Disease on EC 3.2.1.166 - heparanase
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Abortion, Spontaneous
Involvement of heparanase in vaginal and cesarean section deliveries.
Acquired Immunodeficiency Syndrome
Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation.
Acute Kidney Injury
Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury.
Acute Kidney Injury
Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545.
Acute Lung Injury
Heparanase pretreatment attenuates endotoxin-induced acute lung injury in rats.
Adenocarcinoma
A basement-membrane permeability assay which correlates with the metastatic potential of tumour cells.
Adenocarcinoma
A rapid quantitative assay for the detection of mammalian heparanase activity.
Adenocarcinoma
Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.
Adenocarcinoma
Heparanase and a synthetic peptide of heparan sulfate-interacting protein recognize common sites on cell surface and extracellular matrix heparan sulfate.
Adenocarcinoma
Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression.
Adenocarcinoma
Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.
Adenocarcinoma
Heparanase expression is a prognostic indicator for postoperative survival in pancreatic adenocarcinoma.
Adenocarcinoma
Heparanase regulates in vitro VEGF-C expression and its clinical significance to pancreatic ductal cell adenocarcinoma.
Adenocarcinoma
High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.
Adenocarcinoma
Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides.
Adenocarcinoma
Structural requirements for inhibition of melanoma lung colonization by heparanase inhibiting species of heparin.
Adenocarcinoma
The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma.
Adenocarcinoma
[Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]
Adenocarcinoma
[Heparanase and vascular endothelial growth factor expression in non-small-cell lung cancer]
Adenocarcinoma of Lung
CCL19/CCR7 upregulates heparanase via specificity protein-1 (Sp1) to promote invasion of cell in lung cancer.
Adenocarcinoma of Lung
Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro.
Adenocarcinoma of Lung
[Effects of heparanase inhibition by RNA interference on proliferation, invasiveness and apoptosis of lung cancer cells]
Adenoma
Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis.
Adenoma
Immunohistochemical expression of heparanase isoforms and syndecan-1 proteins in colorectal adenomas.
Adrenocortical Carcinoma
Significance of heparanase-1 and vascular endothelial growth factor in adrenocortical carcinoma angiogenesis: potential for therapy.
Albuminuria
Cathepsin L is crucial for the development of early experimental diabetic nephropathy.
Albuminuria
Deterioration of glomerular endothelial surface layer induced by oxidative stress is implicated in altered permeability of macromolecules in Zucker fatty rats.
Albuminuria
Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.
Albuminuria
Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system.
Albuminuria
Plasma heparanase is associated with blood glucose levels but not urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage.
Albuminuria
The protective role of fucosylated chondroitin sulfate, a distinct glycosaminoglycan, in a murine model of streptozotocin-induced diabetic nephropathy.
Alopecia
Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantation.
Alzheimer Disease
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-? in murine brain.
Alzheimer Disease
Heparanase overexpression impedes perivascular clearance of amyloid-? from murine brain: relevance to Alzheimer's disease.
Alzheimer Disease
Heparanase protects the heart against chemical or ischemia/reperfusion injury.
Alzheimer Disease
Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer's Disease.
Ameloblastoma
Expression of heparanase: a possible role in invasiveness and aggressive clinical behavior of ameloblastomas.
Ameloblastoma
Heparanase gene and protein expression in ameloblastoma: possible role in local invasion of tumor cells.
Ameloblastoma
Immunolocalization of cell signaling molecules in the granular cell ameloblastoma.
Amyloidosis
Accelerated resolution of AA amyloid in heparanase knockout mice is associated with matrix metalloproteases.
Amyloidosis
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis.
Angiofibroma
[Significance of heparanase, bFGF and VEGF in angiogenesis for nasopharyngeal angiofibroma outspreding].
Anti-Glomerular Basement Membrane Disease
Heparanase inhibition reduces proteinuria in a model of accelerated anti-glomerular basement membrane antibody disease.
Aortic Aneurysm, Abdominal
Matrix metalloproteinase can facilitate the heparanase-induced promotion of phenotype change in vascular smooth muscle cells.
Aortic Aneurysm, Thoracic
The ?-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men.
Apnea
Serum heparanase levels are associated with endothelial dysfunction in patients with obstructive sleep apnea.
Arthritis, Experimental
Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis.
Arthritis, Rheumatoid
Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis.
Asthma
The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.
Atherosclerosis
Are primed polymorphonuclear leukocytes contributors to the high heparanase levels in hemodialysis patients?
Atherosclerosis
Heparanase inhibition attenuates atherosclerosis progression and liver steatosis in E0 mice.
Atherosclerosis
Heparanase Inhibition Reduces Glucose Levels, Blood Pressure, and Oxidative Stress in Apolipoprotein E Knockout Mice.
Atherosclerosis
Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases.
Atherosclerosis
Heparanase: Multiple functions in inflammation, diabetes and atherosclerosis.
Atherosclerosis
Involvement of heparanase in atherosclerosis and other vessel wall pathologies.
Atherosclerosis
Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis.
Atherosclerosis
Regulation of heparanase expression in coronary artery disease in diabetic, hyperlipidemic swine.
Atrial Fibrillation
Serum heparanase levels and left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation.
Autoimmune Diseases
Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species.
Barrett Esophagus
Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression.
beta-Thalassemia
Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition.
Bone Diseases
Heparanase inhibits osteoblastogenesis and shifts bone marrow progenitor cell fate in myeloma bone disease.
Bone Resorption
Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.
Brain Injuries
Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats.
Brain Ischemia
Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion.
Brain Ischemia
Expression of heparanase in vascular cells and astrocytes of the mouse brain after focal cerebral ischemia.
Brain Neoplasms
Heparanase Promotes Glioma Progression and is Inversely Correlated with Patient Survival.
Brain Neoplasms
Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and In Vivo Tumor Growth.
Brain Neoplasms
Involvement of Heparan Sulfate and Heparanase in Neural Development and Pathogenesis of Brain Tumors.
Brain Neoplasms
MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase.
Breast Neoplasms
A new targeting approach for breast cancer gene therapy using the heparanase promoter.
Breast Neoplasms
Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/-9 and heparanase in MDA-MB-231 cells.
Breast Neoplasms
BRMS1 and HPA as Progression, Clinical Biological Behaviors, and Poor Prognosis-related Biomarkers for Gallbladder Adenocarcinoma.
Breast Neoplasms
DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.
Breast Neoplasms
Elemene inhibits the migration and invasion of 4T1 murine breast cancer cells via heparanase.
Breast Neoplasms
Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data.
Breast Neoplasms
Emergence of nuclear heparanase induces differentiation of human mammary cancer cells.
Breast Neoplasms
Epidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase I activity in brain metastatic breast cancer.
Breast Neoplasms
Expression and correlation of matrix metalloproteinase-9 and heparanase in patients with breast cancer.
Breast Neoplasms
Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.
Breast Neoplasms
Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression.
Breast Neoplasms
Gubenyiliu II Inhibits Breast Tumor Growth and Metastasis Associated with Decreased Heparanase Expression and Phosphorylation of ERK and AKT Pathways.
Breast Neoplasms
Heparan sulfate and heparanase as modulators of breast cancer progression.
Breast Neoplasms
Heparan sulfate containing unsubstituted glucosamine residues: biosynthesis and heparanase-inhibitory activity.
Breast Neoplasms
Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis.
Breast Neoplasms
Heparanase activity and bone loss in postmenopausal breast cancer patients.
Breast Neoplasms
Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors.
Breast Neoplasms
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.
Breast Neoplasms
Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.
Breast Neoplasms
Heparanase expression in circulating lymphocytes of breast cancer patients depends on the presence of the primary tumor and/or systemic metastasis.
Breast Neoplasms
Heparanase from triple?negative breast cancer and platelets acts as an enhancer of metastasis.
Breast Neoplasms
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.
Breast Neoplasms
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.
Breast Neoplasms
Heparanase is a novel biomarker for immune infiltration and prognosis in breast cancer.
Breast Neoplasms
Heparanase link between vasculogenesis and angiogenesis as well as a predictive factor of a shorter survival rate.
Breast Neoplasms
Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer.
Breast Neoplasms
Heparanase promotes growth, angiogenesis and survival of primary breast tumors.
Breast Neoplasms
Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective.
Breast Neoplasms
Heparanase-1 expression is associated with the metastatic potential of breast cancer.
Breast Neoplasms
Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.
Breast Neoplasms
Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes.
Breast Neoplasms
Heparanase: a potential marker of worse prognosis in estrogen receptor-positive breast cancer.
Breast Neoplasms
Impact of Adjuvant Treatment on Heparanase Concentration in Invasive, Unilateral Breast Cancer Patients: Results of a Prospective Single-Centre Cohort Study.
Breast Neoplasms
In silico investigation of heparanase-correlated genes in breast cancer subtypes.
Breast Neoplasms
Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
Breast Neoplasms
Is there an association between high heparanase level and osteoporosis risk in breast cancer patients without clinical evidence of bone metastases?
Breast Neoplasms
MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase.
Breast Neoplasms
Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis.
Breast Neoplasms
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases.
Breast Neoplasms
Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis.
Breast Neoplasms
Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion.
Breast Neoplasms
PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma model.
Breast Neoplasms
Prognostic significance of heparanase expression in primary and metastatic breast carcinoma.
Breast Neoplasms
Role of extracellular matrix in breast cancer development: a brief update.
Breast Neoplasms
SANT,a novel Chinese herbal monomer combination,decreasing tumor growth and angiogenesis via modulating autophagy in heparanase overexpressed triple-negative breast cancer.
Breast Neoplasms
Silencing of Heparanase by siRNA Inhibits Tumor Metastasis and Angiogenesis of Human Breast Cancer In Vitro and In Vivo.
Breast Neoplasms
Specific Inhibition of Heparanase by Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.
Breast Neoplasms
Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase.
Breast Neoplasms
Tamoxifen induces heparanase expression in estrogen receptor-positive breast cancer.
Breast Neoplasms
Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis.
Breast Neoplasms
The expression and clinical significance of microRNA-1258 and heparanase in human breast cancer.
Breast Neoplasms
The improved targeting of an aspirin prodrug albumin-based nanosystem for visualizing and inhibiting lung metastasis of breast cancer.
Breast Neoplasms
Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis.
Breast Neoplasms
[Correlation of expression of heparanase to angiogenesis and prognosis of breast cancer.]
Breast Neoplasms
[Expressions of breast cancer metastasis suppressor-1 and heparanase in primary hepatocellular carcinoma and chronic liver diseases and the clinicopathological significances].
Breast Neoplasms
[Inhibition of invasiveness of human mammary carcinoma cell line MDA435 by heparanase antisense oligodeoxynucleotide]
Breast Neoplasms
[Retracted] Suppression of endoplasmic reticulum stress?induced invasion and migration of breast cancer cells through the downregulation of heparanase.
Carcinogenesis
A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer.
Carcinogenesis
A novel human anti-syndecan-1 antibody inhibits vascular maturation and tumour growth in melanoma.
Carcinogenesis
Downregulation of heparanase by RNA interference inhibits invasion and tumorigenesis of hepatocellular cancer cells in vitro and in vivo.
Carcinogenesis
Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data.
Carcinogenesis
Expression characteristics of heparanase in colon carcinoma and its close relationship with cyclooxygenase-2 and angiogenesis.
Carcinogenesis
Expression of heparanase in hepatocellular carcinoma has prognostic significance: a tissue microarray study.
Carcinogenesis
Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis.
Carcinogenesis
Heparanase expression increases throughout the endometrial hyperplasia-cancer sequence.
Carcinogenesis
Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells.
Carcinogenesis
Heparanase mRNA and Protein Expression Correlates with Clinicopathologic Features of Gastric Cancer Patients: a Meta- analysis.
Carcinogenesis
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.
Carcinogenesis
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.
Carcinogenesis
Identification of strong intron enhancer in the heparanase gene: effect of functional rs4693608 variant on HPSE enhancer activity in hematological and solid malignancies.
Carcinogenesis
Immunohistochemical expression of heparanase isoforms and syndecan-1 proteins in colorectal adenomas.
Carcinogenesis
Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma.
Carcinogenesis
miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase.
Carcinogenesis
Overexpression of heparanase attenuated TGF-?-stimulated signaling in tumor cells.
Carcinogenesis
Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma.
Carcinogenesis
Role of heparanase in tumor progression: Molecular aspects and therapeutic options.
Carcinogenesis
SANT,a novel Chinese herbal monomer combination,decreasing tumor growth and angiogenesis via modulating autophagy in heparanase overexpressed triple-negative breast cancer.
Carcinogenesis
Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase.
Carcinogenesis
Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence.
Carcinogenesis
Tamoxifen induces heparanase expression in estrogen receptor-positive breast cancer.
Carcinogenesis
Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis.
Carcinogenesis
The heparanase inhibitor PG545 is a potent anti-lymphoma drug: Mode of action.
Carcinogenesis
Upregulation of Fecal Epithelial Heparanase mRNA Is Associated with Increased Ulcerative Colitis Activity and Cancerization Risk.
Carcinogenesis
[The expression and clinical significance of heparanase in non-small cell lung cancer.]
Carcinogenesis
[The expression of heparanase and vascular endothelial growth factor-C in human lung cancer]
Carcinoma
A novel human anti-syndecan-1 antibody inhibits vascular maturation and tumour growth in melanoma.
Carcinoma
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.
Carcinoma
Analysis of heparanase isoforms and cathepsin B in the plasma of patients with gastrointestinal carcinomas: analytical cross-sectional study.
Carcinoma
Antiangiogenic Activity of Orally Absorbable Heparin Derivative in Different Types of Cancer Cells.
Carcinoma
Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody.
Carcinoma
Clinicopathological significance of heparanase and basic fibroblast growth factor expression in human esophageal cancer.
Carcinoma
Coexpression of heparanase, basic fibroblast growth factor and vascular endothelial growth factor in human esophageal carcinomas.
Carcinoma
Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.
Carcinoma
Elevated serum heparanase-1 levels in patients with pancreatic carcinoma are associated with poor survival.
Carcinoma
Enoxaparin Attenuates Mouse Colon Cancer Liver Metastases by Inhibiting Heparanase and Interferon-?-inducible Chemokines.
Carcinoma
Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion.
Carcinoma
Expression characteristics of heparanase in colon carcinoma and its close relationship with cyclooxygenase-2 and angiogenesis.
Carcinoma
Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas.
Carcinoma
Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis.
Carcinoma
Expression of heparanase in renal cell carcinomas: implications for tumor invasion and prognosis.
Carcinoma
Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC9706 cells.
Carcinoma
Expression of Tissue Factor and Heparanase in Endometrial Clear Cell Carcinoma: Possible Role for Tissue Factor in Thromboembolic Events.
Carcinoma
Gene silencing of heparanase results in suppression of invasion and migration of gallbladder carcinoma cells.
Carcinoma
Glucose-regulated protein 78 and heparanase expression in oral squamous cell carcinoma: correlations and prognostic significance.
Carcinoma
H-2Kb-restricted CTL epitopes from mouse heparanase elicit an antitumor immune response in vivo.
Carcinoma
Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage.
Carcinoma
Heparanase and Chemotherapy Synergize to Drive Macrophage Activation and Enhance Tumor Growth.
Carcinoma
Heparanase and cyclooxygenase-2 gene and protein expressions during progression of oral epithelial dysplasia to carcinoma.
Carcinoma
Heparanase and tumor invasion patterns in human oral squamous cell carcinoma xenografts.
Carcinoma
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression.
Carcinoma
Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression.
Carcinoma
Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.
Carcinoma
Heparanase expression in head and neck squamous cell carcinomas is associated with reduced proliferation and improved survival.
Carcinoma
Heparanase expression increases throughout the endometrial hyperplasia-cancer sequence.
Carcinoma
Heparanase expression is a prognostic indicator for postoperative survival in pancreatic adenocarcinoma.
Carcinoma
Heparanase expression: a potential ancillary diagnostic tool for distinguishing between malignant cells and reactive mesothelium in body cavity effusions.
Carcinoma
Heparanase gene expression and its correlation with spontaneous apoptosis in hepatocytes of cirrhotic liver and carcinoma.
Carcinoma
Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma.
Carcinoma
Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation: PRECLINICAL AND CLINICAL SIGNIFICANCE IN HEAD AND NECK CANCER.
Carcinoma
Heparanase link between vasculogenesis and angiogenesis as well as a predictive factor of a shorter survival rate.
Carcinoma
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival.
Carcinoma
Heparanase overexpression down-regulates syndecan-1 expression in a gallbladder carcinoma cell line.
Carcinoma
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.
Carcinoma
Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis.
Carcinoma
Heparanase: From basic research to therapeutic applications in cancer and inflammation.
Carcinoma
High-speed gel-permeation chromatography of glycosaminoglycans: its application to the analysis of heparan sulfate of embryonic carcinoma and its degradation products by tumor cell-derived heparanase.
Carcinoma
Hypoxia increases heparanase-dependent tumor cell invasion, which can be inhibited by antiheparanase antibodies.
Carcinoma
Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma.
Carcinoma
Inhibition of Heparanase Expression Results in Suppression of Invasion, Migration and Adhesion Abilities of Bladder Cancer Cells.
Carcinoma
Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival.
Carcinoma
Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
Carcinoma
Localization of heparanase in esophageal cancer cells: respective roles in prognosis and differentiation.
Carcinoma
Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas.
Carcinoma
Maintenance on extracellular matrix and expression of heparanase activity by human ovarian carcinoma cells from biopsy specimens.
Carcinoma
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
Carcinoma
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases.
Carcinoma
Normal colon tissue and colon carcinoma show no difference in heparanase promoter methylation.
Carcinoma
Overexpression of heparanase attenuated TGF-?-stimulated signaling in tumor cells.
Carcinoma
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins.
Carcinoma
Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma.
Carcinoma
Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich element.
Carcinoma
Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma.
Carcinoma
Prognostic value of heparanase expression and cellular localization in oral cancer.
Carcinoma
Quantitative analysis of heparanase gene expression in esophageal squamous cell carcinoma.
Carcinoma
Quantitative analysis of heparanase gene expression in normal cervical, cervical intraepithelial neoplastic, and cervical carcinoma tissues.
Carcinoma
Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence.
Carcinoma
Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase.
Carcinoma
Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds.
Carcinoma
The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach.
Carcinoma
Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue.
Carcinoma
Upregulation of Endothelin-1/Endothelin A Receptor Expression Correlates with Heparanase Expression in Ovarian Carcinoma.
Carcinoma
[Effect of silencing heparanase on the biological behavior of gastric carcinoma in nude mice].
Carcinoma
[Effects of hypoxia on the expression of heparanase and invasiveness of Hep-2 laryngeal carcinoma cell]
Carcinoma
[Increased expression of heparanase mRNA is correlated with metastasis of gastric carcinoma and is probably correlated with c-met protein]
Carcinoma
[Inhibition of invasiveness of human mammary carcinoma cell line MDA435 by heparanase antisense oligodeoxynucleotide]
Carcinoma
[mRNA expression of syndecan-1 and heparanase in relation to tumor progression and prognosis of gastric carcinoma]
Carcinoma
[Prediction of lymph node metastasis with binary logistic regression in gastric carcinoma]
Carcinoma
[Relation of heparanase mRNA expression and angiogenesis to the progression of gastric carcinoma]
Carcinoma
[Relationship between heparanase mRNA expression in human gastric cancer and its clinicopathological features]
Carcinoma
[The clinical significance of heparanase expression in human pancreatic carcinoma tissue]
Carcinoma
[The expression and significance of heparanase in oral squamous cell carcinoma with different metastatic potentials].
Carcinoma
[The expression of acetyl-heparanase, laminin and laminin receptor and their role in the metastasis of ovarian cancer]
Carcinoma
[The expression of hepatocyte growth factor and heparanase in laryngeal squamous cell carcinoma and its clinical significance]
Carcinoma, Basal Cell
Expression of heparanase in basal cell carcinoma and squamous cell carcinoma.
Carcinoma, Ductal
Ductal carcinoma in situ of the breast and heparanase-1 expression: a molecular explanation for more aggressive subtypes.
Carcinoma, Ductal
MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase.
Carcinoma, Endometrioid
Expression of Tissue Factor and Heparanase in Endometrial Clear Cell Carcinoma: Possible Role for Tissue Factor in Thromboembolic Events.
Carcinoma, Hepatocellular
Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence.
Carcinoma, Hepatocellular
Allele loss and down-regulation of heparanase gene are associated with the progression and poor prognosis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations.
Carcinoma, Hepatocellular
Downregulating the expression of heparanase inhibits the invasion, angiogenesis and metastasis of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Downregulation of Heparanase Expression Results in Suppression of Invasion, Migration, and Adhesion Abilities of Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Effects of small interfering RNA targeting heparanase-1 combined with heparin on invasiveness of mouse hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Evaluation of the Antitumor Efficacy of RNAi-Mediated Inhibition of CDC20 and Heparanase in an Orthotopic Liver Tumor Model.
Carcinoma, Hepatocellular
Expression and significance of heparanase and nm23-H1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression of Concern: Synthesized multiple antigenic polypeptide vaccine based on B-cell epitopes of human heparanase could elicit a potent antimetastatic effect on human hepatocellular carcinoma in vivo.
Carcinoma, Hepatocellular
Expression of heparanase in hepatocellular carcinoma has prognostic significance: a tissue microarray study.
Carcinoma, Hepatocellular
Expressions of heparanase and upstream stimulatory factor in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Gene silencing of heparanase results in suppression of invasion and migration of hepatoma cells.
Carcinoma, Hepatocellular
Glycosaminoglycan mimetics inhibit SDF-1/CXCL12-mediated migration and invasion of human hepatoma cells.
Carcinoma, Hepatocellular
Heparanase (HPSE) gene polymorphism (rs12503843) contributes as a risk factor for hepatocellular carcinoma (HCC): a pilot study among Egyptian patients.
Carcinoma, Hepatocellular
Heparanase Contributes To Trans-Endothelial Migration of Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Heparanase expression in hepatocellular carcinoma and the cirrhotic liver.
Carcinoma, Hepatocellular
Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage.
Carcinoma, Hepatocellular
Heparanase mRNA expression and point mutation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Mammalian heparanase as mediator of tumor metastasis and angiogenesis.
Carcinoma, Hepatocellular
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
Carcinoma, Hepatocellular
Multiple antigenic polypeptide composed of heparanase B?cell epitopes shrinks human hepatocellular carcinoma in mice.
Carcinoma, Hepatocellular
PI-88 inhibits postoperative recurrence of hepatocellular carcinoma via disrupting the surge of heparanase after liver resection.
Carcinoma, Hepatocellular
Quantitative analysis of heparanase messenger RNA expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Relationship between serum heparanase and microscopic venous invasion in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Substrate specificity of heparanases from human hepatoma and platelets.
Carcinoma, Hepatocellular
Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme.
Carcinoma, Hepatocellular
Synthesized multiple antigenic polypeptide vaccine based on B-cell epitopes of human heparanase could elicit a potent antimetastatic effect on human hepatocellular carcinoma in vivo.
Carcinoma, Hepatocellular
The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The expression of Heparanase mRNA and its clinical significance in Hepatocellular carcinoma.
Carcinoma, Hepatocellular
Thrombin enhances degradation of heparan sulfate in the extracellular matrix by tumor cell heparanase.
Carcinoma, Hepatocellular
[Expression of heparanase mRNA and its clinical significance in primary hepatocellular carcinoma]
Carcinoma, Hepatocellular
[Expressions of breast cancer metastasis suppressor-1 and heparanase in primary hepatocellular carcinoma and chronic liver diseases and the clinicopathological significances].
Carcinoma, Hepatocellular
[Heparanase promotes trans-endothelial migration of hepatocarcinoma cells by inducing apoptosis of microvascular endothelial cells].
Carcinoma, Hepatocellular
[The expression and significance of heparanase and nm23-H1 in hepatocellular carcinoma]
Carcinoma, Intraductal, Noninfiltrating
COX-2 induction by heparanase in the progression of breast cancer.
Carcinoma, Intraductal, Noninfiltrating
Ductal carcinoma in situ of the breast and heparanase-1 expression: a molecular explanation for more aggressive subtypes.
Carcinoma, Lewis Lung
Heparanase and Chemotherapy Synergize to Drive Macrophage Activation and Enhance Tumor Growth.
Carcinoma, Non-Small-Cell Lung
Clinical significance of heparanase activity in primary resected non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Down-regulation of heparanase leads to the inhibition of invasion and proliferation of A549 cells in vitro and in vivo.
Carcinoma, Non-Small-Cell Lung
Heparanase expression correlates with angiogenesis and lymphangiogenesis in human lung cancer.
Carcinoma, Non-Small-Cell Lung
Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
Carcinoma, Non-Small-Cell Lung
The expression of heparanase and microRNA-1258 in human non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
[Clinical significance of heparanase and basic fibroblast growth factor expression in human non-small cell lung cancer]
Carcinoma, Non-Small-Cell Lung
[Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer.]
Carcinoma, Non-Small-Cell Lung
[Expression of heparanase in human non-small cell lung cancer.]
Carcinoma, Non-Small-Cell Lung
[The expression and clinical significance of heparanase in non-small cell lung cancer.]
Carcinoma, Ovarian Epithelial
Heparanase messenger RNA expression in epithelial ovarian tumor.
Carcinoma, Ovarian Epithelial
Upregulation of Endothelin-1/Endothelin A Receptor Expression Correlates with Heparanase Expression in Ovarian Carcinoma.
Carcinoma, Ovarian Epithelial
[Expression of maspin and its relation to tumor vascularization in epithelian ovarian cancer]
Carcinoma, Papillary
Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis.
Carcinoma, Renal Cell
Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody.
Carcinoma, Renal Cell
Expression of heparanase in renal cell carcinomas: implications for tumor invasion and prognosis.
Carcinoma, Renal Cell
Heparanase expression and glycosaminoglycans profile in renal cell carcinoma.
Carcinoma, Renal Cell
Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances.
Carcinoma, Squamous Cell
Antiangiogenic Activity of Orally Absorbable Heparin Derivative in Different Types of Cancer Cells.
Carcinoma, Squamous Cell
Expression of heparanase in basal cell carcinoma and squamous cell carcinoma.
Carcinoma, Squamous Cell
Heparanase expression in head and neck squamous cell carcinomas is associated with reduced proliferation and improved survival.
Carcinoma, Squamous Cell
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival.
Carcinoma, Squamous Cell
Heparanase, a potential marker for premalignant oral cavity cancer.
Carcinoma, Squamous Cell
Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Influence of Heparanase and VEGF-C mRNA Expressions in Lung Cancer.
Carcinoma, Squamous Cell
Localization of heparanase in esophageal cancer cells: respective roles in prognosis and differentiation.
Carcinoma, Squamous Cell
Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas.
Carcinoma, Squamous Cell
[Expression of heparanase gene and the metastatic activity of lung cancer.]
Carcinoma, Verrucous
Prognostic value of heparanase expression and cellular localization in oral cancer.
Cardiomegaly
Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats.
Cardiomegaly
Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy.
Cardiomyopathies
Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen following Diabetes.
Carotid Artery Diseases
Increased expression of heparanase in symptomatic carotid atherosclerosis.
Carotid Artery Diseases
Involvement of heparanase in atherosclerosis and other vessel wall pathologies.
Central Nervous System Diseases
Implications of heparan sulfate and heparanase in neuroinflammation.
Cholangiocarcinoma
EGFR, FLT1 and heparanase as markers identifying patients at risk of short survival in cholangiocarcinoma.
Choriocarcinoma
Growth-modulatory effects of heparin and VEGF165 on the choriocarcinoma cell-line JEG-3 and its expression of heparanase.
Choriocarcinoma
Heparanase expression correlates with metastatic capability in human choriocarcinoma.
Choriocarcinoma
Inhibition of choriocarcinoma by Fe3O4-dextran-anti-?-human chorionic gonadotropin nanoparticles containing antisense oligodeoxynucleotide of heparanase.
Choriocarcinoma
Role of promoter methylation in regulation of the mammalian heparanase gene.
Choriocarcinoma
Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase.
Choriocarcinoma
[Correlation between expression of heparanase and invasion of choriocarcinoma]
Choroidal Neovascularization
Heparanase-1 activities in the development of laser induced choroidal neovascularization.
Colitis
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.
Colitis
New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis.
Colitis, Ulcerative
Heparanase upregulation by colonic epithelium in inflammatory bowel disease.
Colitis, Ulcerative
Upregulation of Fecal Epithelial Heparanase mRNA Is Associated with Increased Ulcerative Colitis Activity and Cancerization Risk.
Colitis-Associated Neoplasms
Heparanase enzyme in chronic inflammatory bowel disease and colon cancer.
Colonic Neoplasms
Co-expression of CD44v3 and heparanase is correlated with metastasis of human colon cancer.
Colonic Neoplasms
Contribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T.
Colonic Neoplasms
Effect of eIF-4E inhibition on heparanase mRNA and its expression in colon adenocarcinoma cell.
Colonic Neoplasms
Enoxaparin Attenuates Mouse Colon Cancer Liver Metastases by Inhibiting Heparanase and Interferon-?-inducible Chemokines.
Colonic Neoplasms
Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis.
Colonic Neoplasms
Heparanase enzyme in chronic inflammatory bowel disease and colon cancer.
Colonic Neoplasms
Heparanase expression correlates with malignant potential in human colon cancer.
Colonic Neoplasms
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans.
Colonic Neoplasms
Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells.
Colonic Neoplasms
The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression.
Colonic Neoplasms
[Contribution of eukaryotic initiation factor-4E inhibition to heparanase expression and activity in human colon adenocarcinoma cell line LS-174T]
Colonic Neoplasms
[Role of eukaryotic initiation factor-4E (eIF-4E) in regulation of expression of NF-kappaB and its subsequent influence on transcription and activity of heparanase in human colon adenocarcinoma cell line]
Colorectal Neoplasms
Enzymatic function of multiple origins regulates the progression of colorectal cancer and the development of metastases.
Colorectal Neoplasms
Heparanase augments inflammatory chemokine production from colorectal carcinoma cell lines.
Colorectal Neoplasms
Heparanase enzyme in chronic inflammatory bowel disease and colon cancer.
Colorectal Neoplasms
Heparanase expression in human colorectal cancer and its relationship to tumor angiogenesis, hematogenous metastasis, and prognosis.
Colorectal Neoplasms
Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis.
Colorectal Neoplasms
Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis.
Colorectal Neoplasms
[Effect of exogenous expression of heparanase gene on invasive ability of colorectal cancer cell line HT29]
Corneal Neovascularization
Expression of MMP, HPSE, and FAP in stroma promoted corneal neovascularization induced by different etiological factors.
Coronary Artery Disease
Regulation of heparanase expression in coronary artery disease in diabetic, hyperlipidemic swine.
Coronary Artery Disease
Serum Heparanase Level is Decreased in Stable Coronary Artery Disease.
COVID-19
Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients.
COVID-19
Heparanase as a potential player in SARS-CoV-2 infection and induced coagulopathy.
COVID-19
New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis.
COVID-19
Relevance of Heparan Sulfate and Heparanase to Severity of COVID-19 in the Elderly.
Crohn Disease
Syndecan-1 and Heparanase: Potential Markers for Activity Evaluation and Differential Diagnosis of Crohn's Disease.
Cystitis, Interstitial
Heparanase Deficiency Is Associated with Disruption, Detachment, and Folding of the Retinal Pigment Epithelium.
Demyelinating Diseases
Heparanome-Mediated Rescue of Oligodendrocyte Progenitor Quiescence following Inflammatory Demyelination.
Dengue
Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability.
Dentigerous Cyst
Perlecan-rich epithelial linings as a background of proliferative potentials of keratocystic odontogenic tumor.
Diabetes Complications
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.
Diabetes Mellitus
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.
Diabetes Mellitus
Protective effects of Danggui Buxue Tang on renal function, renal glomerular mesangium and heparanase expression in rats with streptozotocin-induced diabetes mellitus.
Diabetes Mellitus, Type 1
Dichotomic role of heparanase in a murine model of metabolic syndrome.
Diabetes Mellitus, Type 1
Heparan sulfate and heparanase play key roles in mouse ? cell survival and autoimmune diabetes.
Diabetes Mellitus, Type 1
Heparanase prevents the development of type 1 diabetes in non-obese diabetic mice by regulating T-cell activation and cytokines production.
Diabetes Mellitus, Type 1
Inhibition of heparanase protects against pancreatic beta cell death in streptozotocin-induced diabetic mice via reducing intra-islet inflammatory cell infiltration.
Diabetes Mellitus, Type 1
Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation.
Diabetes Mellitus, Type 1
Urinary heparanase activity in patients with Type 1 and Type 2 diabetes.
Diabetes Mellitus, Type 2
Dichotomic role of heparanase in a murine model of metabolic syndrome.
Diabetes Mellitus, Type 2
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.
Diabetes Mellitus, Type 2
Urinary heparanase activity in patients with Type 1 and Type 2 diabetes.
Diabetic Foot
Heparanase procoagulant activity as a predictor of wound necrosis following diabetic foot amputation.
Diabetic Nephropathies
A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase-1 and prevents FGF-2-induced renal epithelial-mesenchymal transition.
Diabetic Nephropathies
Abnormal glomerular permeability characteristics in diabetic nephropathy: implications for the therapeutic use of low-molecular weight heparin.
Diabetic Nephropathies
Cathepsin L is crucial for the development of early experimental diabetic nephropathy.
Diabetic Nephropathies
Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria.
Diabetic Nephropathies
Glycosaminoglycan treatment in glomerulonephritis? An interesting option to investigate.
Diabetic Nephropathies
Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy.
Diabetic Nephropathies
Heparanase is essential for the development of diabetic nephropathy in mice.
Diabetic Nephropathies
Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.
Diabetic Nephropathies
Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients.
Diabetic Nephropathies
Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases.
Diabetic Nephropathies
Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression.
Diabetic Nephropathies
Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications.
Diabetic Nephropathies
Involvement of human heparanase in the pathogenesis of diabetic nephropathy.
Diabetic Nephropathies
New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis.
Diabetic Nephropathies
Plasma heparanase is associated with blood glucose levels but not urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage.
Diabetic Nephropathies
Regulation of heparanase by albumin and advanced glycation end products in proximal tubular cells.
Diabetic Nephropathies
Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.
Diabetic Nephropathies
The protective role of fucosylated chondroitin sulfate, a distinct glycosaminoglycan, in a murine model of streptozotocin-induced diabetic nephropathy.
Diabetic Nephropathies
The receptor for advanced glycation endproducts mediates podocyte heparanase expression through NF-?B signaling pathway.
Diabetic Nephropathies
The role of heparanase and the endothelial glycocalyx in the development of proteinuria.
Diabetic Nephropathies
Urinary heparanase activity in patients with Type 1 and Type 2 diabetes.
Diabetic Nephropathies
Vitamin D attenuates proteinuria by inhibition of heparanase expression in the podocyte.
Diabetic Nephropathies
Xiao-Shen-Formula, a Traditional Chinese Medicine, Improves Glomerular Hyper-Filtration in Diabetic Nephropathy via Inhibiting Arginase Activation and Heparanase Expression.
Diabetic Retinopathy
Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy.
Diabetic Retinopathy
Retinal heparanase expression in streptozotocin-induced diabetic rats.
Diabetic Retinopathy
Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes.
Disseminated Intravascular Coagulation
Both UFH and NAH alleviate shedding of endothelial glycocalyx and coagulopathy in LPS-induced sepsis.
Empyema
Involvement of Heparanase in Empyema: Implication for Novel Therapeutic Approaches.
Encephalitis
Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis.
Encephalomyelitis
Differential effects of polysulfated polysaccharide on experimental encephalomyelitis, proliferation of autoimmune T cells, and inhibition of heparanase activity.
Encephalomyelitis
Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene1.
Encephalomyelitis, Autoimmune, Experimental
Differential effects of polysulfated polysaccharide on experimental encephalomyelitis, proliferation of autoimmune T cells, and inhibition of heparanase activity.
Encephalomyelitis, Autoimmune, Experimental
Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene1.
Endometrial Neoplasms
Correlation between heparanase gene polymorphism and susceptibility to endometrial cancer.
Endometrial Neoplasms
Expression of Tissue Factor and Heparanase in Endometrial Clear Cell Carcinoma: Possible Role for Tissue Factor in Thromboembolic Events.
Endometrial Neoplasms
Heparanase expression in both normal endometrium and endometrial cancer.
Endometrial Neoplasms
Heparanase expression in endometrial cancer: analysis of immunohistochemistry.
Endometrial Neoplasms
Heparanase expression increases throughout the endometrial hyperplasia-cancer sequence.
Endometrial Neoplasms
Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival.
Endometriosis
Immunohistochemical detection of heparanase-1 expression in eutopic and ectopic endometrium from women with endometriosis.
Endometriosis
[Expression of heparanase gene in eutopic and ectopic endometrium of women with endometriosis]
Epiretinal Membrane
Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes.
Esophageal Neoplasms
Antisense-mediated suppression of human heparanase gene expression inhibits pleural dissemination of human cancer cells.
Esophageal Neoplasms
Clinicopathological significance of heparanase and basic fibroblast growth factor expression in human esophageal cancer.
Esophageal Neoplasms
Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC9706 cells.
Esophageal Neoplasms
Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.
Esophageal Neoplasms
Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage.
Esophageal Neoplasms
Localization of heparanase in esophageal cancer cells: respective roles in prognosis and differentiation.
Esophageal Neoplasms
The close correlation between heparanase and COX-2 expression in lymphangiogenesis of cervical cancer.
Esophageal Neoplasms
The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach.
Esophageal Squamous Cell Carcinoma
Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC9706 cells.
Esophageal Squamous Cell Carcinoma
Quantitative analysis of heparanase gene expression in esophageal squamous cell carcinoma.
Exostoses
Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses.
Exostoses
Syndecans and Enzymes for Heparan Sulfate Biosynthesis and Modification Differentially Correlate With Presence of Inflammatory Infiltrate in Periodontitis.
Exostoses
The molecular and cellular basis of exostosis formation in hereditary multiple exostoses.
Exostoses, Multiple Hereditary
Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses.
Fatty Liver
Heparanase inhibition attenuates atherosclerosis progression and liver steatosis in E0 mice.
Gallbladder Neoplasms
Heparanase and gallbladder cancer: new insights into understanding tumor growth and invasion.
Gallbladder Neoplasms
Heparanase expression in gallbladder carcinoma and its correlation to prognosis.
Gallbladder Neoplasms
Heparanase overexpression down-regulates syndecan-1 expression in a gallbladder carcinoma cell line.
Gallbladder Neoplasms
Isolation of a human gallbladder cancer cell clone with high invasive phenotype in vitro and metastatic potential in orthotopic model and inhibition of its invasiveness by heparanase antisense oligodeoxynucleotides.
Gastritis
Helicobacter pylori-Induced Heparanase Promotes H. pylori Colonization and Gastritis.
Gastrointestinal Neoplasms
Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
Glioblastoma
Heparanase expression is associated with histone modifications in glioblastoma.
Glioma
Correction: Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival.
Glioma
Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma.
Glioma
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.
Glioma
Heparanase Promotes Glioma Progression and is Inversely Correlated with Patient Survival.
Glioma
Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells.
Glomerulonephritis
Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria.
Glomerulonephritis
Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.
Glomerulonephritis
Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritis.
Glomerulonephritis
Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy.
Glomerulonephritis, IGA
Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy.
Glomerulonephritis, Membranoproliferative
Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy.
Glomerulonephritis, Membranous
A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritis.
Glomerulonephritis, Membranous
Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.
Glomerulonephritis, Membranous
Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritis.
Glomerulonephritis, Membranous
Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy.
Glomerulonephritis, Membranous
Urinary heparanase activity in patients with Type 1 and Type 2 diabetes.
Graft vs Host Disease
Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantation.
Graft vs Host Disease
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.
Head and Neck Neoplasms
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.
Head and Neck Neoplasms
Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis.
Head and Neck Neoplasms
Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation: PRECLINICAL AND CLINICAL SIGNIFICANCE IN HEAD AND NECK CANCER.
Head and Neck Neoplasms
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival.
Head and Neck Neoplasms
Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma.
Head and Neck Neoplasms
Opposing Effects of Heparanase and Heparanase-2 in Head & Neck Cancer.
Heart Diseases
Heparanase protects the heart against chemical or ischemia/reperfusion injury.
Heart Failure
Identification of circulating placental mRNA in maternal blood of pregnancies affected with fetal congenital heart diseases at the second trimester of pregnancy: implications for early molecular screening.
Hematologic Neoplasms
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Hematologic Neoplasms
Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression.
Hematologic Neoplasms
Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis.
Hematologic Neoplasms
Heparanase: From basic research to therapeutic applications in cancer and inflammation.
Hematologic Neoplasms
Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds.
heparanase deficiency
Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase.
heparanase deficiency
Heparanase Deficiency Is Associated with Disruption, Detachment, and Folding of the Retinal Pigment Epithelium.
heparanase deficiency
Is host heparanase required for the rapid spread of heparan sulfate binding viruses?
Hepatic Veno-Occlusive Disease
Heparanase polymorphisms: influence on incidence of hepatic sinusoidal obstruction syndrome in children undergoing allogeneic hematopoietic stem cell transplantation.
Herpes Simplex
Heparanase is a host enzyme required for herpes simplex virus-1 release from cells.
Herpes Simplex
Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus-2 Release from Cells.
Herpes Simplex
Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1.
Hodgkin Disease
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Hodgkin Disease
Heparanase Expression Is Associated With Cancer Stem Cell Features and Radioresistance in Hodgkin's Lymphoma Cells.
Hodgkin Disease
Plasma heparanase as a significant marker of treatment response in children with Hodgkin lymphoma: pilot study.
Hyperalgesia
Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice.
Hyperglycemia
Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus.
Hyperglycemia
Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity.
Hyperglycemia
Endothelial cell injury by high glucose and heparanase is prevented by insulin, heparin and basic fibroblast growth factor.
Hyperglycemia
Endothelial heparanase secretion after acute hypoinsulinemia is regulated by glucose and fatty acid.
Hyperglycemia
Heparanase upregulation from adipocyte associates with inflammation and endothelial injury in diabetic condition.
Hyperglycemia
Inhibition of heparanase protects against pancreatic beta cell death in streptozotocin-induced diabetic mice via reducing intra-islet inflammatory cell infiltration.
Hyperglycemia
Intrinsic and extrinsic regulation of cardiac lipoprotein lipase following diabetes.
Hypersensitivity
A disaccharide that inhibits tumor necrosis factor alpha is formed from the extracellular matrix by the enzyme heparanase.
Hypersensitivity
Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice.
Hypersensitivity
Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell-mediated immunity.
Hypersensitivity
Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins.
Hypersensitivity
The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.
Infarction, Middle Cerebral Artery
Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion.
Infections
Antisense-mediated suppression of human heparanase gene expression inhibits pleural dissemination of human cancer cells.
Infections
Heat Shock Protein Member 8 Is an Attachment Factor for Infectious Bronchitis Virus.
Infections
Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression.
Infections
Helicobacter pylori-Induced Heparanase Promotes H. pylori Colonization and Gastritis.
Infections
Helicobacter pylori infection enhances heparanase leading to cell proliferation via mitogen?activated protein kinase signalling in human gastric cancer cells.
Infections
Heparanase is a host enzyme required for herpes simplex virus-1 release from cells.
Infections
Heparanase Upregulation Contributes to Porcine Reproductive and Respiratory Syndrome Virus Release.
Infections
Heparanase-Regulated Syndecan-1 Shedding Facilitates Herpes Simplex Virus 1 Egress.
Infections
Interaction of human papillomavirus type 16 particles with heparan sulfate and syndecan-1 molecules in the keratinocyte extracellular matrix plays an active role in infection.
Infections
Involvement of Heparanase in Empyema: Implication for Novel Therapeutic Approaches.
Infections
Murine ocular heparanase expression before and during infection with Pseudomonas aeruginosa.
Infections
The interaction of human papillomavirus type 16 particles with heparan sulfate and syndecan-1 molecules in the keratinocyte extracellular matrix plays an active role in infection.
Infections
Transgenic over-expression of mammalian heparanase delays prion disease onset and progression.
Inflammatory Bowel Diseases
Heparanase enzyme in chronic inflammatory bowel disease and colon cancer.
Inflammatory Bowel Diseases
Heparanase upregulation by colonic epithelium in inflammatory bowel disease.
Inflammatory Bowel Diseases
Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications.
Inflammatory Bowel Diseases
Involvement of Syndecan-1 and Heparanase in Cancer and Inflammation.
Inflammatory Breast Neoplasms
Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas.
Intervertebral Disc Degeneration
STUDIES OF MOLECULAR CHANGES IN INTERVERTEBRAL DISC DEGENERATION IN ANIMAL MODEL.
Intervertebral Disc Degeneration
The Expression of Heparanase Isoforms in Intervertebral Discs Classified According to Pfirrmann's Grading System for Disc Degeneration.
Ischemic Stroke
Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats.
Keratoconus
Heparanase Overexpresses in Keratoconic Cornea and Tears Depending on the Pathologic Grade.
Kidney Diseases
Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.
Laryngeal Neoplasms
Tumor heparanase expression in predicting response to induction chemotherapy in patients with locally advanced laryngeal cancer.
Leukemia
Cell surface localization of heparanase on macrophages regulates degradation of extracellular matrix heparan sulfate.
Leukemia
Differentiating human leukemia cells express heparanase that degrades heparan sulfate in subendothelial extracellular matrix.
Leukemia
Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII.
Leukemia
Heparanase expression in human leukemias is restricted to acute myeloid leukemias.
Leukemia
Heparanase induces tissue factor expression in vascular endothelial and cancer cells.
Leukemia
Leukomogenic factors downregulate heparanase expression in acute myeloid leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Heparanase expression in human leukemias is restricted to acute myeloid leukemias.
Leukemia, Lymphoid
Heparanase expression in human leukemias is restricted to acute myeloid leukemias.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Heparanase expression in human leukemias is restricted to acute myeloid leukemias.
Leukemia, Myeloid, Acute
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Leukemia, Myeloid, Acute
Heparanase expression in human leukemias is restricted to acute myeloid leukemias.
Leukemia, Myeloid, Acute
Leukomogenic factors downregulate heparanase expression in acute myeloid leukemia cells.
Leukemia, Promyelocytic, Acute
Leukomogenic factors downregulate heparanase expression in acute myeloid leukemia cells.
Liver Cirrhosis
Expression of heparanase in hepatocellular carcinoma has prognostic significance: a tissue microarray study.
Liver Cirrhosis
Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats.
Liver Diseases
[Expressions of breast cancer metastasis suppressor-1 and heparanase in primary hepatocellular carcinoma and chronic liver diseases and the clinicopathological significances].
Liver Neoplasms
Downregulation of heparanase by RNA interference inhibits invasion and tumorigenesis of hepatocellular cancer cells in vitro and in vivo.
Liver Neoplasms
Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma.
Liver Neoplasms
[Effects of anti-heparanase antibody on the growth and invasion of HCCLM6 human hepatocellular carcinoma cells]
Lung Diseases
[Heparanase and vascular endothelial growth factor expression in non-small-cell lung cancer]
Lung Injury
Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury.
Lung Injury
Heparanase pretreatment attenuates endotoxin-induced acute lung injury in rats.
Lung Neoplasms
Antisense-mediated suppression of human heparanase gene expression inhibits pleural dissemination of human cancer cells.
Lung Neoplasms
CCL19/CCR7 upregulates heparanase via specificity protein-1 (Sp1) to promote invasion of cell in lung cancer.
Lung Neoplasms
Clinical significance of heparanase activity in primary resected non-small cell lung cancer.
Lung Neoplasms
Down-regulation of heparanase leads to the inhibition of invasion and proliferation of A549 cells in vitro and in vivo.
Lung Neoplasms
Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro.
Lung Neoplasms
H-2Kb-restricted CTL epitopes from mouse heparanase elicit an antitumor immune response in vivo.
Lung Neoplasms
Heparanase expression and localization in different types of human lung cancer.
Lung Neoplasms
Heparanase expression correlates with angiogenesis and lymphangiogenesis in human lung cancer.
Lung Neoplasms
Heparanase is overexpressed in lung cancer and correlates inversely with patient survival.
Lung Neoplasms
Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients.
Lung Neoplasms
Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
Lung Neoplasms
Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer.
Lung Neoplasms
The expression of heparanase and microRNA-1258 in human non-small cell lung cancer.
Lung Neoplasms
[Clinical significance of heparanase and basic fibroblast growth factor expression in human non-small cell lung cancer]
Lung Neoplasms
[Effect of 14-membered ring macrolides on heparanase mRNA expression in lung cancer cells]
Lung Neoplasms
[Effects of heparanase inhibition by RNA interference on proliferation, invasiveness and apoptosis of lung cancer cells]
Lung Neoplasms
[Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer.]
Lung Neoplasms
[Heparanase and vascular endothelial growth factor expression in non-small-cell lung cancer]
Lung Neoplasms
[The expression and clinical significance of heparanase in non-small cell lung cancer.]
Lung Neoplasms
[The expression of heparanase and vascular endothelial growth factor-C in human lung cancer]
Lupus Nephritis
Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy.
Lymphatic Metastasis
Clinical relevance of heparanase mRNA expression in bladder cancer and its usefulness as a detection marker in voided urine.
Lymphatic Metastasis
Clinical significance of heparanase activity in primary resected non-small cell lung cancer.
Lymphatic Metastasis
Coexpression of heparanase, basic fibroblast growth factor and vascular endothelial growth factor in human esophageal carcinomas.
Lymphatic Metastasis
Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data.
Lymphatic Metastasis
Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.
Lymphatic Metastasis
Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas.
Lymphatic Metastasis
Expression of resistin-like molecule beta in gastric cancer: its relationship with clinicopathological parameters and prognosis.
Lymphatic Metastasis
Expression of SATB1 and heparanase in gastric cancer and its relationship to clinicopathologic features.
Lymphatic Metastasis
Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors.
Lymphatic Metastasis
Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis.
Lymphatic Metastasis
Heparanase expression correlates with angiogenesis and lymphangiogenesis in human lung cancer.
Lymphatic Metastasis
Heparanase expression correlates with invasion and poor prognosis in gastric cancers.
Lymphatic Metastasis
Heparanase expression in both normal endometrium and endometrial cancer.
Lymphatic Metastasis
Heparanase expression in gallbladder carcinoma and its correlation to prognosis.
Lymphatic Metastasis
Heparanase mRNA and Protein Expression Correlates with Clinicopathologic Features of Gastric Cancer Patients: a Meta- analysis.
Lymphatic Metastasis
High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.
Lymphatic Metastasis
Localization of heparanase in esophageal cancer cells: respective roles in prognosis and differentiation.
Lymphatic Metastasis
Loss of basement membrane heparan sulfate expression is associated with pelvic lymph node metastasis in invasive cervical cancer.
Lymphatic Metastasis
Opposing Effects of Heparanase and Heparanase-2 in Head & Neck Cancer.
Lymphatic Metastasis
Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma.
Lymphatic Metastasis
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor.
Lymphatic Metastasis
The role of heparanase in lymph node metastatic dissemination: dynamic contrast-enhanced MRI of Eb lymphoma in mice.
Lymphatic Metastasis
[Correlation of expression of heparanase to angiogenesis and prognosis of breast cancer.]
Lymphatic Metastasis
[Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer.]
Lymphatic Metastasis
[Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]
Lymphatic Metastasis
[Expression of heparanase gene and the metastatic activity of lung cancer.]
Lymphatic Metastasis
[Prediction of lymph node metastasis with binary logistic regression in gastric carcinoma]
Lymphatic Metastasis
[Relation of heparanase mRNA expression and angiogenesis to the progression of gastric carcinoma]
Lymphatic Metastasis
[The association between the prognosis and the localization and expression?of heparanase in human laryngeal squamous cell carcinoma].
Lymphatic Metastasis
[The expression and clinical significance of heparanase in non-small cell lung cancer.]
Lymphatic Metastasis
[The expression and potentially clinical significance of heparanase in nasopharyngeal carcinoma]
Lymphoma
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis.
Lymphoma
Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation.
Lymphoma
Extracellular matrix-resident basic fibroblast growth factor: implication for the control of angiogenesis.
Lymphoma
H-2Kb-restricted CTL epitopes from mouse heparanase elicit an antitumor immune response in vivo.
Lymphoma
Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix.
Lymphoma
Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis.
Lymphoma
Heparanase: From basic research to therapeutic applications in cancer and inflammation.
Lymphoma
Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species.
Lymphoma
Involvement of both heparanase and plasminogen activator in lymphoma cell-mediated degradation of heparan sulfate in the subendothelial extracellular matrix.
Lymphoma
Murine macrophage heparanase: inhibition and comparison with metastatic tumor cells.
Lymphoma
Role of heparanase in platelet and tumor cell interactions with the subendothelial extracellular matrix.
Lymphoma
Structural requirements for inhibition of melanoma lung colonization by heparanase inhibiting species of heparin.
Lymphoma
The role of heparanase in lymph node metastatic dissemination: dynamic contrast-enhanced MRI of Eb lymphoma in mice.
Lymphoma
Thrombin enhances degradation of heparan sulfate in the extracellular matrix by tumor cell heparanase.
Lymphoma, Non-Hodgkin
Heparanase expression in human leukemias is restricted to acute myeloid leukemias.
Malaria
Genesis of placental sequestration in malaria and possible targets for drugs for placental malaria.
Medulloblastoma
Heparanase Modulates Shh and Wnt3a Signaling in Human Medulloblastoma Cells.
Medulloblastoma
Heparanase, TrkC and p75NTR: their functional involvement in human medulloblastoma cell invasion.
Medulloblastoma
Neurotrophin receptors and heparanase: a functional axis in human medulloblastoma invasion.
Melanoma
A phase II study of the heparanase inhibitor PI-88 in patients with advanced melanoma.
Melanoma
A solid-phase substrate of heparanase: its application to assay of human melanoma for heparan sulfate degradative activity.
Melanoma
Antiangiogenic Activity of Orally Absorbable Heparin Derivative in Different Types of Cancer Cells.
Melanoma
Antisense-mediated suppression of Heparanase gene inhibits melanoma cell invasion.
Melanoma
Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase.
Melanoma
Cell surface heparan sulfate released by heparanase promotes melanoma cell migration and angiogenesis.
Melanoma
Cell surface localization of heparanase on macrophages regulates degradation of extracellular matrix heparan sulfate.
Melanoma
Chemically modified heparins as inhibitors of heparan sulfate specific endo-beta-glucuronidase (heparanase) of metastatic melanoma cells.
Melanoma
Comparison of the heparanase enzymes from mouse melanoma cells, mouse macrophages, and human platelets.
Melanoma
Correlation of overexpression of the low-affinity p75 neurotrophin receptor with augmented invasion and heparanase production in human malignant melanoma cells.
Melanoma
Dominant-negative CREB inhibits heparanase functionality and melanoma cell invasion.
Melanoma
Enzyme responsiveness enhances the specificity and effectiveness of nanoparticles for the treatment of B16F10 melanoma.
Melanoma
Evaluation of heparanase and matrix metalloproteinase-9 in patients with cutaneous malignant melanoma.
Melanoma
FGF2 binding, signaling, and angiogenesis are modulated by heparanase in metastatic melanoma cells.
Melanoma
H-2Kb-restricted CTL epitopes from mouse heparanase elicit an antitumor immune response in vivo.
Melanoma
Heparanase and a synthetic peptide of heparan sulfate-interacting protein recognize common sites on cell surface and extracellular matrix heparan sulfate.
Melanoma
Heparanase and vascular endothelial growth factor expression in the progression of oral mucosal melanoma.
Melanoma
Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies.
Melanoma
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.
Melanoma
Heparanase Level in the Microcirculation as a Possible Modulator of the Metastatic Process.
Melanoma
Heparanase mechanisms of melanoma metastasis to the brain: Development and use of a brain slice model.
Melanoma
Hinokitiol reduces tumor metastasis by inhibiting heparanase via extracellular signal-regulated kinase and protein kinase B pathway.
Melanoma
Human melanoma cell invasion: selected neurotrophin enhancement of invasion and heparanase activity.
Melanoma
Increased levels of ?-catenin, LEF-1, and HPA-1 correlate with poor prognosis for acral melanoma with negative BRAF and NRAS mutation in BRAF exons 11 and 15 and NRAS exons 1 and 2.
Melanoma
Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues.
Melanoma
Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides.
Melanoma
Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis.
Melanoma
Latent Heparanase Facilitates VLA-4-Mediated Melanoma Cell Binding and Emerges As a Relevant Target of Heparin in the Interference with Metastatic Progression.
Melanoma
Lentiviral miR30-based RNA interference against heparanase suppresses melanoma metastasis with lower liver and lung toxicity.
Melanoma
Malignant melanoma metastasis to brain: role of degradative enzymes and responses to paracrine growth factors.
Melanoma
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
Melanoma
Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase.
Melanoma
Modulation of GEF-H1 induced signaling by heparanase in brain metastatic melanoma cells.
Melanoma
Murine macrophage heparanase: inhibition and comparison with metastatic tumor cells.
Melanoma
Mutual enhancement between heparanase and vascular endothelial growth factor: a novel mechanism for melanoma progression.
Melanoma
Nerve growth factor effects on human and mouse melanoma cell invasion and heparanase production.
Melanoma
Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations.
Melanoma
Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity.
Melanoma
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins.
Melanoma
p75 neurotrophin receptor functions as a survival receptor in brain-metastatic melanoma cells.
Melanoma
Pro-Angiogenic Effects of Latent Heparanase and Thrombin Receptor-Mediated Pathways-Do They Share a Common Ground in Melanoma Cells?
Melanoma
Specific degradation of subendothelial matrix proteoglycans by brain-metastatic melanoma and brain endothelial cell heparanases.
Melanoma
Structural requirements for inhibition of melanoma lung colonization by heparanase inhibiting species of heparin.
Melanoma
Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase.
Melanoma
The endothelial glycocalyx anchors von Willebrand factor fibers to the vascular endothelium.
Melanoma
Transcriptomic analysis reveals cell apoptotic signature modified by heparanase in melanoma cells.
Melanoma
Tumor metastasis-associated heparanase (heparan sulfate endoglycosidase) activity in human melanoma cells.
Melanoma
[Construction of heparanase gene-targeted small interfering RNA and its gene silencing effect]
Melanoma, Experimental
Characterization of extracellular matrix-associated glycosaminoglycans produced by untransformed and transformed bovine corneal endothelial cells in culture.
Melanoma, Experimental
Chemically modified heparins as inhibitors of heparan sulfate specific endo-beta-glucuronidase (heparanase) of metastatic melanoma cells.
Melanoma, Experimental
Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies.
Melanoma, Experimental
Heparanase Level in the Microcirculation as a Possible Modulator of the Metastatic Process.
Melanoma, Experimental
Immunoselection of GRP94/endoplasmin from a KNRK cell-specific lambda gt11 library using antibodies directed against a putative heparanase amino-terminal peptide.
Melanoma, Experimental
Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase.
Melanoma, Experimental
Nerve growth factor effects on human and mouse melanoma cell invasion and heparanase production.
Mesothelioma
Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
Mesothelioma, Malignant
Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma.
Mouth Neoplasms
Expression of heparanase in oral cancer cell lines and oral cancer tissues.
Mouth Neoplasms
Mechanisms of OGT2115 inhibition of invasion and migration in KB oral cancer cells.
Mouth Neoplasms
Prognostic value of heparanase expression and cellular localization in oral cancer.
Mucopolysaccharidoses
Activity-based probes for functional interrogation of retaining ?-glucuronidases.
Mucopolysaccharidosis VII
Activity-based probes for functional interrogation of retaining ?-glucuronidases.
Multiple Myeloma
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Multiple Myeloma
FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells.
Multiple Myeloma
Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL.
Multiple Myeloma
Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.
Multiple Myeloma
Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma.
Multiple Myeloma
Heparanase inhibits osteoblastogenesis and shifts bone marrow progenitor cell fate in myeloma bone disease.
Multiple Myeloma
High heparanase activity in multiple myeloma is associated with elevated microvessel density.
Multiple Myeloma
Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.
Multiple Myeloma
MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase.
Multiple Myeloma
NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma.
Multiple Myeloma
Novel N-acetyl-Glycol-split heparin biotin-conjugates endowed with anti-heparanase activity.
Multiple Myeloma
Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function.
Multiple Myeloma
Peripheral neuropathy following bortezomib therapy in multiple myeloma patients: association with cumulative dose, heparanase, and TNF-?.
Multiple Myeloma
Polymorphisms in the heparanase gene in multiple myeloma association with bone morbidity and survival.
Multiple Myeloma
Preclinical studies in support of defibrotide for the treatment of multiple myeloma and other neoplasias.
Multiple Sclerosis
Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis.
Myelodysplastic Syndromes
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Myocardial Infarction
Heparanase is a predictive marker for high thrombus burden in patients with ST-segment elevation myocardial infarction.
Myocardial Infarction
Involvement of heparanase in atherosclerosis and other vessel wall pathologies.
Myoma
Effects of ionizing radiation and HPSE1 inhibition on the invasion of oral tongue carcinoma cells on human extracellular matrices in vitro.
Nasopharyngeal Carcinoma
Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival.
Nasopharyngeal Carcinoma
Heparanase is involved in the proliferation and invasion of nasopharyngeal carcinoma cells.
Nasopharyngeal Carcinoma
[Effects of cisplatin combined with heparanase inhibitor on proliferation and invasion of human nasopharyngeal carcinoma cells].
Nasopharyngeal Carcinoma
[The expression and potentially clinical significance of heparanase in nasopharyngeal carcinoma]
Nasopharyngeal Neoplasms
[The expression and potentially clinical significance of heparanase in nasopharyngeal carcinoma]
Neoplasm Metastasis
1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase.
Neoplasm Metastasis
A novel human anti-syndecan-1 antibody inhibits vascular maturation and tumour growth in melanoma.
Neoplasm Metastasis
A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane.
Neoplasm Metastasis
A rapid quantitative assay for the detection of mammalian heparanase activity.
Neoplasm Metastasis
Abnormal expression of early growth response 1 in gastric cancer: association with tumor invasion, metastasis and heparanase transcription.
Neoplasm Metastasis
Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.
Neoplasm Metastasis
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis.
Neoplasm Metastasis
An ELISA method for the detection and quantification of human heparanase.
Neoplasm Metastasis
An Overview of the Structure, Mechanism and Specificity of Human Heparanase.
Neoplasm Metastasis
Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor.
Neoplasm Metastasis
Anti-heparanase activity of ultra-low-molecular-weight heparin produced by physicochemical depolymerization.
Neoplasm Metastasis
Anti-heparanase aptamers as potential diagnostic and therapeutic agents for oral cancer.
Neoplasm Metastasis
Anti-heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing.
Neoplasm Metastasis
Antimetastatic activities of modified heparins: selectin inhibition by heparin attenuates metastasis.
Neoplasm Metastasis
Antimetastatic effects associated with anticoagulant properties of heparin and chemically modified heparin species in a mouse mammary tumor model.
Neoplasm Metastasis
Antitumor activity and structure-activity relationship of heparanase inhibitors: Recent advances.
Neoplasm Metastasis
Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment.
Neoplasm Metastasis
Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/-9 and heparanase in MDA-MB-231 cells.
Neoplasm Metastasis
Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase.
Neoplasm Metastasis
Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of ?-Carrageenan Derivative as a Potent Anti Angiogenic Agent.
Neoplasm Metastasis
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Neoplasm Metastasis
Association of heparanase gene (HPSE-1) single nucleotide polymorphisms with gastric cancer.
Neoplasm Metastasis
Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase.
Neoplasm Metastasis
Bacterial expression and functional reconstitution of human heparanase.
Neoplasm Metastasis
Berberine inhibits the migration and invasion of T24 bladder cancer cells via reducing the expression of heparanase.
Neoplasm Metastasis
Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells.
Neoplasm Metastasis
BRMS1 and HPA as Progression, Clinical Biological Behaviors, and Poor Prognosis-related Biomarkers for Gallbladder Adenocarcinoma.
Neoplasm Metastasis
Cancer cell heparanase activity associated with invasion and metastasis.
Neoplasm Metastasis
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis.
Neoplasm Metastasis
Cellular uptake of mammalian heparanase precursor involves low density lipoprotein receptor-related proteins, mannose 6-phosphate receptors, and heparan sulfate proteoglycans.
Neoplasm Metastasis
Characterization of mechanisms involved in secretion of active heparanase.
Neoplasm Metastasis
Chemical shift assignments and secondary structure of the surrogate domain for drug discovery studies of human heparanase.
Neoplasm Metastasis
Chemically modified heparins as inhibitors of heparan sulfate specific endo-beta-glucuronidase (heparanase) of metastatic melanoma cells.
Neoplasm Metastasis
Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.
Neoplasm Metastasis
Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior.
Neoplasm Metastasis
CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.
Neoplasm Metastasis
Clinical relevance of heparanase mRNA expression in bladder cancer and its usefulness as a detection marker in voided urine.
Neoplasm Metastasis
Clinical significance of heparanase activity in primary resected non-small cell lung cancer.
Neoplasm Metastasis
Clinical significance of urine heparanase in bladder cancer progression.
Neoplasm Metastasis
Clinical value of combined detection of serum matrix metalloproteinase-9, heparanase, and cathepsin for determining ovarian cancer invasion and metastasis.
Neoplasm Metastasis
Clinicopathological significance of heparanase and basic fibroblast growth factor expression in human esophageal cancer.
Neoplasm Metastasis
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis.
Neoplasm Metastasis
Cloning of two splice variants of Spalax heparanase encoding for truncated proteins.
Neoplasm Metastasis
Cloning, expression, and characterization of an alternatively spliced variant of human heparanase.
Neoplasm Metastasis
Co-expression of CD44v3 and heparanase is correlated with metastasis of human colon cancer.
Neoplasm Metastasis
Coexpression of heparanase, basic fibroblast growth factor and vascular endothelial growth factor in human esophageal carcinomas.
Neoplasm Metastasis
Computational Analyses of the Catalytic and Heparin Binding Sites and their Interactions with Glycosaminoglycans in Glycoside Hydrolase Family 79 Endo-{beta}-D-Glucuronidase (Heparanase).
Neoplasm Metastasis
Contribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T.
Neoplasm Metastasis
Curcumin inhibits CT26 cells metastasis by decreasing heparanase expression.
Neoplasm Metastasis
CXCL7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C, VEGF-D in Human Breast Cancer Cells.
Neoplasm Metastasis
Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycans.
Neoplasm Metastasis
Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy.
Neoplasm Metastasis
Development and NMR validation of minimal pharmacophore hypotheses for the generation of fragment libraries enriched in heparanase inhibitors.
Neoplasm Metastasis
Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening.
Neoplasm Metastasis
DHA/EPA-Enriched Phosphatidylcholine Suppresses Tumor Growth and Metastasis via Activating Peroxisome Proliferator-Activated Receptor ? in Lewis Lung Cancer Mice.
Neoplasm Metastasis
DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.
Neoplasm Metastasis
Down-regulation of heparanase leads to the inhibition of invasion and proliferation of A549 cells in vitro and in vivo.
Neoplasm Metastasis
Downregulating the expression of heparanase inhibits the invasion, angiogenesis and metastasis of human hepatocellular carcinoma.
Neoplasm Metastasis
Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.
Neoplasm Metastasis
Effect of Fraxiparine, a type of low molecular weight heparin, on the invasion and metastasis of lung adenocarcinoma A549 cells.
Neoplasm Metastasis
Effects of small interfering RNA targeting heparanase-1 combined with heparin on invasiveness of mouse hepatocellular carcinoma cell lines.
Neoplasm Metastasis
Elemene inhibits the migration and invasion of 4T1 murine breast cancer cells via heparanase.
Neoplasm Metastasis
Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data.
Neoplasm Metastasis
Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.
Neoplasm Metastasis
Enoxaparin Attenuates Mouse Colon Cancer Liver Metastases by Inhibiting Heparanase and Interferon-?-inducible Chemokines.
Neoplasm Metastasis
Epidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase I activity in brain metastatic breast cancer.
Neoplasm Metastasis
Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro.
Neoplasm Metastasis
Expression and correlation of matrix metalloproteinase-9 and heparanase in patients with breast cancer.
Neoplasm Metastasis
Expression and significance of heparanase and nm23-H1 in hepatocellular carcinoma.
Neoplasm Metastasis
Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.
Neoplasm Metastasis
Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas.
Neoplasm Metastasis
Expression of heparanase in hepatocellular carcinoma has prognostic significance: a tissue microarray study.
Neoplasm Metastasis
Expression of heparanase in human tumor cell lines and human head and neck tumors.
Neoplasm Metastasis
Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion.
Neoplasm Metastasis
Expression of heparanase in oral cancer cell lines and oral cancer tissues.
Neoplasm Metastasis
Expression of heparanase in renal cell carcinomas: implications for tumor invasion and prognosis.
Neoplasm Metastasis
Expression of heparanase in vascular cells and astrocytes of the mouse brain after focal cerebral ischemia.
Neoplasm Metastasis
Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC9706 cells.
Neoplasm Metastasis
Expression of heparanase: a possible role in invasiveness and aggressive clinical behavior of ameloblastomas.
Neoplasm Metastasis
Expression of resistin-like molecule beta in gastric cancer: its relationship with clinicopathological parameters and prognosis.
Neoplasm Metastasis
Expression of SATB1 and heparanase in gastric cancer and its relationship to clinicopathologic features.
Neoplasm Metastasis
Expression of three extracellular matrix degradative enzymes in bladder cancer.
Neoplasm Metastasis
Expression of Tissue Factor and Heparanase in Endometrial Clear Cell Carcinoma: Possible Role for Tissue Factor in Thromboembolic Events.
Neoplasm Metastasis
Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Neoplasm Metastasis
Family of Bioactive Heparin-Coated Iron Oxide Nanoparticles with Positive Contrast in Magnetic Resonance Imaging for Specific Biomedical Applications.
Neoplasm Metastasis
FGF2 binding, signaling, and angiogenesis are modulated by heparanase in metastatic melanoma cells.
Neoplasm Metastasis
Function of heparanase in prostate tumorigenesis: potential for therapy.
Neoplasm Metastasis
Genomic organization and chromosome localization of the newly identified human heparanase gene.
Neoplasm Metastasis
Growth-modulatory effects of heparin and VEGF165 on the choriocarcinoma cell-line JEG-3 and its expression of heparanase.
Neoplasm Metastasis
Gubenyiliu II Inhibits Breast Tumor Growth and Metastasis Associated with Decreased Heparanase Expression and Phosphorylation of ERK and AKT Pathways.
Neoplasm Metastasis
Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression.
Neoplasm Metastasis
Helicobacter pylori infection enhances heparanase leading to cell proliferation via mitogen?activated protein kinase signalling in human gastric cancer cells.
Neoplasm Metastasis
Heparan sulfate and heparanase as modulators of breast cancer progression.
Neoplasm Metastasis
Heparan sulfate chains contribute to the anticoagulant milieu in malignant pleural effusion.
Neoplasm Metastasis
Heparan sulfate containing unsubstituted glucosamine residues: biosynthesis and heparanase-inhibitory activity.
Neoplasm Metastasis
Heparan sulfate endoglycosidase and metastatic potential in murine fibrosarcoma and melanoma.
Neoplasm Metastasis
Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation.
Neoplasm Metastasis
Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis.
Neoplasm Metastasis
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.
Neoplasm Metastasis
Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma.
Neoplasm Metastasis
Heparanase and Chemotherapy Synergize to Drive Macrophage Activation and Enhance Tumor Growth.
Neoplasm Metastasis
Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors.
Neoplasm Metastasis
Heparanase and heparanase 2 display differently deregulation in neuroendocrine tumors, depending on their differentiation grade.
Neoplasm Metastasis
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression.
Neoplasm Metastasis
Heparanase Enhances Early Hepatocyte Inclusion in the Recipient Liver after Transplantation in Partially Hepatectomized Rats.
Neoplasm Metastasis
Heparanase enhances early hepatocyte inclusion in the recipient liver after transplantation in partially hepatectomized rats.
Neoplasm Metastasis
Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL.
Neoplasm Metastasis
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.
Neoplasm Metastasis
Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII.
Neoplasm Metastasis
Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy.
Neoplasm Metastasis
Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis.
Neoplasm Metastasis
Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression.
Neoplasm Metastasis
Heparanase expression correlates with angiogenesis and lymphangiogenesis in human lung cancer.
Neoplasm Metastasis
Heparanase expression correlates with invasion and poor prognosis in gastric cancers.
Neoplasm Metastasis
Heparanase expression correlates with malignant potential in human colon cancer.
Neoplasm Metastasis
Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.
Neoplasm Metastasis
Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies.
Neoplasm Metastasis
Heparanase expression in both normal endometrium and endometrial cancer.
Neoplasm Metastasis
Heparanase expression in circulating lymphocytes of breast cancer patients depends on the presence of the primary tumor and/or systemic metastasis.
Neoplasm Metastasis
Heparanase expression in endometrial cancer: analysis of immunohistochemistry.
Neoplasm Metastasis
Heparanase expression in gallbladder carcinoma and its correlation to prognosis.
Neoplasm Metastasis
Heparanase expression in hepatocellular carcinoma and the cirrhotic liver.
Neoplasm Metastasis
Heparanase expression in human colorectal cancer and its relationship to tumor angiogenesis, hematogenous metastasis, and prognosis.
Neoplasm Metastasis
Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer.
Neoplasm Metastasis
Heparanase expression upregulates platelet adhesion activity and thrombogenicity.
Neoplasm Metastasis
Heparanase expression, degradation of basement membrane and low degree of infiltration by immunocytes correlate with invasion and progression of human gastric cancer.
Neoplasm Metastasis
Heparanase expression: a potential ancillary diagnostic tool for distinguishing between malignant cells and reactive mesothelium in body cavity effusions.
Neoplasm Metastasis
Heparanase from triple?negative breast cancer and platelets acts as an enhancer of metastasis.
Neoplasm Metastasis
Heparanase gene expression and metastatic potential in human gastric cancer.
Neoplasm Metastasis
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.
Neoplasm Metastasis
Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma.
Neoplasm Metastasis
Heparanase induces tissue factor expression in vascular endothelial and cancer cells.
Neoplasm Metastasis
Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells.
Neoplasm Metastasis
Heparanase Inhibition by Pixatimod (PG545): Basic Aspects and Future Perspectives.
Neoplasm Metastasis
Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass.
Neoplasm Metastasis
Heparanase is overexpressed in lung cancer and correlates inversely with patient survival.
Neoplasm Metastasis
Heparanase Level in the Microcirculation as a Possible Modulator of the Metastatic Process.
Neoplasm Metastasis
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival.
Neoplasm Metastasis
Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src.
Neoplasm Metastasis
Heparanase mechanisms of melanoma metastasis to the brain: Development and use of a brain slice model.
Neoplasm Metastasis
Heparanase mediates cell adhesion independent of its enzymatic activity.
Neoplasm Metastasis
Heparanase mRNA and Protein Expression Correlates with Clinicopathologic Features of Gastric Cancer Patients: a Meta- analysis.
Neoplasm Metastasis
Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin.
Neoplasm Metastasis
Heparanase overexpression participates in tumor growth of cervical cancer in vitro and in vivo.
Neoplasm Metastasis
Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1? in osteosarcoma.
Neoplasm Metastasis
Heparanase promotes bone destruction and invasiveness in prostate cancer.
Neoplasm Metastasis
Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantation.
Neoplasm Metastasis
Heparanase promotes growth, angiogenesis and survival of primary breast tumors.
Neoplasm Metastasis
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.
Neoplasm Metastasis
Heparanase promotes the spontaneous metastasis of myeloma cells to bone.
Neoplasm Metastasis
Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis.
Neoplasm Metastasis
Heparanase protects the heart against chemical or ischemia/reperfusion injury.
Neoplasm Metastasis
Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage.
Neoplasm Metastasis
Heparanase regulates in vitro VEGF-C expression and its clinical significance to pancreatic ductal cell adenocarcinoma.
Neoplasm Metastasis
Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.
Neoplasm Metastasis
Heparanase regulates secretion, composition and function of tumor cell-derived exosomes.
Neoplasm Metastasis
Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.
Neoplasm Metastasis
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
Neoplasm Metastasis
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans.
Neoplasm Metastasis
Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective.
Neoplasm Metastasis
Heparanase-1 gene expression in normal, hyperplastic and neoplastic prostatic tissue.
Neoplasm Metastasis
Heparanase-2 and syndecan-1 in colon cancer: the ugly ducklings or the beautiful swans?
Neoplasm Metastasis
Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis.
Neoplasm Metastasis
Heparanase: a key enzyme in invasion and metastasis of gastric carcinoma.
Neoplasm Metastasis
Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes.
Neoplasm Metastasis
Heparanase: From basic research to therapeutic applications in cancer and inflammation.
Neoplasm Metastasis
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate.
Neoplasm Metastasis
Heparin, heparan sulfate and heparanase in cancer: remedy for metastasis?
Neoplasm Metastasis
Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-?B signaling pathway for gastric cancer metastasis.
Neoplasm Metastasis
High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.
Neoplasm Metastasis
High heparanase activity in multiple myeloma is associated with elevated microvessel density.
Neoplasm Metastasis
High-performance liquid chromatographic/mass spectrometric studies on the susceptibility of heparin species to cleavage by heparanase.
Neoplasm Metastasis
Hinokitiol reduces tumor metastasis by inhibiting heparanase via extracellular signal-regulated kinase and protein kinase B pathway.
Neoplasm Metastasis
HPSE enhancer RNA promotes cancer progression through driving chromatin looping and regulating hnRNPU/p300/EGR1/HPSE axis.
Neoplasm Metastasis
Human heparanase. Purification, characterization, cloning, and expression.
Neoplasm Metastasis
Human platelet heparanase: purification, characterization and catalytic activity.
Neoplasm Metastasis
Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression.
Neoplasm Metastasis
Hypoxia activates heparanase expression in an NF-kappaB dependent manner.
Neoplasm Metastasis
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.
Neoplasm Metastasis
Identification of active-site residues of the pro-metastatic endoglycosidase heparanase.
Neoplasm Metastasis
Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity.
Neoplasm Metastasis
Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications.
Neoplasm Metastasis
Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer.
Neoplasm Metastasis
Increased levels of ?-catenin, LEF-1, and HPA-1 correlate with poor prognosis for acral melanoma with negative BRAF and NRAS mutation in BRAF exons 11 and 15 and NRAS exons 1 and 2.
Neoplasm Metastasis
Inhibition of experimental metastasis and extracellular matrix degradation by butanol extracts from B16-F1 murine melanoma.
Neoplasm Metastasis
Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues.
Neoplasm Metastasis
Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides.
Neoplasm Metastasis
Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis.
Neoplasm Metastasis
Inhibition of tumor metastasis by heparanase inhibiting species of heparin.
Neoplasm Metastasis
Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis.
Neoplasm Metastasis
Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.
Neoplasm Metastasis
Involvement of heparanase in atherosclerosis and other vessel wall pathologies.
Neoplasm Metastasis
Involvement of Heparanase in Gastric Cancer Progression and Immunotherapy.
Neoplasm Metastasis
Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
Neoplasm Metastasis
Involvement of heparanase in tumor metastases: a new target in cancer therapy?
Neoplasm Metastasis
Involvement of the heparanase procoagulant domain in bleeding and wound healing.
Neoplasm Metastasis
Isolation of a human gallbladder cancer cell clone with high invasive phenotype in vitro and metastatic potential in orthotopic model and inhibition of its invasiveness by heparanase antisense oligodeoxynucleotides.
Neoplasm Metastasis
Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.
Neoplasm Metastasis
Lentiviral miR30-based RNA interference against heparanase suppresses melanoma metastasis with lower liver and lung toxicity.
Neoplasm Metastasis
Localization of heparanase in esophageal cancer cells: respective roles in prognosis and differentiation.
Neoplasm Metastasis
Loss of basement membrane heparan sulfate expression is associated with pelvic lymph node metastasis in invasive cervical cancer.
Neoplasm Metastasis
Lung colonization by and heparanase activity in in vitro transformed 3T3 cells rendered highly tumorigenic by an in vivo passage.
Neoplasm Metastasis
Maintenance on extracellular matrix and expression of heparanase activity by human ovarian carcinoma cells from biopsy specimens.
Neoplasm Metastasis
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
Neoplasm Metastasis
Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development.
Neoplasm Metastasis
Mechanism of anti-angiogenic activities of chitooligosaccharides may be through inhibiting heparanase activity.
Neoplasm Metastasis
MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase.
Neoplasm Metastasis
MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase.
Neoplasm Metastasis
MicroRNA-1258: An invasion and metastasis regulator that targets heparanase in gastric cancer.
Neoplasm Metastasis
miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase.
Neoplasm Metastasis
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting.
Neoplasm Metastasis
Molecular Aspects of Heparanase Interaction with Heparan Sulfate, Heparin and Glycol Split Heparin.
Neoplasm Metastasis
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
Neoplasm Metastasis
Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis.
Neoplasm Metastasis
Molecular properties and involvement of heparanase in cancer progression and normal development.
Neoplasm Metastasis
Nerve growth factor effects on human and mouse melanoma cell invasion and heparanase production.
Neoplasm Metastasis
New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis.
Neoplasm Metastasis
Normal colon tissue and colon carcinoma show no difference in heparanase promoter methylation.
Neoplasm Metastasis
Novel 1, 3-N, O-Spiroheterocyclic compounds inhibit heparanase activity and enhance nedaplatin-induced cytotoxicity in cervical cancer cells.
Neoplasm Metastasis
Novel peptides that inhibit heparanase activation of the coagulation system.
Neoplasm Metastasis
Novel Symmetrical Benzazolyl Derivatives Endowed with Potent Anti-Heparanase Activity.
Neoplasm Metastasis
Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function.
Neoplasm Metastasis
Oligomannurarate sulfate blocks tumor growth by inhibiting NF-kappaB activation.
Neoplasm Metastasis
Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-?B via targeting of Mre11.
Neoplasm Metastasis
Oligomannurarate Sulfate, a Novel Heparanase Inhibitor Simultaneously Targeting Basic Fibroblast Growth Factor, Combats Tumor Angiogenesis and Metastasis.
Neoplasm Metastasis
Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis.
Neoplasm Metastasis
Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression.
Neoplasm Metastasis
Overexpression of heparanase in ovarian cancer and its clinical significance.
Neoplasm Metastasis
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins.
Neoplasm Metastasis
Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer.
Neoplasm Metastasis
PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma model.
Neoplasm Metastasis
PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer.
Neoplasm Metastasis
PO-49 - Bone microinfarction and microcirculation thrombosis; is it a possible mechanism for bone pain among cancer patients?
Neoplasm Metastasis
Polymeric fluorescent heparin as one-step FRET substrate of human heparanase.
Neoplasm Metastasis
Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma.
Neoplasm Metastasis
Preclinical and clinical significance of heparanase in Ewing's sarcoma.
Neoplasm Metastasis
Predictive value of heparanase expression in the palliative therapy of pancreatic cancer.
Neoplasm Metastasis
Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and ?-actinin.
Neoplasm Metastasis
Production of heparin and ?-carrageenan anti-heparanase derivatives using a combination of physicochemical depolymerization and glycol splitting.
Neoplasm Metastasis
Prognostic significance of heparanase expression in primary and metastatic breast carcinoma.
Neoplasm Metastasis
Properties and function of heparanase in cancer metastasis and angiogenesis.
Neoplasm Metastasis
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.
Neoplasm Metastasis
Quantitative analysis of heparanase gene expression in normal cervical, cervical intraepithelial neoplastic, and cervical carcinoma tissues.
Neoplasm Metastasis
Recent advances in renal cell carcinoma from a pathological point of view.
Neoplasm Metastasis
Recent advances in the discovery of heparanase inhibitors as anti-cancer agents.
Neoplasm Metastasis
Regulation of mouse Heparanase gene expression in T lymphocytes and tumor cells.
Neoplasm Metastasis
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.
Neoplasm Metastasis
Relationships between heparanase activity and increasing metastatic potential of fibroblasts transfected with various oncogenes.
Neoplasm Metastasis
Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.
Neoplasm Metastasis
Role of heparanase in platelet and tumor cell interactions with the subendothelial extracellular matrix.
Neoplasm Metastasis
Role of heparanase in tumor progression: Molecular aspects and therapeutic options.
Neoplasm Metastasis
Role of neurotrophins and neurotrophins receptors in the in vitro invasion and heparanase production of human prostate cancer cells.
Neoplasm Metastasis
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor.
Neoplasm Metastasis
Significance of host heparanase in promoting tumor growth and metastasis.
Neoplasm Metastasis
Silencing of Heparanase by siRNA Inhibits Tumor Metastasis and Angiogenesis of Human Breast Cancer In Vitro and In Vivo.
Neoplasm Metastasis
Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells.
Neoplasm Metastasis
Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells.
Neoplasm Metastasis
Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4.
Neoplasm Metastasis
Specific Inhibition of Heparanase by Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.
Neoplasm Metastasis
Stable knockdown of heparanase expression in gastric cancer cells in vitro.
Neoplasm Metastasis
Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence.
Neoplasm Metastasis
Structure modeling, ligand binding, and binding affinity calculation (LR-MM-PBSA) of human heparanase for inhibition and drug design.
Neoplasm Metastasis
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling.
Neoplasm Metastasis
Subcellular localization of human heparanase and its alternative splice variant in COS-7 cells.
Neoplasm Metastasis
Substitution-Inert Polynuclear Platinum Complexes as Metalloshielding Agents for Heparan Sulfate.
Neoplasm Metastasis
Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase.
Neoplasm Metastasis
Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase.
Neoplasm Metastasis
Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells.
Neoplasm Metastasis
Targeted silencing of heparanase gene by small interfering RNA inhibits invasiveness and metastasis of osteosarcoma cells.
Neoplasm Metastasis
Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds.
Neoplasm Metastasis
Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis.
Neoplasm Metastasis
Testing of potential glycan-based heparanase inhibitors in a fluorescence activity assay using either bacterial heparinase II or human heparanase.
Neoplasm Metastasis
The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma.
Neoplasm Metastasis
The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard.
Neoplasm Metastasis
The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation.
Neoplasm Metastasis
The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression.
Neoplasm Metastasis
The heparanase system and tumor metastasis: is heparanase the seed and soil?
Neoplasm Metastasis
The HPA/SDC1 axis promotes invasion and metastasis of pancreatic cancer cells by activating EMT via FGF2 upregulation.
Neoplasm Metastasis
The impact of heparanese and heparin on cancer metastasis and angiogenesis.
Neoplasm Metastasis
The improved targeting of an aspirin prodrug albumin-based nanosystem for visualizing and inhibiting lung metastasis of breast cancer.
Neoplasm Metastasis
The prognostic significance of heparanase expression in metastatic melanoma.
Neoplasm Metastasis
The role of heparanase in lymph node metastatic dissemination: dynamic contrast-enhanced MRI of Eb lymphoma in mice.
Neoplasm Metastasis
The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target.
Neoplasm Metastasis
The role of VLA-4 binding for experimental melanoma metastasis and its inhibition by heparin.
Neoplasm Metastasis
Thrombin is a selective inducer of heparanase release from platelets and granulocytes via protease-activated receptor-1.
Neoplasm Metastasis
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate.
Neoplasm Metastasis
Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue.
Neoplasm Metastasis
Tumor-elicited polymorphonuclear cells, in contrast to "normal" circulating polymorphonuclear cells, stimulate invasive and metastatic potentials of rat mammary adenocarcinoma cells.
Neoplasm Metastasis
Unraveling the specificity of heparanase utilizing synthetic substrates.
Neoplasm Metastasis
[Clinical significance of heparanase and basic fibroblast growth factor expression in human non-small cell lung cancer]
Neoplasm Metastasis
[Correlation between lymph-node metastasis and combined expression of Hpa and C-erbB-2 of invasive ductal breast carcinoma]
Neoplasm Metastasis
[Correlation of expression of heparanase to angiogenesis and prognosis of breast cancer.]
Neoplasm Metastasis
[Effect of exogenous expression of heparanase gene on invasive ability of colorectal cancer cell line HT29]
Neoplasm Metastasis
[Effect of silencing heparanase on the biological behavior of gastric carcinoma in nude mice].
Neoplasm Metastasis
[Effects of cisplatin combined with heparanase inhibitor on proliferation and invasion of human nasopharyngeal carcinoma cells].
Neoplasm Metastasis
[Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer.]
Neoplasm Metastasis
[Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]
Neoplasm Metastasis
[Expression of heparanase gene and the metastatic activity of lung cancer.]
Neoplasm Metastasis
[Expressions of breast cancer metastasis suppressor-1 and heparanase in primary hepatocellular carcinoma and chronic liver diseases and the clinicopathological significances].
Neoplasm Metastasis
[Heparanase and vascular endothelial growth factor expression in non-small-cell lung cancer]
Neoplasm Metastasis
[Increased expression of heparanase mRNA is correlated with metastasis of gastric carcinoma and is probably correlated with c-met protein]
Neoplasm Metastasis
[Inhibitory effect of silencing heparanase expression with antisense oligodeoxynucleotide on invasive capability of human esophageal squamous cancer cell line TE-13]
Neoplasm Metastasis
[Inhibitory effect of siRNA on heparanase expression and invasion ability of gastric cancer cells: an in vitro experiment]
Neoplasm Metastasis
[mRNA expression of syndecan-1 and heparanase in relation to tumor progression and prognosis of gastric carcinoma]
Neoplasm Metastasis
[Prediction of lymph node metastasis with binary logistic regression in gastric carcinoma]
Neoplasm Metastasis
[Relation of heparanase mRNA expression and angiogenesis to the progression of gastric carcinoma]
Neoplasm Metastasis
[Relationship between heparanase mRNA expression in human gastric cancer and its clinicopathological features]
Neoplasm Metastasis
[The association between the prognosis and the localization and expression?of heparanase in human laryngeal squamous cell carcinoma].
Neoplasm Metastasis
[The expression and potentially clinical significance of heparanase in nasopharyngeal carcinoma]
Neoplasm Metastasis
[The expression and significance of heparanase and nm23-H1 in hepatocellular carcinoma]
Neoplasm Metastasis
[The expression of acetyl-heparanase, laminin and laminin receptor and their role in the metastasis of ovarian cancer]
Neoplasm Micrometastasis
Detection of peritoneal micrometastasis by reverse transcriptase-polymerase chain reaction for heparanase mRNA and cytology in peritoneal wash samples.
Neoplasm Micrometastasis
Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies.
Neoplasm Micrometastasis
Immunochemical localization of heparanase in mouse and human melanomas.
Neoplasms
?-Carrageenan Oligosaccharides of Distinct Anti-Heparanase and Anticoagulant Activities Inhibit MDA-MB-231 Breast Cancer Cell Migration.
Neoplasms
A comparison of the effects of unfractionated heparin, dalteparin and danaparoid on vascular endothelial growth factor-induced tumour angiogenesis and heparanase activity.
Neoplasms
A disaccharide that inhibits tumor necrosis factor alpha is formed from the extracellular matrix by the enzyme heparanase.
Neoplasms
A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer.
Neoplasms
A liquid chromatography-mass spectrometry-based approach to characterize the substrate specificity of mammalian heparanase.
Neoplasms
A novel experimental platform for investigating tumorigenesis and anti-cancer therapy in a human microenvironment derived from embryonic stem cells.
Neoplasms
A novel human anti-syndecan-1 antibody inhibits vascular maturation and tumour growth in melanoma.
Neoplasms
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.
Neoplasms
A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy.
Neoplasms
A phase I biological and pharmacologic study of the heparanase inhibitor PI-88 in patients with advanced solid tumors.
Neoplasms
A phase I pharmacological and biological study of PI-88 and docetaxel in patients with advanced malignancies.
Neoplasms
A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane.
Neoplasms
A simple and rapid assay for heparanase activity using homogeneous time-resolved fluorescence.
Neoplasms
A solid-phase substrate of heparanase: its application to assay of human melanoma for heparan sulfate degradative activity.
Neoplasms
A-72363 A-1, A-2, and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192, II. Biological activities.
Neoplasms
Abnormal expression of early growth response 1 in gastric cancer: association with tumor invasion, metastasis and heparanase transcription.
Neoplasms
Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts.
Neoplasms
Activity-based probes for functional interrogation of retaining ?-glucuronidases.
Neoplasms
Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.
Neoplasms
Allele loss and down-regulation of heparanase gene are associated with the progression and poor prognosis of hepatocellular carcinoma.
Neoplasms
Allogeneic dendritic cells induce potent antitumor immunity by activating KLRG1+CD8 T cells.
Neoplasms
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis.
Neoplasms
Analysis of heparanase isoforms and cathepsin B in the plasma of patients with gastrointestinal carcinomas: analytical cross-sectional study.
Neoplasms
Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor.
Neoplasms
Anti-heparanase activity of ultra-low-molecular-weight heparin produced by physicochemical depolymerization.
Neoplasms
Anti-heparanase aptamers as potential diagnostic and therapeutic agents for oral cancer.
Neoplasms
Anti-heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing.
Neoplasms
Antiangiogenic and antitumor activities of berberine derivative NAX014 compound in a transgenic murine model of HER2/neu-positive mammary carcinoma.
Neoplasms
Antimetastatic activities of heparins and modified heparins. Experimental evidence.
Neoplasms
Antimetastatic activities of modified heparins: selectin inhibition by heparin attenuates metastasis.
Neoplasms
Antisense-mediated suppression of human heparanase gene expression inhibits pleural dissemination of human cancer cells.
Neoplasms
Antitumor activity and structure-activity relationship of heparanase inhibitors: Recent advances.
Neoplasms
Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models.
Neoplasms
Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of ?-Carrageenan Derivative as a Potent Anti Angiogenic Agent.
Neoplasms
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Neoplasms
Association of heparanase gene (HPSE-1) single nucleotide polymorphisms with gastric cancer.
Neoplasms
Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations.
Neoplasms
Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase.
Neoplasms
Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells.
Neoplasms
Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats.
Neoplasms
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis.
Neoplasms
Characterization of HPSE gene single nucleotide polymorphisms in Jewish populations of Israel.
Neoplasms
Chemical shift assignments and secondary structure of the surrogate domain for drug discovery studies of human heparanase.
Neoplasms
Chemically modified heparins as inhibitors of heparan sulfate specific endo-beta-glucuronidase (heparanase) of metastatic melanoma cells.
Neoplasms
Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.
Neoplasms
Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior.
Neoplasms
Clinical relevance of heparanase mRNA expression in bladder cancer and its usefulness as a detection marker in voided urine.
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Clinical significance of heparanase activity in primary resected non-small cell lung cancer.
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Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody.
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Clinicopathological significance of heparanase and basic fibroblast growth factor expression in human esophageal cancer.
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Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member.
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Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis.
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Cloning of two splice variants of Spalax heparanase encoding for truncated proteins.
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Cloning, expression, and characterization of an alternatively spliced variant of human heparanase.
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Co-expression of CD44v3 and heparanase is correlated with metastasis of human colon cancer.
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Coexpression of heparanase, basic fibroblast growth factor and vascular endothelial growth factor in human esophageal carcinomas.
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Comparison of the heparanase enzymes from mouse melanoma cells, mouse macrophages, and human platelets.
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Computational Analyses of the Catalytic and Heparin Binding Sites and their Interactions with Glycosaminoglycans in Glycoside Hydrolase Family 79 Endo-{beta}-D-Glucuronidase (Heparanase).
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Computational Investigation Identified Potential Chemical Scaffolds for Heparanase as Anticancer Therapeutics.
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Contribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T.
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Correlation between heparanase gene polymorphism and susceptibility to endometrial cancer.
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CXCL7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C, VEGF-D in Human Breast Cancer Cells.
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Cytotoxic T lymphocyte epitopes from human heparanase can elicit a potent anti-tumor immune response in mice.
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Deciphering Mode of Action of Heparanase Using Structurally Defined Oligosaccharides.
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Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycans.
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Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy.
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Dendritic cells reconstituted with a human heparanase gene induce potent cytotoxic T-cell responses against gastric tumor cells in vitro.
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Detection of peritoneal micrometastasis by reverse transcriptase-polymerase chain reaction for heparanase mRNA and cytology in peritoneal wash samples.
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Development and NMR validation of minimal pharmacophore hypotheses for the generation of fragment libraries enriched in heparanase inhibitors.
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Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening.
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Development of both colorimetric and fluorescence heparinase activity assays using fondaparinux as substrate.
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Development of the hsp110-heparanase vaccine to enhance antitumor immunity using the chaperoning properties of hsp110.
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Differentiating human leukemia cells express heparanase that degrades heparan sulfate in subendothelial extracellular matrix.
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Distribution of heparan sulfate correlated with the expression of heparanase- 1and matrix metalloproteinase- 9 in ovariectomized rats skin.
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DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.
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Down-regulation of heparanase leads to the inhibition of invasion and proliferation of A549 cells in vitro and in vivo.
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Downregulating Heparanase-Induced Vascular Normalization: A New Approach To Increase the Bioavailability of Chemotherapeutics in Solid Tumors.
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Downregulating the expression of heparanase inhibits the invasion, angiogenesis and metastasis of human hepatocellular carcinoma.
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Downregulation of heparanase by RNA interference inhibits invasion and tumorigenesis of hepatocellular cancer cells in vitro and in vivo.
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Downregulation of Heparanase Expression Results in Suppression of Invasion, Migration, and Adhesion Abilities of Hepatocellular Carcinoma Cells.
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Dual-Responsive and Deep-Penetrating Nanomicelles for Tumor Therapy via Extracellular Matrix Degradation and Oxidative Stress.
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Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.
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Effects of gamma irradiation on cultured rat and mouse microvessel endothelial cells: metastatic tumor cell adhesion, subendothelial matrix degradation, and secretion of tumor cell growth factors.
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Effects of small interfering RNA targeting heparanase-1 combined with heparin on invasiveness of mouse hepatocellular carcinoma cell lines.
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Elemene inhibits the migration and invasion of 4T1 murine breast cancer cells via heparanase.
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Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data.
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Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.
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Emergence of nuclear heparanase induces differentiation of human mammary cancer cells.
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Enzyme responsiveness enhances the specificity and effectiveness of nanoparticles for the treatment of B16F10 melanoma.
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Eosinophil major basic protein: first identified natural heparanase-inhibiting protein.
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Epidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase I activity in brain metastatic breast cancer.
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Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro.
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Evaluation of heparanase and matrix metalloproteinase-9 in patients with cutaneous malignant melanoma.
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Evaluation of the Antitumor Efficacy of RNAi-Mediated Inhibition of CDC20 and Heparanase in an Orthotopic Liver Tumor Model.
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Expression and correlation of matrix metalloproteinase-9 and heparanase in patients with breast cancer.
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Expression characteristics of heparanase in colon carcinoma and its close relationship with cyclooxygenase-2 and angiogenesis.
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Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation.
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Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.
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Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas.
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Expression of heparanase in hepatocellular carcinoma has prognostic significance: a tissue microarray study.
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Expression of heparanase in human tumor cell lines and human head and neck tumors.
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Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion.
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Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis.
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Expression of heparanase in renal cell carcinomas: implications for tumor invasion and prognosis.
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Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC9706 cells.
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Expression of heparanase: a possible role in invasiveness and aggressive clinical behavior of ameloblastomas.
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Expression of resistin-like molecule beta in gastric cancer: its relationship with clinicopathological parameters and prognosis.
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Expression of Tissue Factor and Heparanase in Endometrial Clear Cell Carcinoma: Possible Role for Tissue Factor in Thromboembolic Events.
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Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
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Family of Bioactive Heparin-Coated Iron Oxide Nanoparticles with Positive Contrast in Magnetic Resonance Imaging for Specific Biomedical Applications.
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FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells.
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Flipping the Molecular Switch: Influence of Perlecan and Its Modifiers in the Tumor Microenvironment.
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Fucoidan inhibits the growth of hepatocellular carcinoma independent of angiogenesis.
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Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis.
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Genomic organization and chromosome localization of the newly identified human heparanase gene.
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Glycosaminoglycan / gold nanocluster hybrid nanoparticles as a new sensing platform: Metastatic potential assessment of cancer cells.
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Growth-modulatory effects of heparin and VEGF165 on the choriocarcinoma cell-line JEG-3 and its expression of heparanase.
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Gubenyiliu II Inhibits Breast Tumor Growth and Metastasis Associated with Decreased Heparanase Expression and Phosphorylation of ERK and AKT Pathways.
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H-2Kb-restricted CTL epitopes from mouse heparanase elicit an antitumor immune response in vivo.
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Helicobacter pylori infection enhances heparanase leading to cell proliferation via mitogen?activated protein kinase signalling in human gastric cancer cells.
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Heparan sulfate chains contribute to the anticoagulant milieu in malignant pleural effusion.
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Heparan sulfate containing unsubstituted glucosamine residues: biosynthesis and heparanase-inhibitory activity.
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Heparan sulfate endoglycosidase and metastatic potential in murine fibrosarcoma and melanoma.
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Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation.
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Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis.
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Heparan sulfate proteoglycans and their modification as promising anticancer targets in hepatocellular carcinoma.
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Heparanase (HPSE) gene polymorphism (rs12503843) contributes as a risk factor for hepatocellular carcinoma (HCC): a pilot study among Egyptian patients.
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Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage.
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Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.
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Heparanase Activates Antithrombin through the Binding to Its Heparin Binding Site.
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Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix.
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Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion.
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Heparanase and a synthetic peptide of heparan sulfate-interacting protein recognize common sites on cell surface and extracellular matrix heparan sulfate.
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Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma.
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Heparanase and Chemotherapy Synergize to Drive Macrophage Activation and Enhance Tumor Growth.
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Heparanase and cyclooxygenase-2 gene and protein expressions during progression of oral epithelial dysplasia to carcinoma.
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Heparanase and gallbladder cancer: new insights into understanding tumor growth and invasion.
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Heparanase and heparanase 2 display differently deregulation in neuroendocrine tumors, depending on their differentiation grade.
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Heparanase and tumor invasion patterns in human oral squamous cell carcinoma xenografts.
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Heparanase and vascular endothelial growth factor expression is increased in hypoxia-induced retinal neovascularization.
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Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression.
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Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma.
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Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion.
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Heparanase DNA vaccine delivered by electroporation induces humoral immunity and cytoimmunity in animal models.
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Heparanase Enhances Early Hepatocyte Inclusion in the Recipient Liver after Transplantation in Partially Hepatectomized Rats.
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Heparanase enhances early hepatocyte inclusion in the recipient liver after transplantation in partially hepatectomized rats.
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Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL.
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Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.
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Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII.
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Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.
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Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis.
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Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression.
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Heparanase expression correlates with angiogenesis and lymphangiogenesis in human lung cancer.
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Heparanase expression correlates with invasion and poor prognosis in gastric cancers.
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Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.
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Heparanase expression in blood is sensitive to monitor response to anticancer treatment in pancreatic cancer, a pilot study.
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Heparanase expression in circulating lymphocytes of breast cancer patients depends on the presence of the primary tumor and/or systemic metastasis.
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Heparanase expression in head and neck squamous cell carcinomas is associated with reduced proliferation and improved survival.
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Heparanase expression in human colorectal cancer and its relationship to tumor angiogenesis, hematogenous metastasis, and prognosis.
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Heparanase expression in human leukemias is restricted to acute myeloid leukemias.
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Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival.
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Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival.
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Heparanase expression is a prognostic indicator for postoperative survival in pancreatic adenocarcinoma.
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Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer.
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Heparanase Expression Is Associated With Cancer Stem Cell Features and Radioresistance in Hodgkin's Lymphoma Cells.
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Heparanase expression upregulates platelet adhesion activity and thrombogenicity.
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Heparanase expression, degradation of basement membrane and low degree of infiltration by immunocytes correlate with invasion and progression of human gastric cancer.
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Heparanase from triple?negative breast cancer and platelets acts as an enhancer of metastasis.
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Heparanase gene and protein expression in ameloblastoma: possible role in local invasion of tumor cells.
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Heparanase in Cancer Metastasis - Heparin as a Potential Inhibitor of Cell Adhesion Molecules.
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Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway.
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Heparanase induces endothelial cell migration via protein kinase B/Akt activation.
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Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium.
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Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation: PRECLINICAL AND CLINICAL SIGNIFICANCE IN HEAD AND NECK CANCER.
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Heparanase induces tissue factor expression in vascular endothelial and cancer cells.
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Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells.
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Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.
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Heparanase Inhibition by Pixatimod (PG545): Basic Aspects and Future Perspectives.
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Heparanase inhibits osteoblastogenesis and shifts bone marrow progenitor cell fate in myeloma bone disease.
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Heparanase is a novel biomarker for immune infiltration and prognosis in breast cancer.
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Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.
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Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass.
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Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells.
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Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.
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Heparanase is overexpressed in lung cancer and correlates inversely with patient survival.
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Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice.
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Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition.
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Heparanase Level in the Microcirculation as a Possible Modulator of the Metastatic Process.
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Heparanase levels are elevated in the plasma of pediatric cancer patients and correlate with response to anticancer treatment.
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Heparanase link between vasculogenesis and angiogenesis as well as a predictive factor of a shorter survival rate.
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Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival.
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Heparanase mechanisms of melanoma metastasis to the brain: Development and use of a brain slice model.
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Heparanase mRNA and Protein Expression Correlates with Clinicopathologic Features of Gastric Cancer Patients: a Meta- analysis.
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Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin.
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Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation.
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Heparanase overexpression down-regulates syndecan-1 expression in a gallbladder carcinoma cell line.
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Heparanase overexpression participates in tumor growth of cervical cancer in vitro and in vivo.
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Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1? in osteosarcoma.
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Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity.
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Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.
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Heparanase prevents the development of type 1 diabetes in non-obese diabetic mice by regulating T-cell activation and cytokines production.
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Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients.
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Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantation.
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Heparanase promotes human gastric cancer cells migration and invasion by increasing Src and p38 phosphorylation expression.
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Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.
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Heparanase promotes radiation resistance of cervical cancer by upregulating hypoxia inducible factor 1.
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Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis.
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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.
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Heparanase regulates in vitro VEGF-C expression and its clinical significance to pancreatic ductal cell adenocarcinoma.
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Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.
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Heparanase regulates secretion, composition and function of tumor cell-derived exosomes.
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Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.
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Heparanase released from mesenchymal stem cells activates intergrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis.
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Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
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Heparanase, galectin-3, and tissue factor mRNA are expressed in benign neoplasms of the thyroid.
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Heparanase-1 and Cyclooxygenase-2: prognostic indicators of malignancy in pheochromocytomas.
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Heparanase-1 gene expression in normal, hyperplastic and neoplastic prostatic tissue.
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Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway.
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Heparanase-2 and syndecan-1 in colon cancer: the ugly ducklings or the beautiful swans?
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Heparanase-2 expression in normal ovarian epithelium and in benign and malignant ovarian tumors.
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Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.
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Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.
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Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype.
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Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis.
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Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes.
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Heparanase: a potential marker of worse prognosis in estrogen receptor-positive breast cancer.
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Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases.
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Heparanase: From basic research to therapeutic applications in cancer and inflammation.
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Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.
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Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate.
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Heparin immobilized gold nanoparticles for targeted detection and apoptotic death of metastatic cancer cells.
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Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-?B signaling pathway for gastric cancer metastasis.
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High heparanase activity in multiple myeloma is associated with elevated microvessel density.
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High-speed gel-permeation chromatography of glycosaminoglycans: its application to the analysis of heparan sulfate of embryonic carcinoma and its degradation products by tumor cell-derived heparanase.
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Hinokitiol reduces tumor metastasis by inhibiting heparanase via extracellular signal-regulated kinase and protein kinase B pathway.
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Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions.
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Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches.
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HLA-A2-restricted cytotoxic T lymphocyte epitopes from human heparanase as novel targets for broad-spectrum tumor immunotherapy.
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HPA aptamer functionalized paclitaxel-loaded PLGA nanoparticles for enhanced anticancer therapy through targeted effects and microenvironment modulation.
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HPSE enhancer RNA promotes cancer progression through driving chromatin looping and regulating hnRNPU/p300/EGR1/HPSE axis.
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Hypoxia increases heparanase-dependent tumor cell invasion, which can be inhibited by antiheparanase antibodies.
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Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.
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Identification of active-site residues of the pro-metastatic endoglycosidase heparanase.
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Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity.
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Identification of strong intron enhancer in the heparanase gene: effect of functional rs4693608 variant on HPSE enhancer activity in hematological and solid malignancies.
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Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity.
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Impact of Adjuvant Treatment on Heparanase Concentration in Invasive, Unilateral Breast Cancer Patients: Results of a Prospective Single-Centre Cohort Study.
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Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications.
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In silico investigation of heparanase-correlated genes in breast cancer subtypes.
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In vitro and ex vivo evaluation of a multi-epitope heparinase vaccine for various malignancies.
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Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells.
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Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer.
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Increased levels of ?-catenin, LEF-1, and HPA-1 correlate with poor prognosis for acral melanoma with negative BRAF and NRAS mutation in BRAF exons 11 and 15 and NRAS exons 1 and 2.
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Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.
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Induction of anti-tumor immunity by dendritic cells pulsed with an endoplasmic reticulum retrieval signal modifies heparanase epitope in mice.
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Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma.
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Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas.
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Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.
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Inflammatory cytokines and fatty acids regulate endothelial cell heparanase expression.
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Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells.
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Inhibition of choriocarcinoma by Fe3O4-dextran-anti-?-human chorionic gonadotropin nanoparticles containing antisense oligodeoxynucleotide of heparanase.
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Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues.
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Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides.
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Inhibition of Heparanase Expression Results in Suppression of Invasion, Migration and Adhesion Abilities of Bladder Cancer Cells.
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Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and In Vivo Tumor Growth.
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Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species.
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Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis.
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Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis.
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Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.
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Investigating Glycol-Split-Heparin-Derived Inhibitors of Heparanase: A Study of Synthetic Trisaccharides.
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Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival.
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Involvement of Heparan Sulfate and Heparanase in Neural Development and Pathogenesis of Brain Tumors.
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Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545.
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Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
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Isolation of a human gallbladder cancer cell clone with high invasive phenotype in vitro and metastatic potential in orthotopic model and inhibition of its invasiveness by heparanase antisense oligodeoxynucleotides.
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Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.
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Latent Heparanase Facilitates VLA-4-Mediated Melanoma Cell Binding and Emerges As a Relevant Target of Heparin in the Interference with Metastatic Progression.
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Lewis X oligosaccharides-heparanase complex targeting to DCs enhance antitumor response in mice.
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Lipid profile and serum characteristics of the blind subterranean mole rat, Spalax.
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Localization of heparanase in esophageal cancer cells: respective roles in prognosis and differentiation.
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Loss of basement membrane heparan sulfate expression is associated with pelvic lymph node metastasis in invasive cervical cancer.
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Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas.
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Lung colonization by and heparanase activity in in vitro transformed 3T3 cells rendered highly tumorigenic by an in vivo passage.
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Magnetic Gold Nanoparticle-Labeled Heparanase Monoclonal Antibody and its Subsequent Application for Tumor Magnetic Resonance Imaging.
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Maintenance on extracellular matrix and expression of heparanase activity by human ovarian carcinoma cells from biopsy specimens.
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Major co-localization of the extracellular-matrix degradative enzymes heparanase and gelatinase in tertiary granules of human neutrophils.
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Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
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Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development.
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Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease.
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Mechanism of anti-angiogenic activities of chitooligosaccharides may be through inhibiting heparanase activity.
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Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46.
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Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation.
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MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase.
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MicroRNA-219a-2-3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway.
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Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances.
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miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase.
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Modulating Heparanase Activity: Tuning Sulfation Pattern and Glycosidic Linkage of Oligosaccharides.
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Modulation of GEF-H1 induced signaling by heparanase in brain metastatic melanoma cells.
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Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting.
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Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids.
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Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
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Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis.
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Molecular properties and involvement of heparanase in cancer progression and normal development.
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Multiple antigenic peptides based on H-2K(b)-restricted CTL epitopes from murine heparanase induce a potent antitumor immune response in vivo.
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Multiple Antigenic Peptides of Human Heparanase Elicit a Much More Potent Immune Response against Tumors.
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Murine macrophage heparanase: inhibition and comparison with metastatic tumor cells.
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Mutual enhancement between heparanase and vascular endothelial growth factor: a novel mechanism for melanoma progression.
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Neurotrophin receptors and heparanase: a functional axis in human medulloblastoma invasion.
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New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis.
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Normal colon tissue and colon carcinoma show no difference in heparanase promoter methylation.
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Novel 1, 3-N, O-Spiroheterocyclic compounds inhibit heparanase activity and enhance nedaplatin-induced cytotoxicity in cervical cancer cells.
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Novel Symmetrical Benzazolyl Derivatives Endowed with Potent Anti-Heparanase Activity.
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Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function.
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Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity.
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Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-?B via targeting of Mre11.
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Oligomannurarate Sulfate, a Novel Heparanase Inhibitor Simultaneously Targeting Basic Fibroblast Growth Factor, Combats Tumor Angiogenesis and Metastasis.
Neoplasms
Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis.
Neoplasms
Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion.
Neoplasms
Overexpression of heparanase attenuated TGF-?-stimulated signaling in tumor cells.
Neoplasms
Overexpression of heparanase is associated with preeclampsia by inhibiting invasion of trophocytes.
Neoplasms
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins.
Neoplasms
Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer.
Neoplasms
Peptides inhibiting heparanase procoagulant activity significantly reduce tumour growth and vascularisation in a mouse model.
Neoplasms
Peripheral neuropathy following bortezomib therapy in multiple myeloma patients: association with cumulative dose, heparanase, and TNF-?.
Neoplasms
PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma model.
Neoplasms
PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer.
Neoplasms
Pharmacokinetics of low molecular weight heparin in patients with malignant tumors.
Neoplasms
Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo.
Neoplasms
PO-23 - Expression of heparanase in cancer as biomarker of malignancies: overexpression in an aggressive, poor survival gastric cancer "gastric signet ring cell carcinoma" compared with that of other gastric cancers.
Neoplasms
Polymorphisms and a haplotype in heparanase gene associations with the progression and prognosis of gastric cancer in a northern Chinese population.
Neoplasms
Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma.
Neoplasms
Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich element.
Neoplasms
Predictive value of heparanase expression in the palliative therapy of pancreatic cancer.
Neoplasms
Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma.
Neoplasms
Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and ?-actinin.
Neoplasms
Production of heparin and ?-carrageenan anti-heparanase derivatives using a combination of physicochemical depolymerization and glycol splitting.
Neoplasms
Prognostic significance of heparanase expression in primary and metastatic breast carcinoma.
Neoplasms
Prognostic value of heparanase expression and cellular localization in oral cancer.
Neoplasms
Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer.
Neoplasms
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.
Neoplasms
Purification and characterization of placental heparanase and its expression by cultured cytotrophoblasts.
Neoplasms
Purification and characterization of the endoglycosidase heparanase 1 from human plantar stratum corneum: a key enzyme in epidermal physiology?
Neoplasms
Quantitative analysis of heparanase gene expression in normal cervical, cervical intraepithelial neoplastic, and cervical carcinoma tissues.
Neoplasms
Quantitative analysis of heparanase messenger RNA expression in hepatocellular carcinoma.
Neoplasms
Radiolabeled heparan sulfate immobilized on microplate as substrate for the detection of heparanase activity.
Neoplasms
Reducing LncRNA-5657 expression inhibits the brain inflammatory reaction in septic rats.
Neoplasms
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.
Neoplasms
Relationship between serum heparanase and microscopic venous invasion in patients with hepatocellular carcinoma.
Neoplasms
Relationships between heparanase activity and increasing metastatic potential of fibroblasts transfected with various oncogenes.
Neoplasms
Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.
Neoplasms
Role of heparanase in platelet and tumor cell interactions with the subendothelial extracellular matrix.
Neoplasms
Role of heparanase in tumor progression: Molecular aspects and therapeutic options.
Neoplasms
Role of neurotrophins and neurotrophins receptors in the in vitro invasion and heparanase production of human prostate cancer cells.
Neoplasms
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor.
Neoplasms
SANT,a novel Chinese herbal monomer combination,decreasing tumor growth and angiogenesis via modulating autophagy in heparanase overexpressed triple-negative breast cancer.
Neoplasms
Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines.
Neoplasms
Serum heparanase levels: A protective marker against digital ulcers in patients with systemic sclerosis.
Neoplasms
Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer.
Neoplasms
Significance of heparanase-1 and vascular endothelial growth factor in adrenocortical carcinoma angiogenesis: potential for therapy.
Neoplasms
Silencing of Heparanase by siRNA Inhibits Tumor Metastasis and Angiogenesis of Human Breast Cancer In Vitro and In Vivo.
Neoplasms
Simian virus 40 enhancer does not affect the tumor specificity of human heparanase gene promoter.
Neoplasms
Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase.
Neoplasms
Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells.
Neoplasms
Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells.
Neoplasms
Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4.
Neoplasms
Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence.
Neoplasms
Specific Inhibition of Heparanase by Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.
Neoplasms
SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis.
Neoplasms
Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence.
Neoplasms
Structural requirements for inhibition of melanoma lung colonization by heparanase inhibiting species of heparin.
Neoplasms
Structure modeling, ligand binding, and binding affinity calculation (LR-MM-PBSA) of human heparanase for inhibition and drug design.
Neoplasms
Structure-based design of a selective heparanase inhibitor as an antimetastatic agent.
Neoplasms
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling.
Neoplasms
Subcellular localization of human heparanase and its alternative splice variant in COS-7 cells.
Neoplasms
Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase.
Neoplasms
Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases.
Neoplasms
Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase.
Neoplasms
Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme.
Neoplasms
Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells.
Neoplasms
Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells.
Neoplasms
Syndecans as Modulators and Potential Pharmacological Targets in Cancer Progression.
Neoplasms
Synthesis, cytotoxic and heparanase inhibition studies of 5-oxo-1-arylpyrrolidine-3-carboxamides of hydrazides and 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol.
Neoplasms
Synthesis, radiolabeling with fluorine-18 and preliminary in vivo evaluation of a heparan sulphate mimetic as potent angiogenesis and heparanase inhibitor for cancer applications.
Neoplasms
Tamoxifen induces heparanase expression in estrogen receptor-positive breast cancer.
Neoplasms
Targeting heparan sulfate proteoglycans and their modifying enzymes to enhance anticancer chemotherapy efficacy and overcome drug resistance.
Neoplasms
Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds.
Neoplasms
Targeting heparanase overcomes chemoresistance and diminishes relapse in myeloma.
Neoplasms
Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis.
Neoplasms
Testing of potential glycan-based heparanase inhibitors in a fluorescence activity assay using either bacterial heparinase II or human heparanase.
Neoplasms
The Challenge of Modulating Heparan Sulfate Turnover by Multitarget Heparin Derivatives.
Neoplasms
The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma.
Neoplasms
The close correlation between heparanase and COX-2 expression in lymphangiogenesis of cervical cancer.
Neoplasms
The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach.
Neoplasms
The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma.
Neoplasms
The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard.
Neoplasms
The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation.
Neoplasms
The endothelial glycocalyx anchors von Willebrand factor fibers to the vascular endothelium.
Neoplasms
The expression of heparanase and microRNA-1258 in human non-small cell lung cancer.
Neoplasms
The heparan sulfate mimetic PG545 interferes with Wnt/?-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine.
Neoplasms
The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression.
Neoplasms
The heparanase/heparan sulfate proteoglycan axis: A potential new therapeutic target in sarcomas.
Neoplasms
The HPA/SDC1 axis promotes invasion and metastasis of pancreatic cancer cells by activating EMT via FGF2 upregulation.
Neoplasms
The Immunoexpression of Heparanase 2 in Normal Epithelium, Intraepithelial, and Invasive Squamous Neoplasia of the Cervix.
Neoplasms
The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy.
Neoplasms
The Profile of Heparanase Expression Distinguishes Differentiated Thyroid Carcinoma from Benign Neoplasms.
Neoplasms
The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics.
Neoplasms
The role of heparanase in lymph node metastatic dissemination: dynamic contrast-enhanced MRI of Eb lymphoma in mice.
Neoplasms
The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target.
Neoplasms
The role of VLA-4 binding for experimental melanoma metastasis and its inhibition by heparin.
Neoplasms
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
Neoplasms
Thrombin enhances degradation of heparan sulfate in the extracellular matrix by tumor cell heparanase.
Neoplasms
Total synthesis of (+/-)-trachyspic acid and determination of the relative configuration.
Neoplasms
Trachyspic acid, a new metabolite produced by Talaromyces trachyspermus, that inhibits tumor cell heparanase: taxonomy of the producing strain, fermentation, isolation, structural elucidation, and biological activity.
Neoplasms
Transcriptomic analysis reveals cell apoptotic signature modified by heparanase in melanoma cells.
Neoplasms
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate.
Neoplasms
Tumor heparanase expression in predicting response to induction chemotherapy in patients with locally advanced laryngeal cancer.
Neoplasms
Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue.
Neoplasms
Tumor metastasis-associated heparanase (heparan sulfate endoglycosidase) activity in human melanoma cells.
Neoplasms
Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis.
Neoplasms
Tumor-elicited polymorphonuclear cells, in contrast to "normal" circulating polymorphonuclear cells, stimulate invasive and metastatic potentials of rat mammary adenocarcinoma cells.
Neoplasms
Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells.
Neoplasms
Tumour rejection antigens of the hsp90 family (gp96) closely resemble tumour-associated heparanase enzymes.
Neoplasms
Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation.
Neoplasms
Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells.
Neoplasms
Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes.
Neoplasms
Upregulation of Endothelin-1/Endothelin A Receptor Expression Correlates with Heparanase Expression in Ovarian Carcinoma.
Neoplasms
[Clinical significance of heparanase and basic fibroblast growth factor expression in human non-small cell lung cancer]
Neoplasms
[Correlation of expression of heparanase to angiogenesis and prognosis of breast cancer.]
Neoplasms
[Effect of exogenous expression of heparanase gene on invasive ability of colorectal cancer cell line HT29]
Neoplasms
[Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer.]
Neoplasms
[Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]
Neoplasms
[Expression of heparanase mRNA and its clinical significance in primary hepatocellular carcinoma]
Neoplasms
[Expression of heparanase mRNA in ascitic cells is not a good marker in differential diagnosis of malignancies]
Neoplasms
[Expression of maspin and its relation to tumor vascularization in epithelian ovarian cancer]
Neoplasms
[Heparanase and vascular endothelial growth factor expression in non-small-cell lung cancer]
Neoplasms
[Immune response of heparanase gene modified dendritic cell-based vaccine on gastric cancer cells]
Neoplasms
[Inhibitory effect of silencing heparanase expression with antisense oligodeoxynucleotide on invasive capability of human esophageal squamous cancer cell line TE-13]
Neoplasms
[mRNA expression of syndecan-1 and heparanase in relation to tumor progression and prognosis of gastric carcinoma]
Neoplasms
[Prediction of lymph node metastasis with binary logistic regression in gastric carcinoma]
Neoplasms
[The expression and potentially clinical significance of heparanase in nasopharyngeal carcinoma]
Neoplasms, Squamous Cell
Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer.
Neoplasms, Squamous Cell
[Heparanase and vascular endothelial growth factor expression in non-small-cell lung cancer]
Nephrosis, Lipoid
Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.
Nephrotic Syndrome
Heparanase activity is dysregulated in children with steroid-sensitive nephrotic syndrome.
Nephrotic Syndrome
Nephroprotective effect of heparanase in experimental nephrotic syndrome.
Nephrotic Syndrome
[Gene expression of heparanase in peripheral blood leukocytes from rats with nephrotic syndrome and its relationship to proteinuria]
Nephrotic Syndrome
[Heparanase expression of peripheral blood cells in steroid responsive nephrotic syndrome patients]
Neuroblastoma
miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase.
Neuroblastoma
Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase.
Neuroendocrine Tumors
Heparanase and heparanase 2 display differently deregulation in neuroendocrine tumors, depending on their differentiation grade.
Neuroendocrine Tumors
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.
Neuroinflammatory Diseases
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-? in murine brain.
Neuroinflammatory Diseases
Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats.
Neuroinflammatory Diseases
Implications of heparan sulfate and heparanase in neuroinflammation.
Neuroinflammatory Diseases
Systemic LPS-induced A?-solubilization and clearance in A?PP-transgenic mice is diminished by heparanase overexpression.
Nevus
Evaluation of heparanase and matrix metalloproteinase-9 in patients with cutaneous malignant melanoma.
Obstetric Labor, Premature
The expression of heparanase in term and preterm human placentas.
Odontogenic Cysts
Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor.
Osteoarthritis
Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis.
Osteoarthritis
Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes.
Osteoarthritis
PO-49 - Bone microinfarction and microcirculation thrombosis; is it a possible mechanism for bone pain among cancer patients?
Osteolysis
Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.
Osteolysis
Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL.
Osteolysis
Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases.
Osteolysis
Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function.
Osteoporosis
Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL.
Osteoporosis
Identification of human serum protein targets of Qianggu Decoction () in primary type I osteoporosis based on tandem mass tag labeling and liquid chromatography-tandem mass spectrometry technology.
Osteoporosis
Is there an association between high heparanase level and osteoporosis risk in breast cancer patients without clinical evidence of bone metastases?
Osteosarcoma
Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1? in osteosarcoma.
Osteosarcoma
Involvement of Ext1 and heparanase in migration of mouse FBJ osteosarcoma cells.
Osteosarcoma
Targeted silencing of heparanase gene by small interfering RNA inhibits invasiveness and metastasis of osteosarcoma cells.
Ovarian Neoplasms
Clinical value of combined detection of serum matrix metalloproteinase-9, heparanase, and cathepsin for determining ovarian cancer invasion and metastasis.
Ovarian Neoplasms
Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.
Ovarian Neoplasms
Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma.
Ovarian Neoplasms
Oleuropein represses the radiation resistance of ovarian cancer by inhibiting hypoxia and microRNA-299-targetted heparanase expression.
Ovarian Neoplasms
Overexpression of heparanase in ovarian cancer and its clinical significance.
Ovarian Neoplasms
Upregulation of Endothelin-1/Endothelin A Receptor Expression Correlates with Heparanase Expression in Ovarian Carcinoma.
Ovarian Neoplasms
WITHDRAWN: Heparanase is involved in proliferation and invasion of ovarian cancer cells.
Ovarian Neoplasms
[Expression of maspin and its relation to tumor vascularization in epithelian ovarian cancer]
Overweight
Impact of Adjuvant Treatment on Heparanase Concentration in Invasive, Unilateral Breast Cancer Patients: Results of a Prospective Single-Centre Cohort Study.
Pancreatic Neoplasms
Gemcitabine-induced heparanase promotes aggressiveness of pancreatic cancer cells via activating EGFR signaling.
Pancreatic Neoplasms
Heparanase expression in blood is sensitive to monitor response to anticancer treatment in pancreatic cancer, a pilot study.
Pancreatic Neoplasms
Heparanase expression is a prognostic indicator for postoperative survival in pancreatic adenocarcinoma.
Pancreatic Neoplasms
Heparanase potentiates the invasion and migration of pancreatic cancer cells via epithelial?to?mesenchymal transition through the Wnt/??catenin pathway.
Pancreatic Neoplasms
High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.
Pancreatic Neoplasms
Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46.
Pancreatic Neoplasms
PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer.
Pancreatic Neoplasms
Predictive value of heparanase expression in the palliative therapy of pancreatic cancer.
Pancreatic Neoplasms
Role of heparanase in radiation-enhanced invasiveness of pancreatic carcinoma.
Pancreatic Neoplasms
The heparan sulfate mimetic PG545 interferes with Wnt/?-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine.
Pancreatic Neoplasms
The HPA/SDC1 axis promotes invasion and metastasis of pancreatic cancer cells by activating EMT via FGF2 upregulation.
Pancreatic Neoplasms
Transfection of antisense oligodeoxynucleotide inhibits heparanase gene expression and invasive ability of human pancreatic cancer cell in vitro.
Pancreatic Neoplasms
[The clinical significance of heparanase expression in human pancreatic carcinoma tissue]
Pancreatitis
New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis.
Pancreatitis
Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration.
Pancreatitis
The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target.
Paralysis
Heparanase 2, mutated in urofacial syndrome, mediates peripheral neural development in Xenopus.
Peripheral Nervous System Diseases
Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.
Peripheral Nervous System Diseases
Peripheral neuropathy following bortezomib therapy in multiple myeloma patients: association with cumulative dose, heparanase, and TNF-?.
Peritonitis
Eosinophil major basic protein: first identified natural heparanase-inhibiting protein.
Pheochromocytoma
Differential heparanase-1 expression in malignant and benign pheochromocytomas.
Pheochromocytoma
Heparanase enhances nerve growth factor induced PC12 cell neuritogenesis via the p38 MAPK pathway.
Pheochromocytoma
Heparanase-1 and Cyclooxygenase-2: prognostic indicators of malignancy in pheochromocytomas.
Pituitary Neoplasms
Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells.
Pleural Effusion
Heparan sulfate chains contribute to the anticoagulant milieu in malignant pleural effusion.
Pleural Effusion
Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
Pneumonia
The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.
Porcine Reproductive and Respiratory Syndrome
Heparanase Upregulation Contributes to Porcine Reproductive and Respiratory Syndrome Virus Release.
Porcine Reproductive and Respiratory Syndrome
Pyrithione inhibits porcine reproductive and respiratory syndrome virus replication through interfering with NF-?B and heparanase.
Pre-Eclampsia
Evaluation of glycosaminoglycans and heparanase in placentas of women with preeclampsia.
Pre-Eclampsia
Knockdown of Heparanase Suppresses Invasion of Human Trophoblasts by Activating p38 MAPK Signaling Pathway.
Pre-Eclampsia
Overexpression of heparanase is associated with preeclampsia by inhibiting invasion of trophocytes.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Heparanase expression in human leukemias is restricted to acute myeloid leukemias.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Reply to 'Lack of association of the heparanase gene single-nucleotide polymorphism Arg307Lys with acute lymphoblastic leukemia in patients from Northern Ireland' by Winter et al.
Prion Diseases
Transgenic over-expression of mammalian heparanase delays prion disease onset and progression.
Prostatic Neoplasms
Function of heparanase in prostate tumorigenesis: potential for therapy.
Prostatic Neoplasms
Heparanase promotes bone destruction and invasiveness in prostate cancer.
Prostatic Neoplasms
Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer.
Prostatic Neoplasms
Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer.
Prostatic Neoplasms
Role of neurotrophins and neurotrophins receptors in the in vitro invasion and heparanase production of human prostate cancer cells.
Prostatic Neoplasms
Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells.
Proteinuria
A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritis.
Proteinuria
Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.
Proteinuria
Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria.
Proteinuria
Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx.
Proteinuria
Glomerular endothelial glycocalyx constitutes a barrier to protein permeability.
Proteinuria
Glycosaminoglycan treatment in glomerulonephritis? An interesting option to investigate.
Proteinuria
Heparanase activity is dysregulated in children with steroid-sensitive nephrotic syndrome.
Proteinuria
Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy.
Proteinuria
Heparanase inhibition reduces proteinuria in a model of accelerated anti-glomerular basement membrane antibody disease.
Proteinuria
Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.
Proteinuria
Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritis.
Proteinuria
Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients.
Proteinuria
Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.
Proteinuria
Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression.
Proteinuria
Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy.
Proteinuria
Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system.
Proteinuria
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia.
Proteinuria
Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria.
Proteinuria
The role of heparanase and the endothelial glycocalyx in the development of proteinuria.
Proteinuria
Vitamin D attenuates proteinuria by inhibition of heparanase expression in the podocyte.
Proteinuria
[Gene expression of heparanase in peripheral blood leukocytes from rats with nephrotic syndrome and its relationship to proteinuria]
Proteinuria
[Gene expressions of xylosyltransferase and heparanase in renal tissue of rat with adriamycin nephropathy and relevance for proteinuria]
Psoriasis
Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice.
Pulmonary Disease, Chronic Obstructive
The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.
Radicular Cyst
Perlecan-rich epithelial linings as a background of proliferative potentials of keratocystic odontogenic tumor.
Renal Insufficiency
Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx.
Renal Insufficiency, Chronic
Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.
Respiratory Insufficiency
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.
Retinal Diseases
Heparanase and vascular endothelial growth factor expression is increased in hypoxia-induced retinal neovascularization.
Retinal Neovascularization
Heparanase and vascular endothelial growth factor expression is increased in hypoxia-induced retinal neovascularization.
Retinal Neovascularization
Phosphomannopentaose sulfate (PI-88) suppresses angiogenesis by downregulating heparanase and vascular endothelial growth factor in an oxygen-induced retinal neovascularization animal model.
Retinal Vein Occlusion
INCREASED SYSTEMIC HEPARANASE IN RETINAL VEIN OCCLUSION IS ASSOCIATED WITH ACTIVATION OF INFLAMMATION AND THROMBOPHILIA.
Retinal Vein Occlusion
Serum heparanase concentration and heparanase activity in patients with retinal vein occlusion.
Retinoblastoma
[HIF-1alpha, HPSE and VEGF promote malignant progression of retinoblastoma.]
Retroviridae Infections
Marine-derived oligosaccharide sulfate (JG3) suppresses heparanase-driven cell adhesion events in heparanase over-expressing CHO-K1 cells.
Rhabdomyosarcoma
HPA1 and components of the hedgehog signaling pathway are increased in untreated alveolar orbital rhabdomyosarcoma.
Rhabdomyosarcoma, Embryonal
Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion.
Salivary Gland Neoplasms
Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival.
Sarcoma
Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models.
Sarcoma
Heparanase link between vasculogenesis and angiogenesis as well as a predictive factor of a shorter survival rate.
Sarcoma
Heparanase: From basic research to therapeutic applications in cancer and inflammation.
Sarcoma
Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds.
Sarcoma
The heparanase/heparan sulfate proteoglycan axis: A potential new therapeutic target in sarcomas.
Sarcoma, Ewing
Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models.
Scleroderma, Systemic
Morphologic and molecular study on the lens anterior capsule in systemic sclerosis.
Scleroderma, Systemic
Serum heparanase levels: A protective marker against digital ulcers in patients with systemic sclerosis.
Scrapie
Transgenic over-expression of mammalian heparanase delays prion disease onset and progression.
Sepsis
Both UFH and NAH alleviate shedding of endothelial glycocalyx and coagulopathy in LPS-induced sepsis.
Sepsis
Heparanase expression and activity are increased in platelets during clinical sepsis.
Sepsis
Peptides inhibiting heparanase procoagulant activity significantly reduce tumour growth and vascularisation in a mouse model.
Sepsis
The ?-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men.
Sepsis
The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis.
Sepsis
Unfractionated heparin attenuates intestinal injury in mouse model of sepsis by inhibiting heparanase.
Sepsis
[Impact of unfractionated heparin on serum and liver tissue expression of heparanase in the liver injury of mice with sepsis].
Shock, Septic
The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis.
Sinusitis
Up-regulation of heparanase in the ethmoid sinus mucosa of patients with chronic sinusitis.
Skin Neoplasms
Evaluation of heparanase and matrix metalloproteinase-9 in patients with cutaneous malignant melanoma.
Sleep Apnea, Obstructive
Serum heparanase levels are associated with endothelial dysfunction in patients with obstructive sleep apnea.
Small Cell Lung Carcinoma
Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.
Squamous Cell Carcinoma of Head and Neck
Expression of heparanase in oral cancer cell lines and oral cancer tissues.
Squamous Cell Carcinoma of Head and Neck
Glucose-regulated protein 78 and heparanase expression in oral squamous cell carcinoma: correlations and prognostic significance.
Squamous Cell Carcinoma of Head and Neck
Heparanase and tumor invasion patterns in human oral squamous cell carcinoma xenografts.
Squamous Cell Carcinoma of Head and Neck
Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis.
Squamous Cell Carcinoma of Head and Neck
Heparanase expression in head and neck squamous cell carcinomas is associated with reduced proliferation and improved survival.
Squamous Cell Carcinoma of Head and Neck
Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
[The expression and significance of heparanase in oral squamous cell carcinoma with different metastatic potentials].
Squamous Cell Carcinoma of Head and Neck
[The expression of hepatocyte growth factor and heparanase in laryngeal squamous cell carcinoma and its clinical significance]
Stomach Neoplasms
Abnormal expression of early growth response 1 in gastric cancer: association with tumor invasion, metastasis and heparanase transcription.
Stomach Neoplasms
Association of heparanase gene (HPSE-1) single nucleotide polymorphisms with gastric cancer.
Stomach Neoplasms
Dendritic cells reconstituted with a human heparanase gene induce potent cytotoxic T-cell responses against gastric tumor cells in vitro.
Stomach Neoplasms
Detection of peritoneal micrometastasis by reverse transcriptase-polymerase chain reaction for heparanase mRNA and cytology in peritoneal wash samples.
Stomach Neoplasms
Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas.
Stomach Neoplasms
Expression of resistin-like molecule beta in gastric cancer: its relationship with clinicopathological parameters and prognosis.
Stomach Neoplasms
Expression of SATB1 and heparanase in gastric cancer and its relationship to clinicopathologic features.
Stomach Neoplasms
Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression.
Stomach Neoplasms
Helicobacter pylori-Induced Heparanase Promotes H. pylori Colonization and Gastritis.
Stomach Neoplasms
Helicobacter pylori infection enhances heparanase leading to cell proliferation via mitogen?activated protein kinase signalling in human gastric cancer cells.
Stomach Neoplasms
Heparanase expression correlates with invasion and poor prognosis in gastric cancers.
Stomach Neoplasms
Heparanase expression, degradation of basement membrane and low degree of infiltration by immunocytes correlate with invasion and progression of human gastric cancer.
Stomach Neoplasms
Heparanase gene expression and metastatic potential in human gastric cancer.
Stomach Neoplasms
Heparanase mRNA and Protein Expression Correlates with Clinicopathologic Features of Gastric Cancer Patients: a Meta- analysis.
Stomach Neoplasms
Heparanase promotes human gastric cancer cells migration and invasion by increasing Src and p38 phosphorylation expression.
Stomach Neoplasms
Heparanase: a key enzyme in invasion and metastasis of gastric carcinoma.
Stomach Neoplasms
Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-?B signaling pathway for gastric cancer metastasis.
Stomach Neoplasms
Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression.
Stomach Neoplasms
Involvement of Heparanase in Gastric Cancer Progression and Immunotherapy.
Stomach Neoplasms
MicroRNA-1258: An invasion and metastasis regulator that targets heparanase in gastric cancer.
Stomach Neoplasms
MicroRNA-429 decreases the invasion ability of gastric cancer cell line BGC-823 by downregulating the expression of heparanase.
Stomach Neoplasms
miRNA-558 promotes gastric cancer progression through attenuating Smad4-mediated repression of heparanase expression.
Stomach Neoplasms
Overexpression of heparanase multiple antigenic peptide 2 is associated with poor prognosis in gastric cancer: Potential for therapy.
Stomach Neoplasms
PO-23 - Expression of heparanase in cancer as biomarker of malignancies: overexpression in an aggressive, poor survival gastric cancer "gastric signet ring cell carcinoma" compared with that of other gastric cancers.
Stomach Neoplasms
Polymorphisms and a haplotype in heparanase gene associations with the progression and prognosis of gastric cancer in a northern Chinese population.
Stomach Neoplasms
Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells.
Stomach Neoplasms
Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells.
Stomach Neoplasms
Stable knockdown of heparanase expression in gastric cancer cells in vitro.
Stomach Neoplasms
Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue.
Stomach Neoplasms
Tumor?suppressive miR?299?3p inhibits gastric cancer cell invasion by targeting heparanase.
Stomach Neoplasms
[Immune response of heparanase gene modified dendritic cell-based vaccine on gastric cancer cells]
Stomach Neoplasms
[Increased expression of heparanase mRNA is correlated with metastasis of gastric carcinoma and is probably correlated with c-met protein]
Stomach Neoplasms
[Inhibitory effect of siRNA on heparanase expression and invasion ability of gastric cancer cells: an in vitro experiment]
Stomach Neoplasms
[Prediction of lymph node metastasis with binary logistic regression in gastric carcinoma]
Stomach Neoplasms
[Relation of heparanase mRNA expression and angiogenesis to the progression of gastric carcinoma]
Stomach Neoplasms
[Relationship between heparanase mRNA expression in human gastric cancer and its clinicopathological features]
Stroke
Expression of heparanase in vascular cells and astrocytes of the mouse brain after focal cerebral ischemia.
Subarachnoid Hemorrhage
Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats.
Thalassemia
Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition.
Thrombocytopenia
Specific Inhibition of Heparanase by Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.
Thromboembolism
The relationship between heparanase levels, thrombus burden and thromboembolism in patients receiving unfractionated heparin treatment for prosthetic valve thrombosis.
Thrombophilia
Heparanase as a potential player in SARS-CoV-2 infection and induced coagulopathy.
Thrombophilia
INCREASED SYSTEMIC HEPARANASE IN RETINAL VEIN OCCLUSION IS ASSOCIATED WITH ACTIVATION OF INFLAMMATION AND THROMBOPHILIA.
Thrombosis
Heparan sulfate chains contribute to the anticoagulant milieu in malignant pleural effusion.
Thrombosis
Heparanase is a predictive marker for high thrombus burden in patients with ST-segment elevation myocardial infarction.
Thrombosis
Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients.
Thrombosis
Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance.
Thrombosis
Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases.
Thrombosis
Serum heparanase levels and left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation.
Thrombosis
The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice.
Thrombosis
The relationship between heparanase levels, thrombus burden and thromboembolism in patients receiving unfractionated heparin treatment for prosthetic valve thrombosis.
Thyroid Neoplasms
A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane.
Thyroid Neoplasms
MicroRNA-219a-2-3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway.
Thyroid Neoplasms
The Profile of Heparanase Expression Distinguishes Differentiated Thyroid Carcinoma from Benign Neoplasms.
Triple Negative Breast Neoplasms
SANT,a novel Chinese herbal monomer combination,decreasing tumor growth and angiogenesis via modulating autophagy in heparanase overexpressed triple-negative breast cancer.
Unilateral Breast Neoplasms
Impact of Adjuvant Treatment on Heparanase Concentration in Invasive, Unilateral Breast Cancer Patients: Results of a Prospective Single-Centre Cohort Study.
Urinary Bladder Neck Obstruction
Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.
Urinary Bladder Neoplasms
Berberine inhibits the migration and invasion of T24 bladder cancer cells via reducing the expression of heparanase.
Urinary Bladder Neoplasms
CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.
Urinary Bladder Neoplasms
CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.
Urinary Bladder Neoplasms
Clinical relevance of heparanase mRNA expression in bladder cancer and its usefulness as a detection marker in voided urine.
Urinary Bladder Neoplasms
Clinical significance of urine heparanase in bladder cancer progression.
Urinary Bladder Neoplasms
Expression of three extracellular matrix degradative enzymes in bladder cancer.
Urinary Bladder Neoplasms
Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage.
Urinary Bladder Neoplasms
Inhibition of Heparanase Expression Results in Suppression of Invasion, Migration and Adhesion Abilities of Bladder Cancer Cells.
Urinary Bladder Neoplasms
Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer.
Urinary Bladder Neoplasms
Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells.
Uterine Cervical Neoplasms
Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer.
Uterine Cervical Neoplasms
Heparanase overexpression participates in tumor growth of cervical cancer in vitro and in vivo.
Uterine Cervical Neoplasms
Heparanase promotes radiation resistance of cervical cancer by upregulating hypoxia inducible factor 1.
Uterine Cervical Neoplasms
Interleukin?17A and heparanase promote angiogenesis and cell proliferation and invasion in cervical cancer.
Uterine Cervical Neoplasms
Loss of basement membrane heparan sulfate expression is associated with pelvic lymph node metastasis in invasive cervical cancer.
Uterine Cervical Neoplasms
Novel 1, 3-N, O-Spiroheterocyclic compounds inhibit heparanase activity and enhance nedaplatin-induced cytotoxicity in cervical cancer cells.
Uterine Cervical Neoplasms
Quantitative analysis of heparanase gene expression in normal cervical, cervical intraepithelial neoplastic, and cervical carcinoma tissues.
Uterine Cervical Neoplasms
Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer.
Uterine Cervical Neoplasms
Suramin inhibits cell proliferation in ovarian and cervical cancer by downregulating heparanase expression.
Uterine Cervical Neoplasms
The close correlation between heparanase and COX-2 expression in lymphangiogenesis of cervical cancer.
Uterine Cervical Neoplasms
[Carrageenan oligosaccharides inhibit growth-factor binding and heparanase activity].
Uterine Cervical Neoplasms
[Effect of 1,3-O,N spiroheterocyclic inhibitors of heparanase on the growth of HeLa cells].
Uterine Cervical Neoplasms
[Effect on invasion ability of cervical cancer cells after silence heparanase gene expression in Hela cells].
Uterine Cervical Neoplasms
[Impact of quercetin on the expression of heparanase in cervical cancer cells].
Uterine Prolapse
Expression of Heparanase in uterosacral ligaments of women with or without uterine prolapse.
Vascular Diseases
Heparanase expression in invasive trophoblasts and acute vascular damage.
Vascular System Injuries
Heparanase and platelet factor-4 induce smooth muscle cell proliferation and migration via bFGF release from the ECM.
Vascular System Injuries
Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance.
Vascular System Injuries
Involvement of heparanase in atherosclerosis and other vessel wall pathologies.
Venous Thrombosis
The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice.
Virus Diseases
Antiviral strategies should focus on stimulating the biosynthesis of heparan sulfates, not their inhibition.
Virus Diseases
Heparanase as a potential player in SARS-CoV-2 infection and induced coagulopathy.
Virus Diseases
New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis.
Virus Diseases
Sulfotransferase and Heparanase: Remodeling Engines in Promoting Virus Infection and Disease Development.
Vulvodynia
Localized Provoked Vulvodynia: Association With Nerve Growth Factor and Transient Receptor Potential Vanilloid Type 1 Genes Polymorphisms.
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