show all | hide all No of entries

Information on EC 3.2.1.209 - endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase

for references in articles please use BRENDA:EC3.2.1.209
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme, located in the endoplasmic reticulum, primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2 isomer 8A1,2,3B1,3 (the names of the isomers listed here are based on a nomenclature system proposed by Prien et al ). The removal of the single mannosyl residue occurs in all eukaryotes as part of the processing of N-glycosylated proteins, and is absolutely essential for further elongation of the outer chain of properly-folded N-glycosylated proteins in yeast. In addition, the enzyme is involved in glycoprotein quality control at the ER quality control compartment (ERQC), helping to target misfolded glycoproteins for degradation. When present at very high concentrations in the ERQC, the enzyme can trim the carbohydrate chain further to Man(5-6)GlcNAc2.
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
alpha-(1,2)-mannosidase I, alpha-(1-2)-mannosidase I, alpha1,2-mannosidase, alpha1,2-mannosidases, class I alpha1,2-mannosidase, EDEM1, endoplasmic reticulum alpha-(1-->2)-mannosidase I, endoplasmic reticulum alpha1,2-mannosidase, ER degradation enhancing alpha-mannosidase-like protein 1, ER ManI, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2
show the reaction diagram
Man9GlcNAc2-[protein]2-alpha-mannohydrolase (configuration-inverting)
show the reaction diagram
-
-
-
-
Select items on the left to see more content.