Disease on EC 3.1.3.86 - phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Adenocarcinoma
Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function.
Alzheimer Disease
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.
Alzheimer Disease
Combining data integration and molecular dynamics for target identification in ?-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1).
Alzheimer Disease
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline.
Alzheimer Disease
Hydrogen sulfide and mesenchymal stem cells-extracted microvesicles attenuate LPS-induced Alzheimer's disease.
Alzheimer Disease
INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia.
Alzheimer Disease
INPP5D mRNA Expression and Cognitive Decline in Japanese Alzheimer's Disease Subjects.
Alzheimer Disease
INPP5D rs35349669 polymorphism with late-onset Alzheimer's disease: A replication study and meta-analysis.
Amyloidosis
Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.
Arthritis, Gouty
MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis.
Asthma
Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung.
Autoimmune Diseases
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
Bone Resorption
Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts.
Candidiasis
Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection.
Carcinoma
MicroRNA-155 governs SHIP-1 expression and localization in NK cells and regulates subsequent infiltration into murine AT3 mammary carcinoma.
Cataract
Molecular characterization of the human lens epithelium-derived cell line SRA01/04.
Chronic Urticaria
Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: Relationship to expression of Syk and SHIP-2.
Colitis
IL-10/microRNA-155/SHIP-1 signaling pathway is crucial for commensal bacteria induced spontaneous colitis.
Colitis
MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression.
Colorectal Neoplasms
Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.
Diabetes Mellitus, Type 1
A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation.
Diabetes Mellitus, Type 1
INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy.
Diabetes Mellitus, Type 2
A high-throughput microfluidic assay for SH2 domain-containing inositol 5-phosphatase 2.
Diabetes Mellitus, Type 2
Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
Diabetes Mellitus, Type 2
Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2).
Diabetes Mellitus, Type 2
The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.
Diabetic Nephropathies
INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy.
Diverticulitis
RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis.
Encephalitis, Japanese
MicroRNA 155 Regulates Japanese Encephalitis Virus-Induced Inflammatory Response by Targeting Src Homology 2-Containing Inositol Phosphatase 1.
Essential Hypertension
Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
Glioblastoma
5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
Hematologic Neoplasms
A novel strategy for modulation of MDSC to enhance cancer immunotherapy.
Hypersensitivity
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Hypertension
Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
Hypertension
Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
Ileitis
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
Infections
Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection.
Infections
MicroRNA 155 Regulates Japanese Encephalitis Virus-Induced Inflammatory Response by Targeting Src Homology 2-Containing Inositol Phosphatase 1.
Infections
Porcine Fc?RIIb mediated PRRSV ADE infection through inhibiting IFN-? by cytoplasmic inhibitory signal transduction.
Infections
SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt-STAT5-Trib1 Circuit in Pseudomonas aeruginosa Infection.
Infections
Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection.
Infections
The phosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection.
Influenza, Human
Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease.
Insulin Resistance
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.
Insulin Resistance
Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice.
Insulin Resistance
Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.
Insulin Resistance
INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy.
Insulin Resistance
Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
Insulin Resistance
SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells.
Leukemia
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Leukemia
The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production.
Leukemia
[Effect of SHIP-1 on Invasion, Migration and PI3K-AKT Signaling Pathway of Leukemic Cells].
Leukemia, Erythroblastic, Acute
The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis.
Leukemia, Lymphocytic, Chronic, B-Cell
Overexpression of SH2-Containing Inositol Phosphatase Contributes to Chronic Lymphocytic Leukemia Survival.
Leukemia, Myeloid, Acute
Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.
Leukemia, Myelomonocytic, Juvenile
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Leukemia-Lymphoma, Adult T-Cell
Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL).
Leukemia-Lymphoma, Adult T-Cell
Human T-cell leukemia virus type I tax down-regulates the expression of phosphatidylinositol 3,4,5-trisphosphate inositol phosphatases via the NF-kappaB pathway.
Lung Diseases
Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease.
Lung Diseases
Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.
Lung Diseases
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
Lupus Erythematosus, Systemic
A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation.
Lymphatic Diseases
Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction.
Lymphatic Metastasis
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma.
Lymphoma
Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma.
Lymphoma
B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells.
Lymphoma
Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.
Lymphoma
Quantification of change in phosphorylation of BCR-ABL kinase and its substrates in response to Imatinib treatment in human chronic myelogenous leukemia cells.
Lymphoma, B-Cell
SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity.
Melanoma
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma.
Metabolic Syndrome
Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
Metabolic Syndrome
INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy.
Metabolic Syndrome
Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
Multiple Myeloma
Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.
Myelodysplastic Syndromes
Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155.
Myeloproliferative Disorders
The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling.
Neoplasm Metastasis
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma.
Neoplasms
5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.
Neoplasms
Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL).
Neoplasms
Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer.
Neoplasms
BCL9L expression in pancreatic neoplasia with a focus on SPN: a possible explanation for the enigma of the benign neoplasia.
Neoplasms
Enzymatic and non-enzymatic activities of SHIP-1 in signal transduction and cancer.
Neoplasms
Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models.
Neoplasms
Human T-cell leukemia virus type I tax down-regulates the expression of phosphatidylinositol 3,4,5-trisphosphate inositol phosphatases via the NF-kappaB pathway.
Neoplasms
MicroRNA-155 governs SHIP-1 expression and localization in NK cells and regulates subsequent infiltration into murine AT3 mammary carcinoma.
Neoplasms
Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function.
Neoplasms
Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase: growth factors and beyond.
Neoplasms
The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling.
Neoplasms
Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.
Neoplasms
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma.
Obesity
Genome-wide association study for backfat thickness at 100 kg and loin muscle thickness in domestic pigs based on genotyping by sequencing.
Obesity
Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover.
Obesity, Abdominal
Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples.
Oculocerebrorenal Syndrome
Bleeding disorders in Lowe syndrome patients: evidence for a link between OCRL mutations and primary haemostasis disorders.
Oculocerebrorenal Syndrome
The impact of phosphoinositide 5-phosphatases on phosphoinositides in cell function and human disease.
Oculocerebrorenal Syndrome
The phosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection.
Osteoarthritis
MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis.
Pancreatic Neoplasms
Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer.
Pancreatic Neoplasms
Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function.
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase deficiency
Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease.
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase deficiency
Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development.
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase deficiency
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase deficiency
SHIP-1 increases early oxidative burst and regulates phagosome maturation in macrophages.
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase deficiency
SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity.
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase deficiency
SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt-STAT5-Trib1 Circuit in Pseudomonas aeruginosa Infection.
phosphoinositide 5-phosphatase deficiency
SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.
Pneumonia
Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.
Pneumonia
Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells.
Pneumonia
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
Pneumonia
SHIP-1, a target of miR-155, regulates endothelial cell responses in lung fibrosis.
Pseudomonas Infections
SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt-STAT5-Trib1 Circuit in Pseudomonas aeruginosa Infection.
Pulmonary Disease, Chronic Obstructive
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.
Sepsis
SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt-STAT5-Trib1 Circuit in Pseudomonas aeruginosa Infection.
Stroke
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1: a meaningful and independent marker to predict stroke in the chinese population.
Tauopathies
Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.
Thyroid Cancer, Papillary
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma.
Urticaria
Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: Relationship to expression of Syk and SHIP-2.
Vaccinia
SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells.
html completed