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Disease on EC 3.1.3.4 - phosphatidate phosphatase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
acylglycerol kinase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Adenocarcinoma of Lung
Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy.
Prognostic role of lipid phosphate phosphatases in non-smoker, lung adenocarcinoma patients.
Anaphylaxis
Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
Anemia
A conserved serine residue is required for the phosphatidate phosphatase activity but not transcriptional coactivator functions of lipin-1 and lipin-2.
Asthma
Alleviating airway inflammation by inhibiting ERK-NF-?B signaling pathway by blocking Kv1.3 channels.
Atherosclerosis
Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis.
Correction to: Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.
Effect of the Kv1.3 voltage-gated potassium channel blocker PAP-1 on the initiation and progress of atherosclerosis in a rat model.
Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.
Myeloid-associated lipin-1 transcriptional co-regulatory activity is atheroprotective.
Autoimmune Diseases
Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.
Barth Syndrome
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Brain Diseases
Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway.
Breast Neoplasms
Expression and clinicopathological significance of lipin-1 in human breast cancer and its association with p53 tumor suppressor gene.
IL-33-Induced Transcriptional Activation of LPIN1 Accelerates Breast Tumorigenesis.
Increasing the low lipid phosphate phosphatase 1 activity in breast cancer cells decreases transcription by AP-1 and expressions of matrix metalloproteinases and cyclin D1/D3.
Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment.
LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy.
SRC promotes lipogenesis: implications for obesity and breast cancer.
Carcinogenesis
Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1.
IL-33-Induced Transcriptional Activation of LPIN1 Accelerates Breast Tumorigenesis.
LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Carcinoma
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Carcinoma, Hepatocellular
Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1.
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
Lipin-1 is a novel substrate of protein phosphatase PGAM5.
Cardiomegaly
Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Cardiomyopathies
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Inborn errors of cytoplasmic triglyceride metabolism.
Cardiovascular Diseases
Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes of the metabolic syndrome in humans.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
The potential role of the lipid phosphate phosphatase 3 (Plpp3) gene in cardiovascular disease.
choline kinase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Colitis
PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway.
Colitis, Ulcerative
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Colonic Neoplasms
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Coronary Artery Disease
Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.
Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis.
Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.
Demyelinating Diseases
A hypomorphic mutation in lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.
Phosphatidic acid mediates demyelination in Lpin1 mutant mice.
Dermatitis, Allergic Contact
Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis.
Diabetes Mellitus
Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils.
Genetic variants of LPIN1 indicate an association with Type?2 diabetes mellitus in a Chinese population.
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
PPAR? agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPAR? phosphatase.
The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPAR? on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
Diabetes Mellitus, Type 2
Association of PPARG and LPIN1 gene polymorphisms with metabolic syndrome and type 2 diabetes.
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.
Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes.
Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes.
The Associations of LPIN1 Gene Expression in Adipose Tissue With Metabolic Phenotypes in the Chinese Population.
The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPAR? on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
Drug-Related Side Effects and Adverse Reactions
Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature.
Dyslipidemias
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Fatty Liver
Adipose-Specific Lipin-1 Overexpression Renders Hepatic Ferroptosis and Exacerbates Alcoholic Steatohepatitis in Mice.
Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.
Association between hepatic triacylglycerol accumulation induced by administering orotic acid and enhanced phosphatidate phosphohydrolase activity in rats.
Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism.
Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice.
Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon.
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis.
HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver.
Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Lipin 1 in lipid metabolism.
Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.
Lipin Is a Central Regulator of Adipose Tissue Development and Function in Drosophila melanogaster.
LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.
LPIN1 rs13412852 Polymorphism in Pediatric Non-Alcoholic Fatty Liver Disease.
Phenotypic Modulation of Skeletal Muscle Fibers in LPIN1-Deficient Lipodystrophic ( fld) Mice.
Regulation of fatty acid oxidation and triglyceride and phospholipid metabolism by hypolipidemic sulfur-substituted fatty acid analogues.
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
Fatty Liver, Alcoholic
Adipose-Specific Lipin-1 Overexpression Renders Hepatic Ferroptosis and Exacerbates Alcoholic Steatohepatitis in Mice.
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin-1 signaling.
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emerging Role of Lipin-1.
The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings.
The role of lipin-1 in the pathogenesis of alcoholic Fatty liver.
[Role of lipin-1 in the pathogenesis of alcoholic fatty liver disease].
Glioblastoma
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Glioma
Bimodal distribution of phosphatidic acid phosphohydrolase in NG108-15 cells. Modulation by the amphiphilic lipids oleic acid and sphingosine.
Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma.
Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells.
Glucose Intolerance
Lipin 1 Gene Polymorphisms in Polycystic Ovary Syndrome.
Heart Failure
Alterations of sarcolemmal phospholipase D and phosphatidate phosphohydrolase in congestive heart failure.
Hepatitis C
Differential Roles of Lipin1 and Lipin2 in the Hepatitis C Virus Replication Cycle.
Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation.
Hepatitis, Alcoholic
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Hepatoblastoma
Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
Herpes Zoster
Lipocalins Are Required for Apical Extracellular Matrix Organization and Remodeling in Caenorhabditis elegans.
Hypercholesterolemia
Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.
Hyperglycemia
Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy.
Metformin counteracts glucose-dependent lipogenesis and impairs transdeamination in the liver of gilthead sea bream (Sparus aurata).
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats.
Hyperinsulinism
Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.
Hyperkinesis
Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.
Hyperlipidemias
Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF- ? B/MAPK Signaling Pathways.
Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon.
Hypersensitivity
Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.
Hypertension
A central role for protein kinase C overactivity in diabetic glomerulosclerosis: implications for prevention with antioxidants, fish oil, and ACE inhibitors.
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.
Erratum to: K(+) Channels Expression in Hypertension After Arterial Injury, and Effect of Selective Kv1.3 Blockade with PAP-1 on Intimal Hyperplasia Formation.
K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation.
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
Hyperthyroidism
Mechanisms for the effects of ethanol on hepatic phosphatidate phosphohydrolase.
Phosphatidate phosphohydrolase and palmitoyl-coenzyme A hydrolase in cardiac subcellular fractions of hyperthyroid rabbits and cardiomyopathic hamsters.
Hypertriglyceridemia
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.
Enhanced prereceptor glucocorticoid metabolism and lipogenesis impair insulin signaling in the liver of fructose-fed rats.
Inborn errors of cytoplasmic triglyceride metabolism.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
The PPAR{beta}/{delta} Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation.
Ichthyosis
Inborn errors of cytoplasmic triglyceride metabolism.
Infarction, Middle Cerebral Artery
Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke.
Infections
Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation.
Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.
LPP-1 infection of the blue-green alga Plectonema boryanum. 3. Protein synthesis.
LPP-1 infection of the blue-green alga Plectonema boryanum. I. Electron microscopy.
LPP-1 infection of the blue-green alga Plectonema boryanum. II. Viral deoxyribonucleic acid synthesis and host deoxyribonucleic acid breakdown.
Infertility
Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.
Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility.
Who watches the watchmen? RNAi pathway-derived ribosomal small RNAs burgeon in absence of piRNAs.
Influenza, Human
Pharmacokinetics, toxicity, and functional studies of the selective kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques.
Insulin Resistance
A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes.
A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.
Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men.
Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.
Complementary measures for promoting insulin sensitivity in skeletal muscle.
Decreased lipin 1 beta expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome.
Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes.
Effect of Combined Exercise Versus Aerobic-Only Training on Skeletal Muscle Lipid Metabolism in a Rodent Model of Type1 Diabetes.
Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes.
Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations.
Expression and significance of lipin1 and AMPK? in hepatic insulin resistance in diet-induced insulin resistance rats.
Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis.
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Lipin Expression Is Attenuated in Adipose Tissue of Insulin-Resistant Human Subjects and Increases With Peroxisome Proliferator-Activated Receptor {gamma} Activation.
Liver-Specific Silencing of Lipin1 Reduces Fat Mass as Well as Hepatic Triglyceride Biosynthesis in Mice.
Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes.
Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues.
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue.
Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes.
Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes.
The lipin family: mutations and metabolism.
The role of lipin 1 in adipogenesis and lipid metabolism.
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats.
Ischemic Stroke
Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke.
Leukemia, B-Cell
Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle.
Leukemia, Lymphocytic, Chronic, B-Cell
Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia.
Lipodystrophy
A Frame-Shift Mutation in CAV1 Is Associated with a Severe Neonatal Progeroid and Lipodystrophy Syndrome.
A hypomorphic mutation in lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.
Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism.
Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations.
Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia.
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
Identification of single-nucleotide polymorphisms in the human LPIN1 gene.
Intermuscular and intramuscular adipose tissues: Bad vs. good adipose tissues.
Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice.
Lipin 1 in lipid metabolism.
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.
Lipin Is a Central Regulator of Adipose Tissue Development and Function in Drosophila melanogaster.
Lipin-1 and lipin-3 together determine adiposity in vivo.
Lipin1 regulation by estrogen in uterus and liver: implications for diabetes and fertility.
LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.
miRNA-218 Targets Lipin-1 and Glucose Transporter Type 4 Genes in 3T3-L1 Cells Treated With Lopinavir/Ritonavir.
Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
Phenotypic Modulation of Skeletal Muscle Fibers in LPIN1-Deficient Lipodystrophic ( fld) Mice.
Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes.
Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue.
Testosterone modulates gene expression pathways regulating nutrient accumulation, glucose metabolism and protein turnover in mouse skeletal muscle.
The fat and thin of lipin.
The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1.
The role of lipin 1 in adipogenesis and lipid metabolism.
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
Lipodystrophy, Congenital Generalized
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
Liver Cirrhosis, Biliary
The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings.
Liver Diseases
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
Lipin Is a Central Regulator of Adipose Tissue Development and Function in Drosophila melanogaster.
LPIN1 rs13412852 Polymorphism in Pediatric Non-Alcoholic Fatty Liver Disease.
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emerging Role of Lipin-1.
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Liver Diseases, Alcoholic
Activity and subcellular distribution of phosphatidate phosphohydrolase (EC 3.1.3.4) in alcoholic liver disease.
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis.
The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings.
Lung Neoplasms
Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy.
Lymphoma
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Lymphoma, Large-Cell, Anaplastic
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Melanoma
The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells.
Metabolic Diseases
Induction of Lipin1 by ROS-Dependent SREBP-2 Activation.
Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling.
The lipin family: mutations and metabolism.
Metabolic Syndrome
A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.
Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina.
Association of PPARG and LPIN1 gene polymorphisms with metabolic syndrome and type 2 diabetes.
Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes of the metabolic syndrome in humans.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes.
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
Mitochondrial Diseases
Acute rhabdomyolysis and inflammation.
Muscular Atrophy
Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle.
Muscular Diseases
Acute rhabdomyolysis and inflammation.
Inborn errors of cytoplasmic triglyceride metabolism.
Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle.
Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression.
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Mutations in LPIN1 Cause Recurrent Acute Myoglobinuria in Childhood.
Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components.
Muscular Dystrophies
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Myalgia
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature.
Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.
Myoglobinuria
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood.
Molecular analysis of LPIN1 in Jordanian patients with rhabdomyolysis.
Mutations in LPIN1 Cause Recurrent Acute Myoglobinuria in Childhood.
The lipin family: mutations and metabolism.
Myopia
Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia.
Myositis
Acute rhabdomyolysis and inflammation.
Neoplasm Metastasis
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.
LPPR4 promotes peritoneal metastasis via Sp1/integrin ?/FAK signaling in gastric cancer.
Neoplasms
Coamplification of DDX1 correlates with an improved survival probability in children with MYCN-amplified human neuroblastoma.
Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial.
Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer.
Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1.
Expression and clinicopathological significance of lipin-1 in human breast cancer and its association with p53 tumor suppressor gene.
IL-33-Induced Transcriptional Activation of LPIN1 Accelerates Breast Tumorigenesis.
Increasing the low lipid phosphate phosphatase 1 activity in breast cancer cells decreases transcription by AP-1 and expressions of matrix metalloproteinases and cyclin D1/D3.
Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells.
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma.
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.
Lipid phosphate phosphatase-3 regulates tumor growth via ?-catenin and CYCLIN-D1 signaling.
Lipid profile of platelets and platelet-derived microparticles in ovarian cancer.
Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses.
Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy.
Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment.
Lipin-1, a Versatile Regulator of Lipid Homeostasis, Is a Potential Target for Fighting Cancer.
LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.
Persistent activity modification of phosphatidate phosphohydrolase and fatty acyl-CoA synthetase on incubation of adipocytes with the tumour promoter 12-O-tetradecanoylphorbol 13-acetate.
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy.
Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells.
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Targeting mTOR by CZ415 Suppresses Cell Proliferation and Promotes Apoptosis via Lipin-1 in Cervical Cancer In Vitro and In Vivo.
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats.
Tumor imaging using technetium-99m bound to pH-sensitive peptides.
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Nervous System Diseases
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Neuroblastoma
Bimodal distribution of phosphatidic acid phosphohydrolase in NG108-15 cells. Modulation by the amphiphilic lipids oleic acid and sphingosine.
Coamplification of DDX1 correlates with an improved survival probability in children with MYCN-amplified human neuroblastoma.
Neuroinflammatory Diseases
Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.
Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept.
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.
Transient 5-(4-phenylbutoxy)psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles.
Non-alcoholic Fatty Liver Disease
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.
Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents.
HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver.
LPIN1 rs13412852 Polymorphism in Pediatric Non-Alcoholic Fatty Liver Disease.
Mitigative effects of the bioactive flavonol fisetin on high-fat/high-sucrose induced nonalcoholic fatty liver disease in rats.
Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Obesity
A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes.
A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.
Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes.
Expression and significance of lipin1 and AMPK? in hepatic insulin resistance in diet-induced insulin resistance rats.
Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis.
Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice.
Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.
Lipin1 regulation by estrogen in uterus and liver: implications for diabetes and fertility.
Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes.
Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats.
Phosphatidate phosphatase-1 is functionally conserved in lipid synthesis and storage from human to yeast.
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue.
Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue.
Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes.
Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes.
The role of lipin 1 in adipogenesis and lipid metabolism.
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
Obesity, Abdominal
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.
Association of PPARG and LPIN1 gene polymorphisms with metabolic syndrome and type 2 diabetes.
Optic Nerve Injuries
Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration.
Ovarian Neoplasms
Decreased Peritoneal Ovarian Cancer Growth in Mice Lacking Expression of Lipid Phosphate Phosphohydrolase 1.
MiRNA-584 suppresses the progression of ovarian cancer by negatively regulating LPIN1.
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Translocation of lysophosphatidic acid phosphatase in response to gonadotropin-releasing hormone to the plasma membrane in ovarian cancer cell.
Pancreatic Neoplasms
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.
Paralysis
Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.
Paraplegia
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Parvoviridae Infections
First presentation of LPIN1 acute rhabdomyolysis in adolescence and adulthood.
Peripheral Nervous System Diseases
Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy.
phosphatidate phosphatase deficiency
A neglected cause of recurrent rhabdomyolysis, LPIN1 gene defect: a rare case from Turkey.
Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.
Cardiac function and exercise adaptation in 8 children with LPIN1 mutations.
Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts.
Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.
Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development.
Fat oxidation is impaired during exercise in lipin-1 deficiency.
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
Intermuscular and intramuscular adipose tissues: Bad vs. good adipose tissues.
Investigation of Lpin1 as a candidate gene for fat deposition in pigs.
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Lipin 1 modulates mRNA splicing during fasting adaptation in liver.
Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature.
Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle.
Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression.
Liver-specific loss of lipin 1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic triglyceride accumulation in mice.
Long-term outcomes in a 25-year-old female affected with lipin-1 deficiency.
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Loss of membrane integrity drives myofiber death in lipin1-deficient skeletal muscle.
LPIN1 deficiency with severe recurrent rhabdomyolysis and persistent elevation of creatine kinase levels due to chromosome 2 maternal isodisomy.
LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.
Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
Phenotypic Modulation of Skeletal Muscle Fibers in LPIN1-Deficient Lipodystrophic ( fld) Mice.
PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/?1-Integrin Signaling.
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice.
Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.
Target-controlled infusion of Propofol and Remifentanil in a child with recurrent rhabdomyolysis secondary to LPIN1 deficiency.
The lipin family: mutations and metabolism.
The role of lipin 1 in adipogenesis and lipid metabolism.
Polycystic Ovary Syndrome
Decreased lipin 1 beta expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome.
Lipin 1 Gene Polymorphisms in Polycystic Ovary Syndrome.
Prostatic Neoplasms
Identification of lipidomic profiles associated with drug-resistant prostate cancer cells.
Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1?-LIPIN 1 pathway and increasing CD36 through Nrf2.
Psoriasis
DNA methylation analysis of CD4+ T cells in patients with psoriasis.
Identification of phase-I metabolites and chronic toxicity study of the Kv1.3 blocker PAP-1 (5-(4-phenoxybutoxy)psoralen) in the rat.
Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis.
Retinitis Pigmentosa
Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex.
CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing.
PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor.
Rh Isoimmunization
Biochemical assessment of fetal lung maturity.
Rhabdomyolysis
A neglected cause of recurrent rhabdomyolysis, LPIN1 gene defect: a rare case from Turkey.
A novel therapeutic approach for LPIN1 mutation-associated rhabdomyolysis--The Austrian experience.
A rare case of adult onset LPIN1 associated rhabdomyolysis.
A rare case of pediatric recurrent rhabdomyolysis with compound heterogenous variants in the LPIN1.
Acute recurrent rhabdomyolysis in a Chinese boy associated with a novel compound heterozygous LPIN1 variant: a case report.
Acute rhabdomyolysis and inflammation.
Cardiac function and exercise adaptation in 8 children with LPIN1 mutations.
Case Report: The first probable Hong Kong Chinese case of LPIN1-related acute recurrent rhabdomyolysis in a boy with two novel variants.
Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts.
Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.
Detection of compound heterozygous variants in LPIN1 does not necessarily imply pathogenicity in a patient with rhabdomyolysis.
Fatal rhabdomyolysis in 2 children with LPIN1 mutations.
First presentation of LPIN1 acute rhabdomyolysis in adolescence and adulthood.
Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature.
Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle.
Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle.
Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Lipin1 Regulates Skeletal Muscle Differentiation through Extracellular Signal-regulated Kinase (ERK) Activation and Cyclin D Complex-regulated Cell Cycle Withdrawal.
Long-term outcomes in a 25-year-old female affected with lipin-1 deficiency.
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Loss of membrane integrity drives myofiber death in lipin1-deficient skeletal muscle.
LPIN1 deficiency with severe recurrent rhabdomyolysis and persistent elevation of creatine kinase levels due to chromosome 2 maternal isodisomy.
LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood.
Molecular analysis of LPIN1 in Jordanian patients with rhabdomyolysis.
Mutations in LPIN1 Cause Recurrent Acute Myoglobinuria in Childhood.
Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.
Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.
Target-controlled infusion of Propofol and Remifentanil in a child with recurrent rhabdomyolysis secondary to LPIN1 deficiency.
The etiology of rhabdomyolysis: an interaction between genetic susceptibilities and external triggers.
Volatile anesthesia for a child with LPIN1 gene mutation and recurrent rhabdomyolysis.
Seizures
Dynamic pattern of gene expression of ZnT-1, ZnT-3 and PRG-1 in rat brain following flurothyl-induced recurrent neonatal seizures.
Dynamic Pattern of Gene Expression of ZnT-4, Caspase-3, LC3, and PRG-3 in Rat Cerebral Cortex Following Flurothyl-Induced Recurrent Neonatal Seizures.
Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus.
Long-term Effects of Recurrent Neonatal Seizures on Neurobehavioral Function and Related Gene Expression and Its Intervention by Inhibitor of Cathepsin B.
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Skin Diseases
Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis.
Spinal Cord Injuries
Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
Prognostic value of lipid metabolism-related genes in head and neck squamous cell carcinoma.
Starvation
Appropriate leucine supplementation promotes glucose metabolism and enhances energy homeostasis in juvenile crucian carp (Carassius auratus gibelio var. CAS III).
Effects of starvation, corticotropin injection and ethanol feeding on the activity and amount of phosphatidate phosphohydrolase in rat liver.
Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically.
Glycerolipid biosynthesis in rat adipose tissue. 10. Changes during a starvation and re-feeding cycle.
Reduced insulin/IGF-1 signaling restores germ cell immortality to caenorhabditis elegans Piwi mutants.
Relationship between the inhibition of phosphatidic acid phosphohydrolase-1 by oleate and oleoyl-CoA ester and its apparent translocation.
Some aspects of the physiological and pharmacological control of the synthesis of triacylglycerols and phospholipids.
The activities of lipoprotein lipase and of enzymes involved in triacylglycerol synthesis in rat adipose tissue. Effects of starvation, dietary modification and of corticotropin injection.
Thrombosis
Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo.
Triple Negative Breast Neoplasms
Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival.
Uterine Cervical Neoplasms
Targeting mTOR by CZ415 Suppresses Cell Proliferation and Promotes Apoptosis via Lipin-1 in Cervical Cancer In Vitro and In Vivo.
[Less pap-2 results ('minor abnormalities') in the population screening for cervical cancer since the introduction of new guidelines in 1996]
Vascular System Injuries
Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo.
Virus Diseases
Host Pah1p phosphatidate phosphatase limits viral replication by regulating phospholipid synthesis.