Disease on EC 3.2.1.209 - endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
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DISEASE 
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
Acquired Immunodeficiency Syndrome
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Carcinogenesis
ERManI Is a Target of miR-125b and Promotes Transformation Phenotypes in Hepatocellular Carcinoma (HCC).
Carcinoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Carcinoma, Hepatocellular
Alterations of EDEM1 functions enhance ATF6 pro-survival signaling.
Carcinoma, Hepatocellular
Elucidation of the molecular logic by which misfolded alpha 1-antitrypsin is preferentially selected for degradation.
Carcinoma, Hepatocellular
ERManI Is a Target of miR-125b and Promotes Transformation Phenotypes in Hepatocellular Carcinoma (HCC).
Carcinoma, Renal Cell
Inhibition of Cancer Cell Growth by GRP78 siRNA Lipoplex via Activation of Unfolded Protein Response.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Bi-allelic variants in the ER quality-control mannosidase gene EDEM3 cause a congenital disorder of glycosylation.
COVID-19
Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants.
Dengue
Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress.
Encephalitis, Japanese
Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress.
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
endoplasmic reticulum man9glcnac2 1,2-alpha-mannosidase deficiency
EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression.
Hepatitis B
MicroRNA-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1.
Infections
Coronaviruses Hijack the LC3-I-positive EDEMosomes, ER-derived vesicles exporting short-lived ERAD regulators, for replication.
Infections
Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress.
Liver Diseases
Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency.
Lymphoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Lymphoma, B-Cell
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Lymphoma, B-Cell
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Mania
Mannosidase IA is in Quality Control Vesicles and Participates in Glycoprotein Targeting to ERAD.
Melanoma
Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells.
Melanoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Melanoma
Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.
Neoplasms
Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
Neoplasms
ERManI Is a Target of miR-125b and Promotes Transformation Phenotypes in Hepatocellular Carcinoma (HCC).
Neoplasms
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Neoplasms
Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.
Neurodegenerative Diseases
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Parkinson Disease
Novel biomolecular information in rotenone-induced cellular model of Parkinson's disease.
Pulmonary Disease, Chronic Obstructive
Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure.
Severe Acute Respiratory Syndrome
Coronavirus interactions with the cellular autophagy machinery.
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