Reference on EC 3.1.5.B1 - dNTPase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Miazzi, C.; Ferraro, P.; Pontarin, G.; Rampazzo, C.; Reichard, P.; Bianchi, V.
Allosteric regulation of the human and mouse deoxyribonucleotide triphosphohydrolase sterile alpha-motif/histidine-aspartate domain-containing protein 1 (SAMHD1)
J. Biol. Chem.
289
18339-18346
2014
Mus musculus (Q60710), Mus musculus, Homo sapiens (Q9Y3Z3), Homo sapiens
Vorontsov, I.I.; Wu, Y.; DeLucia, M.; Minasov, G.; Mehrens, J.; Shuvalova, L.; Anderson, W.F.; Ahn, J.
Mechanisms of allosteric activation and inhibition of the deoxyribonucleoside triphosphate triphosphohydrolase from Enterococcus faecalis
J. Biol. Chem.
289
2815-2824
2014
Enterococcus faecalis (Q836G9), Enterococcus faecalis, Enterococcus faecalis ATCC 700802 (Q836G9)
Zhu, C.; Gao, W.; Zhao, K.; Qin, X.; Zhang, Y.; Peng, X.; Zhang, L.; Dong, Y.; Zhang, W.; Li, P.; Wei, W.; Gong, Y.; Yu, X.
Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
Nat. Commun.
4
2722
2013
Homo sapiens
Franzolin, E.; Pontarin, G.; Rampazzo, C.; Miazzi, C.; Ferraro, P.; Palumbo, E.; Reichard, P.; Bianchi, V.
The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells
Proc. Natl. Acad. Sci. USA
110
14272-14277
2013
Homo sapiens (Q9Y3Z3), Homo sapiens
Zhu, C.F.; Wei, W.; Peng, X.; Dong, Y.H.; Gong, Y.; Yu, X.F.
The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP
Acta Crystallogr. Sect. D
71
516-524
2015
Homo sapiens (Q9Y3Z3), Homo sapiens
Mauney, C.H.; Rogers, L.C.; Harris, R.S.; Daniel, L.W.; Devarie-Baez, N.O.; Wu, H.; Furdui, C.M.; Poole, L.B.; Perrino, F.W.; Hollis, T.
The SAMHD1 dNTP triphosphohydrolase is controlled by a redox switch
Antioxid. Redox Signal.
27
1317-1331
2017
Homo sapiens (Q9Y3Z3)
Jang, S.; Zhou, X.; Ahn, J.
Substrate specificity of SAMHD1 triphosphohydrolase activity is controlled by deoxyribonucleoside triphosphates and phosphorylation at Thr592
Biochemistry
55
5635-5646
2016
Homo sapiens
Mauney, C.H.; Perrino, F.W.; Hollis, T.
Identification of inhibitors of the dNTP triphosphohydrolase SAMHD1 using a novel and direct high-throughput assay
Biochemistry
57
6624-6636
2018
Homo sapiens (Q9Y3Z3)
Tramentozzi, E.; Ferraro, P.; Hossain, M.; Stillman, B.; Bianchi, V.; Pontarin, G.
The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592
Cell Cycle
17
1102-1114
2018
Homo sapiens (Q9Y3Z3)
Franzolin, E.; Salata, C.; Bianchi, V.; Rampazzo, C.
The deoxynucleoside triphosphate triphosphohydrolase activity of SAMHD1 protein contributes to the mitochondrial DNA depletion associated with genetic deficiency of deoxyguanosine kinase
J. Biol. Chem.
290
25986-25996
2015
Homo sapiens (Q9Y3Z3), Homo sapiens
Tang, C.; Ji, X.; Wu, L.; Xiong, Y.
Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592
J. Biol. Chem.
290
26352-26359
2015
Homo sapiens (Q9Y3Z3)
Bloch, N.; Glaesker, S.; Sitaram, P.; Hofmann, H.; Shepard, C.N.; Schultz, M.L.; Kim, B.; Landau, N.R.
A highly active isoform of lentivirus restriction factor SAMHD1 in mouse
J. Biol. Chem.
292
1068-1080
2017
Mus musculus (Q60710), Mus musculus
Seamon, K.J.; Stivers, J.T.
A high-throughput enzyme-coupled assay for SAMHD1 dNTPase
J. Biomol. Screen.
20
801-809
2015
Homo sapiens (Q9Y3Z3)
Gelais, C.; Kim, S.; Maksimova, V.; Buzovetsky, O.; Knecht, K.; Shepard, C.; Kim, B.; Xiong, Y.; Wu, L.
A cyclin-binding motif in human SAMHD1 is required for its HIV-1 restriction, dNTPase activity, tetramer formation, and efficient phosphorylation
J. Virol.
92
e01787
2018
Homo sapiens (Q9Y3Z3), Homo sapiens
Lee, E.J.; Seo, J.H.; Park, J.H.; Vo, T.T.L.; An, S.; Bae, S.J.; Le, H.; Lee, H.S.; Wee, H.J.; Lee, D.; Chung, Y.H.; Kim, J.A.; Jang, M.K.; Ryu, S.H.; Yu, E.; Jang, S.H.; Park, Z.Y.; Kim, K.W.
SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferation
Oncotarget
8
68517-68529
2017
Homo sapiens (Q9Y3Z3), Homo sapiens
Choi, J.; Ryoo, J.; Oh, C.; Hwang, S.; Ahn, K.
SAMHD1 specifically restricts retroviruses through its RNase activity
Retrovirology
12
46
2015
Homo sapiens (Q9Y3Z3), Homo sapiens
Bhattacharya, A.; Wang, Z.; White, T.; Buffone, C.; Nguyen, L.A.; Shepard, C.N.; Kim, B.; Demeler, B.; Diaz-Griffero, F.; Ivanov, D.N.
Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect
Sci. Rep.
6
31353
2016
Homo sapiens (Q9Y3Z3)
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