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Information on EC 3.1.4.52 - cyclic-guanylate-specific phosphodiesterase

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IUBMB Comments
Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65, diguanylate cyclase and an allosteric activator of EC 2.4.1.12, cellulose synthase (UDP-forming), rendering it inactive . It is the balance between these two enzymes that determines the cellular level of c-di-GMP .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
Arr, BB0374, BCG_1419c, Bd1817, BifA, BinA, Blrp, BlrP1, blue light-regulated phophodiesterase, BpdA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine
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