Disease on EC 3.1.3.69 - glucosylglycerol 3-phosphatase
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DISEASE 
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Acute Lung Injury
Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury.
Adenocarcinoma of Lung
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Angiomyolipoma
Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma.
Bone Diseases
Moiety-Linkage Map Reveals Selective Nonbisphosphonate Inhibitors of Human Geranylgeranyl Diphosphate Synthase.
Cardiomegaly
The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure.
Diabetes Mellitus, Type 2
Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway.
glucosylglycerol 3-phosphatase deficiency
Cholesterol metabolic enzyme Ggpps regulates epicardium development and ventricular wall architecture integrity in mice.
glucosylglycerol 3-phosphatase deficiency
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions.
glucosylglycerol 3-phosphatase deficiency
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-?1/BMP-4 signaling.
glucosylglycerol 3-phosphatase deficiency
Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury.
glucosylglycerol 3-phosphatase deficiency
GGPPS deficiency aggravates CCl4-induced liver injury by inducing hepatocyte apoptosis.
Hematologic Neoplasms
Metal coordination is crucial for GGPPS-bisphosphonates interactions: A crystallographic and computational analysis.
Idiopathic Pulmonary Fibrosis
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-?1/BMP-4 signaling.
Insulin Resistance
An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism.
Insulin Resistance
Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice.
Insulin Resistance
Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway.
Liver Cirrhosis
HSC-specific knockdown of GGPPS alleviated CCl4-induced chronic liver fibrosis through mediating RhoA/Rock pathway.
Lung Injury
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-?1/BMP-4 signaling.
Lung Injury
Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury.
Lymphangioleiomyomatosis
Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma.
Lymphatic Metastasis
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Lymphoma, T-Cell
Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction.
Metabolic Syndrome
Insulin Resistance-Related Proteins Are Overexpressed in Patients and Rats Treated With Olanzapine and Are Reverted by Pueraria in the Rat Model.
Neoplasm Metastasis
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Neoplasms
Moiety-Linkage Map Reveals Selective Nonbisphosphonate Inhibitors of Human Geranylgeranyl Diphosphate Synthase.
Neoplasms
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Non-alcoholic Fatty Liver Disease
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions.
Parasitic Diseases
Metal coordination is crucial for GGPPS-bisphosphonates interactions: A crystallographic and computational analysis.
Pulmonary Fibrosis
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-?1/BMP-4 signaling.
Schistosomiasis
Characterization of farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni: potential drug targets.
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