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Disease on EC 3.1.26.5 - ribonuclease P

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis, Lactic
Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.
Acquired Immunodeficiency Syndrome
Cooperative RNP Assembly: Complementary Rescue of Structural Defects by Protein and RNA Subunits of Archaeal RNase P.
Acute Lung Injury
Pharmacokinetic and Pharmacodynamic Evaluation of Ravulizumab in Adults with Severe Coronavirus Disease 2019.
Adenocarcinoma of Lung
An Immunohistochemical Analysis of a Newly Developed, Mouse Monoclonal p40 (BC28) in Lung, Bladder, Skin, Breast, Prostate, and Head and Neck Cancers.
Novel 3' ends that support translation.
Atherosclerosis
Complement C5 Protein as a Marker of Subclinical Atherosclerosis.
Atypical Hemolytic Uremic Syndrome
Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action.
Autoimmune Diseases
Antibodies in human serum that precipitate ribonuclease P.
Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P.
Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus.
RNase MRP and disease.
The 40-kilodalton to autoantigen associates with nucleotides 21 to 64 of human mitochondrial RNA processing/7-2 RNA in vitro.
Bone Diseases, Developmental
Type and level of RMRP functional impairment predicts phenotype in the cartilage hair hypoplasia-anauxetic dysplasia spectrum.
Brain Diseases
RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder.
Breast Neoplasms
Effective stimulation of growth in MCF-7 human breast cancer cells by inhibition of syntaxin18 by external guide sequence and ribonuclease P.
PUM1 and RNase P genes as potential cell-free DNA markers in breast cancer.
Carcinogenesis
NcRNA-microchip analysis: A novel approach to identify differential expression of non-coding RNAs.
Carcinoma
An Immunohistochemical Analysis of a Newly Developed, Mouse Monoclonal p40 (BC28) in Lung, Bladder, Skin, Breast, Prostate, and Head and Neck Cancers.
Carcinoma, Squamous Cell
An Immunohistochemical Analysis of a Newly Developed, Mouse Monoclonal p40 (BC28) in Lung, Bladder, Skin, Breast, Prostate, and Head and Neck Cancers.
Cardiomyopathies
Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.
Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein.
Carotid Stenosis
White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition.
Coinfection
A real-time quadriplex PCR assay for the diagnosis of rectal lymphogranuloma venereum and non-lymphogranuloma venereum Chlamydia trachomatis infections.
Colonic Neoplasms
Wnt activated ?-catenin and YAP proteins enhance the expression of non-coding RNA component of RNase MRP in colon cancer cells.
Colorectal Neoplasms
17?-Hydroxysteroid dehydrogenase type 10 predicts survival of patients with colorectal cancer and affects mitochondrial DNA content.
Communicable Diseases
Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences.
Connective Tissue Diseases
hPop1: an autoantigenic protein subunit shared by the human RNase P and RNase MRP ribonucleoproteins.
COVID-19
Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device.
Cytomegalovirus Infections
RNase P ribozymes for the studies and treatment of human cytomegalovirus infections.
Deafness
Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.
Drug Resistant Epilepsy
A novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression.
Dwarfism
The anti-viral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.
Epstein-Barr Virus Infections
NcRNA-microchip analysis: A novel approach to identify differential expression of non-coding RNAs.
Foot-and-Mouth Disease
Characterization of a cyanobacterial RNase P ribozyme recognition motif in the IRES of foot-and-mouth disease virus reveals a unique structural element.
Gastroesophageal Reflux
Volume 241, Number 1 (1997), in Article No. RC977772, "A Bidirectional Promoter Connects the p14.5 Gene to the Gene for RNase P and RNase MRP Protein Subunit hPOP1,rdquo; by Gerno Schmiedeknecht, Christa Büchler, and Gerd Schmitz, pages 59-67:
Genetic Diseases, Inborn
RNase MRP and disease.
RNase MRP RNA and human genetic diseases.
Glioblastoma
RPP30, a transcriptional regulator, is a potential pathogenic factor in glioblastoma.
Glioma
Rpp29 regulates histone H3.3 chromatin assembly through transcriptional mechanisms.
Head and Neck Neoplasms
An Immunohistochemical Analysis of a Newly Developed, Mouse Monoclonal p40 (BC28) in Lung, Bladder, Skin, Breast, Prostate, and Head and Neck Cancers.
Hemoglobinuria
Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action.
Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria.
Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria.
Genetic variants in C5 and poor response to eculizumab.
Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: a treatment versus no-treatment study.
Paroxysmal nocturnal hemoglobinuria: current treatments and unmet needs.
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.
Hemoglobinuria, Paroxysmal
Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action.
Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria.
Genetic variants in C5 and poor response to eculizumab.
Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: a treatment versus no-treatment study.
Paroxysmal nocturnal hemoglobinuria: current treatments and unmet needs.
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.
Hepatitis
Inhibition of gene expression by ribozymes.
Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro.
Ribozymes in the age of molecular therapeutics.
Hepatitis B
Inhibition of Hepatitis B Virus Gene Expression and Replication by Ribonuclease P.
Hepatitis C
Catalytic RNase P RNA from Synechocystis sp. cleaves the hepatitis C virus RNA near the AUG start codon.
Characterization of the structure and variability of an internal region of hepatitis C virus RNA for M1 RNA guide sequence ribozyme targeting.
Characterizing the function and structural organization of the 5' tRNA-like motif within the hepatitis C virus quasispecies.
Inhibition of hepatitis C virus by an M1GS ribozyme derived from the catalytic RNA subunit of Escherichia coli RNase P.
RNA molecules with structure dependent functions are uniquely folded.
Specific cleavage of hepatitis C virus RNA genome by human RNase P.
Herpes Simplex
A ribozyme derived from the catalytic subunit of RNase P from Escherichia coli is highly effective in inhibiting replication of herpes simplex virus 1.
Effective inhibition of herpes simplex virus 1 gene expression and growth by engineered RNase P ribozyme.
In vitro selection of external guide sequences for directing RNase P-mediated inhibition of viral gene expression.
Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli.
Nuclease footprint analyses of the interactions between RNase P ribozyme and a model mRNA substrate.
RNase P ribozymes selected in vitro to cleave a viral mRNA effectively inhibit its expression in cell culture.
Hypersensitivity
Lithium toxicity in yeast is due to the inhibition of RNA processing enzymes.
Infections
Dissecting human cytomegalovirus gene function and capsid maturation by ribozyme targeting and electron cryomicroscopy.
Engineered RNase P Ribozymes Effectively Inhibit the Infection of Murine Cytomegalovirus in Animals.
Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant.
Insight into the functional role of unique determinants in RNA component of RNase P of Mycobacterium tuberculosis.
Infertility
tRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription.
Influenza, Human
Detection of influenza by real time RT-PCR is not affected by delays in respiratory specimen processing.
Effective inhibition of influenza virus production in cultured cells by external guide sequences and ribonuclease P.
Gene silencing in the therapy of influenza and other respiratory diseases: Targeting to RNase P by use of External Guide Sequences (EGS).
Nucleic Acid-Mediated Cleavage of M1 Gene of Influenza A Virus Is Significantly Augmented by Antisense Molecules Targeted to Hybridize Close to the Cleavage Site.
Liver Neoplasms, Experimental
Rat nucleolar 7-2 RNA is homologous to mouse mitochondrial RNase mitochondrial RNA-processing RNA.
Lung Neoplasms
An Immunohistochemical Analysis of a Newly Developed, Mouse Monoclonal p40 (BC28) in Lung, Bladder, Skin, Breast, Prostate, and Head and Neck Cancers.
Lupus Erythematosus, Systemic
Antibodies in human serum that precipitate ribonuclease P.
Lymphogranuloma Venereum
Differentiation of Chlamydia spp. by sequence determination and restriction endonuclease cleavage of RNase P RNA genes.
Measles
[Simultaneous detection of measles and rubella virus by multiplex real-time RT-PCR with an internal control]
Mitochondrial Diseases
Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.
tRNA processing in human mitochondrial disorders.
Mumps
Detection of mumps virus RNA by real-time one-step reverse transcriptase PCR using the LightCycler platform.
Real-time reverse transcription-PCR assay for detection of mumps virus RNA in clinical specimens.
Muscle Hypotonia
Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.
Musculoskeletal Diseases
Utilization of the Department of Defense Peer-Reviewed Orthopaedic Research Program (PRORP): Combating Musculoskeletal Disease With PRORP.
Myasthenia Gravis
Safety and effectiveness of eculizumab in Japanese patients with generalized myasthenia gravis: interim analysis of post-marketing surveillance.
Mycoplasma Infections
Determination of infectious load of Mycoplasma genitalium in clinical samples of human vaginal cells.
Neoplasms
A novel genetic- and cell-based tool for assessing the efficacy and toxicity of anticancer drugs in vitro.
Cancer in Systemic Sclerosis: Analysis of Antibodies Against Components of the Th/To Complex.
Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences.
In vivo inhibition by a site-specific catalytic RNA subunit of RNase P designed against the BCR-ABL oncogenic products: a novel approach for cancer treatment.
Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes.
RPP30, a transcriptional regulator, is a potential pathogenic factor in glioblastoma.
Type and level of RMRP functional impairment predicts phenotype in the cartilage hair hypoplasia-anauxetic dysplasia spectrum.
Picornaviridae Infections
Tailoring the switch from IRES-dependent to 5'-end-dependent translation with the RNase P ribozyme.
Pneumonia
Cloning and characterization of the RNase P RNA genes from two porcine mycoplasmas.
Pharmacokinetic and Pharmacodynamic Evaluation of Ravulizumab in Adults with Severe Coronavirus Disease 2019.
Prostatic Neoplasms
Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties.
Protein Deficiency
Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon.
Structure of the murine fifth complement component (C5) gene. A large, highly interrupted gene with a variant donor splice site and organizational homology with the third and fourth complement component genes.
Psoriasis
Additive inhibitory effect of calcipotriol and anthralin on ribonuclease P activity.
Respiratory Distress Syndrome
Pharmacokinetic and Pharmacodynamic Evaluation of Ravulizumab in Adults with Severe Coronavirus Disease 2019.
Rheumatic Diseases
Antibodies in human serum that precipitate ribonuclease P.
Autoantibodies to the mitochondrial RNA processing (MRP) complex also known as Th/To autoantigen.
ribonuclease p deficiency
Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon.
Structure of the murine fifth complement component (C5) gene. A large, highly interrupted gene with a variant donor splice site and organizational homology with the third and fourth complement component genes.
Yeast mitochondrial RNase P RNA synthesis is altered in an RNase P protein subunit mutant: insights into the biogenesis of a mitochondrial RNA-processing enzyme.
Rubella
[Simultaneous detection of measles and rubella virus by multiplex real-time RT-PCR with an internal control]
Scleroderma, Systemic
Autoantibodies to a novel Rpp38 (Th/To) derived B-cell epitope are specific for systemic sclerosis and associate with a distinct clinical phenotype.
Autoantibodies to the Rpp25 component of the Th/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests.
Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.
Severe Acute Respiratory Syndrome
Hybridization Chain Reactions Targeting the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Smallpox
In search of RNase P RNA from microbial genomes.
Thrombosis
Risk of Disseminated Gonococcal Infections With Terminal Complement Blockade.
Tuberculosis
Functional role of putative critical residues in Mycobacterium tuberculosis RNase P protein.
Hierarchical Natural Move Monte Carlo Refines Flexible RNA Structures into Cryo-EM Densities.
Influence of Conformation of M. tuberculosis RNase P Protein Subunit on Its Function.
Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives.
Insight into the functional role of unique determinants in RNA component of RNase P of Mycobacterium tuberculosis.
Insight into the role of histidine in RNR motif of protein component of RNase P of M. tuberculosis in catalysis.
Phylogenetic comparative mutational analysis of the base-pairing between RNase P RNA and its substrate.
Uterine Cervical Neoplasms
CircASAP1 promotes the development of cervical cancer through sponging miR-338-3p to upregulate RPP25.
LINC00319 promotes migration, invasion and epithelial-mesenchymal transition process in cervical cancer by regulating miR-3127-5p/RPP25 axis.
Randomized trial evaluating self-sampling for HPV DNA based tests for cervical cancer screening in Nigeria.
Vaccinia
Analysis of putative RNase P RNA from orthopoxviruses.
Translation of reovirus RNA species m1 can initiate at either of the first two in-frame initiation codons.
Vesicular Stomatitis
RNA-protein interactions in the human RNase MRP ribonucleoprotein complex.
Virus Diseases
Catalytic M1GS RNA as an antiviral agent in animals.
Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice.
RNA polymerase III and antiviral innate immune response.
The C5 protein encoded by Ageratum leaf curl Sichuan virus is a virulence factor and contributes to the virus infection.
Whooping Cough
Validation and Implementation of a Diagnostic Algorithm for DNA Detection of Bordetella pertussis, B. parapertussis, and B. holmesii in a Pediatric Referral Hospital in Barcelona, Spain.