Reference on EC 3.1.3.4 - phosphatidate phosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Berglund, L.; Bjrkhem, I.; Angelin, B.; Einarsson, K.
Activation of rat liver cytosolic phosphatidic acid phosphatase by nucleoside diphosphates
Biochim. Biophys. Acta
1002
382-387
1989
Rattus norvegicus
Martin, A.; Hales, P.; Brindley, D.N.
A rapid assay for measuring the activity and the Mg2+ and Ca2+ requirements of phosphatidate phosphohydrolase in cytosolic and microsomal fractions of rat liver
Biochem. J.
245
347-355
1987
Rattus norvegicus
Wells, G.N.; Osborne, L.J.; Jamdar, S.C
Isolation and characterization of multiple forms of Mg2+-dependent phosphatidate phosphohydrolase from rat adipose cytosol
Biochim. Biophys. Acta
878
225-237
1986
Rattus norvegicus
Pasquare de Garcia, S.J.; Giusto, N.M.
Phosphatidate phosphatase activity in isolated rod outer segment from bovine retina
Biochim. Biophys. Acta
875
195-202
1986
Bos taurus
Dunlop, M.; Larkins, R.G.
Presence of membrane-associated phosphatidate phosphohydrolase activity in cultured islets and its stimulation by glucose
FEBS Lett.
193
231-235
1985
Rattus norvegicus
Ide, H.; Nakazawa, Y.
Phosphatidate phosphatase in rat liver: the relationship between the activities with membrane-bound phosphatidate and aqueous dispersion of phosphatidate
J. Biochem.
97
45-54
1985
Rattus norvegicus
Walton, P.A.; Possmeyer, F.
The role of Mg2+-dependent phosphatidate phosphohydrolase in pulmonary glycerolipid biosynthesis
Biochim. Biophys. Acta
796
364-372
1984
Rattus norvegicus
Hosaka, K.; Yamashita, S.
Partial purification and properties of phosphatidate phosphatase in Saccharomyces cerevisiae
Biochim. Biophys. Acta
796
102-109
1984
Saccharomyces cerevisiae
Jamdar, S.C.; Osborne, L.J.; Wells, G.N.
Glycerolipid biosynthesis in rat adipose tissue 12. Properties of Mg2+-dependent and -independent phosphatidate phosphohydrolase
Arch. Biochem. Biophys.
233
370-377
1984
Rattus norvegicus
Butterwith, S.C.; Hopewell, R.; Brindley, D.N.
Partial purification and characterization of the soluble phosphatidate phosphohydrolase of rat liver
Biochem. J.
220
825-833
1984
Rattus norvegicus
Joyard, J.; Douce, R.
Characterization of phosphatidate phosphohydrolase activity associated with chloroplast envelope membranes
FEBS Lett.
102
147-150
1979
Spinacia oleracea
Block, M.A.; Dorne, A.J.; Joyard, J.; Douce, R.
The phosphatidic acid phosphatase of the chloroplast envelope is located on the inner envelope membrane
FEBS Lett.
164
111-115
1983
Spinacia oleracea
-
Jamdar, S.C.; Osborne, L.J.
Glycerolipid biosynthesis in rat adipose tissue. 11. Effects of polyamines on Mg2+-dependent phosphatidate phosphohydrolase
Biochim. Biophys. Acta
752
79-88
1983
Rattus norvegicus
Casola, P.G.; Possmayer, F.
Separation and characterization of the membrane-bound and aqueously dispersed phosphatidate phosphatidic acid phosphohydrolase activities in rat lung
Biochim. Biophys. Acta
664
298-315
1981
Rattus norvegicus
Yeung, A.; Casola, P.G.; Wong, C.; Fellows, J.F.; Possmayer, F.
Pulmonary phosphatidic acid phosphatase. A comparative study of the aqueously dispersed phosphatidate-dependent and membrane-bound phosphatidate-dependent phosphatidic acid phosphatase activities of rat lung
Biochim. Biophys. Acta
574
226-239
1979
Rattus norvegicus
Casola, P.G.; Possmayer, F.
Pulmonary phosphatidic acid phosphatase. Properties of membrane-bound phosphatidate-dependent phosphatidic acid phosphatase in rat lung
Biochim. Biophys. Acta
574
212-225
1979
Rattus norvegicus
Spitzer, H.L.; Johnston, J.M.
Characterization of phosphatidate phosphohydrolase activity associated with isolated lamellar bodies
Biochim. Biophys. Acta
531
275-285
1978
Sus scrofa
Ravinuthala, H.R.; Miller, J.C.; Weinhold, P.A.
Phosphatidate phosphatase: activity and properties in fetal and adult rat lung
Biochim. Biophys. Acta
530
347-356
1978
Rattus norvegicus
Bowley, M.; Cooling, J.; Burditt, S.L.; Brindley, D.N.
The effects of amphiphilic cationic drugs and inorganic cations on the activity of phosphatidate phosphohydrolase
Biochem. J.
165
447-454
1977
Rattus norvegicus
Carman, G.M.
Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli
Biochim. Biophys. Acta
1348
45-55
1997
Saccharomyces cerevisiae, Escherichia coli
Hosaka, K.; Yamashita, S.; Numa, S.
Partial purification, properties, and subcellular distribution of rat liver phosphatidate phosphatase
J. Biochem.
77
501-509
1975
Rattus norvegicus
Meban, C.
Localization of phosphatidic acid phosphatase activity in granular pneumocytes
J. Cell Biol.
53
249-252
1972
Mesocricetus auratus
Roberts, R.; Sciorra, V.A.; Morris, A.J.
Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform
J. Biol. Chem.
273
22059-22067
1998
Homo sapiens
Jamdar, S.C.; Cao, W.F.
Properties of phosphatidate phosphohydrolase in rat adipose tissue
Biochem. J.
301
793-799
1994
Rattus norvegicus
Balboa, M.A.; Balsinde, J.; Dennis, E.A.
Involvement of phosphatidate phosphohydrolase in arachidonic acid mobilization in human amniotic WISH cells
J. Biol. Chem.
273
7684-7690
1998
Homo sapiens
Kai, M.; Wada, I.; Imai, S.; Sakane, F.; Kanoh, H.
Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase
J. Biol. Chem.
272
24572-24578
1997
Homo sapiens
Waggoner, D.W.; Martin, A.; Dewald, J.; Gomez-Munoz, A.; Brindley, D.N.
Purification and characterization of a novel plasma membrane phosphatidate phosphohydrolase from rat liver
J. Biol. Chem.
270
19422-19429
1995
Rattus norvegicus
Kanoh, H.; Imai, S.; Yamada, K.; Sakane, F.
Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes
J. Biol. Chem.
267
25309-25314
1992
Sus scrofa
Taylor, G.S.; Ladd, A.; James, J.; Greene, B.; English, D.
Characterization of phosphatidic acid phosphohydrolase in neutrophil subcellular fractions
Biochim. Biophys. Acta
1175
219-224
1993
Homo sapiens
Schoonderwoerd, K.; Broekhoven-Schokker, S.; Hulsmann, W.C.; Stam, H.
Properties of phosphatidate phosphohydrolase and diacylglycerol acyltransferase activities in the isolated rat heart
Biochem. J.
268
487-492
1990
Rattus norvegicus
Day, C.P.; Burt, A.D.; Brown, A.S.M.; Bennett, M.K.; Farrell, D.J.; James, O.F.W.; Yeaman, S.J.
Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis
Clin. Sci.
85
281-287
1993
Homo sapiens
Martin, A.; Gomez-Munoz, A.; Jamal, Z.; Brindley, D.N.
Characterization and assay of phosphatidate phosphatase
Methods Enzymol.
197
553-563
1991
Rattus norvegicus
Berg, S.; Wieslander, A.
Purification of a phosphatase which hydrolyzes phosphatidic acid, a key intermediate in glucolipid synthesis in Acholeplasma laidlawii A membranes
Biochim. Biophys. Acta
1330
225-232
1997
Acholeplasma laidlawii, Acholeplasma laidlawii A
Morlock, K.R.; McLaughlin, J.J.; Lin, Y.P.; Carman, G.M.
Phosphatidate phosphatase from Saccharomyces cerevisiae. Isolation of 45- and 104-kDa forms of the enzyme that are differentially regulated by inositol
J. Biol. Chem.
266
3586-3593
1991
Saccharomyces cerevisiae
Pasquare, S.J.; Giusto, N.M.
Differential properties of phosphatidate phosphohydrolase and diacylglyceride lipase activities in retinal subcellular fractions and rod outer segments
Comp. Biochem. Physiol. B
104
141-148
1993
Bos taurus
Humble, E.; Berglund, L.
Stimulation and inhibition of the activity of rat liver cytosolic phosphatidate phosphohydrolase by various phospholipids
J. Lipid Res.
32
1869-1873
1991
Rattus norvegicus
Kocsis, M.G.; Weselake, R.J.
Phosphatidate phosphatases of mammals, yeast, and higher plants
Lipids
31
785-802
1996
Arachis hypogaea, Saccharomyces cerevisiae, Vicia faba, Vigna radiata, Rattus norvegicus, Sus scrofa
Fleming, I.N.; Yeaman, S.J.
Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver
Biochem. J.
308
983-989
1995
Rattus norvegicus
English, D.; Martin, M.; Harvea, K.A.; Akard, L.P.; Allen, R.; Widlanski, T.S.; Garcia, J.G.; Siddiqui, R.A.
Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase
Biochem. J.
324
941-950
1997
Homo sapiens
-
Malherbe, A.; Block, M.A.; Douce, R.; Joyard, J.
Solubilization and biochemical properties of phosphatidate phosphatase from spinach chloroplast envelope membranes
Plant Physiol. Biochem.
33
149-161
1995
Spinacia oleracea
-
Pasquare, S.J.; Salvador, G.A.; Roque, M.E.; Giusto, N.M.
Effect of light on phosphatidate phosphohydrolase activity of retina rod outer segments: the role of transducin
Arch. Biochem. Biophys.
379
299-306
2000
Bos taurus
Zhang, Q.X.; Pilquil, C.S.; Dewald, J.; Berthiaume, L.G.; Brindley, D.N.
Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action
Biochem. J.
345
181-184
2000
Mus musculus
-
Furneisen, J.M.; Carman, G.M.
Enzymological properties of the LPP1-encoded lipid phosphatase from Saccharomyces cerevisiae
Biochim. Biophys. Acta
1484
71-82
2000
Saccharomyces cerevisiae
Nanjundan, M.; Possmayer, F.
Characterization of the pulmonary N-ethylmaleimide-insensitive phosphatidate phosphohydrolase
Exp. Lung Res.
26
361-381
2000
Rattus norvegicus
Ishikawa, T.; Kai, M.; Wada, I.; Kanoh, H.
Cell surface activities of the human type 2b phosphatidic acid phosphatase
J. Biochem.
127
645-651
2000
Homo sapiens
Rahman, S.M.; Huda, M.N.; Uddin, M.N.; Akhteruzzaman, S.
Short-term administration of conjugated linoleic acid reduces liver triglyceride concentration and phosphatidate phosphohydrolase activity in OLETF rats
J. Biochem. Mol. Biol.
35
494-497
2002
Rattus norvegicus
Fuentes, L.; Perez, R.; Nieto, M.L.; Balsinde, J.; Balboa, M.A.
Bromoenol lactone promotes cell death by a mechanism involving phosphatidate phosphohydrolase-1 rather than calcium-independent phospholipase A2
J. Biol. Chem.
278
44683-44690
2003
Homo sapiens
Elabbadi, N.; Day, C.P.; Virden, R.; Yeaman, S.J.
Regulation of phosphatidic acid phosphohydrolase 1 by fatty acids
Lipids
37
69-73
2002
Rattus norvegicus
Wu, W.I.; Carman, G.M.
Kinetic analysis of sphingoid base inhibition of yeast phosphatidate phosphatase
Methods Enzymol.
312
373-380
2000
Saccharomyces cerevisiae
Long, J.; Darroch, P.; Wan, K.F.; Kong, K.C.; Ktistakis, N.; Pyne, N.J.; Pyne, S.
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools
Biochem. J.
391
25-32
2005
Homo sapiens
Long, J.S.; Yokoyama, K.; Tigyi, G.; Pyne, N.J.; Pyne, S.
Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration
Biochem. J.
394
495-500
2006
Mus musculus
Pyne, S.; Long, J.S.; Ktistakis, N.T.; Pyne, N.J.
Lipid phosphate phosphatases and lipid phosphate signalling
Biochem. Soc. Trans.
33
1370-1374
2005
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Burnett, C.; Makridou, P.; Hewlett, L.; Howard, K.
Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity
BMC Biochem.
5
2
2004
Drosophila melanogaster
Yue, J.; Yokoyama, K.; Balazs, L.; Baker, D.L.; Smalley, D.; Pilquil, C.; Brindley, D.N.; Tigyi, G.
Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level
Cell. Signal.
16
385-399
2004
Mus musculus
Han, G.S.; Wu, W.I.; Carman, G.M.
The Saccharomyces cerevisiae lipin homologue is a Mg2+-dependent phosphatidate phosphatase enzyme
J. Biol. Chem.
281
9210-9218
2006
Saccharomyces cerevisiae, Homo sapiens
Brindley, D.N.
Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer
J. Cell. Biochem.
92
900-912
2004
Drosophila melanogaster, Mus musculus, Rattus norvegicus, Homo sapiens (Q6T4P5), Homo sapiens (Q7Z2D5), Homo sapiens (Q8TBJ4), Homo sapiens (Q96GM1)
Pasquare, S.J.; Salvador, G.A.; Giusto, N.M.
Phospholipase D and phosphatidate phosphohydrolase activities in rat cerebellum during aging
Lipids
39
553-560
2004
Rattus norvegicus
Sun, L.; Gu, S.; Sun, Y.; Zheng, D.; Wu, Q.; Li, X.; Dai, J.; Ji, C.; Xie, Y.; Mao, Y.
Cloning and characterization of a novel human phosphatidic acid phosphatase type 2, PAP2d, with two different transcripts PAP2d_v1 and PAP2d_v2
Mol. Cell. Biochem.
272
91-96
2005
Homo sapiens, Homo sapiens (Q32ZL2)
Garcia-Murillas, I.; Pettitt, T.; Macdonald, E.; Okkenhaug, H.; Georgiev, P.; Trivedi, D.; Hassan, B.; Wakelam, M.; Raghu, P.
Iazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction
Neuron
49
533-546
2006
Drosophila melanogaster
Pyne, S.; Kong, K.C.; Darroch, P.I.
Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases
Semin. Cell Dev. Biol.
15
491-501
2004
Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Burgdorf, C.; Prey, A.; Richardt, G.; Kurz, T.
A HPLC-fluorescence detection method for determination of phosphatidic acid phosphohydrolase activity: application in human myocardium
Anal. Biochem.
374
291-297
2008
Homo sapiens, Rattus norvegicus
Ishida, T.; Iwai, A.; Hijikata, M.; Shimotohno, K.
The expression of phosphatidic acid phosphatase 2a, which hydrolyzes lipids to generate diacylglycerol, is regulated by p73, a member of the p53 family
Biochem. Biophys. Res. Commun.
353
74-79
2007
Homo sapiens
Oshiro, J.; Han, G.S.; Carman, G.M.
Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae
Biochim. Biophys. Acta
1635
1-9
2003
Saccharomyces cerevisiae
Kwon, Y.; Montell, C.
Dependence on the Lazaro phosphatidic acid phosphatase for the maximum light response
Curr. Biol.
16
723-729
2006
Drosophila melanogaster
Gowri, P.M.; Sengupta, S.; Bertera, S.; Katzenellenbogen, B.S.
Lipin1 regulation by estrogen in uterus and liver: implications for diabetes and fertility
Endocrinology
148
3685-3693
2007
Mus musculus
Mechtcheriakova, D.; Wlachos, A.; Sobanov, J.; Bornancin, F.; Zlabinger, G.; Baumruker, T.; Billich, A.
FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3
FEBS Lett.
581
3063-3068
2007
Homo sapiens, Mus musculus
Takeuchi, M.; Harigai, M.; Momohara, S.; Ball, E.; Abe, J.; Furuichi, K.; Kamatani, N.
Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase
Gene
399
174-180
2007
Homo sapiens (Q5VZY2), Homo sapiens (Q8NEB5)
Kai, M.; Sakane, F.; Jia, Y.; Imai, S.; Yasuda, S.; Kanoh, H.
Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts
J. Biochem.
140
677-686
2006
Homo sapiens
Han, G.S.; Johnston, C.N.; Carman, G.M.
Vacuole membrane topography of the DPP1-encoded diacylglycerol pyrophosphate phosphatase catalytic site from Saccharomyces cerevisiae
J. Biol. Chem.
279
5338-5345
2004
Saccharomyces cerevisiae, Saccharomyces cerevisiae W303-1A
Grkovich, A.; Johnson, C.A.; Buczynski, M.W.; Dennis, E.A.
Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent
J. Biol. Chem.
281
32978-32987
2006
Homo sapiens
O'Hara, L.; Han, G.S.; Peak-Chew, S.; Grimsey, N.; Carman, G.M.; Siniossoglou, S.
Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase
J. Biol. Chem.
281
34537-34548
2006
Saccharomyces cerevisiae
Pilquil, C.; Dewald, J.; Cherney, A.; Gorshkova, I.; Tigyi, G.; English, D.; Natarajan, V.; Brindley, D.N.
Lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase D2-dependent phosphatidate generation
J. Biol. Chem.
281
38418-38429
2006
Mus musculus, Rattus norvegicus
Morris, K.E.; Schang, L.M.; Brindley, D.N.
Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts
J. Biol. Chem.
281
9297-9306
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Harris, T.E.; Huffman, T.A.; Chi, A.; Shabanowitz, J.; Hunt, D.F.; Kumar, A.; Lawrence, J.C.
Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1
J. Biol. Chem.
282
277-286
2007
Mus musculus (Q91ZP3)
Nakamura, Y.; Tsuchiya, M.; Ohta, H.
Plastidic phosphatidic acid phosphatases identified in a distinct subfamily of lipid phosphate phosphatases with prokaryotic origin
J. Biol. Chem.
282
29013-29021
2007
Arabidopsis thaliana, Arabidopsis thaliana (Q0WUC2), Arabidopsis thaliana (Q6NLA5), Arabidopsis thaliana (Q6NQL6), Arabidopsis thaliana (Q9SUW4)
Donkor, J.; Sariahmetoglu, M.; Dewald, J.; Brindley, D.N.; Reue, K.
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns
J. Biol. Chem.
282
3450-3457
2007
Saccharomyces cerevisiae, Mus musculus
Han, G.S.; Siniossoglou, S.; Carman, G.M.
The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity
J. Biol. Chem.
282
37026-37035
2007
Saccharomyces cerevisiae
Sigal, Y.J.; Quintero, O.A.; Cheney, R.E.; Morris, A.J.
Cdc42 and ARP2/3-independent regulation of filopodia by an integral membrane lipid-phosphatase-related protein
J. Cell Sci.
120
340-352
2007
Homo sapiens (Q8TBJ4)
Albert, D.; Pergola, C.; Koeberle, A.; Dodt, G.; Steinhilber, D.; Werz, O.
The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes
J. Leukoc. Biol.
83
1019-1027
2008
Homo sapiens
McDermott, M.I.; Sigal, Y.J.; Crump, J.S.; Morris, A.J.
Enzymatic analysis of lipid phosphate phosphatases
Methods
39
169-179
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Carman, G.M.; Wu, W.I.
Lipid phosphate phosphatases from Saccharomyces cerevisiae
Methods Enzymol.
434
305-315
2007
Saccharomyces cerevisiae
Kim, Y.; Gentry, M.S.; Harris, T.E.; Wiley, S.E.; Lawrence, J.C.; Dixon, J.E.
A conserved phosphatase cascade that regulates nuclear membrane biogenesis
Proc. Natl. Acad. Sci. USA
104
6596-6601
2007
Saccharomyces cerevisiae
Carman, G.M.; Han, G.S.
Roles of phosphatidate phosphatase enzymes in lipid metabolism
Trends Biochem. Sci.
31
694-699
2006
Saccharomyces cerevisiae
Long, J.S.; Pyne, N.J.; Pyne, S.
Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function
Biochem. J.
411
371-377
2008
Cavia porcellus, Cricetulus griseus, Homo sapiens, Mus musculus
Theofilopoulos, S.; Lykidis, A.; Leondaritis, G.; Mangoura, D.
Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways
Biochim. Biophys. Acta
1781
731-742
2008
Homo sapiens
Grkovich, A.; Armando, A.; Quehenberger, O.; Dennis, E.A.
TLR-4 mediated group IVA phospholipase A2 activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent
Biochim. Biophys. Acta
1791
975-982
2009
Mus musculus
Zhang, Y.; Yang, Z.; Huang, X.; Peng, J.; Fei, X.; Gu, S.; Xie, Y.; Ji, C.; Mao, Y.
Cloning, expression, and characterization of a thermostable PAP2L2, a new member of the type-2 phosphatidic acid phosphatase family from Geobacillus toebii T-85
Biosci. Biotechnol. Biochem.
72
3134-3141
2008
Parageobacillus toebii (A5HKK6), Parageobacillus toebii, Parageobacillus toebii T-85 (A5HKK6)
Ryu, D.; Oh, K.J.; Jo, H.Y.; Hedrick, S.; Kim, Y.N.; Hwang, Y.J.; Park, T.S.; Han, J.S.; Choi, C.S.; Montminy, M.; Koo, S.H.
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1
Cell Metab.
9
240-251
2009
Mus musculus
Grimsey, N.; Han, G.S.; OHara, L.; Rochford, J.J.; Carman, G.M.; Siniossoglou, S.
Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
J. Biol. Chem.
283
29166-29174
2008
Mus musculus, Homo sapiens (Q14693)
Carman, G.M.; Han, G.
Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis
J. Biol. Chem.
284
2593-2597
2009
Saccharomyces cerevisiae, Homo sapiens, Mus musculus
Gropler, M.C.; Harris, T.E.; Hall, A.M.; Wolins, N.E.; Gross, R.W.; Han, X.; Chen, Z.; Finck, B.N.
Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice
J. Biol. Chem.
284
6763-6772
2009
Mus musculus
Reue, K.; Brindley, D.N.
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism
J. Lipid Res.
49
2493-2503
2008
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Rattus norvegicus
Bou Khalil, M.; Sundaram, M.; Zhang, H.Y.; Links, P.H.; Raven, J.F.; Manmontri, B.; Sariahmetoglu, M.; Tran, K.; Reue, K.; Brindley, D.N.; Yao, Z.
The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL
J. Lipid Res.
50
47-58
2009
Rattus norvegicus
Pasquare, S.J.; Salvador, G.A.; Giusto, N.M.
Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments
Neurochem. Res.
33
1205-1215
2008
Bos taurus
Franca, M.G.; Matos, A.R.; Darcy-Lameta, A.; Passaquet, C.; Lichtle, C.; Zuily-Fodil, Y.; Pham-Thi, A.T.
Cloning and characterization of drought-stimulated phosphatidic acid phosphatase genes from Vigna unguiculata
Plant Physiol. Biochem.
46
1093-1100
2008
Vigna unguiculata
Ong, K.L.; Leung, R.Y.; Wong, L.Y.; Cherny, S.S.; Sham, P.C.; Lam, T.H.; Lam, K.S.; Cheung, B.M.
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men
Am. J. Hypertens.
21
539-545
2008
Homo sapiens
Havriluk, T.; Lozy, F.; Siniossoglou, S.; Carman, G.
Colorimetric determination of pure Mg2+-dependent phosphatidate phosphatase activity
Anal. Biochem.
373
392-394
2008
Saccharomyces cerevisiae
Higashida, K.; Higuchi, M.; Terada, S.
Potential role of lipin-1 in exercise-induced mitochondrial biogenesis
Biochem. Biophys. Res. Commun.
374
587-591
2008
Homo sapiens, Rattus norvegicus
Brindley, D.N.; Pilquil, C.; Sariahmetoglu, M.; Reue, K.
Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases
Biochim. Biophys. Acta
1791
956-961
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Pyne, S.; Lee, S.C.; Long, J.; Pyne, N.J.
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
Cell. Signal.
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2009
Drosophila melanogaster, Homo sapiens, Mus musculus
Mlinar, B.; Pfeifer, M.; Vrtacnik-Bokal, E.; Jensterle, M.; Marc, J.
Decreased lipin 1 beta expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome
Eur. J. Endocrinol.
159
833-839
2008
Homo sapiens
Koh, Y.K.; Lee, M.Y.; Kim, J.W.; Kim, M.; Moon, J.S.; Lee, Y.J.; Ahn, Y.H.; Kim, K.S.
Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2
J. Biol. Chem.
283
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Mus musculus
Ishimoto, K.; Nakamura, H.; Tachibana, K.; Yamasaki, D.; Ota, A.; Hirano, K.; Tanaka, T.; Hamakubo, T.; Sakai, J.; Kodama, T.; Doi, T.
Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells
J. Biol. Chem.
284
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Homo sapiens
Donkor, J.; Zhang, P.; Wong, S.; OLoughlin, L.; Dewald, J.; Kok, B.P.; Brindley, D.N.; Reue, K.
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2
J. Biol. Chem.
284
29968-29978
2009
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Han, G.S.; Carman, G.M.
Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms
J. Biol. Chem.
285
14628-14638
2010
Mus musculus
Peterfy, M.; Harris, T.E.; Fujita, N.; Reue, K.
Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes
J. Biol. Chem.
285
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2010
Mus musculus
Gorjanacz, M.; Mattaj, I.W.
Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans
J. Cell Sci.
122
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2009
Caenorhabditis elegans (Q9XXT5)
Golden, A.; Liu, J.; Cohen-Fix, O.
Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope
J. Cell Sci.
122
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Caenorhabditis elegans
Zhang, P.; OLoughlin, L.; Brindley, D.N.; Reue, K.
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis
J. Lipid Res.
49
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2008
Homo sapiens, Mus musculus
Reue, K.; Dwyer, J.R.
Lipin proteins and metabolic homeostasis
J. Lipid Res.
50 Suppl
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2009
Homo sapiens, Mus musculus, Rattus norvegicus
Brindley, D.N.; Pilquil, C.
Lipid phosphate phosphatases and signaling
J. Lipid Res.
50 Suppl
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2009
Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Wang, Q.; Ji, C.; Huang, J.; Yang, F.; Zhang, H.; Liu, L.; Yin, J.
The mRNA of lipin1 and its isoforms are differently expressed in the longissimus dorsi muscle of obese and lean pigs
Mol. Biol. Rep.
38
319-325
2010
Sus scrofa (B7STY8), Sus scrofa
Humtsoe, J.O.; Liu, M.; Malik, A.B.; Wary, K.K.
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures
Mol. Cell. Biol.
30
1593-1606
2010
Homo sapiens, Mus musculus
Kim, H.B.; Kumar, A.; Wang, L.; Liu, G.H.; Keller, S.R.; Lawrence, J.C.; Finck, B.N.; Harris, T.E.
Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors
Mol. Cell. Biol.
30
3126-3139
2010
Mus musculus
Liu, G.H.; Gerace, L.
Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells
PLoS ONE
4
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2009
Mus musculus
Nakamura, Y.; Koizumi, R.; Shui, G.; Shimojima, M.; Wenk, M.R.; Ito, T.; Ohta, H.
Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism and cope critically with phosphate starvation
Proc. Natl. Acad. Sci. USA
106
20978-20983
2009
Arabidopsis thaliana, Saccharomyces cerevisiae
Siniossoglou, S.
Lipins, lipids and nuclear envelope structure
Traffic
10
1181-1187
2009
Saccharomyces cerevisiae, Mus musculus, Rattus norvegicus
Bou Khalil, M.; Blais, A.; Figeys, D.; Yao, Z.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism
Biochim. Biophys. Acta
1801
1249-1259
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Renault, A.D.; Kunwar, P.S.; Lehmann, R.
Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila
Development
137
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2010
Drosophila melanogaster
Wang, H.; Zhang, J.; Qiu, W.; Han, G.S.; Carman, G.M.; Adeli, K.
Lipin-1gamma isoform is a novel lipid droplet-associated protein highly expressed in the brain
FEBS Lett.
585
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Homo sapiens
Fakas, S.; Qiu, Y.; Dixon, J.L.; Han, G.S.; Ruggles, K.V.; Garbarino, J.; Sturley, S.L.; Carman, G.M.
Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast
J. Biol. Chem.
286
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2011
Saccharomyces cerevisiae, Saccharomyces cerevisiae W303-1A
Ren, H.; Federico, L.; Huang, H.; Sunkara, M.; Drennan, T.; Frohman, M.; Smyth, S.; Morris, A.
A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis
Mol. Biol. Cell
21
3171-3181
2010
Mus musculus
Chatterjee, I.; Humtsoe, J.O.; Kohler, E.E.; Sorio, C.; Wary, K.K.
Lipid phosphate phosphatase-3 regulates tumor growth via beta-catenin and Cyclin-D1 signaling
Mol. Cancer
10
51
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Homo sapiens
Paradis, S.; Villasuso, A.L.; Aguayo, S.S.; Maldiney, R.; Habricot, Y.; Zalejski, C.; Machado, E.; Sotta, B.; Miginiac, E.; Jeannette, E.
Arabidopsis thaliana lipid phosphate phosphatase 2 is involved in abscisic acid signalling in leaves
Plant Physiol. Biochem.
49
357-362
2011
Arabidopsis thaliana
Eastmond, P.J.; Quettier, A.L.; Kroon, J.T.; Craddock, C.; Adams, N.; Slabas, A.R.
A phosphatidate phosphatase double mutant provides a new insight into plant membrane lipid homeostasis
Plant Signal. Behav.
6
526-527
2011
Arabidopsis thaliana
Karanasios, E.; Han, G.S.; Xu, Z.; Carman, G.M.; Siniossoglou, S.
A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase
Proc. Natl. Acad. Sci. USA
107
17539-17544
2010
Saccharomyces cerevisiae
Hernandez, M.A.; Comba, S.; Arabolaza, A.; Gramajo, H.; Alvarez, H.M.
Overexpression of a phosphatidic acid phosphatase type 2 leads to an increase in triacylglycerol production in oleaginous Rhodococcus strains
Appl. Microbiol. Biotechnol.
99
2191-2207
2015
Rhodococcus jostii (Q0SKM5)
Choi, H.S.; Su, W.M.; Han, G.S.; Plote, D.; Xu, Z.; Carman, G.M.
Pho85p-Pho80p phosphorylation of yeast Pah1p phosphatidate phosphatase regulates its activity, location, abundance, and function in lipid metabolism
J. Biol. Chem.
287
11290-11301
2012
Saccharomyces cerevisiae (P32567), Saccharomyces cerevisiae
Pascual, F.; Soto-Cardalda, A.; Carman, G.M.
PAH1-encoded phosphatidate phosphatase plays a role in the growth phase- and inositol-mediated regulation of lipid synthesis in Saccharomyces cerevisiae
J. Biol. Chem.
288
35781-35792
2013
Saccharomyces cerevisiae (P32567), Saccharomyces cerevisiae
Kok, B.P.; Skene-Arnold, T.D.; Ling, J.; Benesch, M.G.; Dewald, J.; Harris, T.E.; Holmes, C.F.; Brindley, D.N.
Conserved residues in the N terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation, and phosphatidate phosphatase activity
J. Biol. Chem.
289
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2014
Homo sapiens (Q14693)
Su, W.M.; Han, G.S.; Carman, G.M.
Cross-talk phosphorylations by protein kinase C and Pho85p-Pho80p protein kinase regulate Pah1p phosphatidate phosphatase abundance in Saccharomyces cerevisiae
J. Biol. Chem.
289
18818-18830
2014
Saccharomyces cerevisiae (P32567), Saccharomyces cerevisiae
Pascual, F.; Hsieh, L.S.; Soto-Cardalda, A.; Carman, G.M.
Yeast Pah1p phosphatidate phosphatase is regulated by proteasome-mediated degradation
J. Biol. Chem.
289
9811-9822
2014
Saccharomyces cerevisiae (P32567), Saccharomyces cerevisiae
Comba, S.; Menendez-Bravo, S.; Arabolaza, A.; Gramajo, H.
Identification and physiological characterization of phosphatidic acid phosphatase enzymes involved in triacylglycerol biosynthesis in Streptomyces coelicolor
Microb. Cell Fact.
12
0009
2013
Streptomyces coelicolor (Q9EWX3), Streptomyces coelicolor (Q9K3P6), Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471 (Q9EWX3), Streptomyces coelicolor ATCC BAA-471 (Q9K3P6)
Dubots, E.; Cottier, S.; Peli-Gulli, M.P.; Jaquenoud, M.; Bontron, S.; Schneiter, R.; De Virgilio, C.
TORC1 regulates Pah1 phosphatidate phosphatase activity via the Nem1/Spo7 protein phosphatase complex
PLoS ONE
9
e104194
2014
Saccharomyces cerevisiae
Cao, H.; Sethumadhavan, K.; Grimm, C.C.; Ullah, A.H.
Characterization of a soluble phosphatidic acid phosphatase in bitter melon (Momordica charantia)
PLoS ONE
9
e106403
2014
Momordica charantia
Carman, G.M.; Han, G.S.
Phosphatidate phosphatase regulates membrane phospholipid synthesis via phosphatidylserine synthase
Adv. Biol. Regul.
67
49-58
2018
Saccharomyces cerevisiae
Busnelli, M.; Manzini, S.; Parolini, C.; Escalante-Alcalde, D.; Chiesa, G.
Lipid phosphate phosphatase 3 in vascular pathophysiology
Atherosclerosis
271
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2018
Homo sapiens (O14495), Mus musculus (Q99JY8)
Wang, W.; Xin, J.; Yang, X.; Lam, S.; Shui, G.; Wang, Y.; Huang, X.
Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide
Biochim. Biophys. Acta
1864
168-180
2019
Drosophila melanogaster
-
Touat-Hamici, Z.; Weidmann, H.; Blum, Y.; Proust, C.; Durand, H.; Iannacci, F.; Codoni, V.; Gaignard, P.; Therond, P.; Civelek, M.; Karabina, S.A.; Lusis, A.J.; Cambien, F.; Ninio, E.
Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function
Cardiovasc. Res.
112
702-713
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Homo sapiens (O14495), Homo sapiens
Mu, C.; Pan, C.; Han, Q.; Liu, Q.; Wang, Y.; Sang, J.
Phosphatidate phosphatase Pah1 has a role in the hyphal growth and virulence of Candida albicans
Fungal Genet. Biol.
124
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2019
Candida albicans
Jin, H.H.; Jiang, J.G.
Phosphatidic acid phosphatase and diacylglycerol acyltransferase potential targets for metabolic engineering of microorganism oil
J. Agric. Food Chem.
63
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2015
Saccharomyces cerevisiae (P32567)
Carman, G.M.; Han, G.S.
Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis
J. Biol. Chem.
284
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Saccharomyces cerevisiae
Han, G.S.; Carman, G.M.
Yeast PAH1-encoded phosphatidate phosphatase controls the expression of CHO1-encoded phosphatidylserine synthase for membrane phospholipid synthesis
J. Biol. Chem.
292
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Saccharomyces cerevisiae, Saccharomyces cerevisiae W303-1A
Park, Y.; Han, G.S.; Carman, G.M.
A conserved tryptophan within the WRDPLVDID domain of yeast Pah1 phosphatidate phosphatase is required for its in vivo function in lipid metabolism
J. Biol. Chem.
292
19580-19589
2017
Saccharomyces cerevisiae (P32567), Saccharomyces cerevisiae, Saccharomyces cerevisiae W303-1A (P32567)
Carman, G.M.
Discoveries of the phosphatidate phosphatase genes in yeast published in the Journal of Biological Chemistry
J. Biol. Chem.
294
1681-1689
2019
Saccharomyces cerevisiae
Pillai, A.N.; Shukla, S.; Gautam, S.; Rahaman, A.
Small phosphatidate phosphatase (TtPAH2) of Tetrahymena complements respiratory function and not membrane biogenesis function of yeast PAH1
J. Biosci.
42
613-621
2017
Tetrahymena thermophila, Tetrahymena thermophila CU428, Tetrahymena thermophila B2086
Carman, G.M.; Han, G.S.
Fat-regulating phosphatidic acid phosphatase a review of its roles and regulation in lipid homeostasis
J. Lipid Res.
60
2-6
2019
Saccharomyces cerevisiae
Nakano, M.; Yoshioka, H.; Ohnishi, K.; Hikichi, Y.; Kiba, A.
Cell death-inducing stresses are required for defense activation in DS1-phosphatidic acid phosphatase-silenced Nicotiana benthamiana
J. Plant Physiol.
184
15-19
2015
Nicotiana benthamiana
Craddock, C.P.; Adams, N.; Bryant, F.M.; Kurup, S.; Eastmond, P.J.
Phosphatidic acid phosphohydrolase regulates phosphatidylcholine biosynthesis in Arabidopsis by phosphatidic acid-mediated activation of CTP phosphocholine cytidylyltransferase activity
Plant Cell
27
1251-1264
2015
Arabidopsis thaliana (Q9FMN2), Arabidopsis thaliana (Q9SF47), Arabidopsis thaliana
Guo, A.; Cai, J.; Luo, X.; Zhang, S.; Hou, J.; Li, H.; Cai, X.
Cloning and characterization of three Eimeria tenella lipid phosphate phosphatases
PLoS ONE
10
e122736
2015
Eimeria tenella (A0A0A7H6F4), Eimeria tenella (A0A0A7H9C0), Eimeria tenella (A0A0A7H9U0), Eimeria tenella
Federico, L.; Yang, L.; Brandon, J.; Panchatcharam, M.; Ren, H.; Mueller, P.; Sunkara, M.; Escalante-Alcalde, D.; Morris, A.J.; Smyth, S.S.
Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice
PLoS ONE
13
e0198063
2018
Mus musculus (Q99JY8)
Mingorance, L.; Castro, V.; Avila-Perez, G.; Calvo, G.; Rodriguez, M.J.; Carrascosa, J.L.; Perez-Del-Pulgar, S.; Forns, X.; Gastaminza, P.
Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation
PLoS Pathog.
14
e1007284
2018
Homo sapiens
Hardman, D.; McFalls, D.; Fakas, S.
Characterization of phosphatidic acid phosphatase activity in the oleaginous yeast Yarrowia lipolytica and its role in lipid biosynthesis
Yeast
34
83-91
2017
Yarrowia lipolytica, Yarrowia lipolytica Po1g
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