Reference on EC 3.1.3.5 - 5'-nucleotidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Itami, H.; Sakai, Y.; Shimamoto, T.; Hama, H.; Tsuda, M.; Tsuciya, T.
Purification and characterization of membrane-bound 5'-nucleotidase of Vibrio parahaemolyticus
J. Biochem.
105
785-789
1989
Vibrio parahaemolyticus
Ikura, Y.; Horikoshi, K.
Manganese-dependent production, and properties, of 5'-nucleotidase by alkalophilic Bacillus No. A-59
Agric. Biol. Chem.
53
645-649
1989
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) No. A-59
-
Willadsen, P.; Nielsen, J.M.; Riding, G.A.
Purification and properties of a novel nucleotide-hydrolysing enzyme (5'-nucleotidase) from Boophilus microplus
Biochem. J.
258
79-85
1989
Rhipicephalus microplus
Mittal, R.; Das, J.; Sharma, C.B.
Purification and characterization of 5'-nucleotidase from the Golgi apparatus of peanut cotyledons
Plant Sci.
55
93-101
1988
Arachis hypogaea
-
Lee, R.S.F.; Ford, H.C.
5'-Nucleotidase of human placental trophoblastic microvilli possesses cobalt-stimulated FAD pyrophosphatase activity
J. Biol. Chem.
263
14878-14883
1988
Homo sapiens
Spychala, J.; Madrid-Marina, V.; Fox, I.H.
High Km soluble 5'-nucleotidase from human placenta. Properties and allosteric regulation by IMP and ATP
J. Biol. Chem.
263
18759-18765
1988
Homo sapiens
Zekri, M.; Harb, J.; Bernard, S.; Meflah, K.
Purification of bovine liver cytosolic 5'-nucleotidase. Kinetic and structural studies as compared to the membrane isoenzyme
Eur. J. Biochem.
172
93-99
1988
Bos taurus
Sakai, Y.; Toda, K.; Mitani, Y.; Tsuda, M.; Shinoda, S.; Tsuchiya, T.
Properties of the membrane-bound 5'-nucleotidase and utilization of extracellular ATP in Vibrio parahaemolyticus
J. Gen. Microbiol.
133
2751-2757
1987
Vibrio parahaemolyticus
Grondal, E.J.M.; Zimmermann, H.
Purification, characterization and cellular localization of 5'-nucleotidase from Torpedo electric organ
Biochem. J.
245
805-810
1987
Torpedo marmorata
Wada, I.; Eto, S.; Himeno, M.; Kato, K.
5'-Nucleotidase in rat liver lysosomes
J. Biochem.
101
1077-1085
1987
Rattus norvegicus
Sharma, C.B.; Mittal, R.; Tanner, W.
Purification and properties of a glycoprotein adenosine 5'-monophosphatase from the plasma membrane fraction of Arachis hypogaea cotyledons
Biochim. Biophys. Acta
884
567-577
1986
Arachis hypogaea
-
Singh, A.; Singh, R.
Properties of 5'-nucleotidase from nodules of pigeonpea (Cajanus cajan)
Phytochemistry
25
2267-2270
1986
Cajanus cajan
-
Tsushima, K.
Properties of cytosol 5-nucleotidase and its role in purine nucleotide metabolism
Adv. Enzyme Regul.
25
181-200
1986
Gallus gallus
Yamamoto, H.; Tomioka, K.; Kawai, H.; Endo, K.
Purification and properties of 5'-nucleotidase from cod muscle
Agric. Biol. Chem.
50
1123-1129
1986
Gadus macrocephalus
-
Carter, S.G.; Tipton, C.L.
Purification and characterization of a 5'-nucleotidase from Zea mays microsomes
Phytochemistry
25
33-37
1986
Zea mays
-
Madrid-Marina, V.; Fox, I.H.
Human placental cytoplasmic 5'-nucleotidase. Kinetic properties and inhibition
J. Biol. Chem.
261
444-452
1986
Homo sapiens
Bengis-Garber, C.
Membrane-bound 5'-nucleotidase in marine luminous bacteria: biochemical and immunological properties
Can. J. Microbiol.
31
543-548
1985
Aliivibrio fischeri, Photobacterium leiognathi, Photobacterium phosphoreum, Vibrio alginolyticus, Vibrio harveyi, Vibrio cholerae serotype O1
Camici, M.; Fini, C.; Ipata, P.L.
Isolation and kinetic properties of 5'-nucleotidase from guinea-pig skeletal muscle
Biochim. Biophys. Acta
840
6-12
1985
Cavia porcellus
Onishi, H.; Kobayashi, T.; Kamekura, M.
Purification and some properties of an extracellular halophilic 5'-nucleotidase from a moderate halophile, Micrococcus varians subsp. Halophilus
FEMS Microbiol. Lett.
24
303-306
1984
Kocuria varians
-
Harb, J.; Meflah, K.; Duflos, Y.; Bernard, S.
Purification and properties of bovine liver plasma membrane 5' nucleotidase
Eur. J. Biochem.
137
131-138
1983
Bos taurus
Lamers, J.M.J.; Heyliger, C.E.; Panagia, V.; Dhalla, N.S.
Properties of 5-nucleotidase in rat heart sarcolemma
Biochim. Biophys. Acta
742
568-575
1983
Rattus norvegicus
Itoh, R.
Studies on some molecular properties of cytosol 5'-nucleotidase from rat liver
Biochim. Biophys. Acta
716
110-113
1982
Rattus norvegicus
Naito, Y.; Lowenstein, J.M.
5'-Nucleotidase from rat heart
Biochemistry
20
5188-5194
1981
Rattus norvegicus
Broad, D.F.; Smith, J.T.
Escherichia coli 5'-nucleotidase: purification, properties and its release by osmotic shock
J. Gen. Microbiol.
123
241-247
1981
Escherichia coli
Bengis-Garber, C.; Kushner, D.J.
Purification and properties of 5'-nucleotidase from the membrane of Vibrio costicola, a moderately halophilic bacterium
J. Bacteriol.
146
24-32
1981
Salinivibrio costicola
Itoh, R.
Purification and some properties of cytosol 5'-nucleotidase from rat liver
Biochim. Biophys. Acta
657
402-410
1981
Rattus norvegicus
Itoh, R.; Usami, C.; Nishino, T.; Tsushima, K.
Kinetic properties of cytosol 5'-nucleotidase from chicken liver
Biochim. Biophys. Acta
526
154-162
1978
Gallus gallus
Dornand, J.; Bonnafous, J.C.; Mani, J.C.
Purification and properties of 5'-nucleotidase from lymphocyte plasma membranes
Eur. J. Biochem.
87
459-465
1978
Sus scrofa
Naito, Y.; Tsushima, K.
Cytosol 5'-nucleotidase from chicken liver. Purification and some properties
Biochim. Biophys. Acta
438
159-168
1976
Gallus gallus
Newby, A.; Luzio, P.; Hales, C.N.
The properties and extracellular location of 5'-nucleotidase of the rat fat-cell plasma membrane
Biochem. J.
146
625-633
1975
Rattus norvegicus
Widnell, C.C.
Purification of rat liver 5'-nucleotidase as a complex with sphingomyelin
Methods Enzymol.
32
368-374
1974
Rattus norvegicus
Olson, A.C.; Fraser, M.J.
A 5'-nucleotidase from Neurospora crassa
Biochim. Biophys. Acta
334
156-167
1974
Neurospora crassa
-
Evans, W.H.; Gurd, J.W.
Properties of a 5'-nucleotidase purified from mouse liver plasma membranes
Biochem. J.
133
189-199
1973
Mus musculus
Gibson, W.B.; Drummond, G.I.
Properties of 5'-nucleotidase from avian heart
Biochemistry
11
223-229
1972
Gallus gallus, Columba livia, Rattus norvegicus, Sturnus vulgaris
Drummond, G.I.; Yamamoto, M.
Nucleotide phosphomonoesterases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
337-354
1971
Bothrops atrox, Saccharomyces cerevisiae, Crotalus adamanteus, Escherichia coli, Hemachatus haemachatus, Ovis aries, Naja naja, Proteus vulgaris, Daboia russelii, Salmonella enterica subsp. enterica serovar Heidelberg, Shigella sonnei, Solanum tuberosum
-
Gupta, A.; Sharma, C.B.
Purification to homogeneity and characterization of plasma membrane and Golgi apparatus-specific 5'-adenosine monophosphatases from peanut cotyledons
Plant Sci.
117
65-74
1996
Arachis hypogaea
-
Turnay, J.; Olmo, N.; Navarro, J.M.; Gavilanes, J.G.; Lizarbe, M.A.
Isolation and characterization of the ecto-5'-nucleotidase from a rat glioblastoma cell line
Mol. Cell. Biol.
117
23-33
1992
Rattus norvegicus
Yegutkin, G.G.
Effects of Triton X-100 and concanavalin A on the properties of 5'-nucleotidase in rat liver and adipose plasma membranes: a role of membrane structure in the regulation of enzyme activity
Membr. Cell Biol.
10
631-638
1997
Rattus norvegicus
Garvey, E.P.; Lowen, G.T.; Almond, M.R.
Nucleotide and nucleoside analogues as inhibitors of cytosolic 5'-nucleotidase I from heart
Biochemistry
37
9043-9051
1998
Oryctolagus cuniculus
Marseno, D.W.; Hori, K.; Miyazawa, K.
Purification and properties of membrane-bound 5'-nucleotidase from black rockfish (Sebastes inermis) muscle
J. Agric. Food Chem.
41
863-869
1993
Sebastes inermis
Marseno, D.W.; Hori, K.; Miyazawa, K.
Purification and properties of cytosol 5'-nucleotidase from black rockfish (Sebastes inermis) muscle
J. Agric. Food Chem.
41
1208-1212
1993
Sebastes inermis
Garcia, L.; Chayet, L.; Kettlun, A.M.; Collados, L.; Chiong, M.; Traverso-Cori, A.; Mancilla, M.; Valenzuela, M.A.
Kinetic characteristics of nucleoside mono-, di- and triphosphate activities of the periplasmic 5'-nucleotidase of Escherichia coli
Comp. Biochem. Physiol. B
117
135-142
1997
Escherichia coli
Klemens, M.R.; Sherman, W.R.; Holmberg, N.J.; Ruedi, J.M.; Low, M.G.; Thompson, L.F.
Characterization of soluble vs membrane-bound human placental 5'-nucleotidase
Biochem. Biophys. Res. Commun.
172
1371-1377
1990
Homo sapiens
Niedzwiecka, J.; Jaroszewicz, L.
Soluble 5'-nucleotidase from thyroid gland partial purification and properties
Biochem. Biophys. Res. Commun.
221
471-476
1996
Sus scrofa
Lee, R.S.F.; Ford, H.C.
Purification and characterization of 5'-nucleotidase/FAD pyrophosphatase from human placenta
Methods Enzymol.
280
424-436
1997
Homo sapiens
Skladanowski, A.C.; Newby, A.C.
Partial purification and properties of an AMP-specific 5'-nucleotidase from pigeon heart
Biochem. J.
268
117-122
1990
Columba livia
Servos, J.; Reilnder, H.; Zimmermann, H.
Catalytically active soluble ecto-5'-nucleotidase purified after heterologous expression as a tool for drug screening
Drug Develop. Res.
45
269-276
1998
Rattus norvegicus
-
Orford, M.R.; Saggerson, E.D.
A low-Km 5'-nucleotidase from rat brain cytosolic fraction: purification, kinetic properties, and description of regulation by a novel factor that increases sensitivity to inhibition by ATP and ADP
J. Neurochem.
67
795-804
1996
Rattus norvegicus
Lai, K.M.; Wong, P.C.L.
A comparison of the properties of 5'-nucleotidase purified from the cytosolic and synaptic plasma membrane fractions of rat forebrain
Int. J. Biochem.
23
1123-1130
1991
Rattus norvegicus
Rajput, A.; Chakravarthy, B.R.; DSouza, C.J.M.
Isolation and characterization of 5'-nucleotidase inhibitor from rat liver
Indian J. Biochem. Biophys.
29
204-208
1992
Rattus norvegicus
Garvey, E.P.; Prus, K.L.
A specific inhibitor of heart cytosolic 5'-nucleotidase I attenuates hydrolysis of adenosine 5'-monophosphate in primary rat myocytes
Arch. Biochem. Biophys.
364
235-240
1999
Rattus norvegicus
Fini, C.; Coli, M.; Floridi, A.; DAuria, S.; Staiano, M.; Nucci, R.; Rossi, M.
Temperature effects on the structural and functional properties of GPI-anchored and anchor-less bull seminal plasma ecto-5'-nucleotidase
J. Biochem.
123
269-274
1998
Bos taurus
Pesi, R.; Baiocchi, C.; Allegrini, S.; Moretti, E.; Sgarrella, F.; Camici, M.; Tozzi, M.G.
Identification, separation and characterization of two forms of cytosolic 5'-nucleotidase/nucleoside phosphotransferase in calf thymus
Biol. Chem.
379
699-704
1998
Bos taurus
Flocke, K.; Mannherz, H.G.
Isolation and characterization of 5'-nucleotidase of a human pancreatic tumor cell line
Biochim. Biophys. Acta
1076
273-281
1991
Homo sapiens
Martinez-Martinez, A.; Flores-Flores, C.; Campoy, F.J.; Munoz-Delgado, E.; Fini, C.; Vidal, C.J.
Biochemical properties of 5'-nucleotidase from mouse skeletal muscle
Biochim. Biophys. Acta
1386
16-28
1998
Mus musculus
Kalsi, K.K.; Lawson, C.; McCormack, A.; Kochan, Z.; Yacoub, M.H.; Smolenski, R.T.
TNF-a reduces the activity of ecto-5'-nucleotidase in human endothelial cells
Adv. Exp. Med. Biol.
486
149-152
2000
Homo sapiens
Trifilo, M.; Page, T.
NAPDD patients exhibit altered electrophoretic mobility of cytosolic 5' nucleotidase
Adv. Exp. Med. Biol.
486
87-90
2000
Homo sapiens
Sala-Newby, G.B.; Freeman, N.V.; Curto, M.A.; Newby, A.C.
Metabolic and functional consequences of cytosolic 5'-nucleotidase-IA overexpression in neonatal rat cardiomyocytes
Am. J. Physiol.
285
H991-998
2003
Columba sp.
Kocic, G.; Pavlovic, D.; Jevtovic, T.; Kocic, R.; Bojic, A.; Vlahovic, P.; Djordjevic, V.; Sokolovic, D.; Djindjic, B.
Oxidative modification of rat liver 5'-nucleotidase: the mechanisms for protection and re-activation
Arch. Physiol. Biochem.
109
323-330
2001
Rattus norvegicus
Fini, C.; Talamo, F.; Cherri, S.; Coli, M.; Floridi, A.; Ferrara, L.; Scaloni, A.
Biochemical and mass spectrometric characterization of soluble ecto-5'-nucleotidase from bull seminal plasma
Biochem. J.
372
443-451
2003
Bos taurus
McMillen, L.; Beacham, I.R.; Burns, D.M.
Cobalt activation of Escherichia coli 5'-nucleotidase is due to zinc ion displacement at only one of two metal-ion-binding sites
Biochem. J.
372
625-630
2003
Escherichia coli
Martinez-Martinez, A.; Munoz-Delgado, E.; Campoy, F.J.; Flores-Flores, C.; Rodriguez-Lopez, J.N.; Fini, C.; Vidal, C.J.
The ecto-5'-nucleotidase subunits in dimers are not linked by disulfide bridges but by non-covalent bonds
Biochim. Biophys. Acta
1478
300-308
2000
Bos taurus
Kawashima, Y.; Nagasawa, T.; Ninomiya, H.
Contribution of ecto-5'-nucleotidase to the inhibition of platelet aggregation by human endothelial cells
Blood
96
2157-2162
2000
Homo sapiens
Itoh, R.; Kimura, K.
Occurrence of IMP-GMP 5'-nucleotidase in three fish species: a comparative study on Trachurus japonicus, Oncorhynchus masou masou and Triakis scyllium
Comp. Biochem. Physiol. B
132
401-408
2002
Trachurus japonicus, Oncorhynchus masou, Triakis scyllium
Liyou, N.; Hamilton, S.; McKenna, R.; Elvin, C.; Willadsen, P.
Localisation and functional studies on the 5'-nucleotidase of the cattle tick Boophilus microplus
Exp. Appl. Acarol.
24
235-246
2000
Rhipicephalus microplus
Johnson, S.; Pitcher, D.
Distribution of ecto 5'-nucleotidase on Mycoplasma species associated with arthritis
FEMS Microbiol. Lett.
192
59-65
2000
Mycoplasma arthritidis, Mycoplasmopsis fermentans, Ureaplasma urealyticum, Mycoplasmopsis pulmonis, Mycoplasma buccale, Mycoplasmopsis pulmonis NCTC 10139
Zagursky, R.J.; Ooi, P.; Jones, K.F.; Fiske, M.J.; Smith, R.P.; Green, B.A.
Identification of a Haemophilus influenzae 5'-nucleotidase protein: cloning of the nucA gene and immunogenicity and characterization of the NucA protein
Infect. Immun.
68
2525-2534
2000
Haemophilus influenzae
Ribeiro, J.M.C.; Rowton, E.D.; Charlab, R.
The salivary 5'-nucleotidase/phosphodiesterase of the haematophagus sand fly,Lutzomyia longipalpis
Insect Biochem. Mol. Biol.
30
279-285
2000
Lutzomyia longipalpis
Balz, D.; de Souza Wyse, A.T.; Morsch, V.M.; da Silva, A.C.; Vieira, V.L.; Morsch, A.L.; Schetinger, M.R.
In vitro effects of L-arginine and guanidino compounds on NTPDase1 and 5'-nucleotidase activities from rat brain synaptosomes
Int. J. Dev. Neurosci.
21
75-82
2003
Rattus norvegicus
Innes, D.; Beacham, I.R.; Burns, D.M.
The role of the intracellular inhibitor of periplasmic UDP-sugar hydrolase (5'-nucleotidase) in Escherichia coli: cytoplasmic localisation of 5'-nucleotidase is conditionally lethal
J. Basic Microbiol.
41
329-337
2001
Escherichia coli
Hunsucker, S.A.; Spychala, J.; Mitchell, B.S.
Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance
J. Biol. Chem.
276
10498-10504
2001
Homo sapiens (Q9BXI3), Homo sapiens
Allegrini, S.; Scaloni, A.; Ferrara, L.; Pesi, R.; Pinna, P.; Sgarrella, F.; Camici, M.; Eriksson, S.; Tozzi, M.G.
Bovine cytosolic 5'-nucleotidase acts through the formation of an aspartate 52-phosphoenzyme intermediate
J. Biol. Chem.
276
33526-33532
2001
Bos taurus
Picher, M.; Burch, L.H.; Hirsh, A.J.; Spychala, J.; Boucher, R.C.
Ecto 5'-nucleotidase and nonspecific alkaline phosphatase. Two-AMP-hydrolyzing ectoenzymes with distinct roles in human airways
J. Biol. Chem.
278
13468-13479
2003
Homo sapiens
Knofel, T.; Strater, N.
Mechanism of hydrolysis of phosphate esters by the dimetal center of 5'-nucleotidase based on crystal structures
J. Mol. Biol.
309
239-254
2001
Escherichia coli (P07024)
Knfel, T.; Strter, N.
E. coli 5'-nucleotidase undergoes a hinge-bending domain rotation resembling a ball-and-socket motion
J. Mol. Biol.
309
255-266
2001
Escherichia coli
Garcia-Ayllon, M.S.; Campoy, F.J.; Vidal, C.J.; Munoz-Delgado, E.
Identification of inactive ecto-5'-nucleotidase in normal mouse muscle and its increased activity in dystrophic Lama2dy mice
J. Neurosci. Res.
66
656-665
2001
Mus musculus
Ubeidat, M.; Eristi, C.M.; Rutherford, C.L.
Expression pattern of 5'-nucleotidase in Dictyostelium
Mech. Dev.
110
237-239
2002
Dictyostelium sp.
Liu, X.W.; Sok, D.E.
Oxidative inactivation of brain ecto-5'-nucleotidase by thiols/Fe2+ system
Neurochem. Res.
25
1475-1484
2000
Bos taurus
Reilly, T.J.; Calcutt, M.J.
The class C acid phosphatase of Helicobacter pylori is a 5' nucleotidase
Protein Expr. Purif.
33
48-56
2004
Helicobacter pylori (Q6UC93), Helicobacter pylori
Kuznetsova, E.; Proudfoot, M.; Sanders, S.A.; Reinking, J.; Savchenko, A.; Arrowsmith, C.H.; Edwards, A.M.; Yakunin, A.F.
Enzyme genomics: Application of general enzymatic screens to discover new enzymes
FEMS Microbiol. Rev.
29
263-279
2005
Pseudomonas aeruginosa (Q9I767)
Proudfoot, M.; Kuznetsova, E.; Brown, G.; Rao, N.N.; Kitagawa, M.; Mori, H.; Savchenko, A.; Yakunin, A.F.
General Enzymatic Screens Identify Three New Nucleotidases in Escherichia coli. Biochemical Characterization of SurE, YfbR, and Yjjg
J. Biol. Chem.
279
54687-54694
2004
Escherichia coli (P0A840), Escherichia coli (P76491)
Wu, J.Z.; Larson, G.; Walker, H.; Shim, J.H.; Hong, Z.
Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes
Antimicrob. Agents Chemother.
49
2164-2171
2005
Homo sapiens (P49902)
Tkacz-Stachowska, K.; Lechward, K.; Skladanowski, A.C.
Isolation and characterization of pigeon breast muscle cytosolic 5'-nucleotidase-I (cN-I)
Acta Biochim. Pol.
52
789-796
2005
Columba livia
Vekaria, R.M.; Shirley, D.G.; Sevigny, J.; Unwin, R.J.
Immunolocalization of ectonucleotidases along the rat nephron
Am. J. Physiol.
290
F550-F560
2006
Rattus norvegicus
Schultz-Heienbrok, R.; Maier, T.; Strater, N.
A large hinge bending domain rotation is necessary for the catalytic function of Escherichia coli 5'-nucleotidase
Biochemistry
44
2244-2252
2005
Escherichia coli (P07024), Escherichia coli
Hanisch, F.; Hellsten, Y.; Zierz, S.
Ecto- and cytosolic 5'-nucleotidases in normal and AMP deaminase-deficient human skeletal muscle
Biol. Chem.
387
53-58
2006
Homo sapiens
Henz, S.L.; Ribeiro, C.G.; Rosa, A.; Chiarelli, R.A.; Casali, E.A.; Sarkis, J.J.
Kinetic characterization of ATP diphosphohydrolase and 5'-nucleotidase activities in cells cultured from submandibular salivary glands of rats
Cell Biol. Int.
30
214-220
2006
Rattus norvegicus
Brouwer, C.; Vogels-Mentink, T.M.; Keizer-Garritsen, J.J.; Trijbels, F.J.; Bokkerink, J.P.; Hoogerbrugge, P.M.; van Wering, E.R.; Veerman, A.J.; De Abreu, R.A.
Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment
Clin. Chim. Acta
361
95-103
2005
Homo sapiens
Senger, M.R.; Rico, E.P.; Dias, R.D.; Bogo, M.R.; Bonan, C.D.
Ecto-5'-nucleotidase activity in brain membranes of zebrafish (Danio rerio)
Comp. Biochem. Physiol. B
139
203-207
2004
Danio rerio
Itoh, R.; Kimura, K.
IMP-GMP 5'-nucleotidase in reptiles: Occurrence and tissue distribution in a crocodile and three species of lizards
Comp. Biochem. Physiol. B
142B
107-112
2005
Crocodylus siamensis, Varanus gouldii, Salvator rufescens
-
Allegrini, S.; Scaloni, A.; Careddu, M.G.; Cuccu, G.; D'Ambrosio, C.; Pesi, R.; Camici, M.; Ferrara, L.; Tozzi, M.G.
Mechanistic studies on bovine cytosolic 5'-nucleotidase II, an enzyme belonging to the HAD superfamily
Eur. J. Biochem.
271
4881-4891
2004
Bos taurus
Morote-Garcia, J.C.; Garcia-Ayllon, M.S.; Campoy, F.J.; Vidal, C.J.; Munoz-Delgado, E.
Active and inactive ecto-5'-nucleotidase variants in liver of control and dystrophic Lama2dy mice
Int. J. Biochem. Cell Biol.
36
422-433
2004
Mus musculus
Barsotti, C.; Pesi, R.; Giannecchini, M.; Ipata, P.L.
Evidence for the involvement of cytosolic 5'-nucleotidase (cN-II) in the synthesis of guanine nucleotides from xanthosine
J. Biol. Chem.
280
13465-13469
2005
Rattus norvegicus
Gounaris, K.; Selkirk, M.E.; Sadeghi, S.J.
A nucleotidase with unique catalytic properties is secreted by Trichinella spiralis
Mol. Biochem. Parasitol.
136
257-264
2004
Trichinella spiralis (Q8MQS9), Trichinella spiralis
Proudfoot, M.
corresponding Author: Dr. Alexander Yakunin, C.H. Best Institute, 112 College St. Room 72, Toronto On M5G 1L6, Canada
Private Communication
10
1-1
2007
Saccharomyces cerevisiae (P40025)
-
Borowiec, A.; Lechward, K.; Tkacz-Stachowska, K.; Skladanowski, A.C.
Adenosine as a metabolic regulator of tissue function: production of adenosine by cytoplasmic 5'-nucleotidases
Acta Biochim. Pol.
53
269-278
2006
Homo sapiens
Satriano, J.; Wead, L.; Cardus, A.; Deng, A.; Boss, G.R.; Thomson, S.C.; Blantz, R.C.
Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation
Am. J. Physiol. Renal Physiol.
291
F1078-F1082
2006
Rattus norvegicus
Boeck, C.R.; Kroth, E.H.; Bronzatto, M.J.; Vendite, D.
Effect of the L- or D-aspartate on ecto-5'nucleotidase activity and on cellular viability in cultured neurons: participation of the adenosine A(2A) receptors
Amino Acids
33
439-444
2007
Rattus norvegicus
Iqbal, J.; Jirovsky, D.; Lee, S.Y.; Zimmermann, H.; Mueller, C.E.
Capillary electrophoresis-based nanoscale assays for monitoring ecto-5'-nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes
Anal. Biochem.
373
129-140
2008
Homo sapiens, Rattus norvegicus
Babiychuk, E.B.; Draeger, A.
Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement?
Biochem. Soc. Trans.
34
374-376
2006
Rattus norvegicus
Braganhol, E.; Tamajusuku, A.S.; Bernardi, A.; Wink, M.R.; Battastini, A.M.
Ecto-5'-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell line
Biochim. Biophys. Acta
1770
1352-1359
2007
Homo sapiens
Levesque, S.A.; Lavoie, E.G.; Lecka, J.; Bigonnesse, F.; Sevigny, J.
Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases
Br. J. Pharmacol.
152
141-150
2007
Homo sapiens (Q53Z63), Homo sapiens
Nedeljkovic, N.; Bjelobaba, I.; Subasic, S.; Lavrnja, I.; Pekovic, S.; Stojkov, D.; Vjestica, A.; Rakic, L.; Stojiljkovic, M.
Up-regulation of ectonucleotidase activity after cortical stab injury in rats
Cell Biol. Int.
30
541-546
2006
Rattus norvegicus
Zernecke, A.; Bidzhekov, K.; Ozueyaman, B.; Fraemohs, L.; Liehn, E.A.; Luescher-Firzlaff, J.M.; Luescher, B.; Schrader, J.; Weber, C.
CD73/ecto-5'-nucleotidase protects against vascular inflammation and neointima formation
Circulation
113
2120-2127
2006
Mus musculus
Bernardi, A.; Bavaresco, L.; Wink, M.R.; Jacques-Silva, M.C.; Delgado-Canedo, A.; Lenz, G.; Battastini, A.M.
Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines
Eur. J. Pharmacol.
569
8-15
2007
Homo sapiens, Rattus norvegicus
Morote-Garcia, J.C.; Sanchez Del Campo, L.F.; Campoy, F.J.; Vidal, C.J.; Munoz-Delgado, E.
The increased ecto-5'-nucleotidase activity in muscle, heart and liver of laminin alpha2-deficient mice is not caused by an elevation in the mRNA content
Int. J. Biochem. Cell Biol.
38
1092-1101
2006
Mus musculus
Kittel, A.; Sperlagh, B.; Pelletier, J.; Sevigny, J.; Kirley, T.L.
Transient changes in the localization and activity of ecto-nucleotidases in rat hippocampus following lipopolysaccharide treatment
Int. J. Dev. Neurosci.
25
275-282
2007
Rattus norvegicus
Wallden, K.; Stenmark, P.; Nyman, T.; Flodin, S.; Graeslund, S.; Loppnau, P.; Bianchi, V.; Nordlund, P.
Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition
J. Biol. Chem.
282
17828-17836
2007
Homo sapiens
Volmer, J.B.; Thompson, L.F.; Blackburn, M.R.
Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury
J. Immunol.
176
4449-4458
2006
Mus musculus
Pedrazza, E.L.; Senger, M.R.; Rico, E.P.; Zimmermann, F.F.; Pedrazza, L.; de Freitas Sarkis, J.J.; Bonan, C.D.
Fluoxetine and nortriptyline affect NTPDase and 5'-nucleotidase activities in rat blood serum
Life Sci.
81
1205-1210
2007
Rattus norvegicus
Andrade, C.M.; Roesch, G.C.; Wink, M.R.; Guimaraes, E.L.; Souza, L.F.; Jardim, F.R.; Guaragna, R.M.; Bernard, E.A.; Margis, R.; Borojevic, R.; Battastini, A.M.; Guma, F.C.
Activity and expression of ecto-5'-nucleotidase/CD73 are increased during phenotype conversion of a hepatic stellate cell line
Life Sci.
82
21-29
2008
Mus musculus
Sadej, R.; Spychala, J.; Skladanowski, A.C.
Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma
Melanoma Res.
16
213-222
2006
Homo sapiens
Tamajusuku, A.S.; Carrillo-Sepulveda, M.A.; Braganhol, E.; Wink, M.R.; Sarkis, J.J.; Barreto-Chaves, M.L.; Battastini, A.M.
Activity and expression of ecto-5-nucleotidase/CD73 are increased by thyroid hormones in vascular smooth muscle cells
Mol. Cell. Biochem.
289
65-72
2006
Rattus norvegicus
Miron, V.R.; Bauermann, L.; Morsch, A.L.; Zanin, R.F.; Correa, M.; da Silva, A.C.; Mazzanti, C.; Morsch, V.M.; Lunkes, G.I.; Schetinger, M.R.
Enhanced NTPDase and 5'-nucleotidase activities in diabetes mellitus and iron-overload model
Mol. Cell. Biochem.
298
101-107
2007
Rattus norvegicus
Rico, E.P.; Rosemberg, D.B.; Senger, M.R.; Arizi, M.d.e.B.; Dias, R.D.; Souto, A.A.; Bogo, M.R.; Bonan, C.D.
Ethanol and acetaldehyde alter NTPDase and 5'-nucleotidase from zebrafish brain membranes
Neurochem. Int.
52
290-296
2008
Danio rerio
Spanevello, R.M.; Mazzanti, C.M.; Kaizer, R.; Zanin, R.; Cargnelutti, D.; Hannel, L.; Correa, M.; Mazzanti, A.; Festugatto, R.; Graca, D.; Schetinger, M.R.; Morsch, V.M.
Apyrase and 5'-nucleotidase activities in synaptosomes from the cerebral cortex of rats experimentally demyelinated with ethidium bromide and treated with interferon-beta
Neurochem. Res.
31
455-462
2006
Rattus norvegicus
Delwing, D.; Delwing, D.; Goncalves, M.C.; Sarkis, J.J.; Wyse, A.T.
NTPDase and 5'-nucleotidase activities of synaptosomes from hippocampus of rats subjected to hyperargininemia
Neurochem. Res.
32
1209-1216
2007
Rattus norvegicus
Rico, E.P.; Rosemberg, D.B.; Senger, M.R.; Arizi, M.d.e.B.; Bernardi, G.F.; Dias, R.D.; Bogo, M.R.; Bonan, C.D.
Methanol alters ecto-nucleotidases and acetylcholinesterase in zebrafish brain
Neurotoxicol. Teratol.
28
489-496
2006
Danio rerio
Jordheim, L.P.; Cros, E.; Galmarini, C.M.; Dumontet, C.; Bretonnet, A.; Krimm, I.; Lancelin, J.; Gagnieu, M.
F-ara-AMP is a substrate of cytoplasmic 5'-nucleotidase II (cN-II): HPLC and NMR studies of enzymatic dephosphorylation
Nucleosides Nucleotides Nucleic Acids
25
289-297
2006
Homo sapiens
Zhou, X.; Zhi, X.; Zhou, P.; Chen, S.; Zhao, F.; Shao, Z.; Ou, Z.; Yin, L.
Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo
Oncol. Rep.
17
1341-1346
2007
Homo sapiens
Senger, M.R.; Rico, E.P.; de Bem Arizi, M.; Frazzon, A.P.; Dias, R.D.; Bogo, M.R.; Bonan, C.D.
Exposure to Hg2+ and Pb2+ changes NTPDase and ecto-5'-nucleotidase activities in central nervous system of zebrafish (Danio rerio)
Toxicology
226
229-237
2006
Danio rerio
Dhananjaya, B.L.; Nataraju, A.; Rajesh, R.; Raghavendra Gowda, C.D.; Sharath, B.K.; Vishwanath, B.S.; DSouza, C.J.
Anticoagulant effect of Naja naja venom 5'-nucleotidase: demonstration through the use of novel specific inhibitor, vanillic acid
Toxicon
48
411-421
2006
Naja naja
Borges, F.P.; Gottardi, B.; Stuepp, C.; Larre, A.B.; Tasca, T.; De Carli, G.A.; Bonan, C.D.
Characterization of an ecto-5'-nucleotidase (EC 3.1.3.5) activity in intact trophozoites of Trichomonas gallinae
Vet. Parasitol.
143
106-111
2007
Trichomonas gallinae, Trichomonas gallinae TG7
Li, R.W.; Man, R.Y.; Vanhoutte, P.M.; Leung, G.P.
Stimulation of ecto-5'-nucleotidase in human umbilical vein endothelial cells by lipopolysaccharide
Am. J. Physiol. Heart Circ. Physiol.
295
H1177-H1181
2008
Homo sapiens
Hart, M.L.; Koehler, D.; Eckle, T.; Kloor, D.; Stahl, G.L.; Eltzschig, H.K.
Direct treatment of mouse or human blood with soluble 5'-nucleotidase inhibits platelet aggregation
Arterioscler. Thromb. Vasc. Biol.
28
1477-1483
2008
Crotalus atrox
Sadej, R.; Inai, K.; Rajfur, Z.; Ostapkowicz, A.; Kohler, J.; Skladanowski, A.C.; Mitchell, B.S.; Spychala, J.
Tenascin C interacts with Ecto-5-nucleotidase (eN) and regulates adenosine generation in cancer cells
Biochim. Biophys. Acta
1782
35-40
2008
Homo sapiens
Careddu, M.G.; Allegrini, S.; Pesi, R.; Camici, M.; Garcia-Gil, M.; Tozzi, M.G.
Knockdown of cytosolic 5'-nucleotidase II (cN-II) reveals that its activity is essential for survival in astrocytoma cells
Biochim. Biophys. Acta
1783
1529-1535
2008
Homo sapiens
Pochmann, D.; Innocente, A.M.; Cotomacci, G.; Barreto-Chaves, M.L.; Sarkis, J.J.
AMP hydrolysis in soluble and microsomal rat cardiac cell fractions: kinetic characterization and molecular identification of 5'-nucleotidase
Biosci. Rep.
28
267-273
2008
Rattus norvegicus
Hasegawa, T.; Bouis, D.; Liao, H.; Visovatti, S.H.; Pinsky, D.J.
Ecto-5' nucleotidase (CD73)-mediated adenosine generation and signaling in murine cardiac allograft vasculopathy
Circ. Res.
103
1410-1421
2008
Mus musculus
Sales, P.B.; Santoro, M.L.
Nucleotidase and DNase activities in Brazilian snake venoms
Comp. Biochem. Physiol. C
147C
85-95
2008
Bothrops atrox, Bothrops jararaca, Bothrops marajoensis, Bothrops moojeni, Crotalus adamanteus, Crotalus durissus terrificus, Bothrops jararacussu, Crotalus durissus cascavella, Bothrops alternatus, Lachesis muta muta, Bothrops pirajai, Bothrops cotiara, Bothrops neuwiedi, Bothrops pradoi, Bothrops insularis, Bothrops alcatraz, Bothrops brazili, Bothrops diporus, Bothrops erythromelas, Bothrops fonsecai, Bothrops itapetiningae, Bothrops matogrossensis, Bothrops pauloensis, Bothrops pubescens, Bothrops taeniatus, Micrurus frontalis, no activity in Philodryas olfersii, Crotalus durissus cumanensis, Loxosceles gaucho, Crotalus durissus collilineatus
-
Lunkes, G.I.; Lunkes, D.S.; Leal, D.; Araujo, M.d.o..C.; Correa, M.; Becker, L.; Rosa, C.S.; Morsch, V.M.; Schetinger, M.R.
Effect of high glucose levels in human platelet NTPDase and 5'-nucleotidase activities
Diabetes Res. Clin. Pract.
81
351-357
2008
Homo sapiens
Pedrazza, E.L.; Rico, E.P.; Senger, M.R.; Pedrazza, L.; Zimmermann, F.F.; Sarkis, J.J.; Bogo, M.R.; Bonan, C.D.
Ecto-nucleotidase pathway is altered by different treatments with fluoxetine and nortriptyline
Eur. J. Pharmacol.
583
18-25
2008
Rattus norvegicus
Peng, Z.; Fernandez, P.; Wilder, T.; Yee, H.; Chiriboga, L.; Chan, E.S.; Cronstein, B.N.
Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis
FASEB J.
22
2263-2272
2008
Mus musculus
Hart, M.L.; Henn, M.; Koehler, D.; Kloor, D.; Mittelbronn, M.; Gorzolla, I.C.; Stahl, G.L.; Eltzschig, H.K.
Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury
FASEB J.
22
2784-2797
2008
Mus musculus
Pacheco-Aguilar, R.; Ramirez-Suarez, J.C.; Castillo-Yanez, F.J.; Pena-Ramos, E.A.; Valenzuela-Soto, E.M.; Marquez-Rios, E.
Isolation and properties of 5'-nucleotidase isolated from jumbo squid (Dosidicus gigas) mantle muscle from the Gulf of California, Mexico
Food Chem.
112
880-884
2008
Dosidicus gigas
-
Hart, M.L.; Much, C.; Gorzolla, I.C.; Schittenhelm, J.; Kloor, D.; Stahl, G.L.; Eltzschig, H.K.
Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning
Gastroenterology
135
1739-1750
2008
Mus musculus
Johnson, S.M.
The importance of B-cells and ecto-5'nucleotidase in Mycoplasma fermentans infection and the relevance to rheumatoid arthritis
Immunology
123
187-196
2008
Homo sapiens
Wang, L.; Zhou, X.; Zhou, T.; Ma, D.; Chen, S.; Zhi, X.; Yin, L.; Shao, Z.; Ou, Z.; Zhou, P.
Ecto-5'-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells
J. Cancer Res. Clin. Oncol.
134
365-372
2008
Homo sapiens
Fini, C.; Coli, M.; Angelini, A.; Brusco, G.; Pasqualucci, P.; Tiziani, F.
5'-Nucleotidase activity is decreased in seminal plasma and spermatozoa from varicocele patients
J. Endocrinol. Invest.
31
666-671
2008
Homo sapiens
Ruecker, B.; Almeida, M.E.; Libermann, T.A.; Zerbini, L.F.; Wink, M.R.; Sarkis, J.J.
E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings
Life Sci.
82
477-486
2008
Rattus norvegicus
Roszkowska, A.; Klimek, J.; Kaletha, K.
Expression patterns of AMP-deaminase and cytosolic 5'-nucleotidase genes in human term placenta
Mol. Cell. Biochem.
311
249-251
2008
Homo sapiens
Bavaresco, L.; Bernardi, A.; Braganhol, E.; Cappellari, A.R.; Rockenbach, L.; Farias, P.F.; Wink, M.R.; Delgado-Canedo, A.; Battastini, A.M.
The role of ecto-5'-nucleotidase/CD73 in glioma cell line proliferation
Mol. Cell. Biochem.
319
61-68
2008
Homo sapiens, Rattus norvegicus
Fuerstenau, C.R.; Trentin, D.d.a..S.; Gossenheimer, A.N.; Ramos, D.B.; Casali, E.A.; Barreto-Chaves, M.L.; Sarkis, J.J.
Ectonucleotidase activities are altered in serum and platelets of L-NAME-treated rats
Blood Cells Mol. Dis.
41
223-229
2008
Rattus norvegicus
Aliagas, E.; Torrejon-Escribano, B.; Lavoie, E.G.; de Aranda, I.G.; Sevigny, J.; Solsona, C.; Martin-Satue, M.
Changes in expression and activity levels of ecto-5-nucleotidase/CD73 along the mouse female estrous cycle
Acta Physiol. (Oxf.)
199
191-197
2010
Mus musculus
Braun, J.S.
Ecto-5'-nucleotidase-positive cells in the choroid and ciliary body of the rat eye
Anat. Rec. (Hoboken)
293
379-382
2010
Rattus norvegicus
Schmatz, R.; Mazzanti, C.M.; Spanevello, R.; Stefanello, N.; Gutierres, J.; Maldonado, P.A.; Correa, M.; da Rosa, C.S.; Becker, L.; Bagatini, M.; Goncalves, J.F.; Jaques, J.d.o.s..S.; Schetinger, M.R.; Morsch, V.M.
Ectonucleotidase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of streptozotocin-induced diabetic rats and treated with resveratrol
Brain Res. Bull.
80
371-376
2009
Rattus norvegicus
Langer, D.; Hammer, K.; Koszalka, P.; Schrader, J.; Robson, S.; Zimmermann, H.
Distribution of ectonucleotidases in the rodent brain revisited
Cell Tissue Res.
334
199-217
2008
Mus musculus
Mandapathil, M.; Szczepanski, M.J.; Szajnik, M.; Ren, J.; Lenzner, D.E.; Jackson, E.K.; Gorelik, E.; Lang, S.; Johnson, J.T.; Whiteside, T.L.
Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer
Clin. Cancer Res.
15
6348-6357
2009
Homo sapiens
Bjelobaba, I.; Stojiljkovic, M.; Lavrnja, I.; Stojkov, D.; Pekovic, S.; Dacic, S.; Laketa, D.; Rakic, L.; Nedeljkovic, N.
Regional changes in ectonucleotidase activity after cortical stab injury in rat
Gen. Physiol. Biophys.
28 Spec No
62-68
2009
Rattus norvegicus
Fujita, M.; Asakura, M.; Sanada, S.; Funaya, H.; Tsukamoto, O.; Komamura, K.; Asanuma, H.; Taketani, S.; Isomura, T.; Nakamaru, K.; Furukawa, H.; Sawa, Y.; Hori, M.; Kitakaze, M.
Activation of ecto-5'-nucleotidase in the blood and hearts of patients with chronic heart failure
J. Card. Fail.
14
426-430
2008
Homo sapiens
El-Tayeb, A.; Iqbal, J.; Behrenswerth, A.; Romio, M.; Schneider, M.; Zimmermann, H.; Schrader, J.; Mueller, C.E.
Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5-nucleotidase
J. Med. Chem.
52
7669-7677
2009
Rattus norvegicus
Baqi, Y.; Lee, S.Y.; Iqbal, J.; Ripphausen, P.; Lehr, A.; Scheiff, A.B.; Zimmermann, H.; Bajorath, J.; Mueller, C.E.
Development of potent and selective inhibitors of ecto-5-nucleotidase based on an anthraquinone scaffold
J. Med. Chem.
53
2076-2086
2010
Rattus norvegicus
Sowa, N.A.; Taylor-Blake, B.; Zylka, M.J.
Ecto-5-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits
J. Neurosci.
30
2235-2244
2010
Mus musculus
Giordani, R.B.; Weizenmann, M.; Rosemberg, D.B.; De Carli, G.A.; Bogo, M.R.; Zuanazzi, J.A.; Tasca, T.
Trichomonas vaginalis nucleoside triphosphate diphosphohydrolase and ecto-5-nucleotidase activities are inhibited by lycorine and candimine
Parasitol. Int.
59
226-231
2010
Trichomonas vaginalis
Schreiber, R.; Castrop, H.; Kunzelmann, K.
Allergen-induced airway hyperresponsiveness is absent in ecto-5-nucleotidase (CD73)-deficient mice
Pflugers Arch.
457
431-440
2008
Mus musculus
Shirley, D.G.; Vekaria, R.M.; Sevigny, J.
Ectonucleotidases in the kidney
Purinergic Signal.
5
501-511
2009
Mus musculus, Rattus norvegicus
Siebel, A.M.; Rico, E.P.; Capiotti, K.M.; Piato, A.L.; Cusinato, C.T.; Franco, T.M.; Bogo, M.R.; Bonan, C.D.
In vitro effects of antiepileptic drugs on acetylcholinesterase and ectonucleotidase activities in zebrafish (Danio rerio) brain
Toxicol. In Vitro
24
1279-1284
2010
Danio rerio
Ogawa, Y.; Murayama, N.; Yanoshita, R.
Molecular cloning and characterization of ecto-5-nucleotidase from the venoms of Gloydius blomhoffi
Toxicon
54
408-412
2009
Gloydius brevicaudus (B6EWW8), Gloydius brevicaudus
Russo-Abrahao, T.; Cosentino-Gomes, D.; Daflon-Yunes, N.; Meyer-Fernandes, J.R.
Giardia duodenalis: biochemical characterization of an ecto-5'-nucleotidase activity
Exp. Parasitol.
127
66-71
2011
Giardia intestinalis
Vieira, D.P.; Paletta-Silva, R.; Saraiva, E.M.; Lopes, A.H.; Meyer-Fernandes, J.R.
Leishmania chagasi: an ecto-3'-nucleotidase activity modulated by inorganic phosphate and its possible involvement in parasite-macrophage interaction
Exp. Parasitol.
127
702-707
2011
Leishmania chagasi, Leishmania chagasi MHOM/BR/1974/PP75
Pesi, R.; Allegrini, S.; Careddu, M.G.; Filoni, D.N.; Camici, M.; Tozzi, M.G.
Active and regulatory sites of cytosolic 5'-nucleotidase
FEBS J.
277
4863-4872
2010
Bos taurus (O46411)
Russo-Abrahao, T.; Cosentino-Gomes, D.; Gomes, M.T.; Alviano, D.S.; Alviano, C.S.; Lopes, A.H.; Meyer-Fernandes, J.R.
Biochemical properties of Candida parapsilosis ecto-5'-nucleotidase and the possible role of adenosine in macrophage interaction
FEMS Microbiol. Lett.
317
34-42
2011
Candida parapsilosis, Candida parapsilosis CCT 3834
Martin-Satue, M.; Lavoie, E.G.; Fausther, M.; Lecka, J.; Aliagas, E.; Kukulski, F.; Sevigny, J.
High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract
Histochem. Cell Biol.
133
659-668
2010
Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
Wallden, K.; Nordlund, P.
Structural basis for the allosteric regulation and substrate recognition of human cytosolic 5-nucleotidase II
J. Mol. Biol.
408
684-696
2011
Homo sapiens (P49902), Homo sapiens
Bjelobaba, I.; Parabucki, A.; Lavrnja, I.; Stojkov, D.; Dacic, S.; Pekovic, S.; Rakic, L.; Stojiljkovic, M.; Nedeljkovic, N.
Dynamic changes in the expression pattern of ecto-5'-nucleotidase in the rat model of cortical stab injury
J. Neurosci. Res.
89
862-873
2011
Rattus norvegicus, Rattus norvegicus Wistar
Bogan, K.; Brenner, C.
5'-Nucleotidases and their new roles in NAD+ and phosphate metabolism
New J. Chem.
34
845-853
2010
Corynebacterium glutamicum, Saccharomyces cerevisiae, Homo sapiens
-
De Jesus, J.B.; Cosentino-Gomes, D.; Meyer-Fernandes, J.R.
Characterization of an ecto-5'-nucleotidase activity present on the cell surface of Tritrichomonas foetus
Vet. Parasitol.
179
50-56
2011
Tritrichomonas suis
Sadej, R.; Skladanowski, A.C.
Dual, enzymatic and non-enzymatic, function of ecto-5-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells
Acta Biochim. Pol.
59
647-652
2012
Homo sapiens
Heuts, D.P.; Weissenborn, M.J.; Olkhov, R.V.; Shaw, A.M.; Gummadova, J.; Levy, C.; Scrutton, N.S.
Crystal structure of a soluble form of human CD73 with ecto-5-nucleotidase activity
ChemBioChem
13
2384-2391
2012
Homo sapiens (Q6NZX3), Homo sapiens
Iqbal, J.; Saeed, A.; Raza, R.; Matin, A.; Hameed, A.; Furtmann, N.; Lecka, J.; Sevigny, J.; Bajorath, J.
Identification of sulfonic acids as efficient ecto-5-nucleotidase inhibitors
Eur. J. Med. Chem.
70
685-691
2013
Homo sapiens, Rattus norvegicus
Meurillon, M.; Marton, Z.; Hospital, A.; Jordheim, L.P.; Bejaud, J.; Lionne, C.; Dumontet, C.; Perigaud, C.; Chaloin, L.; Peyrottes, S.
Structure-activity relationships of beta-hydroxyphosphonate nucleoside analogues as cytosolic 5-nucleotidase II potential inhibitors: synthesis, in vitro evaluation and molecular modeling studies
Eur. J. Med. Chem.
77
18-37
2014
Homo sapiens (P49902)
Srinivasan, B.; Forouhar, F.; Shukla, A.; Sampangi, C.; Kulkarni, S.; Abashidze, M.; Seetharaman, J.; Lew, S.; Mao, L.; Acton, T.B.; Xiao, R.; Everett, J.K.; Montelione, G.T.; Tong, L.; Balaram, H.
Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila
FEBS J.
281
1613-1628
2014
Legionella pneumophila (Q5ZZB6), Legionella pneumophila DSM 7513 (Q5ZZB6)
Krug, U.; Patzschke, R.; Zebisch, M.; Balbach, J.; Straeter, N.
Contribution of the two domains of E. coli 5'-nucleotidase to substrate specificity and catalysis
FEBS Lett.
587
460-466
2013
Escherichia coli
Cali, T.; Fedrizzi, L.; Ottolini, D.; Gomez-Villafuertes, R.; Mellstroem, B.; Naranjo, J.R.; Carafoli, E.; Brini, M.
Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), is involved in protein folding and degradation
J. Biol. Chem.
287
18478-18491
2012
Mus musculus (Q8VCF1), Mus musculus
Pettengill, M.; Robson, S.; Tresenriter, M.; Millan, J.L.; Usheva, A.; Bingham, T.; Belderbos, M.; Bergelson, I.; Burl, S.; Kampmann, B.; Gelinas, L.; Kollmann, T.; Bont, L.; Levy, O.
Soluble ecto-5-nucleotidase (5-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine
J. Biol. Chem.
288
27315-27326
2013
Homo sapiens
Grobosky, C.L.; Lopez, J.B.; Rennie, S.; Skopelitis, D.J.; Wiest, A.T.; Bingman, C.A.; Bitto, E.
Structural basis of substrate specificity and selectivity of murine cytosolic 5-nucleotidase III
J. Mol. Biol.
423
540-554
2012
Mus musculus (Q9D020), Mus musculus
Santos, C.A.; Saraiva, A.M.; Toledo, M.A.; Beloti, L.L.; Crucello, A.; Favaro, M.T.; Horta, M.A.; Santiago, A.S.; Mendes, J.S.; Souza, A.A.; Souza, A.P.
Initial biochemical and functional characterization of a 5-nucleotidase from Xylella fastidiosa related to the human cytosolic 5-nucleotidase I
Microb. Pathog.
59-60
1-6
2013
Xylella fastidiosa (Q9PBQ1), Xylella fastidiosa, Xylella fastidiosa 9a5c (Q9PBQ1)
Knapp, K.; Zebisch, M.; Pippel, J.; El-Tayeb, A.; Mueller, C.E.; Straeter, N.
Crystal structure of the human ecto-5-nucleotidase (CD73): insights into the regulation of purinergic signaling
Structure
20
2161-2173
2012
Homo sapiens (P21589), Homo sapiens
Spychala, J.; Chen, V.; Oka, J.; Mitchell, B.S.
ATP and phosphate reciprocally affect subunit association of human recombinant High Km 5'-nucleotidase. Role for the C-terminal polyglutamic acid tract in subunit association and catalytic activity
Eur. J. Biochem.
259
851-858
1999
Homo sapiens
Salman, S.; Vollmer, C.; McClelland, G.B.; Nurse, C.A.
Characterization of ectonucleotidase expression in the rat carotid body regulation by chronic hypoxia
Am. J. Physiol. Cell Physiol.
313
C274-C284
2017
Rattus norvegicus (P21588)
Cividini, F.; Filoni, D.N.; Pesi, R.; Allegrini, S.; Camici, M.; Tozzi, M.G.
IMP-GMP specific cytosolic 5'-nucleotidase regulates nucleotide pool and prodrug metabolism
Biochim. Biophys. Acta
1850
1354-1361
2015
Homo sapiens (P49902), Homo sapiens
Hassan, S.; Ejaz, S.A.; Saeed, A.; Shehzad, M.; Ullah Khan, S.; Lecka, J.; Sevigny, J.; Shabir, G.; Iqbal, J.
4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity
Bioorg. Chem.
76
237-248
2018
Homo sapiens (P21589)
Kozarski, M.; Kubacka, D.; Wojtczak, B.A.; Kasprzyk, R.; Baranowski, M.R.; Kowalska, J.
7-Methylguanosine monophosphate analogues with 5-(1,2,3-triazoyl) moiety Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase
Bioorg. Med. Chem.
26
191-199
2018
Homo sapiens
Seibt, K.J.; Oliveira, R.d.a. .L.; Bogo, M.R.; Senger, M.R.; Bonan, C.D.
Investigation into effects of antipsychotics on ectonucleotidase and adenosine deaminase in zebrafish brain
Fish Physiol. Biochem.
41
1383-1392
2015
Danio rerio
Adzic, M.; Nedeljkovic, N.
Unveiling the role of ecto-5'-nucleotidase/CD73 in astrocyte migration by using pharmacological tools
Front. Pharmacol.
9
153
2018
Rattus norvegicus
Villamonte, M.L.; Torrejon-Escribano, B.; Rodriguez-Martinez, A.; Trapero, C.; Vidal, A.; Gomez de Aranda, I.; Sevigny, J.; Matias-Guiu, X.; Martin-Satue, M.
Characterization of ecto-nucleotidases in human oviducts with an improved approach simultaneously identifying protein expression and in situ enzyme activity
Histochem. Cell Biol.
149
269-276
2018
Homo sapiens (P21589)
Kao, D.J.; Saeedi, B.J.; Kitzenberg, D.; Burney, K.M.; Dobrinskikh, E.; Battista, K.D.; Vazquez-Torres, A.; Colgan, S.P.; Kominsky, D.J.
Intestinal epithelial ecto-5'-nucleotidase (CD73) regulates intestinal colonization and infection by nontyphoidal Salmonella
Infect. Immun.
85
e01022-16
2017
Mus musculus (Q61503)
Yu, J.; Wang, X.; Lu, Q.; Wang, J.; Li, L.; Liao, X.; Zhu, W.; Lv, L.; Zhi, X.; Yu, J.; Jin, Y.; Zou, Q.; Ou, Z.; Liu, X.; Zhou, P.
Extracellular 5'-nucleotidase (CD73) promotes human breast cancer cells growth through AKT/GSK-3beta/beta-catenin/cyclinD1 signaling pathway
Int. J. Cancer
142
959-967
2018
Homo sapiens (P21589), Homo sapiens
Zheng, L.; Khemlani, A.; Lorenz, N.; Loh, J.M.; Langley, R.J.; Proft, T.
Streptococcal 5'-nucleotidase A (S5nA), a novel Streptococcus pyogenes virulence factor that facilitates immune evasion
J. Biol. Chem.
290
31126-31137
2015
Streptococcus pyogenes (Q9A0A2), Streptococcus pyogenes, Streptococcus pyogenes ATCC 700294 (Q9A0A2)
Shali, S.; Yu, J.; Zhang, X.; Wang, X.; Jin, Y.; Su, M.; Liao, X.; Yu, J.; Zhi, X.; Zhou, P.
Ecto-5'-nucleotidase (CD73) is a potential target of hepatocellular carcinoma
J. Cell. Physiol.
234
10248-10259
2018
Homo sapiens (P21589), Homo sapiens
Eguchi, R.; Yamaguchi, S.; Otsuguro, K.I.
Fibroblast growth factor 2 modulates extracellular purine metabolism by upregulating ecto-5'-nucleotidase and adenosine deaminase in cultured rat spinal cord astrocytes
J. Pharmacol. Sci.
139
98-104
2018
Rattus norvegicus (P21588)
Baqi, Y.
Ecto-nucleotidase inhibitors recent developments in drug discovery
Mini Rev. Med. Chem.
15
21-33
2015
Homo sapiens (P21589)
Menezes, C.B.; Durgante, J.; de Oliveira, R.R.; Dos Santos, V.H.; Rodrigues, L.F.; Garcia, S.C.; Dos Santos, O.; Tasca, T.
Trichomonas vaginalis NTPDase and ecto-5'-nucleotidase hydrolyze guanine nucleotides and increase extracellular guanosine levels under serum restriction
Mol. Biochem. Parasitol.
207
10-18
2016
Trichomonas vaginalis, Trichomonas vaginalis ATCC30238, Trichomonas vaginalis ATCC 30236
Bertoni, A.P.S.; Bracco, P.A.; de Campos, R.P.; Lutz, B.S.; Assis-Brasil, B.M.; Meyer, E.L.S.; Saffi, J.; Braganhol, E.; Furlanetto, T.W.; Wink, M.R.
Activity of ecto-5'-nucleotidase (NT5E/CD73) is increased in papillary thyroid carcinoma and its expression is associated with metastatic lymph nodes
Mol. Cell. Endocrinol.
479
54-60
2019
Homo sapiens (P21589), Homo sapiens
Miliutina, M.; Janke, J.; Hassan, S.; Zaib, S.; Iqbal, J.; Lecka, J.; Sevigny, J.; Villinger, A.; Friedrich, A.; Lochbrunner, S.; Langer, P.
A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5'-nucleotidase inhibitory effects
Org. Biomol. Chem.
16
717-732
2018
Rattus norvegicus (P21588), Homo sapiens (P21589)
Doleski, P.H.; Mendes, R.E.; Leal, D.B.; Bottari, N.B.; Piva, M.M.; Da Silva, E.S.; Gabriel, M.E.; Lucca, N.J.; Schwertz, C.I.; Giacomim, P.; Morsch, V.M.; Schetinger, M.R.; Baldissera, M.D.; Da Silva, A.S.
Seric and hepatic NTPDase and 5'nucleotidase activities of rats experimentally infected by Fasciola hepatica
Parasitology
143
551-556
2016
Rattus norvegicus
Rahimova, R.; Fontanel, S.; Lionne, C.; Jordheim, L.P.; Peyrottes, S.; Chaloin, L.
Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface
PLoS Comput. Biol.
14
e1005943
2018
Homo sapiens (P21589)
Cividini, F.; Tozzi, M.G.; Galli, A.; Pesi, R.; Camici, M.; Dumontet, C.; Jordheim, L.P.; Allegrini, S.
Cytosolic 5'-nucleotidase II interacts with the leucin rich repeat of NLR family member Ipaf
PLoS ONE
10
e0121525
2015
Homo sapiens (P49902), Homo sapiens
Zakataeva, N.P.; Romanenkov, D.V.; Yusupova, Y.R.; Skripnikova, V.S.; Asahara, T.; Gronskiy, S.V.
Identification, heterologous expression, and functional characterization of Bacillus subtilis YutF, a HAD superfamily 5'-nucleotidase with broad substrate specificity
PLoS ONE
11
e0167580
2016
Bacillus subtilis (O32125), Bacillus subtilis, Bacillus subtilis 168 (O32125)
Saeed, A.; Ejaz, S.; Shehzad, M.; Hassan, S.; Al-Rashida, M.; Lecka, J.; Sevigny, J.; Iqbal, J.
3-(5-(Benzylideneamino)thiazol-3-yl)-2H-chromen-2-ones A new class of alkaline phosphatase and ecto-5'-nucleotidase inhibitors
RSC Adv.
6
21026-21036
2016
Homo sapiens, Rattus norvegicus
-
Al-Haj, L.; Khabar, K.S.A.
The intracellular pyrimidine 5'-nucleotidase NT5C3A is a negative epigenetic factor in interferon and cytokine signaling
Sci. Signal.
11
eaal2434
2018
Homo sapiens
Krug, U.; Alexander, N.S.; Stein, R.A.; Keim, A.; Mchaourab, H.S.; Straeter, N.; Meiler, J.
Characterization of the domain orientations of E. coli 5'-nucleotidase by fitting an ensemble of conformers to DEER distance distributions
Structure
24
43-56
2016
Escherichia coli (P07024), Escherichia coli
Bradaschia-Correa, V.; Josephson, A.M.; Egol, A.J.; Mizrahi, M.M.; Leclerc, K.; Huo, J.; Cronstein, B.N.; Leucht, P.
Ecto-5'-nucleotidase (CD73) regulates bone formation and remodeling during intramembranous bone repair in aging mice
Tissue Cell
49
545-551
2017
Mus musculus (Q61503)
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