Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.1.26.3 - ribonuclease III

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Research advances of Dicer in regulating reproductive function.
The effects of DICER1 and DROSHA polymorphisms on susceptibility to recurrent spontaneous abortion.
Acquired Immunodeficiency Syndrome
Characterization of the reactivity determinants of a novel hairpin substrate of yeast RNase III.
Adenocarcinoma
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1.
Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.
DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma.
DICER1 mutations in a patient with an ovarian Sertoli-Leydig tumor, well-differentiated fetal adenocarcinoma of the lung, and familial multinodular goiter.
DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification.
Germline and Somatic DICER1 Mutations in a Well-Differentiated Fetal Adenocarcinoma of the Lung.
Immunohistochemical study of Dicer and Drosha expression in the benign and malignant lesions of gallbladder and their clinicopathological significances.
miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma.
Overexpression of Dicer in precursor lesions of lung adenocarcinoma.
Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma.
Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma.
The prevalence of germline DICER1 pathogenic variation in cancer populations.
The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer.
Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma.
[A negative correlation between Drosha expression and gastric adenocarcinoma malignancy and invasion].
Adenocarcinoma of Lung
Overexpression of Dicer in precursor lesions of lung adenocarcinoma.
Adenocarcinoma, Follicular
Analyzing the Role of DICER1 Germline Variations in Papillary Thyroid Carcinoma.
GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours.
Macrofollicular variant follicular thyroid tumors are DICER1 mutated and exhibit distinct histological features.
Macrofollicular Variant of Follicular Thyroid Carcinoma (MV-FTC) with a Somatic DICER1 Gene Mutation: Case Report and Review of the Literature.
Predominant DICER1 Pathogenic Variants in Pediatric Follicular Thyroid Carcinomas.
Adenocarcinoma, Mucinous
An Unusual Enteric Yolk Sac Tumor: First Report of an Ovarian Germ Cell Tumor Associated With a Germline Pathogenic Variant in DICER1.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Adenoma
Clinical and functional impact of TARBP2 over-expression in adrenocortical carcinoma.
Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma.
Predominant DICER1 Pathogenic Variants in Pediatric Follicular Thyroid Carcinomas.
Adenomatous Polyposis Coli
Familial non-medullary thyroid cancer: unraveling the genetic maze.
Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors.
Adenosarcoma
DICER1 mutations are frequent in müllerian adenosarcomas and are independent of rhabdomyosarcomatous differentiation.
DICER1-associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: Pathology, molecular genetics, and indications for molecular testing.
Endometrial adenosarcoma in the setting of a germline DICER1 mutation: A case report.
Endometrial Stem/Progenitor cell (ES/PC) Marker Expression Profile in Adenosarcoma and Endometrial Stromal Sarcoma.
Significantly greater prevalence of DICER1 alterations in uterine embryonal rhabdomyosarcoma compared to adenosarcoma.
Adrenocortical Carcinoma
Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma.
Agenesis of Corpus Callosum
Biallelic PMS2 Mutation and Heterozygous DICER1 Mutation Presenting as Constitutional Mismatch Repair Deficiency With Corpus Callosum Agenesis: Case Report and Review of Literature.
Alphavirus Infections
Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma.
Alzheimer Disease
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via A?42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression.
Exercise-mediated alteration of hippocampal Dicer mRNA and miRNAs is associated with lower BACE1 gene expression and A?1-42 in female 3xTg-AD mice.
p38 MAPK-mediated loss of nuclear RNase III enzyme Drosha underlies amyloid beta-induced neuronal stress in Alzheimer's disease.
Anaphylaxis
Global microRNA expression is essential for murine mast cell development in vivo.
Anemia
Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.
Arthritis
Reduced DICER1 expression bestows rheumatoid arthritis synoviocytes proinflammatory properties and resistance to apoptotic stimuli.
Transcriptome study of differential expression in schizophrenia.
Arthritis, Rheumatoid
DICER and DROSHA gene expression in peripheral mononuclear blood cells from rheumatoid arthritis patients under methotrexate therapy.
DICER1: A Key Player in Rheumatoid Arthritis, at the Crossroads of Cellular Stress, Innate Immunity, and Chronic Inflammation in Aging.
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
Expression of Dicer in rheumatoid arthritis is associated with disease activity and balances the production of TNF??.
Reduced DICER1 expression bestows rheumatoid arthritis synoviocytes proinflammatory properties and resistance to apoptotic stimuli.
Asthma
CEACAM3 decreases asthma exacerbations and modulates respiratory syncytial virus latent infection in children.
Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes.
Outcome of two pairs of monozygotic twins with pleuropulmonary blastoma: case report.
Astrocytoma
Markers of mRNA stabilization and degradation, and RNAi within astrocytoma GW bodies.
Ataxia
Cerebellar neurodegeneration in the absence of microRNAs.
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration.
The deletion of dicer in mature myelinating glial cells causes progressive axonal degeneration but not overt demyelination in adult mice.
Ataxia Telangiectasia
Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB.
Atherosclerosis
Correction to: Dicer in Macrophages Prevents Atherosclerosis by Promoting Mitochondrial Oxidative Metabolism.
Corrigendum: Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4.
Dicer in Macrophages Prevents Atherosclerosis by Promoting Mitochondrial Oxidative Metabolism.
Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4.
Autoimmune Diseases
Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease.
Evidence for microRNA-mediated regulation in rheumatic diseases.
Avian Leukosis
Development of a new duplex real-time polymerase chain reaction assay for detection of dicer in G. gallus.
Azoospermia
Association of rs1057035polymorphism in microRNA biogenesis pathway gene (DICER1) with azoospermia among Iranian population.
Research advances of Dicer in regulating reproductive function.
The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis.
[Association of polymorphisms of miRNA biogenesis related genes DICER and DROSHA with azoospermia].
Bacterial Infections
Dual-action of thermoresponsive gels containing DsiRNA-loaded gold nanoparticles for diabetic wound therapy: Characterization, in vitro safety and healing efficacy.
Basal Cell Nevus Syndrome
Gynecological lesions in hereditary cancer predisposition syndromes.
Beckwith-Wiedemann Syndrome
Germline predisposition to genitourinary rhabdomyosarcoma.
Bicuspid Aortic Valve Disease
Genetic polymorphisms of miRNA machinery genes in bicuspid aortic valve and associated aortopathy.
Blindness
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation.
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Bloom Syndrome
Contribution of domain structure to the RNA 3' end processing and degradation functions of the nuclear exosome subunit Rrp6p.
Recent advances in Wilms tumor predisposition.
Bone Marrow Failure Disorders
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.
Bone Resorption
Impaired micro-RNA pathways diminish osteoclast differentiation and function.
Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption.
Brain Injuries, Traumatic
Increased miR-21-3p in injured brain microvascular endothelial cells following traumatic brain injury aggravates blood-brain barrier damage by promoting cellular apoptosis and inflammation through targeting MAT2B.
Brain Neoplasms
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Breast Neoplasms
A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.
A dual role of miR-22 modulated by RelA/p65 in resensitizing fulvestrant-resistant breast cancer cells to fulvestrant by targeting FOXP1 and HDAC4 and constitutive acetylation of p53 at Lys382.
Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression.
Amplification of Hsa-miR-191/425 Locus Promotes Breast Cancer Proliferation and Metastasis by Targeting DICER1.
Cellular Delivery of siRNAs Using Bolaamphiphiles.
Complexity in Regulation of microRNA Machinery Components in Invasive Breast Carcinoma.
Complexity in the regulation of Dicer expression: Dicer variant proteins are differentially expressed in epithelial and mesenchymal breast cancer cells and decreased during EMT.
Concordant and Discordant Regulation of Target Genes by miR-31 and Its Isoforms.
Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer.
Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL.
Dicer expression in estrogen receptor-positive versus triple-negative breast cancer: an antibody comparison.
Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells.
Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer.
Dysregulated Expression of Dicer and Drosha in Breast Cancer.
Dysregulated expression of Dicer in invasive ductal breast carcinoma.
Evaluation of genetic variants in microRNA biosynthesis genes and risk of breast cancer in Chinese women.
Expression of Dicer and Drosha in triple-negative breast cancer.
Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis.
Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.
Germline mutations of DICER1 in Chinese women with BRCA1/BRCA2-negative familial breast cancer.
Hippo/MST blocks breast cancer by downregulating WBP2 oncogene expression via miRNA processor Dicer.
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.
Hypoxia represses microRNA biogenesis proteins in breast cancer cells.
Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells.
Identification of aberrantly methylated differentially expressed genes in breast cancer by integrated bioinformatics analysis.
Impaired expression of Drosha in breast cancer.
Impaired MicroRNA Processing Facilitates Breast Cancer Cell Invasion by Upregulating Urokinase-Type Plasminogen Activator Expression.
Knockdown of Dicer in MCF-7 human breast carcinoma cells results in G1 arrest and increased sensitivity to cisplatin.
Loss of Dicer expression is associated with breast cancer progression and recurrence.
Metastasis suppression: a role of the Dice(r).
MicroRNA related polymorphisms and breast cancer risk.
MicroRNAs Link Estrogen Receptor Alpha Status and Dicer Levels in Breast Cancer.
MiR-18a upregulation decreases Dicer expression and confers paclitaxel resistance in triple negative breast cancer.
MiR-208a stimulates the cocktail of SOX2 and ?-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1.
miR-559 polymorphism rs58450758 is linked to breast cancer.
miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis.
mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer.
Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Prognostic significance of deregulated dicer expression in breast cancer.
Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype.
Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods.
Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators.
Retraction: Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL.
The Effect of (E)-1-(4'-aminophenyl)-3-phenylprop-2-en-1-one on MicroRNA-18a, Dicer1, and MMP-9 Expressions against DMBA-Induced Breast Cancer.
The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer.
The microRNA maturation regulator Drosha is an independent predictor of outcome in breast cancer patients.
Bronchopulmonary Sequestration
Extending the phenotypes associated with DICER1 mutations.
Carcinogenesis
A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report.
A Positive Feedback Loop Between DICER1 and Differentiation Transcription Factors Is Important for Thyroid Tumorigenesis.
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.
Aberrant expression of cyclin D1 in cancer.
Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
Absence of mature microRNAs inactivates the response of gene expression to carcinogenesis induced by N-ethyl-N-nitrosourea in mouse liver.
Analyzing the Role of DICER1 Germline Variations in Papillary Thyroid Carcinoma.
Association between genetic variants in DICER1 and cancer risk: An updated meta-analysis.
Cell survival is dicey without Dicer.
Clinical Characteristics and Mutation Analyses of Ovarian Sertoli-Leydig Cell Tumors.
Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.
Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy.
Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice.
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Dicer regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1.
Dicer suppresses cytoskeleton remodeling and tumorigenesis of colorectal epithelium by miR-324-5p mediated suppression of HMGXB3 and WASF-2.
Dicer1 functions as a haploinsufficient tumor suppressor.
DICER1 mutations are frequent in müllerian adenosarcomas and are independent of rhabdomyosarcomatous differentiation.
DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.
Down-regulation of Dicer expression in cervical cancer tissues.
Downregulation of Dicer enhances tumor cell proliferation and invasion.
Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma.
Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity.
Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma.
Expression of Dicer and Its Related MiRNAs in the Progression of Prostate Cancer.
GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours.
Germline and somatic DICER1 mutations in familial and sporadic liver tumors.
Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels.
Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree.
Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis.
Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.
MicroRNA Processing Gene Methylation and Cancer Risk.
MicroRNAs in Neural Stem Cells and Neurogenesis.
MicroRNAs in thyroid development, function and tumorigenesis.
miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma.
Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Predominant DICER1 Pathogenic Variants in Pediatric Follicular Thyroid Carcinomas.
Prognostic significance of Dicer expression in hepatocellular carcinoma.
Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype.
Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.
Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study.
Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour.
Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis.
RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer.
Rolling the dice to discover the role of DICER in tumorigenesis.
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.
Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in DICER1 syndrome: a unique variant of the two-hit tumor suppression model.
The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities.
The paradox of dicer in cancer.
The polymorphic terminal-loop of pre-miR-1307 binding with MBNL1 contributes to colorectal carcinogenesis via interference with Dicer1 recruitment.
The role of dicer in DNA damage repair.
Unique Haploinsufficient Role of the MicroRNA-Processing Molecule Dicer1 in a Murine Colitis-Associated Tumorigenesis Model.
Carcinoma
A low dicer expression is associated with resistance to 5-FU-based chemoradiotherapy and a shorter overall survival in patients with oral squamous cell carcinoma.
A precursor microRNA in a cancer cell nucleus: Get me out of here!
Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients.
An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression.
Argonaute, Dicer, and Drosha are up-regulated along tumor progression in serous ovarian carcinoma.
Clinical and functional impact of TARBP2 over-expression in adrenocortical carcinoma.
Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.
Development of a metastatic fluorescent Lewis Lung carcinoma mouse model: identification of mRNAs and microRNAs involved in tumor invasion.
Diagnostic and Prognostic Potential of MicroRNA Maturation Regulators Drosha, AGO1 and AGO2 in Urothelial Carcinomas of the Bladder.
Dicer ablation promotes a mesenchymal and invasive phenotype in bladder cancer cells.
Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice.
Dicer is down-regulated in clear cell renal cell carcinoma and in vitro Dicer knockdown enhances malignant phenotype transformation.
Dicer protein levels elevated by mild hyperthermia promote a pro-survival phenotype.
Dicer Sequencing, Whole Genome Methylation Profiling, mRNA and smallRNA Sequencing Analysis in Basal Cell Carcinoma.
Dicer suppresses MMP-2-mediated invasion and VEGFA-induced angiogenesis and serves as a promising prognostic biomarker in human clear cell renal cell carcinoma.
Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2?.
DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma.
DICER1 syndrome can mimic different genetic tumor predispositions.
Down-regulation of Dicer in hepatocellular carcinoma.
Downregulation of Dicer, a component of the microRNA machinery, in bladder cancer.
Dysregulation of the miRNA biogenesis components DICER1, DROSHA, DGCR8 and AGO2 in clear cell renal cell carcinoma in both a Korean cohort and the cancer genome atlas kidney clear cell carcinoma cohort.
EIF2C, Dicer, and Drosha are up-regulated along tumor progression and associated with poor prognosis in bladder carcinoma.
Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas.
Functional evidence that Drosha overexpression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles.
GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours.
Generation of Self-Inhibitory Recombinant Viral Hemorrhagic Septicemia Virus (VHSV) by Insertion of Viral P Gene-Targeting Artificial MicroRNA into Viral Genome and Effect of Dicer Gene Knockout on the Recombinant VHSV Replication.
Genetic polymorphisms of microRNA machinery genes predict overall survival of esophageal squamous carcinoma.
Genetic profiling of rhabdomyosarcoma with clinicopathological and radiological correlation.
Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population.
Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels.
Gynecological lesions in hereditary cancer predisposition syndromes.
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
High-grade serous ovarian cancer arises from fallopian tube in a mouse model.
Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder.
Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma.
MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF.
Metachronous anaplastic sarcoma of the kidney and thyroid follicular carcinoma as manifestations of DICER1 abnormalities.
miR-122 Promotes Metastasis of Clear-Cell Renal Cell Carcinoma by Downregulating Dicer.
miRNA profiling along tumor progression in ovarian carcinoma.
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells.
Overexpression of Dicer in precursor lesions of lung adenocarcinoma.
Pediatric Renal Tumors: Updates in the Molecular Era.
Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins.
Prognostic significance of Dicer expression in ovarian cancer-link to global microRNA changes and oestrogen receptor expression.
Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators.
RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer.
Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis.
Sertoli-Leydig cell tumor, thyroid follicular carcinoma and rhabdomyosarcoma of the uterine cervix in a prepubertal girl with pathogenic germline variant in DICER1 gene.
Silencing Dicer expression enhances cellular proliferative and invasive capacities in human tongue squamous cell carcinoma.
Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma.
[A negative correlation between Drosha expression and gastric adenocarcinoma malignancy and invasion].
Carcinoma, Basal Cell
Dicer Sequencing, Whole Genome Methylation Profiling, mRNA and smallRNA Sequencing Analysis in Basal Cell Carcinoma.
DICER1 syndrome can mimic different genetic tumor predispositions.
Gynecological lesions in hereditary cancer predisposition syndromes.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Carcinoma, Ductal
The microRNA maturation regulator Drosha is an independent predictor of outcome in breast cancer patients.
Carcinoma, Hepatocellular
A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT.
Ablation of Dicer leads to widespread perturbation of signaling pathways.
Corrigendum to "Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells" [383 (2016) 282-294].
Down-regulation of Dicer in hepatocellular carcinoma.
Genetic variant in DICER gene is associated with prognosis of hepatocellular carcinoma in a Chinese cohort.
Germline and somatic DICER1 mutations in familial and sporadic liver tumors.
Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells.
Hypoxia causes down-regulation of Dicer in hepatocellular carcinoma, which is required for up-regulation of hypoxia inducible factor 1? and epithelial-mesenchymal transition.
microRNA-18a Promotes Cell Migration and Invasion Through Inhibiting Dicer l Expression in Hepatocellular Carcinoma In Vitro.
Prognostic significance of Dicer expression in hepatocellular carcinoma.
RNA-binding protein AUF1 suppresses miR-122 biogenesis by down-regulating Dicer1 in hepatocellular carcinoma.
The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.
Variation in the Dicer and RAN Genes Are Associated with Survival in Patients with Hepatocellular Carcinoma.
Carcinoma, Intraductal, Noninfiltrating
Loss of Dicer expression is associated with breast cancer progression and recurrence.
The microRNA maturation regulator Drosha is an independent predictor of outcome in breast cancer patients.
Carcinoma, Lewis Lung
Development of a metastatic fluorescent Lewis Lung carcinoma mouse model: identification of mRNAs and microRNAs involved in tumor invasion.
Carcinoma, Mucoepidermoid
Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression.
Carcinoma, Non-Small-Cell Lung
Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer.
DICER activates autophagy and promotes cisplatin resistance in non-small cell lung cancer by binding with let-7i-5p.
DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification.
Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival.
Reduced expression of Dicer associated with poor prognosis in lung cancer patients.
Carcinoma, Ovarian Epithelial
Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression.
Dicer affects cisplatin?mediated apoptosis in epithelial ovarian cancer cells.
Dicer, Drosha, and outcomes in patients with ovarian cancer.
miR-98-5p contributes to cisplatin resistance in epithelial ovarian cancer by suppressing miR-152 biogenesis via targeting Dicer1.
The dicey role of Dicer: implications for RNAi therapy.
Carcinoma, Renal Cell
Dicer is down-regulated in clear cell renal cell carcinoma and in vitro Dicer knockdown enhances malignant phenotype transformation.
Dicer suppresses MMP-2-mediated invasion and VEGFA-induced angiogenesis and serves as a promising prognostic biomarker in human clear cell renal cell carcinoma.
Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2?.
Dysregulation of the miRNA biogenesis components DICER1, DROSHA, DGCR8 and AGO2 in clear cell renal cell carcinoma in both a Korean cohort and the cancer genome atlas kidney clear cell carcinoma cohort.
Gynecological lesions in hereditary cancer predisposition syndromes.
miR-122 Promotes Metastasis of Clear-Cell Renal Cell Carcinoma by Downregulating Dicer.
Pediatric Renal Tumors: Updates in the Molecular Era.
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Carcinoma, Small Cell
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Carcinoma, Squamous Cell
Functional evidence that Drosha overexpression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles.
Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels.
Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells.
Overexpression of Dicer in precursor lesions of lung adenocarcinoma.
Silencing Dicer expression enhances cellular proliferative and invasive capacities in human tongue squamous cell carcinoma.
Carcinoma, Transitional Cell
Downregulation of Dicer, a component of the microRNA machinery, in bladder cancer.
Carcinosarcoma
A rare malignant thyroid carcinosarcoma with aggressive behavior and DICER1 gene mutation: a case report with literature review.
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.
DICER1 mutations are frequent in müllerian adenosarcomas and are independent of rhabdomyosarcomatous differentiation.
Mutational and Immunophenotypic Profiling of a Series of 8 Tubo-ovarian Carcinosarcomas Revealed a Monoclonal Origin of the Disease.
Cardiomyopathies
Differential Expression of Dicer, miRNAs, and Inflammatory Markers in Diabetic Ins2+/- Akita Hearts.
miR-1 mediated suppression of Sorcin regulates myocardial contractility through modulation of Ca(2+) signaling.
Suppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction.
Cardiomyopathy, Dilated
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.
Cardiovascular Abnormalities
Loss of MicroRNAs in Neural Crest Leads to Cardiovascular Syndromes Resembling Human Congenital Heart Defects.
Cardiovascular Diseases
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
MicroRNAs Are Involved in Homocysteine-Induced Cardiac Remodeling.
Carney Complex
Familial non-medullary thyroid cancer: unraveling the genetic maze.
Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors.
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
The clinical aspects of pituitary tumour genetics.
Cerebellar Neoplasms
Loss of H3K27me3 and nuclear expression of TLE1 in primary intracranial sarcoma, DICER1-mutant.
Cholangiocarcinoma
CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma.
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Choroidal Neovascularization
Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice.
Cleft Lip
Genetic variants of microRNA processing genes and risk of non-syndromic orofacial clefts.
Colitis
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.
Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis.
Colonic Neoplasms
3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.
A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.
Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients.
Dicer regulates non-homologous end joining and is associated with chemosensitivity in colon cancer patients.
DICER1 and PRKRA in Colon Adenocarcinoma.
Dicer1 Promotes Colon Cancer Cell Invasion and Migration Through Modulation of tRF-20-MEJB5Y13 Expression Under Hypoxia.
Impaired DICER1 function promotes stemness and metastasis in colon cancer.
Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A(DCAF1) to promote colon cancer development.
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs.
Regulation of coagulation factor XI expression by microRNAs in the human liver.
Role of Dicer in regulating oxaliplatin resistance of colon cancer cells.
Colorectal Neoplasms
3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.
A distinct expression pattern of the long 3'-untranslated region dicer mRNA and its implications for posttranscriptional regulation in colorectal cancer.
Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression.
Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients.
Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells.
Dicer and Drosha expression and response to Bevacizumab-based therapy in advanced colorectal cancer patients.
Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients.
Dicer suppresses cytoskeleton remodeling and tumorigenesis of colorectal epithelium by miR-324-5p mediated suppression of HMGXB3 and WASF-2.
DICER1-AS1 Promotes the Malignant Behaviors of Colorectal Cancer Cells by Regulating miR-296-5p/STAT3 Axis.
Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A?>?G Polymorphism Relative to Colorectal Cancer Risk.
Differences in the Drosha and Dicer Cleavage Profiles in Colorectal Cancer and Normal Colon Tissue Samples.
Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer.
Evaluating genomic biomarkers associated with resistance or sensitivity to chemotherapy in patients with advanced breast and colorectal cancer.
Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas.
Impaired DICER1 function promotes stemness and metastasis in colon cancer.
MicroRNA-103 promotes colorectal cancer by targeting tumor suppressor DICER and PTEN.
MicroRNA-143 is a putative predictive factor for the response to fluoropyrimidine-based chemotherapy in patients with metastatic colorectal cancer.
miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma.
Overexpression of Dicer predicts poor survival in colorectal cancer.
Single-nucleotide polymorphisms of microRNA processing machinery genes and risk of colorectal cancer.
The colorectal microRNAome.
Colorectal Neoplasms, Hereditary Nonpolyposis
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs.
The clinical aspects of pituitary tumour genetics.
Coronary Artery Disease
Influence of genetic polymorphisms in DICER and XPO5 genes on the risk of coronary artery disease and circulating levels of vascular miRNAs.
Costello Syndrome
Germline predisposition to genitourinary rhabdomyosarcoma.
COVID-19
The relative expression of miR-31, miR-29, miR-126, and miR-17 and their mRNA targets in the serum of COVID-19 patients with different grades during hospitalization.
Cystadenoma, Papillary
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Cysts
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1.
Current Management of Pleuropulmonary Blastoma: A Surgical Perspective.
Deletion of Dicer in somatic cells of the female reproductive tract causes sterility.
Diagnosis and Treatment of Pleuropulmonary Blastoma in Children: A Single-Center Report of 41 Cases.
Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney.
DICER1 mutations in twelve Chinese patients with pleuropulmonary blastoma.
Evolution of Renal Cysts to Anaplastic Sarcoma of Kidney in a Child With DICER1 Syndrome.
Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome.
Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma.
Hotspot mutations in DICER1 causing GLOW Syndrome-associated macrocephaly via modulation of specific microRNA populations results in activation of PI3K/ATK/mTOR signaling.
Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.
Lung cyst and multinodular thyroid goiter: Keys to DICER1 syndrome diagnosis in a 16-year-old female.
MicroRNAs regulate renal tubule maturation through modulation of Pkd1.
Multiple DICER1-related tumors in a child with a large interstitial 14q32 deletion.
Mutiple DICER1-related lesions associated with a germline deep intronic mutation.
Stem cell division is regulated by the microRNA pathway.
Unraveling the Mechanistic Complexity of the Glomerulocystic Phenotype in Dicer Conditional KO Mice by 2D Gel Electrophoresis Coupled Mass Spectrometry.
Unusual phenotypes in patients with a pathogenic germline variant in DICER1.
Demyelinating Diseases
Dicer ablation in oligodendrocytes provokes neuronal impairment in mice.
Dicer Deletion in Astrocytes Inhibits Oligodendroglial Differentiation and Myelination.
The deletion of dicer in mature myelinating glial cells causes progressive axonal degeneration but not overt demyelination in adult mice.
Dengue
Drosha, DGCR8, and Dicer mRNAs are down-regulated in human cells infected with dengue virus 4, and play a role in viral pathogenesis.
Letter to the Editor "Drosha, DGCR8, and Dicer mRNAs are downregulated in human cells infected with dengue virus 4" - Genet. Mol. Res. 15 (2): gmr.15027891 - Drosha, Dicer, and TRBP mRNA are downregulated in Vero cells with the 3'UTR of Dengue virus.
Rapid intraspecific evolution of miRNA and siRNA genes in the mosquito Aedes aegypti.
Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor.
Specificity of resistance to dengue virus isolates is associated with genotypes of the mosquito antiviral gene Dicer-2.
Dermatitis, Atopic
Aggravated TSLP-Induced Atopic Dermatitis in Mice Lacking Dicer in Adult Skin Keratinocytes.
Diabetes Mellitus
Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population.
Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus.
Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence.
Diabetes Mellitus, Type 2
Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population.
Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes.
Diabetes, Gestational
Upregulation of microRNA processing enzymes Drosha and Dicer in gestational diabetes mellitus.
Diabetic Angiopathies
Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population.
Diabetic Cardiomyopathies
Differential Expression of Dicer, miRNAs, and Inflammatory Markers in Diabetic Ins2+/- Akita Hearts.
DiGeorge Syndrome
'Black sheep' that don't leave the double-stranded RNA-binding domain fold.
A microRNA expression signature of osteoclastogenesis.
CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.
Complexity in Regulation of microRNA Machinery Components in Invasive Breast Carcinoma.
Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation.
DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2.
Distinct requirements of microRNAs in NK cell activation, survival, and function.
Endo-siRNA deficiency results in oocyte maturation failure and apoptosis in porcine oocytes.
Expression of DGCR8-Dependent MicroRNAs Is Indispensable for Osteoclastic Development and Bone-Resorbing Activity.
In vitro and in vivo assays for the activity of drosha complex.
MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex.
MicroRNA biogenesis and cancer.
MicroRNA biogenesis: isolation and characterization of the microprocessor complex.
MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.
Noncanonical functions of microRNA pathway enzymes - Drosha, DGCR8, Dicer and Ago proteins.
Overexpression of Drosha, DiGeorge syndrome critical region gene 8 (DGCR8), and Dicer mRNAs in the pathogenesis of psoriasis.
Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients.
Processing of microRNA primary transcripts requires heme in mammalian cells.
Processing of virus-derived cytoplasmic primary-microRNAs.
RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells.
The Microprocessor complex mediates the genesis of microRNAs.
Double Outlet Right Ventricle
Loss of MicroRNAs in Neural Crest Leads to Cardiovascular Syndromes Resembling Human Congenital Heart Defects.
miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation.
Embolism
The RNA-Binding Protein DDX18 Promotes Gastric Cancer by Affecting the Maturation of MicroRNA-21.
Encephalitis
Increased Viral Dissemination in the Brain and Lethality in MCMV-Infected, Dicer-Deficient Neonates.
Encephalomyelitis
The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.
Encephalomyelitis, Autoimmune, Experimental
The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.
Encephalomyelitis, Venezuelan Equine
Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.
Enchondromatosis
Genetics and genomics of ovarian sex cord-stromal tumors.
Endodermal Sinus Tumor
An Unusual Enteric Yolk Sac Tumor: First Report of an Ovarian Germ Cell Tumor Associated With a Germline Pathogenic Variant in DICER1.
Endometrial Neoplasms
Dicer1 dysfunction promotes stemness and aggression in endometrial carcinoma.
DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma.
DICER1 regulates endometrial carcinoma invasion via histone acetylation and methylation.
Genetic variants in the microRNA machinery gene (Dicer) have a prognostic value in the management of endometrial cancer.
Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer.
MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review.
miR-130b is an EMT-related microRNA that targets DICER1 for aggression in endometrial cancer.
Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma.
Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells.
The prevalence of germline DICER1 pathogenic variation in cancer populations.
Endometriosis
DROSHA rs10719 and DICER1 rs3742330 polymorphisms in endometriosis and different diseases: Case-control and review studies.
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
Enzootic Bovine Leukosis
Identification of tri-phosphatase activity in the biogenesis of retroviral microRNAs and RNAP III-generated shRNAs.
Epilepsy
Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis.
Epilepsy, Temporal Lobe
Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis.
Esophageal Neoplasms
miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression.
Esophageal Squamous Cell Carcinoma
Genetic polymorphisms of microRNA machinery genes predict overall survival of esophageal squamous carcinoma.
Eye Diseases
DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation.
Fanconi Anemia
Dicer prevents genome instability in response to replication stress.
Recent advances in Wilms tumor predisposition.
Fatty Liver
Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis.
Fibrosarcoma
Genomics of a pediatric ovarian fibrosarcoma. Association with the DICER1 syndrome.
Primary Lung Tumors in Children: Radiologic-Pathologic Correlation From the Radiologic Pathology Archives.
Fibrous Dysplasia, Polyostotic
An update on the genetics of benign pituitary adenomas in children and adolescents.
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
The clinical aspects of pituitary tumour genetics.
Foot-and-Mouth Disease
Autophagic degradation of SQSTM1 inhibits ovarian cancer motility by decreasing DICER1 and AGO2 to induce MIRLET7A-3P.
Fragile X Syndrome
Involvement of FMRP in Primary MicroRNA Processing via Enhancing Drosha Translation.
The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer.
Frontotemporal Dementia
Drosha Inclusions Are New Components of Dipeptide-Repeat Protein Aggregates in FTLD-TDP and ALS C9orf72 Expansion Cases.
Frontotemporal Lobar Degeneration
Drosha Inclusions Are New Components of Dipeptide-Repeat Protein Aggregates in FTLD-TDP and ALS C9orf72 Expansion Cases.
Gardner Syndrome
Familial non-medullary thyroid cancer: unraveling the genetic maze.
Gastritis
Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.
Gastrointestinal Neoplasms
Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma.
Genetic Diseases, Inborn
DICER1 screening in 15 paediatric paratesticular sarcomas unveils an unusual DICER1-associated sarcoma.
DICER1 Syndrome: DICER1 Mutations in Rare Cancers.
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
Primary Biphasic Hepatic Sarcoma in DICER1 Syndrome.
Secondary Sarcomas: Biology, Presentation, and Clinical Care.
Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group.
Geographic Atrophy
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation.
DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.
Glioblastoma
DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma.
Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1.
MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF.
miRNA-independent function of long noncoding pri-miRNA loci.
Regulation of p27Kip1 by miRNA 221/222 in glioblastoma.
The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome.
The QKI-5 and QKI-6 RNA Binding Proteins Regulate the Expression of MicroRNA 7 in Glial Cells.
[The effect of silencing Dicer by small interferance RNA on the biological characteristics of human glioma cells.]
Glioma
DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma.
Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1.
[The effect of silencing Dicer by small interferance RNA on the biological characteristics of human glioma cells.]
Goiter
A family with Sertoli-Leydig cell tumour, multinodular goiter, and DICER1 mutation.
A Genome-First Approach to Characterize DICER1 Pathogenic Variant Prevalence, Penetrance, and Phenotype.
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report.
DICER1 Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association.
DICER1 mutations in a patient with an ovarian Sertoli-Leydig tumor, well-differentiated fetal adenocarcinoma of the lung, and familial multinodular goiter.
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.
DICER1 Syndrome and Cancer Predisposition: From a Rare Pediatric Tumor to Lifetime Risk.
DICER1 syndrome can mimic different genetic tumor predispositions.
DICER1 Syndrome.
Extending the phenotypes associated with DICER1 mutations.
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame
Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides.
Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree.
Intrathyroidal Thymus (Incidentaloma) Mimicking Thyroid Neoplasia in DICER1 Syndrome.
Lung cyst and multinodular thyroid goiter: Keys to DICER1 syndrome diagnosis in a 16-year-old female.
MicroRNAs in thyroid development, function and tumorigenesis.
Multinodular Goiter in Children: an Important Pointer to a Germline DICER1 Mutation.
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Mutiple DICER1-related lesions associated with a germline deep intronic mutation.
Novel DICER1 mutation as cause of multinodular goiter in children.
Ovarian embryonal rhabdomyosarcoma is a rare manifestation of the DICER1 syndrome.
Ovarian Sertoli-Leydig Cell Tumor, Multinodular Goiter, Cystic Nephromas and DICER1 Mutations: Case Report and Literature Review.
Ovarian tumors related to intronic mutations in DICER1: a report from the international ovarian and testicular stromal tumor registry.
Prevalence and Spectrum of DICER1 Mutations in Adult-onset Thyroid Nodules with Indeterminate Cytology.
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study.
Selective dicer suppression in the kidney alters GSK3?/?-catenin pathways promoting a glomerulocystic disease.
THYROCYTE-SPECIFIC DICER1 DEFICIENCY ALTERS THYROID FOLLICULAR ORGANIZATION AND PREVENTS GOITER DEVELOPMENT.
Unusual phenotypes in patients with a pathogenic germline variant in DICER1.
[Hereditary predispositions to follicular thyroid tumors].
Granulosa Cell Tumor
An immunohistochemical and molecular analysis of problematic and unclassified ovarian sex cord-stromal tumors.
DICER1 hot-spot mutations in ovarian gynandroblastoma.
Ovarian sex cord-stromal tumours: an update in recent molecular advances.
Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli-Leydig cell tumour, microcystic stromal tumour and their mimics.
Rare DICER1 and Absent FOXL2 Mutations Characterize Ovarian Juvenile Granulosa Cell Tumors.
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT) Commonly Exhibits Positivity With Sex Cord Markers FOXL2 and SF-1 but Lacks FOXL2 and DICER1 Mutations.
[Application of molecular analysis in differential diagnosis of ovarian adult granulosa cell tumors].
Graves Disease
DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases.
Hamartoma
DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.
DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome: a unique constellation of neoplastic conditions.
Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides.
Imaging of DICER1 syndrome.
Mesenchymal Hamartoma of the Liver and DICER1 Syndrome.
Mesenchymal Hamartoma of the Liver and DICER1 Syndrome. Reply.
Nasal chondromesenchymal hamartomas arise secondary to germline and somatic mutations of DICER1 in the pleuropulmonary blastoma tumor predisposition disorder.
Nasal chondromesenchymal hamartomas in a cohort with pathogenic germline variation in DICER1.
Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome.
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
THE "-OMAS" and "-OPIAS":  Targeted and Philosophical Considerations Regarding Hamartomas, Choristomas, Teratomas, Ectopias, and Heterotopias in Pediatric Otorhinolaryngologic Pathology.
Hamartoma Syndrome, Multiple
A Case Report of Syndromic Multinodular Goitre in Adolescence: Exploring the Phenotype Overlap between Cowden and DICER1 Syndromes.
Familial non-medullary thyroid cancer: unraveling the genetic maze.
Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors.
Gynecological lesions in hereditary cancer predisposition syndromes.
High Prevalence of DICER1 Mutations and Low Frequency of Gene Fusions in Pediatric Follicular-Patterned Tumors of the Thyroid.
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Hearing Loss, Sensorineural
Dicer Is Down-regulated and Correlated with Drosha in Idiopathic Sudden Sensorineural Hearing Loss.
Heart Defects, Congenital
Individual and joint effects of genetic polymorphisms in microRNA-machinery genes on congenital heart disease susceptibility.
Heart Diseases
ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis.
MicroRNAs as a therapeutic target for cardiovascular diseases.
Heart Failure
Differential Expression of Dicer, miRNAs, and Inflammatory Markers in Diabetic Ins2+/- Akita Hearts.
MicroRNAs as a therapeutic target for cardiovascular diseases.
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.
Heart Septal Defects, Ventricular
Loss of MicroRNAs in Neural Crest Leads to Cardiovascular Syndromes Resembling Human Congenital Heart Defects.
miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation.
Hemangiosarcoma
Biallelic Dicer1 loss mediated by aP2-Cre drives angiosarcoma.
Hematologic Neoplasms
Role of Dicer as a prognostic predictor for survival in cancer patients: a systematic review with a meta-analysis.
Stop the dicing in hematopoiesis: What have we learned?
Hemorrhagic Septicemia, Viral
Generation of Self-Inhibitory Recombinant Viral Hemorrhagic Septicemia Virus (VHSV) by Insertion of Viral P Gene-Targeting Artificial MicroRNA into Viral Genome and Effect of Dicer Gene Knockout on the Recombinant VHSV Replication.
Species specific inhibition of viral replication using dicer substrate siRNAs (DsiRNAs) targeting the viral nucleoprotein of the fish pathogenic rhabdovirus viral hemorrhagic septicemia virus (VHSV).
Hepatitis
Outcome of two pairs of monozygotic twins with pleuropulmonary blastoma: case report.
Resistance of human hepatitis delta virus RNAs to dicer activity.
Hepatitis B
Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV.
MicroRNA-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1.
Hepatitis C
Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies.
Evaluation of Canonical siRNA and Dicer Substrate RNA for Inhibition of Hepatitis C Virus Genome Replication - A Comparative Study.
Refractoriness of hepatitis C virus internal ribosome entry site to processing by Dicer in vivo.
RNase III cleavage demonstrates a long range RNA: RNA duplex element flanking the hepatitis C virus internal ribosome entry site.
Herpes Simplex
Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.
Hidradenitis Suppurativa
Inflammation induced changes in the expression levels of components of the microRNA maturation machinery Drosha, Dicer, Drosha co-factor DGRC8 and Exportin-5 in inflammatory lesions of hidradenitis suppurativa patients.
Hip Dislocation
Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies.
HIV-Associated Lipodystrophy Syndrome
Role of microRNA biogenesis in adipocyte and lipodystrophy.
Hodgkin Disease
Hodgkin lymphoma as a novel presentation of familial DICER1 syndrome.
Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo.
Whole genome sequencing reveals DICER1 as a candidate predisposing gene in familial Hodgkin lymphoma.
Huntington Disease
Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases.
Ribonuclease dicer cleaves triplet repeat hairpins into shorter repeats that silence specific targets.
Hydronephrosis
Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.
Hypercalcemia
Micro-RNAs in the parathyroid: a new portal in understanding secondary hyperparathyroidism.
Hypertension
3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.
rs10719 Polymorphism Located within DROSHA 3'-Untranslated Region is Responsible for Development of Primary Hypertension by Disrupting Binding with microRNA-27b.
Hypertension, Pregnancy-Induced
Genetic variants in DICER1, DROSHA, RAN, and XPO5 genes and risk of pregnancy-induced hypertension.
Hypertriglyceridemia
Altered pattern of circulating miRNAs in HIV lipodystrophy perturbs key adipose differentiation and inflammation pathways.
Hypocalcemia
Parathyroid-specific deletion of dicer-dependent microRNAs abrogates the response of the parathyroid to acute and chronic hypocalcemia and uremia.
Post-transcriptional mechanisms regulating parathyroid hormone gene expression in secondary hyperparathyroidism.
Hypothyroidism
Deletion of the RNaseIII enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations.
The microRNA-processing enzyme Dicer is essential for thyroid function.
THYROCYTE-SPECIFIC DICER1 DEFICIENCY ALTERS THYROID FOLLICULAR ORGANIZATION AND PREVENTS GOITER DEVELOPMENT.
Idiopathic Pulmonary Fibrosis
DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis.
Immune System Diseases
MHC class II regulation by epigenetic agents and microRNAs.
Infarction, Middle Cerebral Artery
Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome.
Infections
A Glimpse of "Dicer Biology" Through the Structural and Functional Perspective.
A single Argonaute gene is required for induction of RNA silencing antiviral defense and promotes viral RNA recombination.
Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination.
Alteration of Escherichia coli RNase D by infection with bacteriophage T4.
An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections.
An Ascovirus-encoded RNase III autoregulates its expression and suppresses RNA interference-mediated gene silencing.
Antiviral RNA interference in mammalian cells.
Characterization of hypovirus-derived small RNAs generated in the chestnut blight fungus by an inducible DCL-2-dependent pathway.
Cleavage of Dicer protein by I7 protease during vaccinia virus infection.
Comprehensive analysis of full genome sequence and Bd-milRNA/target mRNAs to discover the mechanism of hypovirulence in Botryosphaeria dothidea strains on pear infection with BdCV1 and BdPV1.
Comprehensive characterization of viral miRNAs involved in white spot syndrome virus (WSSV) infection.
Cross-species comparative analysis of Dicer proteins during Sindbis virus infection.
Cytoplasmic RNA viruses as potential vehicles for the delivery of therapeutic small RNAs.
Deregulation of Type I IFN-Dependent Genes Correlates with Increased Susceptibility to Cytomegalovirus Acute Infection of Dicer Mutant Mice.
Development of a new duplex real-time polymerase chain reaction assay for detection of dicer in G. gallus.
Dicer regulates Nosema ceranae proliferation in honey bees.
Dicer-2 processes diverse viral RNA species.
Dicer-2- and Piwi-mediated RNA interference in Rift Valley fever virus-infected mosquito cells.
Dicing with viruses: microRNAs as antiviral factors.
Differential Expression of Six Rnase2 and Three Rnase3 Paralogs Identified in Blunt Snout Bream in Response to Aeromonas hydrophila Infection.
Differential expression of small RNA pathway genes associated with the Biomphalaria glabrata/Schistosoma mansoni interaction.
Discovery of Two Mycoviruses by High-Throughput Sequencing and Assembly of Mycovirus-Derived Small Silencing RNAs From a Hypovirulent Strain of Sclerotinia sclerotiorum.
Drosha, DGCR8, and Dicer mRNAs are down-regulated in human cells infected with dengue virus 4, and play a role in viral pathogenesis.
Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Efficient Dicer processing of virus-derived double-stranded RNAs and its modulation by RIG-I-like receptor LGP2.
Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer.
Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila.
Evidence for a cytoplasmic microprocessor of pri-miRNAs.
Evidence for Host Epigenetic Signatures Arising From Arbovirus Infections: A Systematic Review.
Evidence that RNA silencing functions as an antiviral defense mechanism in fungi.
Genetic variability and evolutionary implications of RNA silencing suppressor genes in RNA1 of sweet potato chlorotic stunt virus isolates infecting sweetpotato and related wild species.
HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication.
Human Antimicrobial RNases Inhibit Intracellular Bacterial Growth and Induce Autophagy in Mycobacteria-Infected Macrophages.
Human DICER helicase domain recruits PKR and modulates its antiviral activity.
Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model.
Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.
Immune signaling pathways activated in response to different pathogenic micro-organisms in Bombyx mori.
Infections of virulent and avirulent viruses differentially influenced the expression of dicer-1, ago-1, and microRNAs in Bombus terrestris.
In vivo study of Dicer-2-mediated immune response of the small interfering RNA pathway upon systemic infections of virulent and avirulent viruses in Bombus terrestris.
KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.
Leishmania donovani Targets Dicer1 to Downregulate miR-122, Lower Serum Cholesterol, and Facilitate Murine Liver Infection.
Letter to the Editor "Drosha, DGCR8, and Dicer mRNAs are downregulated in human cells infected with dengue virus 4" - Genet. Mol. Res. 15 (2): gmr.15027891 - Drosha, Dicer, and TRBP mRNA are downregulated in Vero cells with the 3'UTR of Dengue virus.
Mechanism of induction and suppression of antiviral immunity directed by virus-derived small RNAs in Drosophila.
MicroRNAs Modulate Pathogenesis Resulting from Chlamydial Infection in Mice.
Monocyte chemoattractant protein-induced protein 1 directly degrades viral miRNAs with a specific motif and inhibits KSHV infection.
Protective immunity induced by CpG ODNs against white spot syndrome virus (WSSV) via intermediation of virus replication indirectly in Litopenaeus vannamei.
Rapid intraspecific evolution of miRNA and siRNA genes in the mosquito Aedes aegypti.
Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.
RNA interference directs innate immunity against viruses in adult Drosophila.
RNA interference-based antiviral immune response against the salivary gland hypertrophy virus in Glossina pallidipes.
RNA-based immunity terminates viral infection in adult Drosophila in the absence of viral suppression of RNA interference: characterization of viral small interfering RNA populations in wild-type and mutant flies.
Small interfering RNA pathway contributes to antiviral immunity in Spodoptera frugiperda (Sf9) cells following Autographa californica multiple nucleopolyhedrovirus infection.
Small RNA Bidirectional Crosstalk During the Interaction Between Wheat and Zymoseptoria tritici.
Stimuli-dependent cleavage of Dicer during apoptosis.
Suppression of RNA interference by adenovirus virus-associated RNA.
Suppression of RNA interference pathway in vitro by Grass carp reovirus.
Synergistic interactions of begomoviruses with Sweet potato chlorotic stunt virus (genus Crinivirus) in sweet potato (Ipomoea batatas?L.).
The cII-independent expression of the phage lambda int gene in RNase III-defective E. coli.
The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection.
The microRNA pathway is involved in Spodoptera frugiperda (Sf9) cells antiviral immune defense against Autographa californica multiple nucleopolyhedrovirus infection.
The negative regulation of piscine CD44c in viral and bacterial infection.
The preferred route for the degradation of silencing target RNAs in transgenic plants depends on pre-established silencing conditions.
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-? receptor.
Transcriptomic analysis of Macrobrachium rosenbergii (giant fresh water prawn) post-larvae in response to M. rosenbergii nodavirus (MrNV) infection: de novo assembly and functional annotation.
Virus-Mediated Alterations in miRNA Factors and Degradation of Viral miRNAs by MCPIP1.
Yellow Fever Virus Modulates the Expression of Key Proteins Related to the microRNA Pathway in the Human Hepatocarcinoma Cell Line HepG2.
Infertility
CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A†.
Comparative rna-seq analysis of region-specific miRNA expression in the epididymis of cattleyak.
Deletion of Dicer in somatic cells of the female reproductive tract causes sterility.
Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1.
Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects.
High-throughput sequencing reveals differential expression of miRNAs in yak and cattleyak epididymis.
Involvement of miRNAs and Cell-Secreted Vesicles in Mammalian Ovarian Antral Follicle Development.
microRNA 376a Regulates Follicle Assembly by Targeting Pcna in Fetal and Neonatal Mouse Ovaries.
MiR-125b Regulates Primordial Follicle Assembly by Targeting Activin Receptor Type 2a in Neonatal Mouse Ovary.
Next-generation sequencing analysis reveals segmental patterns of microRNA expression in yak epididymis.
Prevention of Chlamydia-induced infertility by inhibition of local caspase activity.
Requirement for ERI/DICER Complex in Endogenous RNAi and Sperm Development in Caenorhabditis elegans.
Sertoli cell Dicer is essential for spermatogenesis in mice.
[Advance on Dicer gene and its role in female reproduction].
Infertility, Female
Deletion of Dicer in somatic cells of the female reproductive tract causes sterility.
Essential Role for Endogenous siRNAs during Meiosis in Mouse Oocytes.
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice.
Murine follicular development requires oocyte DICER, but not DROSHA.
Infertility, Male
Dicer1 is required for differentiation of the mouse male germline.
Genetic variants in microRNA biogenesis pathway genes are associated with semen quality in a Han-Chinese population.
Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility.
microRNAs in the Testis: Building Up Male Fertility.
The role of Dicer1 in the male reproductive tract.
Influenza, Human
Dicer is involved in protection against influenza A virus infection.
Efficient Dicer processing of virus-derived double-stranded RNAs and its modulation by RIG-I-like receptor LGP2.
Influenza A Virus Expresses High Levels of an Unusual Class of Small Viral Leader RNAs in Infected Cells.
Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer.
Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.
Vero cells as a model to study the effects of adenoviral gene delivery vectors on the RNAi system in context of viral infection.
Insulin Resistance
Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy.
Altered pattern of circulating miRNAs in HIV lipodystrophy perturbs key adipose differentiation and inflammation pathways.
Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice.
Recent advances on the role of microRNAs in both insulin resistance and cancer.
Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development.
Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients.
Intellectual Disability
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1.
Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner.
Expression of MicroRNA machinery proteins in different types of chronic rhinosinusitis.
Functional and selective RNA interference in developing axons and growth cones.
The role of PIWI and the miRNA machinery in Drosophila germline determination.
Kidney Failure, Chronic
Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end-stage renal disease.
Kidney Neoplasms
Structural renal abnormalities in the DICER1 syndrome: a family-based cohort study.
Laryngeal Neoplasms
Association of miRNA biosynthesis genes DROSHA and DGCR8 polymorphisms with cancer susceptibility: a systematic review and meta-analysis.
Evaluation of polymorphisms in microRNA biosynthesis genes and risk of laryngeal cancer in the Polish population.
Leiomyoma
Immunohistochemical analysis of the endoribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Leiomyomatosis
Gynecological lesions in hereditary cancer predisposition syndromes.
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Leiomyosarcoma
Immunohistochemical analysis of the endoribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues.
Leukemia
DICER1 gene and miRNA dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia.
Dysfunctional niches as a root of hematopoietic malignancy.
Hematologic indices in individuals with pathogenic germline DICER1 variants.
Overexpression of DICER1 induced by the upregulation of GATA1 contributes to the proliferation and apoptosis of leukemia cells.
Stop the dicing in hematopoiesis: What have we learned?
Leukemia, Lymphocytic, Chronic, B-Cell
Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia.
Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province.
Downregulated Dicer expression predicts poor prognosis in chronic lymphocytic leukemia.
Investigation of AID, Dicer, and Drosha Expressions in Patients with Chronic Lymphocytic Leukemia.
MicroRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells.
Leukemia, Myeloid, Acute
Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia.
Dicer and outcomes in patients with acute myeloid leukemia (AML).
DICER1 gene and miRNA dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia.
Expression and Clinical Significance of ANXA1 and DICER1 in Myelodysplastic Syndromes.
Overexpression of DICER1 induced by the upregulation of GATA1 contributes to the proliferation and apoptosis of leukemia cells.
Leukemia-Lymphoma, Adult T-Cell
Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients.
Leydig Cell Tumor
Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome.
Li-Fraumeni Syndrome
Germline predisposition to genitourinary rhabdomyosarcoma.
Predisposition to pediatric and hematologic cancers: a moving target.
Secondary Sarcomas: Biology, Presentation, and Clinical Care.
Lipodystrophy
Adipose-derived circulating miRNAs regulate gene expression in other tissues.
Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy.
Altered pattern of circulating miRNAs in HIV lipodystrophy perturbs key adipose differentiation and inflammation pathways.
Liposarcoma
Deregulation of dicer and mir-155 expression in liposarcoma.
Liver Cirrhosis
MicroRNA-21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis.
Liver Failure
Amino acid-induced regulation of hepatocyte growth: possible role of Drosha.
Liver Neoplasms
MicroRNA-21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis.
Lung Neoplasms
Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.
Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma.
Concordant and Discordant Regulation of Target Genes by miR-31 and Its Isoforms.
Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer.
Diagnostic value of plasma expression of microRNAs complementary to Drosha and Dicer in lung cancer patients.
DICER activates autophagy and promotes cisplatin resistance in non-small cell lung cancer by binding with let-7i-5p.
DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification.
High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer.
Impaired microRNA processing enhances cellular transformation and tumorigenesis.
MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration.
Predictive value of microRNA let-7a expression for efficacy and prognosis of radiotherapy in patients with lung cancer brain metastasis: A case-control study.
Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival.
Reduced expression of Dicer associated with poor prognosis in lung cancer patients.
rs10719 Polymorphism Located within DROSHA 3'-Untranslated Region is Responsible for Development of Primary Hypertension by Disrupting Binding with microRNA-27b.
Suppression of Dicer Increases Sensitivity to Gefitinib in Human Lung Cancer Cells.
The prevalence of germline DICER1 pathogenic variation in cancer populations.
Usefulness of predictive tests for cancer treatment.
Lyme Disease
RNase III Processing of rRNA in the Lyme Disease Spirochete Borrelia burgdorferi.
Lymphatic Metastasis
Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients.
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
DROSHA rs10719 T>C is associated with lymph node metastasis and clinical stage of gastric cancer patients.
Dysregulated expression of Dicer in invasive ductal breast carcinoma.
Immunohistochemical study of Dicer and Drosha expression in the benign and malignant lesions of gallbladder and their clinicopathological significances.
The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer.
The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer.
The RNA-Binding Protein DDX18 Promotes Gastric Cancer by Affecting the Maturation of MicroRNA-21.
Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma.
[A negative correlation between Drosha expression and gastric adenocarcinoma malignancy and invasion].
Lymphoma
High expression of Dicer reveals a negative prognostic influence in certain subtypes of primary cutaneous T cell lymphomas.
Hodgkin lymphoma as a novel presentation of familial DICER1 syndrome.
Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.
MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival.
Variation in dicer gene is associated with increased survival in T-cell lymphoma.
Lymphoma, B-Cell
Downregulated expression of Dicer1 predicts inferior survival in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.
Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.
Methods for assembling B-cell lymphoma specific and internalizing aptamer-siRNA nanoparticles via the sticky bridge.
MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival.
Lymphoma, Follicular
MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response.
Lymphoma, Large B-Cell, Diffuse
Downregulated expression of Dicer1 predicts inferior survival in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.
Lymphoma, Non-Hodgkin
Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in the Childhood Cancer Survivor Study.
Lymphoma, T-Cell
Variation in dicer gene is associated with increased survival in T-cell lymphoma.
[Association of microRNA-related genes (DROSHA, DICER1 and GEMIN4) polymorphisms with T-cell lymphoma prognosis].
Lymphoma, T-Cell, Cutaneous
Low Drosha protein expression in cutaneous T-cell lymphoma is associated with worse disease outcome.
Lymphopenia
Survival of Naïve T Cells Requires the Expression of Let-7 miRNAs.
Macular Degeneration
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation.
DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Histological Characterization of the Dicer1 Mutant Zebrafish Retina.
Lutein improves cell viability and reduces Alu RNA accumulation in hydrogen peroxide challenged retinal pigment epithelial cells.
Z-DNA and Z-RNA in human disease.
Malaria
Anopheles gambiae miRNAs as actors of defence reaction against Plasmodium invasion.
Characterization of RNA interference in an Anopheles gambiae cell line.
Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population.
Malaria, Cerebral
Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population.
Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children.
Measles
Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.
Medulloblastoma
Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation.
Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.
MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development.
Megalencephaly
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1.
Hotspot mutations in DICER1 causing GLOW Syndrome-associated macrocephaly via modulation of specific microRNA populations results in activation of PI3K/ATK/mTOR signaling.
Macrocephaly associated with the DICER1 syndrome.
Melanoma
ADAR1p150 regulates the biosynthesis and function of miRNA-149* in human melanoma.
Altered expression of the miRNA processing endoribonuclease Dicer has prognostic significance in human cancers.
DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis.
Expression of the RNase III enzyme DROSHA is reduced during progression of human cutaneous melanoma.
Feed-forward microprocessing and splicing activities at a microRNA-containing intron.
Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors.
Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi.
Loss of tumor suppressors KAI1 and p27 identifies a unique subgroup of primary melanoma patients with poor prognosis.
microRNAs exhibit high frequency genomic alterations in human cancer.
Mutation Scanning of D1705 and D1709 in the RNAse IIIb Domain of MicroRNA Processing Enzyme Dicer in Cutaneous Melanoma.
Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells.
Reduced expression of nuclear Dicer correlates with melanoma progression.
Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion.
Stage-specific prognostic biomarkers in melanoma.
The modulation of Dicer regulates tumor immunogenicity in melanoma.
Up-regulated Dicer expression in patients with cutaneous melanoma.
Metabolic Diseases
Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes.
Microcephaly
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus.
The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis.
Microphthalmos
Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development.
Monoclonal Gammopathy of Undetermined Significance
Upregulation of Dicer is more frequent in monoclonal gammopathies of undetermined significance than in multiple myeloma patients and is associated with longer survival in symptomatic myeloma patients.
Mouth Neoplasms
Genetic variations in key microRNA processing genes and risk of head and neck cancer: a case-control study in Chinese population.
Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells.
Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells.
Multiple Endocrine Neoplasia
An update on the genetics of benign pituitary adenomas in children and adolescents.
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
Predisposition to pediatric and hematologic cancers: a moving target.
The clinical aspects of pituitary tumour genetics.
Multiple Endocrine Neoplasia Type 1
An update on the genetics of benign pituitary adenomas in children and adolescents.
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
The clinical aspects of pituitary tumour genetics.
Multiple Myeloma
Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells.
Upregulation of Dicer is more frequent in monoclonal gammopathies of undetermined significance than in multiple myeloma patients and is associated with longer survival in symptomatic myeloma patients.
Multiple Sclerosis
Decreased Dicer expression is linked to increased expression of co-stimulatory molecule CD80 on B cells in multiple sclerosis.
Dicer and microRNA expression in multiple sclerosis and response to interferon therapy.
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients.
Muscle Neoplasms
Immunohistochemical analysis of the endoribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues.
Muscular Atrophy, Spinal
Author Correction: Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy.
Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy.
Muscular Diseases
Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training.
Mycoses
Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling.
Mycosis Fungoides
Low Drosha protein expression in cutaneous T-cell lymphoma is associated with worse disease outcome.
Myelodysplastic Syndromes
DICER1 gene and miRNA dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia.
Down-regulation of Dicer1 promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells in patients with myelodysplastic syndrome.
Evaluating the Effect of 3'-UTR Variants in DICER1 and DROSHA on Their Tissue-Specific Expression by miRNA Target Prediction.
Expression and Clinical Significance of ANXA1 and DICER1 in Myelodysplastic Syndromes.
Hematologic indices in individuals with pathogenic germline DICER1 variants.
Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndromes patients.
Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis.
Myocarditis
ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis.
Myotonic Dystrophy
Ribonuclease dicer cleaves triplet repeat hairpins into shorter repeats that silence specific targets.
Nasal Polyps
Expression of MicroRNA machinery proteins in different types of chronic rhinosinusitis.
Nasopharyngeal Carcinoma
Effects of Dicer1 targeted by EBV-miR-BART6-5p on biological properties and radiosensitivity of nasopharyngeal carcinoma.
IKK?-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy.
miR-18a downregulates DICER1 and promotes proliferation and metastasis of nasopharyngeal carcinoma.
The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma.
Nasopharyngitis
Reduced expression of Dicer11 is associated with poor prognosis in patients with nasopharyngeal carcinoma.
Nematode Infections
RNA interference of an orthologue of Dicer of Meloidogyne incognita alludes to the gene's importance in nematode development.
Neoplasm Metastasis
?-catenin downregulates Dicer to promote ovarian cancer metastasis.
A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.
A MicroRNA targeting dicer for metastasis control.
Ago2 promotes tumor metastasis via upregulating FAK expression in hepatocellular carcinoma.
Amplification of Hsa-miR-191/425 Locus Promotes Breast Cancer Proliferation and Metastasis by Targeting DICER1.
Application of microRNA in diagnosis and treatment of ovarian cancer.
Argonaute, Dicer, and Drosha are up-regulated along tumor progression in serous ovarian carcinoma.
Biallelic Dicer1 loss mediated by aP2-Cre drives angiosarcoma.
Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients.
Comprehensive Analysis of MicroRNA (miRNA) Targets in Breast Cancer Cells.
Corrigendum to "Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells" [383 (2016) 282-294].
Crosstalk between NRF2 and Dicer through metastasis regulating MicroRNAs; Mir-34a, Mir-200 family and mir-103/107 family.
Crosstalk between p53 and TGF-? Signalling.
Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.
Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients.
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Dicer reprograms stromal fibroblasts to a pro-inflammatory and tumor-promoting phenotype in ovarian cancer.
Dicer suppresses MMP-2-mediated invasion and VEGFA-induced angiogenesis and serves as a promising prognostic biomarker in human clear cell renal cell carcinoma.
Down-regulation of Dicer expression in cervical cancer tissues.
Down-regulation of Dicer in hepatocellular carcinoma.
Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer.
DROSHA rs10719 T>C is associated with lymph node metastasis and clinical stage of gastric cancer patients.
Dual mechanism of DICER downregulation facilitates cancer metastasis.
Dysregulated expression of Dicer in invasive ductal breast carcinoma.
Effects of Dicer1 targeted by EBV-miR-BART6-5p on biological properties and radiosensitivity of nasopharyngeal carcinoma.
Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis.
Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells.
HIF-1? promotes autophagic proteolysis of Dicer and enhances tumor metastasis.
Hypoxia-Induced LIN28A mRNA Promotes the Metastasis of Colon Cancer in a Protein-Coding-Independent Manner.
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.
Immunohistochemical study of Dicer and Drosha expression in the benign and malignant lesions of gallbladder and their clinicopathological significances.
Impaired DICER1 function promotes stemness and metastasis in colon cancer.
Impaired expression of Drosha in breast cancer.
In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.
Metastasis suppression: a role of the Dice(r).
Metastasis: It's nicer with DICER.
MicroRNA-107, an Oncogene MicroRNA that Regulates Tumor Invasion and Metastasis By Targeting DICER1 in Gastric Cancer: MiR-107 promotes gastric cancer invasion and metastasis.
MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.
miR-122 Promotes Metastasis of Clear-Cell Renal Cell Carcinoma by Downregulating Dicer.
miR-18a downregulates DICER1 and promotes proliferation and metastasis of nasopharyngeal carcinoma.
Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing.
Mutation Scanning of D1705 and D1709 in the RNAse IIIb Domain of MicroRNA Processing Enzyme Dicer in Cutaneous Melanoma.
NKp46-mediated Dicer1 inactivation results in defective NK-cell differentiation and effector functions in mice.
Oncogene dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.
Predictive value of microRNA let-7a expression for efficacy and prognosis of radiotherapy in patients with lung cancer brain metastasis: A case-control study.
Prognostic significance of Dicer expression in hepatocellular carcinoma.
Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer.
Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype.
Reduced expression of Dicer11 is associated with poor prognosis in patients with nasopharyngeal carcinoma.
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.
The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer.
The microRNA maturation regulator Drosha is an independent predictor of outcome in breast cancer patients.
The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer.
The RNA-Binding Protein DDX18 Promotes Gastric Cancer by Affecting the Maturation of MicroRNA-21.
Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma.
[A negative correlation between Drosha expression and gastric adenocarcinoma malignancy and invasion].
Neoplasm, Residual
Predictive factors for the sensitivity of radiotherapy and prognosis of esophageal squamous cell carcinoma.
Neoplasms
A case of neuroblastoma in DICER1 syndrome: Chance finding or noncanonical causation?
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1.
A Cystic Renal Mass in the Setting of a Pneumothorax: More Than Meets the Eye?
A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.
A family with Sertoli-Leydig cell tumour, multinodular goiter, and DICER1 mutation.
A Genome-First Approach to Characterize DICER1 Pathogenic Variant Prevalence, Penetrance, and Phenotype.
A Japanese Family with DICER1 Syndrome Found in Childhood-Onset Multinodular Goitre.
A low dicer expression is associated with resistance to 5-FU-based chemoradiotherapy and a shorter overall survival in patients with oral squamous cell carcinoma.
A MicroRNA targeting dicer for metastasis control.
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report.
A pair of DICER1-positive monozygotic twins: One with pleuropulmonary blastoma, another with acute transient hepatitis.
A pan-cancer atlas of somatic mutations in miRNA biogenesis genes.
A Positive Feedback Loop Between DICER1 and Differentiation Transcription Factors Is Important for Thyroid Tumorigenesis.
A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
Aberrant splicing in B-cell acute lymphoblastic leukemia.
Ablation of Dicer leads to widespread perturbation of signaling pathways.
Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
Absence of mature microRNAs inactivates the response of gene expression to carcinogenesis induced by N-ethyl-N-nitrosourea in mouse liver.
ADAR and Immune Silencing in Cancer.
Ago2 promotes tumor metastasis via upregulating FAK expression in hepatocellular carcinoma.
Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland.
Altered expression of the miRNA processing endoribonuclease Dicer has prognostic significance in human cancers.
Altered microRNA processing proteins in HPV-induced cancers.
An autopsy case of prostatic rhabdomyosarcoma with DICER1 hotspot mutation.
An immunohistochemical and molecular analysis of problematic and unclassified ovarian sex cord-stromal tumors.
An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression.
An Unusual Enteric Yolk Sac Tumor: First Report of an Ovarian Germ Cell Tumor Associated With a Germline Pathogenic Variant in DICER1.
An update on the central nervous system manifestations of DICER1 syndrome.
An update on the genetics of benign pituitary adenomas in children and adolescents.
Analyzing the Role of DICER1 Germline Variations in Papillary Thyroid Carcinoma.
Anaplastic Sarcoma of the Kidney With Heterologous Ganglioneuroblastic Differentiation: Another DICER1-Associated Tumor.
Anaplastic sarcomas of the kidney are characterized by DICER1 mutations.
Androgen-Secreting Ovarian Tumors.
Argonaute, Dicer, and Drosha are up-regulated along tumor progression in serous ovarian carcinoma.
Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma.
Association between genetic variants in DICER1 and cancer risk: An updated meta-analysis.
Association between the DICER rs1057035 polymorphism and cancer risk: evidence from a meta-analysis of 1,2675 individuals.
Association of miRNA biosynthesis genes DROSHA and DGCR8 polymorphisms with cancer susceptibility: a systematic review and meta-analysis.
ATRX driver mutation in a composite malignant pheochromocytoma.
Autophagic degradation of SQSTM1 inhibits ovarian cancer motility by decreasing DICER1 and AGO2 to induce MIRLET7A-3P.
Being Small and Intronic: miRNAs That Count!
Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma.
Biallelic DICER1 mutations occur in Wilms tumours.
Biallelic Dicer1 loss mediated by aP2-Cre drives angiosarcoma.
BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex.
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.
Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis.
Case report: an identical twin with Sertoli-Leydig cell tumor.
Characterization of a naturally occurring truncated Dicer.
Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes.
Chromosomal anomalies at 1q, 3, 16q, and mutations of SIX1 and DROSHA genes underlie Wilms tumor recurrences.
Clinical and functional impact of TARBP2 over-expression in adrenocortical carcinoma.
Clinical and Molecular Characteristics May Alter Treatment Strategies of Thyroid Malignancies in DICER1-syndrome.
Clinical Characteristics and Mutation Analyses of Ovarian Sertoli-Leydig Cell Tumors.
Clinical Outcomes and Complications of Pituitary Blastoma.
Clinical relevance of screening checklists for detecting cancer predisposition syndromes in Asian childhood tumours.
Clinicians Practicing Obstetrics and Gynecology Are Uniquely Situated to Recognize DICER1 Syndrome.
Clinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer.
Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients.
Common genetic polymorphisms of microRNA biogenesis pathway genes and risk of breast cancer: a case-control study in Korea.
Comprehensive Analysis of MicroRNA (miRNA) Targets in Breast Cancer Cells.
Consensus recommendations from the EXPeRT/PARTNER groups for the diagnosis and therapy of sex cord stromal tumors in children and adolescents.
Crosstalk between p53 and TGF-? Signalling.
CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth.
CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma.
Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology-histopathology correlation in 7 patients.
Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.
Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy.
Decreased expression of DICER1 in gastric cancer.
Deep sequencing reveals spatially distributed distinct hotspot mutations in DICER1-related multinodular goiter.
Deregulation of dicer and mir-155 expression in liposarcoma.
Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.
Detection of the DICER1 hotspot mutation alongside immunohistochemical analysis may provide a better diagnostic measure for ovarian Sertoli-Leydig cell tumors.
Development of a metastatic fluorescent Lewis Lung carcinoma mouse model: identification of mRNAs and microRNAs involved in tumor invasion.
Development of Novel Genetically Engineered Adenoviruses Based on Functional Analyses of Adenovirus-encoded Small RNAs.
Diagnostic and Prognostic Potential of MicroRNA Maturation Regulators Drosha, AGO1 and AGO2 in Urothelial Carcinomas of the Bladder.
Dicer ablation promotes a mesenchymal and invasive phenotype in bladder cancer cells.
Dicer affects cisplatin?mediated apoptosis in epithelial ovarian cancer cells.
Dicer and Drosha expression and response to Bevacizumab-based therapy in advanced colorectal cancer patients.
Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients.
Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice.
Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL.
Dicer expression and microRNA dysregulation associate with aggressive features in thyroid cancer.
Dicer expression in estrogen receptor-positive versus triple-negative breast cancer: an antibody comparison.
Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province.
DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma.
Dicer in action at replication-transcription collisions.
Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia.
Dicer Knockdown Inhibits Endothelial Cell Tumor Growth via MicroRNA 21a-3p Targeting of Nox-4.
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Dicer regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1.
Dicer reprograms stromal fibroblasts to a pro-inflammatory and tumor-promoting phenotype in ovarian cancer.
Dicer suppresses cytoskeleton remodeling and tumorigenesis of colorectal epithelium by miR-324-5p mediated suppression of HMGXB3 and WASF-2.
Dicer suppresses MMP-2-mediated invasion and VEGFA-induced angiogenesis and serves as a promising prognostic biomarker in human clear cell renal cell carcinoma.
Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2?.
Dicer, Drosha, and outcomes in patients with ovarian cancer.
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis.
Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1.
DICER1 and FOXL2 Mutation Status Correlates With Clinicopathologic Features in Ovarian Sertoli-Leydig Cell Tumors.
DICER1 and FOXL2 mutations in ovarian sex cord-stromal tumours: a GINECO Group study.
Dicer1 dysfunction promotes stemness and aggression in endometrial carcinoma.
DICER1 exons 25 and 26 mutations are rare in common human tumours besides Sertoli-Leydig cell tumour.
DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma.
Dicer1 functions as a haploinsufficient tumor suppressor.
DICER1 hot-spot mutations in ovarian gynandroblastoma.
DICER1 hotspot mutations in non-epithelial gonadal tumours.
DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects.
DICER1 Hotspot Mutations in Pleuropulmonary Blastoma: A Case Series From a Tertiary Center.
Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression.
DICER1 mutation and pituitary prolactinoma
DICER1 mutation and tumors associated with a familial tumor predisposition syndrome: practical considerations.
DICER1 Mutation Detected in an Infant Guides Accurate Diagnosis of Auto-Amputated Embryonal Rhabdomyosarcoma.
DICER1 Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association.
DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.
DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma.
DICER1 mutations are frequent in müllerian adenosarcomas and are independent of rhabdomyosarcomatous differentiation.
DICER1 mutations in a patient with an ovarian Sertoli-Leydig tumor, well-differentiated fetal adenocarcinoma of the lung, and familial multinodular goiter.
DICER1 Mutations in embryonal rhabdomyosarcomas from children with and without familial PPB-tumor predisposition syndrome.
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.
DICER1 mutations in familial pleuropulmonary blastoma.
DICER1 Mutations in the Era of Expanding Integrative Clinical Sequencing in Pediatric Oncology.
Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination.
DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: What the paediatric urologist needs to know.
Dicer1 Promotes Colon Cancer Cell Invasion and Migration Through Modulation of tRF-20-MEJB5Y13 Expression Under Hypoxia.
DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.
DICER1 screening in 15 paediatric paratesticular sarcomas unveils an unusual DICER1-associated sarcoma.
DICER1 somatic mutations strongly impair miRNA processing even in benign thyroid lesions.
DICER1 Syndrome and Cancer Predisposition: From a Rare Pediatric Tumor to Lifetime Risk.
DICER1 syndrome can mimic different genetic tumor predispositions.
DICER1 Syndrome.
DICER1 syndrome: a new cancer syndrome.
DICER1 syndrome: Approach to testing and management at a large pediatric tertiary care center.
DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome.
DICER1 Syndrome: DICER1 Mutations in Rare Cancers.
DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification.
DICER1-associated central nervous system sarcoma in children: comprehensive clinicopathologic and genetic analysis of a newly described rare tumor.
DICER1-associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: Pathology, molecular genetics, and indications for molecular testing.
DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female.
DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.
DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome: a unique constellation of neoplastic conditions.
DICER1-Related Embryonal Rhabdomyosarcoma of the Uterine Corpus in a Prepubertal Girl.
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.
DICER1: mutations, microRNAs and mechanisms.
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
Differential Expression of Dicer, miRNAs, and Inflammatory Markers in Diabetic Ins2+/- Akita Hearts.
Disruption of Dicer1 Induces Dysregulated Fetal Gene Expression and Promotes Hepatocarcinogenesis.
Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion.
Distinct DICER1 Hotspot Mutations Identify Bilateral Tumors as Separate Events.
DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker.
DNA nanoclew templated spherical nucleic acids for siRNA delivery.
Docosahexaenoic Acid Modulates the Enterocyte Caco-2 Cell Expression of MicroRNAs Involved in Lipid Metabolism.
Down-regulation of Dicer expression in cervical cancer tissues.
Down-regulation of dicer expression in ovarian cancer tissues.
Down-regulation of Dicer in hepatocellular carcinoma.
Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer.
Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer.
Downregulated Dicer expression predicts poor prognosis in chronic lymphocytic leukemia.
Downregulated expression of Dicer1 predicts inferior survival in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.
Downregulation of Dicer enhances tumor cell proliferation and invasion.
DROSHA rs10719 and DICER1 rs3742330 polymorphisms in endometriosis and different diseases: Case-control and review studies.
DROSHA rs10719 T>C is associated with lymph node metastasis and clinical stage of gastric cancer patients.
Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism.
Dual mechanism of DICER downregulation facilitates cancer metastasis.
Dysregulated expression of Dicer in invasive ductal breast carcinoma.
Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity.
Dysregulation of microRNA biosynthesis enzyme Dicer plays an important role in gastric cancer progression.
Dysregulation of the miRNA biogenesis components DICER1, DROSHA, DGCR8 and AGO2 in clear cell renal cell carcinoma in both a Korean cohort and the cancer genome atlas kidney clear cell carcinoma cohort.
E2F1-regulated DROSHA promotes miR-630 biosynthesis in cisplatin-exposed cancer cells.
Effect of estrogen-related receptor silencing on miRNA protein machinery expression, global methylation, and deacetylation in bank vole (Myodes glareolus) and mouse tumor Leydig cells.
Effects of Dicer1 targeted by EBV-miR-BART6-5p on biological properties and radiosensitivity of nasopharyngeal carcinoma.
EIF2C, Dicer, and Drosha are up-regulated along tumor progression and associated with poor prognosis in bladder carcinoma.
Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome.
Embryonal Rhabdomyosarcoma of the Ovary and Fallopian Tube: Rare Neoplasms Associated With Germline and Somatic DICER1 Mutations.
Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations.
EpCAM Aptamer-mediated Survivin Silencing Sensitized Cancer Stem Cells to Doxorubicin in a Breast Cancer Model.
Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines.
Epithelial inactivation of Yy1 abrogates lung branching morphogenesis.
ERK-mediated transcriptional activation of Dicer is involved in gemcitabine resistance of pancreatic cancer.
Erratum: Publisher Correction: Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.
Establishment and characterization of VOA1066 cells: An undifferentiated endometrial carcinoma cell line.
ETMR: a tumor entity in its infancy.
Evaluation of molecular analysis in challenging ovarian sex cord-stromal tumours: a review of 50 cases.
Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells.
Evolution of Renal Cysts to Anaplastic Sarcoma of Kidney in a Child With DICER1 Syndrome.
Exogenous expression of miRNA-3613-3p causes APAF1 downregulation and affects several proteins involved in apoptosis in BE(2)-C human neuroblastoma cells.
Exosomal miRNA-107 induces myeloid-derived suppressor cell expansion in gastric cancer.
Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome.
Expanding the spectrum of dicer1-associated sarcomas.
Exploring the association between DICER1 mutations and differentiated thyroid carcinoma.
Exploring the endocrine manifestations of DICER1 mutations.
Expression levels of microRNA machinery components Drosha, Dicer and DGCR8 in human (AGS, HepG2, and KEYSE-30) cancer cell lines.
Expression Levels of the microRNA Processing Enzymes Drosha and Dicer in Epithelial Skin Cancer.
Expression of Dicer and Drosha in triple-negative breast cancer.
Expression of Dicer and Its Related MiRNAs in the Progression of Prostate Cancer.
Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas.
Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas.
Extending the phenotypes associated with DICER1 mutations.
Extensive post-transcriptional regulation of microRNAs and its implications for cancer.
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame
Familial pleuropulmonary blastoma in Australia.
Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in the Childhood Cancer Survivor Study.
GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression.
GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours.
Gemcitabine exhibits a suppressive effect on pancreatic cancer cell growth by regulating processing of PVT1 to miR1207.
Gene of the month: DICER1: ruler and controller.
Genetic Causes of Rare Pediatric Ovarian Tumors.
Genetic changes in nonepithelial ovarian cancer.
Genetic variants in the microRNA machinery gene (Dicer) have a prognostic value in the management of endometrial cancer.
Genetics and genomics of ovarian sex cord-stromal tumors.
Genomics of a pediatric ovarian fibrosarcoma. Association with the DICER1 syndrome.
Germ-line and somatic DICER1 mutations in pineoblastoma.
Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides.
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
Germline and Somatic DICER1 Mutations in a Well-Differentiated Fetal Adenocarcinoma of the Lung.
Germline and somatic DICER1 mutations in familial and sporadic liver tumors.
Germline Genetics and Childhood Cancer: Emerging Cancer Predisposition Syndromes and Psychosocial Impacts.
Germline mutations of DICER1 in Chinese women with BRCA1/BRCA2-negative familial breast cancer.
Global microRNA depletion suppresses tumor angiogenesis.
Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1.
Gynecologic Manifestations of the DICER1 Syndrome.
Gynecological lesions in hereditary cancer predisposition syndromes.
Hematologic indices in individuals with pathogenic germline DICER1 variants.
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Hereditary Renal Cystic Disorders: Imaging of the Kidneys and Beyond.
HIF-1? promotes autophagic proteolysis of Dicer and enhances tumor metastasis.
High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer.
High Prevalence of DICER1 Mutations and Low Frequency of Gene Fusions in Pediatric Follicular-Patterned Tumors of the Thyroid.
High-grade Müllerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 Pathway Alterations and Aggressive Behavior.
High-sensitivity sequencing reveals multi-organ somatic mosaicism causing DICER1 syndrome.
Hodgkin lymphoma as a novel presentation of familial DICER1 syndrome.
Hypoxia causes down-regulation of Dicer in hepatocellular carcinoma, which is required for up-regulation of hypoxia inducible factor 1? and epithelial-mesenchymal transition.
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.
Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition.
Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.
Identification of Familial Hodgkin Lymphoma Predisposing Genes Using Whole Genome Sequencing.
Identification of germline DICER1 mutations and loss of heterozygosity in familial Wilms tumour.
Identification of Homozygous Somatic DICER1 Mutation in Pleuropulmonary Blastoma.
Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree.
Identification of two 14q32 deletions involving DICER1 associated with the development of DICER1-related tumors.
IKK?-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy.
Imaging of DICER1 syndrome.
Immunohistochemical analysis of the endoribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues.
Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi.
Impaired DICER1 function promotes stemness and metastasis in colon cancer.
Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients.
Impaired expression of Drosha in breast cancer.
Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness.
Impaired microRNA processing enhances cellular transformation and tumorigenesis.
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs.
Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.
Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo.
Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions.
Interplay between steroid signalling and microRNAs: implications for hormone-dependent cancers.
Intrathyroidal Thymus (Incidentaloma) Mimicking Thyroid Neoplasia in DICER1 Syndrome.
Involvement of microRNA in AU-rich element-mediated mRNA instability.
Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A(DCAF1) to promote colon cancer development.
Judicious DICER1 testing and surveillance imaging facilitates early diagnosis and cure of pleuropulmonary blastoma.
Knockdown of Dicer in MCF-7 human breast carcinoma cells results in G1 arrest and increased sensitivity to cisplatin.
Lack of mutation of DICER1 and FOXL2 genes in microcystic stromal tumor of the ovary.
Lack of pathogenic germline DICER1 variants in males with testicular germ-cell tumors.
let-7 regulates Dicer expression and constitutes a negative feedback loop.
Letter to the editor: Does Dicer Expression Affect shRNA processing?
Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.
Long noncoding RNA LINC00899 suppresses breast cancer progression by inhibiting miR-425.
Loss of Dicer expression is associated with breast cancer progression and recurrence.
Loss of H3K27me3 and nuclear expression of TLE1 in primary intracranial sarcoma, DICER1-mutant.
Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation.
Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma.
Low Drosha protein expression in cutaneous T-cell lymphoma is associated with worse disease outcome.
Lung tumours reprogram pulmonary dendritic cell immunogenicity at the microRNA level.
Macrocephaly associated with the DICER1 syndrome.
Macrofollicular variant follicular thyroid tumors are DICER1 mutated and exhibit distinct histological features.
Macrofollicular Variant of Follicular Thyroid Carcinoma (MV-FTC) with a Somatic DICER1 Gene Mutation: Case Report and Review of the Literature.
Macrofollicular Variant of Follicular Thyroid Carcinoma: A Rare Underappreciated Pitfall in the Diagnosis of Thyroid Carcinoma.
Major clinical research advances in gynecologic cancer in 2012.
Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer.
Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term "thyroblastoma" more appropriate?
Malignant teratomas of the thyroid gland: clinico-radiologic and cytomorphologic features of a rare entity.
MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation.
MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF.
Mesenchymal Hamartoma of the Liver and DICER1 Syndrome.
Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report.
Metachronous Type I pleuropulmonary blastoma and atypical choroid plexus papilloma in a young child.
Metformin shows anti-inflammatory effects in murine macrophages through Dicer/microribonucleic acid-34a-5p and microribonucleic acid-125b-5p.
Methods for assembling B-cell lymphoma specific and internalizing aptamer-siRNA nanoparticles via the sticky bridge.
MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development.
MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival.
MicroRNA biogenesis takes another single hit from microsatellite instability.
MicroRNA biogenesis: dicing assay.
MicroRNA drop in the bloodstream and microRNA boost in the tumour caused by treatment with ribonuclease A leads to an attenuation of tumour malignancy.
MicroRNA expression profiling of human breast cancer identifies new markers of tumour subtype.
microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma.
MicroRNA-103 promotes colorectal cancer by targeting tumor suppressor DICER and PTEN.
MicroRNA-107, an Oncogene MicroRNA that Regulates Tumor Invasion and Metastasis By Targeting DICER1 in Gastric Cancer: MiR-107 promotes gastric cancer invasion and metastasis.
MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration.
MicroRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells.
MicroRNA-143 is a putative predictive factor for the response to fluoropyrimidine-based chemotherapy in patients with metastatic colorectal cancer.
microRNA-18a, a member of the oncogenic miR-17-92 cluster, targets Dicer and suppresses cell proliferation in bladder cancer T24 cells.
MicroRNA-221 governs tumor suppressor HDAC6 to potentiate malignant progression of liver cancer.
MicroRNAs and cancer: past, present, and potential future.
MicroRNAs Link Estrogen Receptor Alpha Status and Dicer Levels in Breast Cancer.
MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells.
miR-126 in human cancers: clinical roles and current perspectives.
miR-130b is an EMT-related microRNA that targets DICER1 for aggression in endometrial cancer.
MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer.
miRNA processing and human cancer: DICER1 cuts the mustard.
MiRNA-103/107 in Primary High-Grade Serous Ovarian Cancer and Its Clinical Significance.
Mixed Epithelial and Stromal Tumor of the Kidney: Mutation Analysis of the DICER 1 Gene in 29 Cases.
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.
Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.
Monitoring Dicer-Mediated miRNA-21 Maturation and Ago2 Loading by a Dual-Colour FIT PNA Probe Set.
Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.
Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression.
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Multinodular goitre is a gateway for molecular testing of DICER1 syndrome.
Multiple DICER1-related tumors in a child with a large interstitial 14q32 deletion.
Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing.
Mutation analysis of DICER1 gene in hematologic tumors.
Mutation Scanning of D1705 and D1709 in the RNAse IIIb Domain of MicroRNA Processing Enzyme Dicer in Cutaneous Melanoma.
Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors.
Mutiple DICER1-related lesions associated with a germline deep intronic mutation.
Nasal Chondromesenchymal Hamartoma (NCMH): a systematic review of the literature with a new case report.
Nasal chondromesenchymal hamartomas arise secondary to germline and somatic mutations of DICER1 in the pleuropulmonary blastoma tumor predisposition disorder.
Nasal chondromesenchymal hamartomas in a cohort with pathogenic germline variation in DICER1.
NCAM1/FGF module serves as a putative pleuropulmonary blastoma therapeutic target.
Neoplasm Risk Among Individuals With a Pathogenic Germline Variant in DICER1.
New roles for Dicer in the nucleolus and its relevance to cancer.
New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma.
Next-generation sequencing of the basal cell carcinoma miRNome and a description of novel microRNA candidates under neoadjuvant vismodegib therapy: an integrative molecular and surgical case study.
Novel DICER1 mutation as cause of multinodular goiter in children.
Novel intronic DICER1 variation associated with pleuropulmonary blastoma in two siblings.
Novel, abundant Drosha isoforms are deficient in miRNA processing in cancer cells.
NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake.
Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer.
Oncogene dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.
Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Oncogenic MicroRNAs Biogenesis as a Drug Target: Structure-Activity Relationship Studies on New Aminoglycoside Conjugates.
Outcome of two pairs of monozygotic twins with pleuropulmonary blastoma: case report.
Ovarian embryonal rhabdomyosarcoma is a rare manifestation of the DICER1 syndrome.
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation.
Ovarian Sertoli-Leydig Cell Tumor, Multinodular Goiter, Cystic Nephromas and DICER1 Mutations: Case Report and Literature Review.
Ovarian sex cord-stromal tumors in patients with probable or confirmed germline DICER1 mutations.
Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: A report from the International Pleuropulmonary Blastoma Registry.
Ovarian Sex Cord-Stromal Tumors.
Ovarian sex cord-stromal tumours: an update in recent molecular advances.
Ovarian tumors related to intronic mutations in DICER1: a report from the international ovarian and testicular stromal tumor registry.
Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells.
Overexpression of Dicer predicts poor survival in colorectal cancer.
Overexpression of DICER1 induced by the upregulation of GATA1 contributes to the proliferation and apoptosis of leukemia cells.
Paired comparisons of mutational profiles before and after brachytherapy in asian uveal melanoma patients.
Pediatric Cystic Nephroma Is Morphologically, Immunohistochemically, and Genetically Distinct From Adult Cystic Nephroma.
Pediatric imaging in DICER1 syndrome.
Pediatric Renal Tumors: Updates in the Molecular Era.
Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins.
Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study.
Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations.
Pleuropulmonary blastoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations.
Pleuropulmonary Blastoma in Pediatric Lung Lesions.
Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.
Pleuropulmonary Blastoma: A Single-center Case Series of 6 Patients.
Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome.
Pleuropulmonary Blastoma: More Than a Lung Neoplasm of Childhood.
Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations.
Potentially functional genetic variants in microRNA processing genes and risk of HBV-related hepatocellular carcinoma.
Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli-Leydig cell tumour, microcystic stromal tumour and their mimics.
Predictive factors for the sensitivity of radiotherapy and prognosis of esophageal squamous cell carcinoma.
Predisposition to pediatric and hematologic cancers: a moving target.
Predominant DICER1 Pathogenic Variants in Pediatric Follicular Thyroid Carcinomas.
Presacral malignant teratoid neoplasm in association with pathogenic DICER1 variation.
Primary Biphasic Hepatic Sarcoma in DICER1 Syndrome.
Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.
Primary Lung Tumors in Children: Radiologic-Pathologic Correlation From the Radiologic Pathology Archives.
Primary uterine ectomesenchymoma harboring a DICER1 mutation: case report with molecular analysis.
Prognostic significance of deregulated dicer expression in breast cancer.
Prognostic significance of Dicer cellular levels in soft tissue sarcomas.
Prognostic significance of Dicer expression in hepatocellular carcinoma.
Prognostic significance of Dicer expression in ovarian cancer-link to global microRNA changes and oestrogen receptor expression.
Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer.
Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype.
Programmed Death Ligand 1 Expression and Related Markers in Pleuropulmonary Blastoma.
Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.
Proteomic identification of target proteins following Drosha knockdown in cervical cancer.
Psychological stress enhances tumor growth and diminishes radiation response in preclinical model of lung cancer.
Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma.
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study.
Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas.
Radiographic screening of infants and young children with genetic predisposition for rare malignancies: DICER1 mutations and pleuropulmonary blastoma.
Rare DICER1 and Absent FOXL2 Mutations Characterize Ovarian Juvenile Granulosa Cell Tumors.
Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells.
Rare Germline DICER1 Variants in Pediatric Patients With Cushing's Disease: What Is Their Role?
Recent advances in Wilms tumor predisposition.
Recent advances on the role of microRNAs in both insulin resistance and cancer.
Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors.
Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.
Recurrent DICER1 Hotspot Mutations in Malignant Thyroid Gland Teratomas: Molecular Characterization and Proposal for a Separate Classification.
Recurrent gynandroblastoma of the ovary with germline DICER1 mutation: A case report and review of the literature.
Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma.
Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.
Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells.
Reduced expression of Dicer associated with poor prognosis in lung cancer patients.
Regulatory RNAs: future perspectives in diagnosis, prognosis, and individualized therapy.
Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer.
Rescuing dicer defects via inhibition of an anti-dicing nuclease.
Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis.
Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators.
Restoration of miRNA-149 Expression by TmPyP4 Induced Unfolding of Quadruplex within Its Precursor.
Retraction: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
Retraction: Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL.
Rewiring macrophages for anti-tumour immunity.
Role of components of microRNA machinery in carcinogenesis.
Role of Dicer as a prognostic predictor for survival in cancer patients: a systematic review with a meta-analysis.
Role of Dicer in regulating oxaliplatin resistance of colon cancer cells.
Role of Dicer1 in thyroid cell proliferation and differentiation.
Role of miRNAs in tumor and endothelial cell interactions during tumor progression.
Rolling the dice to discover the role of DICER in tumorigenesis.
Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome.
Sensitively distinguishing intracellular precursor and mature microRNA abundance.
Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome: A case report and literature review.
Sertoli-Leydig cell tumor, thyroid follicular carcinoma and rhabdomyosarcoma of the uterine cervix in a prepubertal girl with pathogenic germline variant in DICER1 gene.
Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature.
Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma.
Serum levels of mature microRNAs in DICER1-mutated pleuropulmonary blastoma.
Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells.
Significantly greater prevalence of DICER1 alterations in uterine embryonal rhabdomyosarcoma compared to adenosarcoma.
Silencing Dicer expression enhances cellular proliferative and invasive capacities in human tongue squamous cell carcinoma.
Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition.
Somatic DICER1 gene mutation in sporadic intraocular medulloepithelioma without pleuropulmonary blastoma syndrome.
Somatic DICER1 Mutations in a Pubertal Girl with Cervical Embryonal Rhabdomyosarcoma and Papillary Thyroid Adenoma.
Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.
Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.
Somatic tumour testing establishes that bilateral DICER1-associated ovarian Sertoli-Leydig cell tumours represent independent primary neoplasms.
Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion.
Spectrum of DICER1 Germline Pathogenic Variants in Ovarian Sertoli-Leydig Cell Tumor.
Successful Management of a Patient with Malignant Thyroid Teratoma.
Suppression of collagen synthesis by Dicer gene silencing in hepatic stellate cells.
Suppression of Dicer Increases Sensitivity to Gefitinib in Human Lung Cancer Cells.
Suppression of microRNA activity amplifies IFN-?-induced macrophage activation and promotes anti-tumour immunity.
Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group.
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.
Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression.
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.
Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in DICER1 syndrome: a unique variant of the two-hit tumor suppression model.
Ten years of DICER1 mutations: Provenance, distribution, and associated phenotypes.
Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome.
THE "-OMAS" and "-OPIAS":  Targeted and Philosophical Considerations Regarding Hamartomas, Choristomas, Teratomas, Ectopias, and Heterotopias in Pediatric Otorhinolaryngologic Pathology.
The antileukemia activity of natural product HQ17(3) is possibly associated with downregulation of miR-17-92 cluster.
The clinical aspects of pituitary tumour genetics.
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome.
The development of Wilms tumor: from WT1 and microRNA to animal models.
The epigenetic regulation of Dicer and microRNA biogenesis by Panobinostat.
The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer.
The impact of variations in transcription of DICER and AGO2 on exacerbation of childhood B-cell lineage acute lymphoblastic leukaemia.
The insertion in the double-stranded RNA binding domain of human Drosha is important for its function.
The microRNA maturation regulator Drosha is an independent predictor of outcome in breast cancer patients.
The modulation of Dicer regulates tumor immunogenicity in melanoma.
The molecular landscape of ETMR at diagnosis and relapse.
The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma-differences in histological subtypes.
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.
The paradox of dicer in cancer.
The prevalence of DICER1 pathogenic variation in population databases.
The prevalence of germline DICER1 pathogenic variation in cancer populations.
The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer.
The regulatory roles of miRNA and methylation on oncogene and tumor suppressor gene expression in pancreatic cancer cells.
The RNA-Binding Protein DDX18 Promotes Gastric Cancer by Affecting the Maturation of MicroRNA-21.
The role of FOXL2, SOX9, and ?-catenin expression and DICER1 mutation in differentiating sex cord tumor with annular tubules from other sex cord tumors of the ovary.
The role of RNA editing enzyme ADAR1 in human disease.
The Value of DICER1 Mutation Analysis in "Subtle" Diagnostically Challenging Embryonal Rhabdomyosarcomas of the Uterine Cervix.
Thoracic Sertoli-Leydig cell tumor: An alternative type of pleuropulmonary blastoma associated with DICER1 variation.
Three synchronous malignancies in a patient with DICER1 syndrome.
Transcript Level of MicroRNA Processing Elements in Gastric Cancer.
Tumor Progression in DICER1-mutated Cystic Nephroma - witnessing the genesis of Anaplastic Sarcoma of the Kidney.
Type II pleuropulmonary blastoma in a 3-years-old female with dyspnea: a case report and review of literature.
Ultrasensitive electrochemical detection of Dicer1 3'UTR for the fast analysis of alternative cleavage and polyadenylation.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Unique Haploinsufficient Role of the MicroRNA-Processing Molecule Dicer1 in a Murine Colitis-Associated Tumorigenesis Model.
Unusual phenotypes in patients with a pathogenic germline variant in DICER1.
Up-regulated Dicer expression in patients with cutaneous melanoma.
Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma.
Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma.
Upregulation of Dicer is more frequent in monoclonal gammopathies of undetermined significance than in multiple myeloma patients and is associated with longer survival in symptomatic myeloma patients.
Using Pan RNA-Seq Analysis to Reveal the Ubiquitous Existence of 5' and 3' End Small RNAs.
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT) Commonly Exhibits Positivity With Sex Cord Markers FOXL2 and SF-1 but Lacks FOXL2 and DICER1 Mutations.
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Morphologic and Molecular Study of 26 Cases Confirms Recurrent NCOA1-3 Rearrangement.
Variation in dicer gene is associated with increased survival in T-cell lymphoma.
Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup.
Wilms Tumor Suppressor, WT1, Cooperates with MicroRNA-26a and MicroRNA-101 to Suppress Translation of the Polycomb Protein, EZH2, in Mesenchymal Stem Cells.
Wilms tumor, pleuropulmonary blastoma, and DICER1: case report and literature review.
[A family with a congenital DICER1 mutation].
[A negative correlation between Drosha expression and gastric adenocarcinoma malignancy and invasion].
[Application of molecular analysis in differential diagnosis of ovarian adult granulosa cell tumors].
[Cystic nephroma in a 15-month-old boy with DICER1 mutation].
[Dicer efficiently converts large dsRNAs into siRNAs suitable for COX-2 gene]
[DICER1 mutated, solid/trabecular thyroid papillary carcinoma in an 11-year-old child].
[Effect of estrogen or progesterone combined with paclitaxel on human ovarian cancer cell growth and Drosha expression].
[Hereditary predispositions to follicular thyroid tumors].
[MiRNA regulatory mechanism in tumor initiation and progression].
[Ovarian Sertoli-Leydig cell tumors: DICER1 hotspot mutations and associated clinicopathological features].
[Progress in studies on the relationship between ?Dicer and ovarian tumor].
[The pathology of hereditary ovarian tumors].
[Virilizing ovarian tumor: the challenges of differential diagnosis].
Neoplasms, Germ Cell and Embryonal
An Unusual Enteric Yolk Sac Tumor: First Report of an Ovarian Germ Cell Tumor Associated With a Germline Pathogenic Variant in DICER1.
DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.
DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome.
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Lack of pathogenic germline DICER1 variants in males with testicular germ-cell tumors.
Nephroma, Mesoblastic
Pediatric Renal Tumors: Updates in the Molecular Era.
Nephrotic Syndrome
Dicer and Drosha expression in patients with nephrotic syndrome.
Nervous System Diseases
Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes.
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus.
Neuroblastoma
A case of neuroblastoma in DICER1 syndrome: Chance finding or noncanonical causation?
A child with neuroblastoma and metachronous anaplastic sarcoma of the kidney: Underlying DICER1 syndrome?
A novel splice variant of the human dicer gene is expressed in neuroblastoma cells.
Characterization of a naturally occurring truncated Dicer.
Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.
Exogenous expression of miRNA-3613-3p causes APAF1 downregulation and affects several proteins involved in apoptosis in BE(2)-C human neuroblastoma cells.
Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma.
microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma.
MiR-192 directly binds and regulates Dicer1 expression in neuroblastoma.
Role of Dicer as a prognostic predictor for survival in cancer patients: a systematic review with a meta-analysis.
Neurodegenerative Diseases
Cerebellar neurodegeneration in the absence of microRNAs.
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.
Neuroectodermal Tumors, Primitive
DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome.
DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female.
DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome: a unique constellation of neoplastic conditions.
Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome.
Extending the phenotypes associated with DICER1 mutations.
Eye Tumors in Childhood as First Sign of Tumor Predisposition Syndromes: Insights from an Observational Study Conducted in Germany and Austria.
Imaging of DICER1 syndrome.
Intraocular medulloepithelioma - A review of clinical features, DICER 1 mutation, and management.
Medulloepithelioma in DICER1 syndrome treated with resection.
Multiple DICER1-related tumors in a child with a large interstitial 14q32 deletion.
Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome.
Somatic DICER1 gene mutation in sporadic intraocular medulloepithelioma without pleuropulmonary blastoma syndrome.
Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.
Successful Management of a Patient with Malignant Thyroid Teratoma.
Neurofibromatoses
An update on the genetics of benign pituitary adenomas in children and adolescents.
Genetic and Epigenetic Causes of Pituitary Adenomas.
Germline predisposition to genitourinary rhabdomyosarcoma.
Novel Genetic Causes of Pituitary Adenomas.
Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1.
Secondary Sarcomas: Biology, Presentation, and Clinical Care.
Neurofibromatosis 1
An update on the genetics of benign pituitary adenomas in children and adolescents.
Genetic and Epigenetic Causes of Pituitary Adenomas.
Germline predisposition to genitourinary rhabdomyosarcoma.
Novel Genetic Causes of Pituitary Adenomas.
Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1.
Secondary Sarcomas: Biology, Presentation, and Clinical Care.
Neurofibrosarcoma
Common genetic variants in the microRNA biogenesis pathway are associated with malignant peripheral nerve sheath tumor risk in a Chinese population.
Neuroinflammatory Diseases
JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss.
Nevus, Pigmented
Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi.
Noonan Syndrome
Germline predisposition to genitourinary rhabdomyosarcoma.
Obesity
A Neuron-Specific Deletion of the MicroRNA-Processing Enzyme DICER Induces Severe but Transient Obesity in Mice.
Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity.
Hypothalamic miR-103 protects from hyperphagic obesity in mice.
Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients.
Osteoarthritis
Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.
Osteosarcoma
Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis.
Ovarian Neoplasms
?-catenin downregulates Dicer to promote ovarian cancer metastasis.
Application of microRNA in diagnosis and treatment of ovarian cancer.
Autophagic degradation of SQSTM1 inhibits ovarian cancer motility by decreasing DICER1 and AGO2 to induce MIRLET7A-3P.
Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.
Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression.
Dicer affects cisplatin?mediated apoptosis in epithelial ovarian cancer cells.
Dicer and Drosha in ovarian cancer.
Dicer reprograms stromal fibroblasts to a pro-inflammatory and tumor-promoting phenotype in ovarian cancer.
Dicer, Drosha, and outcomes in patients with ovarian cancer.
DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.
Down-regulation of dicer expression in ovarian cancer tissues.
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.
Major clinical research advances in gynecologic cancer in 2012.
microRNAs exhibit high frequency genomic alterations in human cancer.
MiRNA-103/107 in Primary High-Grade Serous Ovarian Cancer and Its Clinical Significance.
Overexpression of Dicer predicts poor survival in colorectal cancer.
Potential role of miR-9 and miR-223 in recurrent ovarian cancer.
Prognostic significance of Dicer expression in ovarian cancer-link to global microRNA changes and oestrogen receptor expression.
Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.
Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer.
Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators.
Role of Dicer as a prognostic predictor for survival in cancer patients: a systematic review with a meta-analysis.
Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome: A case report and literature review.
Somatic tumour testing establishes that bilateral DICER1-associated ovarian Sertoli-Leydig cell tumours represent independent primary neoplasms.
[Effect of estrogen or progesterone combined with paclitaxel on human ovarian cancer cell growth and Drosha expression].
Pancreatic Neoplasms
Dicer regulates differentiation and viability during mouse pancreatic cancer initiation.
ERK-mediated transcriptional activation of Dicer is involved in gemcitabine resistance of pancreatic cancer.
Papilloma
Revisiting pleuropulmonary blastoma and atypical choroid plexus papilloma in a young child: DICER1 syndrome or not?
Papilloma, Choroid Plexus
Revisiting pleuropulmonary blastoma and atypical choroid plexus papilloma in a young child: DICER1 syndrome or not?
Paraganglioma
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
Predisposition to pediatric and hematologic cancers: a moving target.
Paralysis
Israeli acute paralysis virus associated paralysis symptoms, viral tissue distribution and Dicer-2 induction in bumblebee workers (Bombus terrestris).
The deletion of dicer in mature myelinating glial cells causes progressive axonal degeneration but not overt demyelination in adult mice.
Paraproteinemias
Upregulation of Dicer is more frequent in monoclonal gammopathies of undetermined significance than in multiple myeloma patients and is associated with longer survival in symptomatic myeloma patients.
Parasitic Diseases
Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.
Parkinson Disease
A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA.
Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson's disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin.
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
Loss of Drosha underlies dopaminergic neuron toxicity in models of Parkinson's disease.
Perivascular Epithelioid Cell Neoplasms
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Persistent Infection
Potentially functional genetic variants in microRNA processing genes and risk of HBV-related hepatocellular carcinoma.
Peutz-Jeghers Syndrome
Genetics and genomics of ovarian sex cord-stromal tumors.
Gynecological lesions in hereditary cancer predisposition syndromes.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
[The pathology of hereditary ovarian tumors].
Pilomatrixoma
DICER1 syndrome can mimic different genetic tumor predispositions.
Pinealoma
DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome: a unique constellation of neoplastic conditions.
Germ-line and somatic DICER1 mutations in pineoblastoma.
Germline DICER1 mutation and associated loss of heterozygosity in a pineoblastoma.
Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.
Loss of H3K27me3 and nuclear expression of TLE1 in primary intracranial sarcoma, DICER1-mutant.
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.
Pediatric imaging in DICER1 syndrome.
Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1, DROSHA or DGCR8.
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.
Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma.
Pituitary ACTH Hypersecretion
Germline and somatic DICER1 mutations in a pituitary blastoma causing infantile-onset Cushing's disease.
Rare Germline DICER1 Variants in Pediatric Patients With Cushing's Disease: What Is Their Role?
Pituitary Diseases
DICER1 mutation and pituitary prolactinoma
Pituitary Neoplasms
An update on the genetics of benign pituitary adenomas in children and adolescents.
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
Insights into pituitary tumorigenesis: from Sanger sequencing to next-generation sequencing and beyond.
Novel Genetic Causes of Pituitary Adenomas.
Pituitary tumours in MEN1 syndrome - the new insight into the diagnosis and treatment.
Rare Germline DICER1 Variants in Pediatric Patients With Cushing's Disease: What Is Their Role?
The clinical aspects of pituitary tumour genetics.
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS.
Pneumonia
DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis.
Pneumothorax
Diagnosis and Treatment of Pleuropulmonary Blastoma in Children: A Single-Center Report of 41 Cases.
Polycystic Kidney Diseases
MicroRNAs regulate renal tubule maturation through modulation of Pkd1.
Polycystic Ovary Syndrome
MicroRNA-9119 regulates cell viability of granulosa cells in polycystic ovarian syndrome via mediating Dicer expression.
Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients.
Polymyositis
Comparative sequence analysis of ribonucleases HII, III, II PH and D.
Pre-Eclampsia
Relationships between Dicer 1 polymorphism and expression levels in the etiopathogenesis of preeclampsia.
The Drosha rs10719 T>C polymorphism is associated with preeclampsia susceptibility.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province.
Evaluation of the clinical significance of RNase III enzyme DROSHA in pediatrics acute lymphocytic leukemia.
Influence of variants of the drosha, mir499a, and mir938 genes on susceptibility to acute lymphoblastic leukemia in an admixed population from the brazilian amazon.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression.
Primary Myelofibrosis
Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis.
Primary Ovarian Insufficiency
Association of polymorphisms in microRNA machinery genes (DROSHA, DICER1, RAN, and XPO5) with risk of idiopathic primary ovarian insufficiency in Korean women.
Murine follicular development requires oocyte DICER, but not DROSHA.
Prolactinoma
DICER1 mutation and pituitary prolactinoma
Prostatic Intraepithelial Neoplasia
Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma.
Prostatic Neoplasms
A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.
Down-regulation of Dicer and Ago2 is associated with cell proliferation and apoptosis in prostate cancer.
Expression of Dicer and Its Related MiRNAs in the Progression of Prostate Cancer.
Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.
Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.
MicroRNAs Are Mediators of Androgen Action in Prostate and Muscle.
Proteomics analyses of prostate cancer cells reveal cellular pathways associated with androgen resistance.
Syndecan-1 up-regulates microRNA-331-3p and mediates epithelial-to-mesenchymal transition in prostate cancer.
Proteinuria
MicroRNAs and their role in progressive kidney diseases.
MiRNA expression profile and miRNA-mRNA integrated analysis (MMIA) during podocyte differentiation.
Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis.
Review: The role of microRNAs in kidney disease.
Selective dicer suppression in the kidney alters GSK3?/?-catenin pathways promoting a glomerulocystic disease.
Psoriasis
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
Overexpression of Drosha, DiGeorge syndrome critical region gene 8 (DGCR8), and Dicer mRNAs in the pathogenesis of psoriasis.
Pulmonary Blastoma
Somatic DICER1 mutations in adult-onset pulmonary blastoma.
Pulmonary Disease, Chronic Obstructive
A pan-cancer atlas of somatic mutations in miRNA biogenesis genes.
Pulmonary Embolism
Dicer1 mediated miRNA processing shapes the mRNA profile and function of murine platelets.
Pulmonary Fibrosis
DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis.
Rectal Neoplasms
Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients.
Renal Insufficiency
Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT).
Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.
Selective dicer suppression in the kidney alters GSK3?/?-catenin pathways promoting a glomerulocystic disease.
Reperfusion Injury
Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury.
Retinal Degeneration
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.
DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.
Retinal Neovascularization
Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice.
Retinoblastoma
Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.
Secondary Sarcomas: Biology, Presentation, and Clinical Care.
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.
Rhabdoid Tumor
Gynecological lesions in hereditary cancer predisposition syndromes.
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Pediatric Renal Tumors: Updates in the Molecular Era.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Rhabdomyosarcoma
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.
An autopsy case of prostatic rhabdomyosarcoma with DICER1 hotspot mutation.
Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes.
DICER1 mutations are frequent in müllerian adenosarcomas and are independent of rhabdomyosarcomatous differentiation.
Embryonic cervical rhabdomyosarcoma complicated with uterine inversion with cerebral venous sinus thrombosis as the first symptom: a case report and literature review.
Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree.
Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome.
Sertoli-Leydig cell tumor, thyroid follicular carcinoma and rhabdomyosarcoma of the uterine cervix in a prepubertal girl with pathogenic germline variant in DICER1 gene.
Two cases of primary supratentorial intracranial rhabdomyosarcoma with DICER1 mutation which may belong to a "spindle cell sarcoma with rhabdomyosarcoma-like feature, DICER1 mutant".
Rhabdomyosarcoma, Embryonal
Adult-Onset Cervical Embryonal Rhabdomyosarcoma and DICER1 Mutations.
An Unusual Enteric Yolk Sac Tumor: First Report of an Ovarian Germ Cell Tumor Associated With a Germline Pathogenic Variant in DICER1.
Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup.
DICER1 Mutation Detected in an Infant Guides Accurate Diagnosis of Auto-Amputated Embryonal Rhabdomyosarcoma.
DICER1 mutation-positive Giant Botryoid Fibroepithelial polyp of the urinary bladder mimicking embryonal rhabdomyosarcoma.
DICER1 mutations in an adolescent with cervical embryonal rhabdomyosarcoma (cERMS).
DICER1 Mutations in embryonal rhabdomyosarcomas from children with and without familial PPB-tumor predisposition syndrome.
DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: What the paediatric urologist needs to know.
DICER1-associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: Pathology, molecular genetics, and indications for molecular testing.
DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.
DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome: a unique constellation of neoplastic conditions.
Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome.
Embryonal Rhabdomyosarcoma of the Ovary and Fallopian Tube: Rare Neoplasms Associated With Germline and Somatic DICER1 Mutations.
Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations.
Expanding the spectrum of dicer1-associated sarcomas.
Extending the phenotypes associated with DICER1 mutations.
Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1.
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Ovarian embryonal rhabdomyosarcoma is a rare manifestation of the DICER1 syndrome.
Pediatric imaging in DICER1 syndrome.
Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.
Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome.
Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.
Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma.
Significantly greater prevalence of DICER1 alterations in uterine embryonal rhabdomyosarcoma compared to adenosarcoma.
Somatic DICER1 Mutations in a Pubertal Girl with Cervical Embryonal Rhabdomyosarcoma and Papillary Thyroid Adenoma.
The Value of DICER1 Mutation Analysis in "Subtle" Diagnostically Challenging Embryonal Rhabdomyosarcomas of the Uterine Cervix.
Unusual phenotypes in patients with a pathogenic germline variant in DICER1.
Rheumatic Diseases
The RNA interference pathway: a new target for autoimmunity.
Rhinitis, Allergic
Identification of polymorphisms in the RNase3 gene and the association with allergic rhinitis.
ribonuclease iii deficiency
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.
Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes.
An emerging role of Alu RNA in geographic atrophy pathogenesis: the implication for novel therapeutic strategies.
Calvarial bone development and suture closure in Dicer-deficient mice.
Canonical and alternate functions of the microRNA biogenesis machinery.
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice.
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage.
Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain.
Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates Smad2/3.
Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex.
Dicer1 Deficiency in the IPF Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis.
Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression.
DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation.
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.
Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis.
Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.
Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.
DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis.
Endo-siRNA deficiency results in oocyte maturation failure and apoptosis in porcine oocytes.
Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4.
Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.
Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice.
Gene of the month: DICER1: ruler and controller.
Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice.
Meiotic maturation failure induced by DICER1 deficiency is derived from primary oocyte ooplasm.
Mesenchymal cell differentiation and diseases: involvement of translin/TRAX complexes and associated proteins.
MicroRNA-Deficient NK Cells Exhibit Decreased Survival but Enhanced Function.
MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.
Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption.
Rescuing dicer defects via inhibition of an anti-dicing nuclease.
Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients.
Suppression of microRNA activity amplifies IFN-?-induced macrophage activation and promotes anti-tumour immunity.
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.
THYROCYTE-SPECIFIC DICER1 DEFICIENCY ALTERS THYROID FOLLICULAR ORGANIZATION AND PREVENTS GOITER DEVELOPMENT.
TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.
RNA Virus Infections
Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs.
Small RNAs tackle large viruses: RNA interference-based antiviral defense against DNA viruses in insects.
The evolving world of small RNAs from RNA viruses.
Sarcoidosis
Expression of DROSHA and DICER genes in peripheral blood leukocytes in lung sarcoidosis.
Sarcoma
A child with neuroblastoma and metachronous anaplastic sarcoma of the kidney: Underlying DICER1 syndrome?
Anaplastic sarcomas of the kidney are characterized by DICER1 mutations.
DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma.
DICER1 screening in 15 paediatric paratesticular sarcomas unveils an unusual DICER1-associated sarcoma.
DICER1 Syndrome and Cancer Predisposition: From a Rare Pediatric Tumor to Lifetime Risk.
DICER1-associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: Pathology, molecular genetics, and indications for molecular testing.
DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female.
DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.
Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome.
Evolution of Renal Cysts to Anaplastic Sarcoma of Kidney in a Child With DICER1 Syndrome.
Expanding the spectrum of dicer1-associated sarcomas.
Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma.
Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in the Childhood Cancer Survivor Study.
Imaging of DICER1 syndrome.
Metachronous anaplastic sarcoma of the kidney and thyroid follicular carcinoma as manifestations of DICER1 abnormalities.
MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.
Multiple DICER1-related tumors in a child with a large interstitial 14q32 deletion.
Nasal chondromesenchymal hamartomas arise secondary to germline and somatic mutations of DICER1 in the pleuropulmonary blastoma tumor predisposition disorder.
Ovarian tumors related to intronic mutations in DICER1: a report from the international ovarian and testicular stromal tumor registry.
Pediatric Renal Tumors: Updates in the Molecular Era.
Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.
Primary Biphasic Hepatic Sarcoma in DICER1 Syndrome.
Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1.
Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.
Prognostic significance of Dicer cellular levels in soft tissue sarcomas.
Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.
Sarcoma and germ-line DICER1 mutations - Authors' reply.
Sarcoma and germ-line DICER1 mutations.
Secondary Sarcomas: Biology, Presentation, and Clinical Care.
Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma.
Tumor Progression in DICER1-mutated Cystic Nephroma - witnessing the genesis of Anaplastic Sarcoma of the Kidney.
Two cases of primary supratentorial intracranial rhabdomyosarcoma with DICER1 mutation which may belong to a "spindle cell sarcoma with rhabdomyosarcoma-like feature, DICER1 mutant".
Sarcoma, Clear Cell
Pediatric Renal Tumors: Updates in the Molecular Era.
Seizures
Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis.
Seminoma
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Sertoli Cell Tumor
Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome.
Sertoli-Leydig Cell Tumor
A family with Sertoli-Leydig cell tumour, multinodular goiter, and DICER1 mutation.
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report.
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.
Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
An immunohistochemical and molecular analysis of problematic and unclassified ovarian sex cord-stromal tumors.
An Unusual Enteric Yolk Sac Tumor: First Report of an Ovarian Germ Cell Tumor Associated With a Germline Pathogenic Variant in DICER1.
Deep sequencing reveals spatially distributed distinct hotspot mutations in DICER1-related multinodular goiter.
Detection of the DICER1 hotspot mutation alongside immunohistochemical analysis may provide a better diagnostic measure for ovarian Sertoli-Leydig cell tumors.
DICER1 and FOXL2 Mutation Status Correlates With Clinicopathologic Features in Ovarian Sertoli-Leydig Cell Tumors.
DICER1 and FOXL2 mutations in ovarian sex cord-stromal tumours: a GINECO Group study.
DICER1 exons 25 and 26 mutations are rare in common human tumours besides Sertoli-Leydig cell tumour.
DICER1 hot-spot mutations in ovarian gynandroblastoma.
DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects.
DICER1 Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association.
DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.
DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: What the paediatric urologist needs to know.
DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.
DICER1 Syndrome.
DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.
DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome: a unique constellation of neoplastic conditions.
Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome.
Evaluation of molecular analysis in challenging ovarian sex cord-stromal tumours: a review of 50 cases.
Extending the phenotypes associated with DICER1 mutations.
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame
Genetic Causes of Rare Pediatric Ovarian Tumors.
Genetics and genomics of ovarian sex cord-stromal tumors.
Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides.
Germline and Somatic DICER1 Mutations in a Well-Differentiated Fetal Adenocarcinoma of the Lung.
Germline and somatic DICER1 mutations in familial and sporadic liver tumors.
Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1.
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Imaging of DICER1 syndrome.
Judicious DICER1 testing and surveillance imaging facilitates early diagnosis and cure of pleuropulmonary blastoma.
Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report.
Mutiple DICER1-related lesions associated with a germline deep intronic mutation.
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation.
Ovarian Sertoli-Leydig Cell Tumor, Multinodular Goiter, Cystic Nephromas and DICER1 Mutations: Case Report and Literature Review.
Ovarian sex cord-stromal tumors in patients with probable or confirmed germline DICER1 mutations.
Ovarian Sex Cord-Stromal Tumors.
Ovarian sex cord-stromal tumours: an update in recent molecular advances.
Ovarian tumors related to intronic mutations in DICER1: a report from the international ovarian and testicular stromal tumor registry.
Pediatric imaging in DICER1 syndrome.
Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.
Pleuropulmonary Blastoma: More Than a Lung Neoplasm of Childhood.
Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli-Leydig cell tumour, microcystic stromal tumour and their mimics.
Rare DICER1 and Absent FOXL2 Mutations Characterize Ovarian Juvenile Granulosa Cell Tumors.
Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome.
Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome: A case report and literature review.
Sertoli-Leydig cell tumor, thyroid follicular carcinoma and rhabdomyosarcoma of the uterine cervix in a prepubertal girl with pathogenic germline variant in DICER1 gene.
Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature.
Somatic tumour testing establishes that bilateral DICER1-associated ovarian Sertoli-Leydig cell tumours represent independent primary neoplasms.
Spectrum of DICER1 Germline Pathogenic Variants in Ovarian Sertoli-Leydig Cell Tumor.
Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome.
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome.
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.
The prevalence of DICER1 pathogenic variation in population databases.
Thoracic Sertoli-Leydig cell tumor: An alternative type of pleuropulmonary blastoma associated with DICER1 variation.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT) Commonly Exhibits Positivity With Sex Cord Markers FOXL2 and SF-1 but Lacks FOXL2 and DICER1 Mutations.
[A family with a congenital DICER1 mutation].
[Ovarian Sertoli-Leydig cell tumors: DICER1 hotspot mutations and associated clinicopathological features].
[The pathology of hereditary ovarian tumors].
Severe Acute Respiratory Syndrome
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses.
Sex Cord-Gonadal Stromal Tumors
A family with Sertoli-Leydig cell tumour, multinodular goiter, and DICER1 mutation.
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.
DICER1 and FOXL2 mutations in ovarian sex cord-stromal tumours: a GINECO Group study.
DICER1 hot-spot mutations in ovarian gynandroblastoma.
DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.
DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: What the paediatric urologist needs to know.
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.
Extending the phenotypes associated with DICER1 mutations.
Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides.
Germline mutations of DICER1 in Chinese women with BRCA1/BRCA2-negative familial breast cancer.
Identification of two 14q32 deletions involving DICER1 associated with the development of DICER1-related tumors.
Ovarian sex cord-stromal tumors in patients with probable or confirmed germline DICER1 mutations.
Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: A report from the International Pleuropulmonary Blastoma Registry.
Pediatric imaging in DICER1 syndrome.
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.
Recurrent gynandroblastoma of the ovary with germline DICER1 mutation: A case report and review of the literature.
Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome: A case report and literature review.
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT) Commonly Exhibits Positivity With Sex Cord Markers FOXL2 and SF-1 but Lacks FOXL2 and DICER1 Mutations.
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Morphologic and Molecular Study of 26 Cases Confirms Recurrent NCOA1-3 Rearrangement.
[Ovarian Sertoli-Leydig cell tumors: DICER1 hotspot mutations and associated clinicopathological features].
Skin Neoplasms
Expression Levels of the microRNA Processing Enzymes Drosha and Dicer in Epithelial Skin Cancer.
Up-regulated Dicer expression in patients with cutaneous melanoma.
Smoldering Multiple Myeloma
Upregulation of Dicer is more frequent in monoclonal gammopathies of undetermined significance than in multiple myeloma patients and is associated with longer survival in symptomatic myeloma patients.
Smooth Muscle Tumor
Immunohistochemical analysis of the endoribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues.
Spinal Cord Injuries
Functional requirement of dicer1 and miR-17-5p in reactive astrocyte proliferation after spinal cord injury in the mouse.
Spinocerebellar Ataxias
Ribonuclease dicer cleaves triplet repeat hairpins into shorter repeats that silence specific targets.
Spondylitis, Ankylosing
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
Expression levels of the microRNA maturing microprocessor complex components; Drosha, Dicer, and DGCR8 in PBMCs from ankylosing spondylitis patients.
Squamous Cell Carcinoma of Head and Neck
A low dicer expression is associated with resistance to 5-FU-based chemoradiotherapy and a shorter overall survival in patients with oral squamous cell carcinoma.
Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells.
Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators.
Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma.
Starvation
The convergence of autophagy, small RNA and the stress response - implications for transgenerational epigenetic inheritance in plants.
Stomach Neoplasms
Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination.
Clinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer.
Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.
Decreased expression of DICER1 in gastric cancer.
Dicer increases the indication for trastuzumab treatment in gastric cancer patients via overexpression of human epidermal growth factor receptor 2.
DROSHA rs10719 T>C is associated with lymph node metastasis and clinical stage of gastric cancer patients.
Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism.
Dysregulation of microRNA biosynthesis enzyme Dicer plays an important role in gastric cancer progression.
Exosomal miRNA-107 induces myeloid-derived suppressor cell expansion in gastric cancer.
Genetic variants in miRNA machinery genes associated with clinicopathological characteristics and outcomes of gastric cancer patients.
MicroRNA-107, an Oncogene MicroRNA that Regulates Tumor Invasion and Metastasis By Targeting DICER1 in Gastric Cancer: MiR-107 promotes gastric cancer invasion and metastasis.
Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer.
Single-nucleotide polymorphisms of microRNA processing machinery genes are associated with risk for gastric cancer.
Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression.
Targeting the Production of Oncogenic MicroRNAs with Multimodal Synthetic Small Molecules.
The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer.
The RNA-Binding Protein DDX18 Promotes Gastric Cancer by Affecting the Maturation of MicroRNA-21.
Transcript Level of MicroRNA Processing Elements in Gastric Cancer.
[A negative correlation between Drosha expression and gastric adenocarcinoma malignancy and invasion].
[Knockdown of Drosha promotes chemosensitivity of epirubicin for gastric cancer MGC-803 cells].
Supratentorial Neoplasms
Two cases of primary supratentorial intracranial rhabdomyosarcoma with DICER1 mutation which may belong to a "spindle cell sarcoma with rhabdomyosarcoma-like feature, DICER1 mutant".
Telangiectasia, Hereditary Hemorrhagic
Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.
Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.
Telangiectasis
Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.
Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.
Teratoma
Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term "thyroblastoma" more appropriate?
Malignant teratomas of the thyroid gland: clinico-radiologic and cytomorphologic features of a rare entity.
Presacral malignant teratoid neoplasm in association with pathogenic DICER1 variation.
Recurrent DICER1 Hotspot Mutations in Malignant Thyroid Gland Teratomas: Molecular Characterization and Proposal for a Separate Classification.
Successful Management of a Patient with Malignant Thyroid Teratoma.
THE "-OMAS" and "-OPIAS":  Targeted and Philosophical Considerations Regarding Hamartomas, Choristomas, Teratomas, Ectopias, and Heterotopias in Pediatric Otorhinolaryngologic Pathology.
Teratozoospermia
Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns.
Thrombosis
Analysis of the Association Between MicroRNA Biogenesis Gene Polymorphisms and Venous Thromboembolism in Koreans.
Thyroid Cancer, Papillary
Analyzing the Role of DICER1 Germline Variations in Papillary Thyroid Carcinoma.
DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma.
GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression.
Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas.
Role of Dicer1 in thyroid cell proliferation and differentiation.
Thyroid Diseases
A Genome-First Approach to Characterize DICER1 Pathogenic Variant Prevalence, Penetrance, and Phenotype.
Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology-histopathology correlation in 7 patients.
DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases.
DICER1 gene alterations in thyroid diseases.
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
Thyroid Neoplasms
A Genome-First Approach to Characterize DICER1 Pathogenic Variant Prevalence, Penetrance, and Phenotype.
A Positive Feedback Loop Between DICER1 and Differentiation Transcription Factors Is Important for Thyroid Tumorigenesis.
Analyzing the Role of DICER1 Germline Variations in Papillary Thyroid Carcinoma.
Clinical and Molecular Characteristics May Alter Treatment Strategies of Thyroid Malignancies in DICER1-syndrome.
Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology-histopathology correlation in 7 patients.
Development of metastatic poorly differentiated thyroid cancer from a sub-centimeter papillary thyroid carcinoma in a young patient with a germline MET mutation - association or random chance?
Dicer expression and microRNA dysregulation associate with aggressive features in thyroid cancer.
DICER1 Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association.
DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma.
DICER1 Syndrome and Cancer Predisposition: From a Rare Pediatric Tumor to Lifetime Risk.
DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.
DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome: a unique constellation of neoplastic conditions.
Exploring the association between DICER1 mutations and differentiated thyroid carcinoma.
Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors.
Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness.
Macrofollicular variant follicular thyroid tumors are DICER1 mutated and exhibit distinct histological features.
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Neoplasm Risk Among Individuals With a Pathogenic Germline Variant in DICER1.
Ovarian tumors related to intronic mutations in DICER1: a report from the international ovarian and testicular stromal tumor registry.
Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations.
Prevalence and Spectrum of DICER1 Mutations in Adult-onset Thyroid Nodules with Indeterminate Cytology.
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study.
Recurrent DICER1 Hotspot Mutations in Malignant Thyroid Gland Teratomas: Molecular Characterization and Proposal for a Separate Classification.
Role of Dicer1 in thyroid cell proliferation and differentiation.
Somatic DICER1 Mutations in a Pubertal Girl with Cervical Embryonal Rhabdomyosarcoma and Papillary Thyroid Adenoma.
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome.
[DICER1 mutated, solid/trabecular thyroid papillary carcinoma in an 11-year-old child].
[Hereditary predispositions to follicular thyroid tumors].
Thyroid Nodule
A Japanese Family with DICER1 Syndrome Found in Childhood-Onset Multinodular Goitre.
Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology-histopathology correlation in 7 patients.
DICER1 Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association.
DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma.
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Prevalence and Spectrum of DICER1 Mutations in Adult-onset Thyroid Nodules with Indeterminate Cytology.
Triple Negative Breast Neoplasms
Dicer expression in estrogen receptor-positive versus triple-negative breast cancer: an antibody comparison.
Expression of Dicer and Drosha in triple-negative breast cancer.
MiR-18a upregulation decreases Dicer expression and confers paclitaxel resistance in triple negative breast cancer.
The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer.
Tuberculosis
DROSHA rs10719 and DICER1 rs3742330 polymorphisms in endometriosis and different diseases: Case-control and review studies.
Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A.
Tuberous Sclerosis
An update on the genetics of benign pituitary adenomas in children and adolescents.
Gynecological lesions in hereditary cancer predisposition syndromes.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Uremia
Parathyroid-specific deletion of dicer-dependent microRNAs abrogates the response of the parathyroid to acute and chronic hypocalcemia and uremia.
Ureteral Obstruction
Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates Smad2/3.
Urinary Bladder Neoplasms
Dicer ablation promotes a mesenchymal and invasive phenotype in bladder cancer cells.
Downregulation of Dicer, a component of the microRNA machinery, in bladder cancer.
EIF2C, Dicer, and Drosha are up-regulated along tumor progression and associated with poor prognosis in bladder carcinoma.
Genetic variation in DROSHA 3'UTR regulated by hsa-miR-27b is associated with bladder cancer risk.
microRNA-18a, a member of the oncogenic miR-17-92 cluster, targets Dicer and suppresses cell proliferation in bladder cancer T24 cells.
Reduction of protein kinase C ? (PKC-?) promote apoptosis via down-regulation of Dicer in bladder cancer.
Urogenital Diseases
DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: What the paediatric urologist needs to know.
Uterine Cervical Neoplasms
Calcitriol increases Dicer expression and modifies the microRNAs signature in SiHa cervical cancer cells.
Down-regulation of Dicer expression in cervical cancer tissues.
Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha.
Interference with endogenous EZH2 reverses the chemotherapy drug resistance in cervical cancer cells partly by up-regulating Dicer expression.
Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer.
Proteomic identification of target proteins following Drosha knockdown in cervical cancer.
Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators.
Vaccinia
Cleavage of Dicer protein by I7 protease during vaccinia virus infection.
Vascular Diseases
Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.
Vascular System Injuries
Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair.
Dicer promotes endothelial recovery and limits lesion formation after vascular injury through miR-126-5p.
Vesico-Ureteral Reflux
Increased rates of vesicoureteral reflux in mice from deletion of Dicer in the peri-Wolffian duct stroma.
Vesicular Stomatitis
Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler's Virus Replication.
Characterization and mapping of RNase III cleavage sites in VSV genome RNA.
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.
Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.
Vero cells as a model to study the effects of adenoviral gene delivery vectors on the RNAi system in context of viral infection.
Virus Diseases
Characterization of shrimp Drosha in virus infection.
Cleavage of Dicer protein by I7 protease during vaccinia virus infection.
Cross-species comparative analysis of Dicer proteins during Sindbis virus infection.
Dicer 1 of Candida albicans cleaves plant viral dsRNA in vitro and provides tolerance in plants against virus infection.
Dicer functions transcriptionally and posttranscriptionally in a multilayer antiviral defense.
Dicer is involved in protection against influenza A virus infection.
Dicer-2 processes diverse viral RNA species.
Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.
Distinct requirements of microRNAs in NK cell activation, survival, and function.
Drosha as an interferon-independent antiviral factor.
Endogenous siRNAs: regulators of internal affairs.
Establishment of Neurospora crassa as a model organism for fungal virology.
Evidence for a cytoplasmic microprocessor of pri-miRNAs.
Functional analysis of a crustacean microRNA in host-virus interactions.
Human DICER helicase domain recruits PKR and modulates its antiviral activity.
Increased Viral Dissemination in the Brain and Lethality in MCMV-Infected, Dicer-Deficient Neonates.
Opposing forces fight over the same ground to regulate interferon signaling.
Reduced Dicer expression in the cord blood of infants admitted with severe respiratory syncytial virus disease.
Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor.
Small creatures use small RNAs to direct antiviral defenses.
Super-induction of Dicer-2 expression by alien double-stranded RNAs: an evolutionary ancient response to viral infection?
The convergence of autophagy, small RNA and the stress response - implications for transgenerational epigenetic inheritance in plants.
The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.
The dsRNA binding protein family: critical roles, diverse cellular functions.
The Single von Willebrand factor C-domain protein (SVC) coding gene is not involved in the hymenoptaecin upregulation after Israeli acute paralysis virus (IAPV) injection in the bumblebee Bombus terrestris.
Transcriptional response of immune-related genes after endogenous expression of VP1 and exogenous exposure to VP1-based VLPs and CPV virions in lepidopteran cell lines.
Transfection of BmCPV genomic dsRNA in silkmoth-derived Bm5 cells: Stability and interactions with the core RNAi machinery.
Viral Infection and Stress Affect Protein Levels of Dicer 2 and Argonaute 2 in Drosophila melanogaster.
Viral RNAi Suppressor Reversibly Binds siRNA to Outcompete Dicer and RISC via Multiple Turnover.
von Hippel-Lindau Disease
Gynecological lesions in hereditary cancer predisposition syndromes.
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Werner Syndrome
A gene encoding an RNase D exonuclease-like protein is required for post-transcriptional silencing in Arabidopsis.
Comparative sequence analysis of ribonucleases HII, III, II PH and D.
Familial non-medullary thyroid cancer: unraveling the genetic maze.
Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors.
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs.
West Nile Fever
Mosquito Small RNA Responses to West Nile and Insect-Specific Virus Infections in Aedes and Culex Mosquito Cells.
Wilms Tumor
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1.
Biallelic DICER1 mutations occur in Wilms tumours.
Chromosomal anomalies at 1q, 3, 16q, and mutations of SIX1 and DROSHA genes underlie Wilms tumor recurrences.
DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma.
DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome.
Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome.
Extending the phenotypes associated with DICER1 mutations.
Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in the Childhood Cancer Survivor Study.
Hotspot mutations in DICER1 causing GLOW Syndrome-associated macrocephaly via modulation of specific microRNA populations results in activation of PI3K/ATK/mTOR signaling.
Identification of germline DICER1 mutations and loss of heterozygosity in familial Wilms tumour.
Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation.
Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour.
Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.
The development of Wilms tumor: from WT1 and microRNA to animal models.
Wilms tumor, pleuropulmonary blastoma, and DICER1: case report and literature review.
Yellow Fever
Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.
Zika Virus Infection
Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection in Drosophila.
The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis.