Disease on EC 3.1.26.11 - tRNase Z
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Abetalipoproteinemia
Chorea, psychosis, acanthocytosis, and prolonged survival associated with ELAC2 mutations.
Abscess
Genes Contributing to Porphyromonas gingivalis Fitness in Abscess and Epithelial Cell Colonization Environments.
Acidosis, Lactic
Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3'-end processing.
Carcinogenesis
Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3'-end processing.
Carcinogenesis
The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the gamma-tubulin complex.
Carcinoma
Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma.
Cardiomyopathies
The Phenotype and Outcome of Infantile Cardiomyopathy Caused by a Homozygous ELAC2 Mutation.
Cardiomyopathy, Dilated
Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z.
Cardiomyopathy, Hypertrophic
A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement.
Cardiomyopathy, Hypertrophic
ELAC2 Mutations Cause a Mitochondrial RNA Processing Defect Associated with Hypertrophic Cardiomyopathy.
Cardiomyopathy, Hypertrophic
Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3'-end processing.
Chorea
Chorea, psychosis, acanthocytosis, and prolonged survival associated with ELAC2 mutations.
Infections
ELAC2, an Enzyme for tRNA Maturation, Plays a Role in the Cleavage of a Mature tRNA to Produce a tRNA-Derived RNA Fragment During Respiratory Syncytial Virus Infection.
Infections
Genes Contributing to Porphyromonas gingivalis Fitness in Abscess and Epithelial Cell Colonization Environments.
Infertility, Male
The structural characteristics and the substrate recognition properties of RNase ZS1.
Infertility, Male
The transcription factor GATA10 regulates fertility conversion of a two-line hybrid tms5 mutant rice via the modulation of UbL40 expression.
Intellectual Disability
A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement.
Mitochondrial Diseases
Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3'-end processing.
Mitochondrial Diseases
Naturally Occurring Mutations in Human Mitochondrial Pre-tRNASer(UCN) Can Affect the Transfer Ribonuclease Z Cleavage Site, Processing Kinetics, and Substrate Secondary Structure.
nadh:ubiquinone reductase (h+-translocating) deficiency
A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement.
nadh:ubiquinone reductase (h+-translocating) deficiency
ELAC2 Mutations Cause a Mitochondrial RNA Processing Defect Associated with Hypertrophic Cardiomyopathy.
Neoplasm Metastasis
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy.
Neoplasms
ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case-control studies.
Neoplasms
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy.
Neoplasms
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.
Neoplasms
The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the gamma-tubulin complex.
Neoplasms
TRUE Gene Silencing: Screening of a Heptamer-type Small Guide RNA Library for Potential Cancer Therapeutic Agents.
Pericardial Effusion
The Phenotype and Outcome of Infantile Cardiomyopathy Caused by a Homozygous ELAC2 Mutation.
Prostatic Diseases
ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case-control studies.
Prostatic Neoplasms
A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.
Prostatic Neoplasms
A Study of Ser217Leu and Ala541Thr Polymorphism in the Men Afflicted with Prostate Cancer and in the Men being Suspicious of Prostate Cancer.
Prostatic Neoplasms
A survey of green plant tRNA 3'-end processing enzyme tRNase Zs, homologs of the candidate prostate cancer susceptibility protein ELAC2.
Prostatic Neoplasms
Association between RNASEL, MSR1, and ELAC2 single nucleotide polymorphisms and gene expression in prostate cancer risk.
Prostatic Neoplasms
Association of common missense changes in ELAC2 ( HPC2) with prostate cancer in a Japanese case-control series.
Prostatic Neoplasms
Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma.
Prostatic Neoplasms
Characterization of linkage disequilibrium structure, mutation history, and tagging SNPs, and their use in association analyses: ELAC2 and familial early-onset prostate cancer.
Prostatic Neoplasms
Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z.
Prostatic Neoplasms
ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case-control studies.
Prostatic Neoplasms
ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells.
Prostatic Neoplasms
ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer.
Prostatic Neoplasms
Genetic analysis of the principal genes related to prostate cancer: A review.
Prostatic Neoplasms
Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1.
Prostatic Neoplasms
Identification and analysis of candidate fungal tRNA 3'-end processing endonucleases tRNase Zs, homologs of the putative prostate cancer susceptibility protein ELAC2.
Prostatic Neoplasms
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study.
Prostatic Neoplasms
Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer.
Prostatic Neoplasms
Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene.
Prostatic Neoplasms
Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer.
Prostatic Neoplasms
Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3'-end processing.
Prostatic Neoplasms
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy.
Prostatic Neoplasms
Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism.
Prostatic Neoplasms
Prevalence of the Ser217Leu Variant of the ELAC2 Gene and Its Association with Prostate Cancer in Population of the Littoral Region of Cameroon.
Prostatic Neoplasms
Prognostic role of genetic biomarkers in clinical progression of prostate cancer.
Prostatic Neoplasms
Sequence variants of elaC homolog 2 (Escherichia coli) (ELAC2) gene and susceptibility to prostate cancer in the Health Professionals Follow-Up Study.
Prostatic Neoplasms
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.
Prostatic Neoplasms
Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2.
Prostatic Neoplasms
The Caenorhabditis elegans homolog of the putative prostate cancer susceptibility gene ELAC2, hoe-1, plays a role in germline proliferation.
Prostatic Neoplasms
The missense mutations in the candidate prostate cancer gene ELAC2 do not alter enzymatic properties of its product.
Prostatic Neoplasms
The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the gamma-tubulin complex.
Respiratory Syncytial Virus Infections
ELAC2, an Enzyme for tRNA Maturation, Plays a Role in the Cleavage of a Mature tRNA to Produce a tRNA-Derived RNA Fragment During Respiratory Syncytial Virus Infection.
Severe Combined Immunodeficiency
Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism.
Starvation
Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast.
Virus Diseases
ELAC2, an Enzyme for tRNA Maturation, Plays a Role in the Cleavage of a Mature tRNA to Produce a tRNA-Derived RNA Fragment During Respiratory Syncytial Virus Infection.
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