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Information on EC 3.1.4.52 - cyclic-guanylate-specific phosphodiesterase

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IUBMB Comments
Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3,5-guanylate, the product of EC 2.7.7.65, diguanylate cyclase and an allosteric activator of EC 2.4.1.12, cellulose synthase (UDP-forming), rendering it inactive . It is the balance between these two enzymes that determines the cellular level of c-di-GMP .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
hd-gyp, c-di-gmp phosphodiesterase, phosphodiesterase a, blrp1, putative uncharacterized protein, pa4781, cyclic di-gmp phosphodiesterase, c-di-gmp-specific phosphodiesterase, pde-a, pa2567, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine
show the reaction diagram
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