engraftment of mouse embryonic stem cell-derived implants in the guinea pig brain.
Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis.
[Adult leukoencephalopathy caused by alpha-mannosidosis deficiency]
[Mannosidosis. Study of two families and prenatal diagnosis]
Macular Degeneration
A donor-age-dependent change in the activity of alpha-mannosidase in human cultured RPE cells.
Progressive cone dystrophy associated with low alpha-L-fucosidase activity in serum and leukocytes.
Malnutrition
Serum lysosomal hydrolases in cystic fibrosis.
Mannosidase Deficiency Diseases
A granulocyte test for detection of cattle heterozygous for mannosidosis.
A serological investigation into the acidic alpha-D-mannosidase in normal Angus cattle and in a calf with mannosidosis.
Activation of residual acidic alpha-mannosidase activity in mannosidosis tissues by metal ions.
An improved fluorimetric determination of alpha-mannosidase activity in bovine plasma.
Apparently normal extracellular acidic alpha-mannosidase in fibroblast cultures from patients with mannosidosis.
Bilateral patellar dislocation associated with alpha-mannosidase deficiency.
Cemented total hip arthroplasty in a patient with alpha-mannosidosis: a case report.
Characterization of alpha-mannosidase in feline mannosidosis.
Characterization of human liver alpha-D-mannosidase purified by affinity chromatography.
Characterization of oligosaccharides from the urine of loco-intoxicated sheep.
Characterization of the mutant alpha-mannosidase in bovine mannosidosis.
Comparison of the residual acidic alpha-D-mannosidase in three cases of mannosidosis.
Direct enzyme transfer from lymphocytes corrects a lysosomal storage disease.
Evidence for material from mannosidosis fibroblasts crossreacting with anti-acidic alpha-mannosidase antibodies.
Evidence that the mutant enzyme in fibroblasts of a patient with mannosidosis does not crossreact with antiserum raised against normal acidic alpha-D-mannosidase.
Glycopeptide storage in skin fibroblasts cultured from a patient with alpha-mannosidase deficiency.
Hereditary neurovisceral mannosidosis associated with alpha-mannosidase deficiency in a family of Persian cats.
Identification of mannosidosis heterozygotes--factors affecting normal plasma alpha-mannosidase levels.
Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.
Intermediate golgi alpha-D-mannosidosis and mucolipidosis II and III.
Isozyme pattern of leukocyte alpha-D-mannosidase in patients with mannosidosis.
Lymphocyte alpha-mannosidase -- a supplementary test for determining mannosidosis genotype in cattle.
Lymphocytes transfer only the lysosomal form of alpha-D-mannosidase during cell-to-cell contact.
Lysosomal alpha-mannosidase and alpha-mannosidosis.
Lysosomal glycosidase activities in human hair roots.
Mannosidosis in Galloway calves.
Mannosidosis. New clinical presentation, enzyme studied, and carbohydrate analysis.
Mannosidosis: assignment of the lysosomal alpha-mannosidase B gene to chromosome 19 in man.
Mannosidosis: clinical, morphologic, immunologic, and biochemical studies.
Mannosidosis: deficiency of a specific alpha-mannosidase component in cultured fibroblasts.
Mannosidosis: phenotype of a severely affected child and characterization of alpha-mannosidase activity in cultured fibroblasts from the patient and his parents.
Mannosidosis: separation and characterization of two acid alpha-mannosidase forms in mutant fibroblasts.
Mannosidosis: studies of the alpha-D-mannosidase isozymes in health and disease.
Mannosidosis: two brothers with different degrees of disease severity.
Measurement of the alpha-mannosidase activities in human plasma by a differential assay.
Modified granulocyte test for determination of mannosidosis genotype of cattle.
Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment.
Neutral alpha-mannosidase activity in human serum.
Normal extracellular excretion of acidic alpha-mannosidase activity by mannosidosis fibroblast cultures.
Novel human pathological mutations. Gene symbol: MAN2B1. Disease: Mannosidosis, alpha.
Ocular findings in mannosidosis.
Preliminary characterization of the mutant alpha-mannosidase in bovine mannosidosis [proceedings]
Properties of alpha-mannosidase in mannosidosis.
Reactivating factors of human alpha-mannosidase mutant.
Residual altered alpha-mannosidase in human mannosidosis.
Residual mannosidase activity in human mannosidosis: characterization of the mutant enzyme.
Storage of mannose-containing material in cultured human mannosidosis cells and metabolic correction by pig kidney alpha-mannosidase.
Synthesis of lysosomal alpha-mannosidase in normal and mannosidosis fibroblasts.
The nature of the residual alpha-mannosidase in plasma in bovine mannosidosis.
The storage products in genetic and swainsonine-induced human mannosidosis.
Unusual clinical and ultrastructural features in a boy with biochemically typical mannosidosis.
[Mannosidosis. Study of two families and prenatal diagnosis]
Massive Hepatic Necrosis
Activities of serum enzymes in patients with viral hepatitis B, posthepatitic cirrhosis and hepatocellular carcinoma.
Megalencephaly
Multiple suture synostosis, macrocephaly, and intracranial hypertension in a child with alpha-D-mannosidase deficiency. Case report.
Melanoma
Approaches to prove the melanoma origin in amelanotic human melanoma cell lines.
Biochemical characterization of a new melanoma model--the minipig MeLiM strain.
Disparate behaviour of two melanosomal enzymes (alpha-mannosidase and gamma-glutamyltransferase).
Enzyme histochemistry of human melanomas and pigmented naevi with special reference to alpha-D-mannosidase activity.
Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells.
Human melanoma cell invasion is inhibited in vitro by swainsonine and deoxymannojirimycin with a concomitant decrease in collagenase IV expression.
Human melanoma cell lines: morphology, growth, and alpha-mannosidase characteristics.
Influence of N-glycan processing disruption on tyrosinase and melanin synthesis in HM3KO melanoma cells.
Inhibition of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A.
Meningitis, Aseptic
Increased activity of lysosomal acid hydrolases in the cell-free cerebrospinal fluid of bacterial meningitis.
Meningitis, Bacterial
CSF lysosomal hydrolase activity as an aid in the diagnosis of bacterial meningitis.
Increased activity of lysosomal acid hydrolases in the cell-free cerebrospinal fluid of bacterial meningitis.
Mesenteric Lymphadenitis
Increased activity of lysosomal enzymes in the peritoneal fluid of bacterial peritonitis.
Mucolipidoses
alpha-D-mannosidase in the liver and brain from patients with I-cell disease.
Altered serum alpha-D-mannosidase activity in mucolipidosis II and mucolipidosis III.
Electrophoretic analysis of glycoprotein enzymes in the sialidoses and mucolipidoses.
Intermediate golgi alpha-D-mannosidosis and mucolipidosis II and III.
Light and heavy lysosomes: characterization of N-acetyl-beta-D-hexosaminidase isolated from normal and I-cell disease lymphoblasts.
Molecular forms of beta-hexosaminidase and alpha-mannosidase in cell cultures from patients with mucolipidosis types II and III.
Plasma alpha-D-mannosidase in mucolipidosis II and mucolipidosis III.
Prenatal diagnosis of I-cell disease by measuring altered alpha-mannosidase activity in amniotic fluid.
Mucopolysaccharidoses
[Biochemical diagnosis of mannosidosis in 2 families]
Mucopolysaccharidosis IV
An autophagic vacuolar myopathy-like disorder presenting as nonimmune hydrops in a female fetus.
Multiple Sclerosis
Quality of life as a measure of rehabilitation outcome in patients with multiple sclerosis.
Muscle Weakness
Skeletal muscle pathology of mannosidosis in two siblings with spastic paraplegia.
Muscular Atrophy, Spinal
Plasma lysosomal enzyme levels in patients with motor neuron disease.
Mycosis Fungoides
[Outline of the pathology of the Langerhans cell system]
Myeloproliferative Disorders
Platelet lysosomal enzymes are normal in myeloproliferative disorders.
Myocardial Infarction
Influence of isoproterenol-induced myocardial infarction on certain glycohydrolases and cathepsins in rats.
Myopia
Progressive cone dystrophy associated with low alpha-L-fucosidase activity in serum and leukocytes.
Nasopharyngeal Carcinoma
Inhibition of 6A8 alpha-mannosidase gene expression resulted in telomere length shortening in nasopharyngeal carcinoma cell CNE-2L2.
Inhibition of malignant activities of nasopharyngeal carcinoma cells with high expression of CD44 by siRNA.
Inhibition of metastasis to lung of a human nasopharyngeal carcinoma cell line CNE- 2L2 transfected with pRc/ CMV-antisense 6A8 cDNA in nude mice.
Suppression of 6A8 alpha-mannosidase gene expression reduced the potentiality of growth and metastasis of human nasopharyngeal carcinoma.
[6A8 cDNA encodes A type of alpha-mannosidase]
[Differential gene expression in nasopharyngeal carcinoma cell with reduced and normal expression of 6A8 alpha-mannosidase]
[Growth inhibition of human nasopharyngeal carcinoma cell CNE-2L2 caused by suppression of 6A8 alpha-mannosidase expression]
[Molecular mechanism of metastasis inhibition of nasopharyngeal carcinoma cell CNE-2L2 induced by reduction of 6A8 alpha-mannosidase expression]
Neoplasm Metastasis
A phase I study of swainsonine in patients with advanced malignancies.
Inhibition of metastasis to lung of a human nasopharyngeal carcinoma cell line CNE- 2L2 transfected with pRc/ CMV-antisense 6A8 cDNA in nude mice.
Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies.
Stimulation of DNA synthesis in murine lymphocytes by the drug swainsonine: immunomodulatory properties.
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
Suppression of 6A8 alpha-mannosidase gene expression reduced the potentiality of growth and metastasis of human nasopharyngeal carcinoma.
[Effects of human alpha-mannosidase Man2c1 transgene on growth and metastasis of transplanted tumor in mice]
[Inhibition effect of Swainsonine on the growth and metastasis of gastric cancer in vivo]
[Molecular mechanism of metastasis inhibition of nasopharyngeal carcinoma cell CNE-2L2 induced by reduction of 6A8 alpha-mannosidase expression]
Neoplasms
?-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.
A long-wavelength fluorescent substrate for continuous fluorometric determination of alpha-mannosidase activity: resorufin alpha-D-mannopyranoside.
A phase I study of swainsonine in patients with advanced malignancies.
An exoglycosidase-sensitive triggering site on NK cells which is coupled to transmethylation of membrane phospholipids.
Beta-N-acetylglucosaminidase, beta-galactosidase, and alpha-mannosidase activities in human female genital cancer.
Biochemical characterization of a new melanoma model--the minipig MeLiM strain.
Differential extraction of tumor-specific antigens from two ultraviolet light-induced murine fibrosarcomas with the use of 1-butanol.
Disparate behaviour of two melanosomal enzymes (alpha-mannosidase and gamma-glutamyltransferase).
Dolichol-bound oligosaccharides and the transfer of distal monosaccharides in the synthesis of glycoproteins by normal and tumor mammary epithelial cells.
Enzyme activity profiles in mouse teratocarcinomas. A quantitative ultramicroscale analysis.
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Inhibition of N-linked oligosaccharide processing in tumor cells is associated with enhanced tissue inhibitor of metalloproteinases (TIMP) gene expression.
Measuring swainsonine in serum of cancer patients: phase I clinical trial.
Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies.
Oligosaccharide modification by swainsonine treatment inhibits pulmonary colonization by B16-F10 murine melanoma cells.
Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies.
Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II.
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
Studies of lectin binding to the human cervix uteri: II. Cervical intraepithelial neoplasia and invasive squamous carcinoma.
Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition.
Study of some lysosomal glycohydrolases in tumors of the nervous system.
Suppression of 6A8 alpha-mannosidase gene expression reduced the potentiality of growth and metastasis of human nasopharyngeal carcinoma.
The histochemistry of glycosidases in human benign and malignant breast tissue.
The role of protein glycosylation inhibitors in the prevention of metastasis and therapy of cancer.
Vaginal fluid alpha-mannosidase: with special reference to cancer of the cervix.
[Differential gene expression in nasopharyngeal carcinoma cell with reduced and normal expression of 6A8 alpha-mannosidase]
[Effects of human alpha-mannosidase Man2c1 transgene on growth and metastasis of transplanted tumor in mice]
[Molecular mechanism of metastasis inhibition of nasopharyngeal carcinoma cell CNE-2L2 induced by reduction of 6A8 alpha-mannosidase expression]
Nephritis
Alteration of N-glycosylation in the kidney in a mouse model of systemic lupus erythematosus: relative quantification of N-glycans using an isotope-tagging method.
Nephrotic Syndrome
Nephrotic syndrome and collagenizing glomerulopathy in PVG/c rats treated with the alpha-mannosidase inhibitor "swainsonine".
Neurologic Manifestations
The pathogenesis and toxicokinetics of locoweed (Astragalus and Oxytropis spp.) poisoning in livestock.
Neuromuscular Diseases
Lysosomal enzyme activities in skeletal muscle of patients with neuromuscular diseases.
Ovarian Cysts
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Pancreatic Diseases
Serum lysosomal hydrolases in cystic fibrosis.
Pancreatitis
Serum lysosomal hydrolases in cystic fibrosis.
Paramyxoviridae Infections
Antiviral effects of glycosylation and glucose trimming inhibitors on human parainfluenza virus type 3.
Paraplegia
Skeletal muscle pathology of mannosidosis in two siblings with spastic paraplegia.
Paratuberculosis
Analysis of culture filtrate and cell wall-associated antigens of Mycobacterium paratuberculosis with monoclonal antibodies.
Serum biochemical changes in calves with Johne's disease.
Patellar Dislocation
Bilateral patellar dislocation associated with alpha-mannosidase deficiency.
Pelvic Inflammatory Disease
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Peritonitis
Increased activity of lysosomal enzymes in the peritoneal fluid of bacterial peritonitis.
Pleural Effusion
Diagnostic potential of lysosomal hydrolases in body cavity effusions.
Pre-Eclampsia
The relationship between urinary Tamm-Horsfall glycoprotein excretion and urinary activity of glycosidases in normal pregnancy and pre-eclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Synteny mapping of four genes from the short arm of human chromosome 19 to bovine chromosome 7.
Prostatic Intraepithelial Neoplasia
?-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.
Protein-Energy Malnutrition
Lysosomal enzymuria in protein energy malnutrition.
Metabolism of lysosomal enzymes in the protein-deficient weanling rat.
Proteinuria
Nephrotic syndrome and collagenizing glomerulopathy in PVG/c rats treated with the alpha-mannosidase inhibitor "swainsonine".
Respiratory Tract Infections
Mannosidosis: two brothers with different degrees of disease severity.
Unusual clinical and ultrastructural features in a boy with biochemically typical mannosidosis.
Retinal Detachment
Progressive cone dystrophy associated with low alpha-L-fucosidase activity in serum and leukocytes.
Sarcoma, Avian
Glycosidases in normal and regenerating chicken liver, hepatoma Mc-29, Rous sarcoma, in turkey poult liver and hemocytoblastomes, provoked by the leukosis virus strain Mc-31.
Seizures
Unusual clinical and ultrastructural features in a boy with biochemically typical mannosidosis.
Severe Acute Respiratory Syndrome
Coronavirus interactions with the cellular autophagy machinery.
Starvation
Characterization of the signal transduction pathways and cis-acting DNA sequence responsible for the transcriptional induction during growth and development of the lysosomal alpha-mannosidase gene in Dictyostelium discoideum.
Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway.
Examination of the endosomal and lysosomal pathways in Dictyostelium discoideum myosin I mutants.
Transitory effects of glucose starvation on the synthesis of dolichol-linked oligosaccharides in mammalian cells.
Stomach Neoplasms
[Inhibition effect of Swainsonine on the growth and metastasis of gastric cancer in vivo]
Synostosis
Multiple suture synostosis, macrocephaly, and intracranial hypertension in a child with alpha-D-mannosidase deficiency. Case report.
Synovitis
Bilateral patellar dislocation associated with alpha-mannosidase deficiency.
Teratocarcinoma
Transfer of nonglucosylated oligosaccharide from lipid to protein in a mammalian cell.
Tuberculosis
Molecular cloning and expression of an alpha-mannosidase gene in Mycobacterium tuberculosis.
Structural and immunochemical studies on D-arabino-D-mannans and D-mannans of Mycobacterium tuberculosis and other Mycobacterium species.
Uterine Cervical Neoplasms
Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population.
Vaginal fluid alpha-mannosidase: with special reference to cancer of the cervix.
Varicocele
Abnormal expression of acid glycosidases in seminal plasma and spermatozoa from infertile men with varicocele.
Vesicular Stomatitis
Involvement of carbohydrates in vesicular stomatitis virus-cell early interaction.
Xanthogranuloma, Juvenile
Congenital histiocytosis. A heterogeneous group of diseases, one presenting as so-called congenital self-healing histiocytosis.