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4-methylumbelliferyl N-acetyl-beta-D-glucosamine 6-sulfate + H2O
4-methylumbelliferyl N-acetyl-beta-D-glucosamine + sulfate
-
-
-
-
?
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
alpha-D-glucosamine N2,O6-bissulfate + H2O
?
-
-
-
-
?
beta-D-GlcNAc6S-(1->4)-beta-D-GlcA-(1->4)-2,5-anhydro-D-mannitol + H2O
beta-D-GlcNAc-(1->4)-beta-D-GlcA-(1->4)-2,5-anhydro-D-mannitol + sulfate
-
-
-
-
?
glucose 6-sulfate + H2O
glucose + sulfate
N-acetyl galactosamine 6-sulfate + H2O
N-acetyl galactosamine + sulfate
-
very low activity in cultured skin fibroblasts
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idonic acid + H2O
O-(alpha-2-sulfamino glucosamine)-(1-4)-L-idose + sulfate
-
-
-
-
?
O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idose + H2O
O-(alpha-2-sulfamino glucosamine)-(1-4)-L-idose + sulfate
-
-
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-glucosamine)-(1-3)-L-idonic acid + sulfate
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + H2O
O-(alpha-glucosamine)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + sulfate
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-N-acetyl glucosamine)-(1-3)-L-idonic acid + sulfate
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-idose-2-sulfate + H2O
O-(alpha-N-acetyl glucosamine)-(1-4)-L-idose-2-sulfate + sulfate
-
same activity in cultured skin fibroblasts compared to monosaccharides
-
-
?
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-mannitol-6-sulfate + H2O
O-(alpha-N-acetyl glucosamine)-(1-4)-L-iduronic acid-2-sulfate-(1-4)-2,5-anhydro-D-mannitol-6-sulfate + sulfate
-
30 fold higher activity in cultured skin fibroblasts compared to di- and monosaccharides
-
-
?
O-(beta-N-acetyl glucosamine 6-sulfate)-(1-3)-D-galactitol + H2O
O-(alpha-N-acetyl glucosamine)-(1-3)-D-galactitol + sulfate
-
activity 100-fold less
-
-
?
trisaccharide derived from heparansulfate with a N-acetylglucosamine 6-sulfate residue + H2O
trisaccharide with a N-acetylglucosamine + sulfate
trisaccharide with an N-acetylglucosamine 6-sulfate residue + H2O
trisaccharide with an N-acetylglucosamine + sulfate
-
-
-
-
?
additional information
?
-
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
-
fluorogenic substrate
-
-
?
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
fluorogenic substrate 4-MUS
-
-
?
glucose 6-sulfate + H2O
glucose + sulfate
-
-
-
-
?
glucose 6-sulfate + H2O
glucose + sulfate
-
no activity detected in cultured skin fibroblasts
-
-
?
glucose 6-sulfate + H2O
glucose + sulfate
-
about 55% of the activity with N-acetyl-D-glucosamine 6-sulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
lower activity in cultured skin fibroblasts compared to trisaccharides
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
higher activity in liver compared to trisaccharides
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
in heparan
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
in heparan
-
?
N-acetyl-D-glucosamine 6-sulfate + H2O
N-acetyl-D-glucosamine + sulfate
-
in heparan
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
acts also as endosulfatase
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
catalyzes hydrolysis of sulfate from internal N-acetylglucosamine 6-sulfate at a lower rate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
in substrates bearing a N-acetylglucosamine 6-sulfate residue at its nonreducing terminus derived from heparan sulfate and keratan sulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
specific exosulfatase for desulfation of the nonreducing terminal N-acetylglucosamine 6-sulfate residues of heparansulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
different enzymatic activities towards oligosaccharides derived from keratan sulfate or heparan sulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
has no activity towards heparin, heparansulfate and keratansulfate, increase of activity in monosulfated tetra- or trisaccharides, maximum activity in sulfated monosaccharides
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
non-arylsulfatase
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate
135579, 135580, 135581, 135582, 135583, 135584, 135585, 135586, 135587, 135589, 135590 -
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
different enzymatic hydrolysis for heparan sulfate and keratan sulfate
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
Tagelus gibbus
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
Tagelus gibbus
-
acts on polymer chain prior to depolymerization
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-glucosamine)-(1-3)-L-idonic acid + sulfate
-
-
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-glucosamine)-(1-3)-L-idonic acid + sulfate
-
-
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + H2O
O-(alpha-glucosamine)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + sulfate
-
-
-
-
?
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + H2O
O-(alpha-glucosamine)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + sulfate
-
N-sulfated and N-acetylated derivates of
-
-
?
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-N-acetyl glucosamine)-(1-3)-L-idonic acid + sulfate
-
-
-
-
?
O-(alpha-N-acetyl glucosamine 6-sulfate)-(1-3)-L-idonic acid + H2O
O-(alpha-N-acetyl glucosamine)-(1-3)-L-idonic acid + sulfate
-
-
-
-
?
trisaccharide derived from heparansulfate with a N-acetylglucosamine 6-sulfate residue + H2O
trisaccharide with a N-acetylglucosamine + sulfate
-
30 fold higher activity in cultured skin fibroblasts compared to di- and monosaccharides
-
-
?
trisaccharide derived from heparansulfate with a N-acetylglucosamine 6-sulfate residue + H2O
trisaccharide with a N-acetylglucosamine + sulfate
-
lower activity in liver compared to monosaccharides
-
-
?
additional information
?
-
-
involved in catabolism of heparan sulfate
-
?
additional information
?
-
-
the enzyme shows O-desulphation activity towards heparan sulphate-derived saccharides. No activity with glucose 3-sulfate, galactose 4-sulfate, galactose 6-sulfate and N-acetylgalactosamine 4-sulfate
-
-
?
additional information
?
-
involved in degradation of heparan sulfate, causing Mucopolysaccharidosis type IIID
-
-
?
additional information
?
-
-
involved in degradation of heparan sulfate, causing Mucopolysaccharidosis type IIID
-
-
?
additional information
?
-
-
heparin/heparan sulfate 6-O-sulfatase is a predominantly exolytic enzyme that specifically acts on N-sulfated or N-acetylated 6-O-sulfated glucosamines present at the non-reducing end of heparin and heparan sulfate glycosaminoglycan oligosaccharide substrates
-
-
?
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arylsulfatase (type i) deficiency
A screening method for mucopolysaccharidoses with increased urinary excretion of sulfated N-acetylhexosamines.
Carcinoma, Ductal
Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma.
Carcinoma, Hepatocellular
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Carcinoma, Intraductal, Noninfiltrating
Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma.
Liver Neoplasms
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Liver Neoplasms
Sulfatase-1 knockdown promotes in vitro and in vivo aggressive behavior of murine hepatocarcinoma Hca-P cells through up-regulation of mesothelin.
Lung Neoplasms
MicroRNA-527 inhibits TGF-?/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer.
Lymphatic Metastasis
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Lymphatic Metastasis
Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells in vitro and in vivo.
Lysosomal Storage Diseases
Caprine mucopolysaccharidosis IIID: fetal and neonatal brain and liver glycosaminoglycan and morphological perturbations.
Lysosomal Storage Diseases
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Lysosomal Storage Diseases
Update of the spectrum of mucopolysaccharidoses type III in Tunisia: identification of three novel mutations and in silico structural analysis of the missense mutations.
Mucopolysaccharidoses
Caprine mucopolysaccharidosis IIID: a preliminary trial of enzyme replacement therapy.
Mucopolysaccharidoses
Caprine mucopolysaccharidosis IIID: fetal and neonatal brain and liver glycosaminoglycan and morphological perturbations.
Mucopolysaccharidoses
Diagnosis of caprine mucopolysaccharidosis type IIID by real-time polymerase chain reaction-based genotyping.
Mucopolysaccharidoses
Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase.
Mucopolysaccharidoses
Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase.
Mucopolysaccharidoses
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Mucopolysaccharidoses
Sanfilippo D syndrome: estimation of N-acetylglucosamine-6-sulfatase activity with a radiolabeled monosulfated disaccharide substrate.
Mucopolysaccharidoses
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene.
Mucopolysaccharidoses
Update of the spectrum of mucopolysaccharidoses type III in Tunisia: identification of three novel mutations and in silico structural analysis of the missense mutations.
Mucopolysaccharidosis III
A screening method for mucopolysaccharidoses with increased urinary excretion of sulfated N-acetylhexosamines.
Mucopolysaccharidosis III
Caprine mucopolysaccharidosis IIID: a preliminary trial of enzyme replacement therapy.
Mucopolysaccharidosis III
Diagnosis of caprine mucopolysaccharidosis type IIID by real-time polymerase chain reaction-based genotyping.
Mucopolysaccharidosis III
Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase.
Mucopolysaccharidosis III
Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase.
Mucopolysaccharidosis III
Molecular characterization of MPS IIIA, MPS IIIB and MPS IIIC in Tunisian patients.
Mucopolysaccharidosis III
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Mucopolysaccharidosis III
Recombinant caprine 3H-[N-acetylglucosamine-6-sulfatase] and human 3H-[N-acetylgalactosamine-4-sulfatase]: plasma clearance, tissue distribution, and cellular uptake in the rat.
Mucopolysaccharidosis III
Sanfilippo D syndrome: estimation of N-acetylglucosamine-6-sulfatase activity with a radiolabeled monosulfated disaccharide substrate.
Mucopolysaccharidosis III
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene.
Mucopolysaccharidosis III
Sanfilippo syndrome, type D: a spectrophotometric assay with prenatal diagnostic potential.
Multiple Sulfatase Deficiency Disease
A screening method for mucopolysaccharidoses with increased urinary excretion of sulfated N-acetylhexosamines.
Neoplasm Metastasis
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Neoplasm Metastasis
SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15.
Neoplasm Metastasis
Sulfatase-1 knockdown promotes in vitro and in vivo aggressive behavior of murine hepatocarcinoma Hca-P cells through up-regulation of mesothelin.
Neoplasm Metastasis
Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells in vitro and in vivo.
Neoplasms
Endo-sulfatase Sulf-1 protein expression is down-regulated in gastric cancer.
Neoplasms
Identification and characterization of unique tumoricidal genes in rat umbilical cord matrix stem cells.
Neoplasms
Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.
Neoplasms
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Neoplasms
SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15.
Neoplasms
Sulfatase-1 knockdown promotes in vitro and in vivo aggressive behavior of murine hepatocarcinoma Hca-P cells through up-regulation of mesothelin.
Osteoarthritis
Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage.
Osteoarthritis
Suppression of cartilage degeneration by intra-articular injection of heparan sulfate 6-O endosulfatase in a mouse osteoarthritis model.
Osteoarthritis, Knee
Suppression of cartilage degeneration by intra-articular injection of heparan sulfate 6-O endosulfatase in a mouse osteoarthritis model.
Ovarian Neoplasms
Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells in vitro and in vivo.
Pneumonia
Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses.
Stomach Neoplasms
Endo-sulfatase Sulf-1 protein expression is down-regulated in gastric cancer.
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Freeman, C.; Clements, P.R.; Hopwood, J.J.
Human liver N-acetylglucosamine-6-sulphate sulphatase. Purification and characterization
Biochem. J.
246
347-354
1987
Homo sapiens
brenda
Freeman, C.; Hopwood, J.J.
Human liver N-acetylglucosamine-6-sulphate sulphatase. Catalytic properties
Biochem. J.
246
355-365
1987
Bos taurus, Homo sapiens, Rattus norvegicus
brenda
Basner, R.; Kresse, H.; von Figura, K.
N-Acetylglucosamine-6-sulfate sulfatase from human urine
J. Biol. Chem.
254
1151-1158
1979
Homo sapiens
brenda
Elliott, H.; Hopwood, J.J.
Detection of the Sanfilippo D syndrome by the use of a radiolabeled monosaccharide sulfate as the substrate for the estimation of N-acetylglucosamine-6-sulfate sulfatase
Anal. Biochem.
138
205-209
1984
Homo sapiens
brenda
Di Ferrante, N.
N-acetylglucosamine-6-sulfate sulfatase deficiency reconsidered
Science
210
448
1980
Homo sapiens
brenda
Kresse, H.; Fuchs, W.; Glossl, J.; Holtfrerich, D.; Gilberg, W.
Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A
J. Biol. Chem.
256
12926-12932
1981
Homo sapiens
brenda
Kresse, H.; von Figura, K.; Klein, U.; Glossl, J.; Paschke, E.; Pohlmann, R.
Enzymic diagnosis of the genetic mucopolysaccharide storage disorders
Methods Enzymol.
83
559-572
1982
Homo sapiens
brenda
Freeman, C.; Hopwood, J.J.
Sanfilippo D syndrome: estimation of N-acetylglucosamine-6-sulfatase activity with a radiolabeled monosulfated disaccharide substrate
Anal. Biochem.
176
244-248
1989
Homo sapiens
brenda
Kresse, H.; Paschke, E.; von Figura, K.; Gilberg, W.; Fuchs, W.
Sanfilippo disease type D: deficiency of N-acetylglucosamine-6-sulfate sulfatase required for heparan sulfate degradation
Proc. Natl. Acad. Sci. USA
77
6822-6826
1980
Homo sapiens
brenda
Thompson, J.N.; Jones, M.Z.; Dawson, G.; Huffman, P.S.
N-Acetylglucosamine 6-sulphatase deficiency in a Nubian goat: a model of Sanfilippo syndrome type D (mucopolysaccharidosis IIID)
J. Inherit. Metab. Dis.
15
760-768
1992
Capra hircus
brenda
Robertson, D.A.; Freeman, C.; Morris, C.P.; Hopwood, J.J.
A cDNA clone for human glucosamine-6-sulphatase reveals differences between arylsulphatases and non-arylsulphatases
Biochem. J.
288
539-544
1992
Homo sapiens
brenda
Freeman, C.; Hopwood, J.J.
Human glucosamine-6-sulphatase deficiency. Diagnostic enzymology towards heparin-derived trisaccharide substrates
Biochem. J.
282
605-614
1992
Homo sapiens
brenda
Shilatifard, A.; Cummings, R.D.
Purification and characterization of N-acetylglucosamine-6-sulfate sulfatase from bovine kidney: evidence for the presence of a novel endosulfatase activity
Biochemistry
33
4273-4282
1994
Bos taurus
brenda
Medeiros, M.G.; Ferreira, T.M.; Leite, E.L.; Toma, L.; Dietrich, C.P.; Nader, H.B.
New pathway of heparan sulphate degradation. Iduronate sulphatase and N-sulphoglucosamine 6-sulphatase act on the polymer chain prior to depolymerisation by a N-sulpho-glucosaminidase and glycuronidases in the mollusc Tagelus gibbus
Comp. Biochem. Physiol. B
119
539-547
1998
Tagelus gibbus
brenda
Sleat, D.E.; Kraus, S.R.; Sohar, I.; Lackland, H.; Lobel, P.
alpha-Glucosidase and N-acetylglucosamine-6-sulphatase are the major mannose-6-phosphate glycoproteins in human urine
Biochem. J.
324
33-39
1997
Homo sapiens
brenda
Litjens, T.; Bielicki, J.; Anson, D.S.; Friderici, K.; Jones, M.Z.; Hopwood, J.J.
Expression, purification and characterization of recombinant caprine N-acetylglucosamine-6-sulphatase
Biochem. J.
327
89-94
1997
Capra hircus
brenda
Wright, D.P.; Rosendale, D.I.; Robertson, A.M.
Prevotella enzymes involved in mucin oligosaccharide degradation and evidence for a small operon of genes expressed during growth on mucin
FEMS Microbiol. Lett.
190
73-79
2000
Prevotella sp., Prevotella sp. RS2
brenda
Beesley, C.E.; Burke, D.; Jackson, M.; Vellodi, A.; Winchester, B.G.; Young, E.P.
Sanfilippo syndrome type D: identification of the first mutation in the N-acetylglucosamine-6-sulphatase gene
J. Med. Genet.
40
192-194
2003
Homo sapiens
brenda
Xu, S.; Zhao, L.; Larsson, A.; Smeds, E.; Kusche-Gullberg, M.; Venge, P.
Purification of a 75 kDa protein from the organelle matrix of human neutrophils and identification as N-acetylglucosamine-6-sulphatase
Biochem. J.
387
841-847
2005
Homo sapiens
brenda
Jansen, A.C.; Cao, H.; Kaplan, P.; Silver, K.; Leonard, G.; De Meirleir, L.; Lissens, W.; Liebaers, I.; Veilleux, M.; Andermann, F.; Hegele, R.A.; Andermann, E.
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene
Arch. Neurol.
64
1629-1634
2007
Homo sapiens (P15586), Homo sapiens
brenda
Myette, J.R.; Soundararajan, V.; Shriver, Z.; Raman, R.; Sasisekharan, R.
Heparin/heparan sulfate 6-O-sulfatase from Flavobacterium heparinum: integrated structural and biochemical investigation of enzyme active site and substrate specificity
J. Biol. Chem.
284
35177-35188
2009
Pedobacter heparinus
brenda
Zhou, X.; Li, L.; Linhardt, R.J.; Liu, J.
Neutralizing the anticoagulant activity of ultra-low-molecular-weight heparins using N-acetylglucosamine 6-sulfatase
FEBS J.
280
2523-2532
2013
Homo sapiens
brenda
Sikora, A.-S.; Hellec, C.; Carpentier, M.; Martinez, P.; Delos, M.; Denys, A.; Allain, F.
Tumour-necrosis factor-alpha induces heparan sulfate 6-O-endosulfatase1 (Sulf-1) expression in fibroblasts
Int. J. Biochem. Cell Biol.
80
57-65
2016
Homo sapiens (P15586), Homo sapiens
brenda