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The enzyme appears in viruses and cellular organisms
Synonyms
acetoacetyl-coa hydrolase,
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acetoacetyl CoA deacylase
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acetoacetyl coenzyme A deacylase
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acetoacetyl coenzyme A hydrolase
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hydrolase, acetoacetyl coenzyme A
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acetoacetyl-CoA + H2O = CoA + acetoacetate
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hydrolysis of thioester
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acetoacetyl-CoA hydrolase
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acetoacetyl-CoA + H2O
acetoacetate + CoA
acetoacetyl-CoA + H2O
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liver ketogenesis
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acetoacetyl-CoA + H2O
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cytoplasmic fatty acid synthesis
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acetoacetyl-CoA + H2O
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provision of cytosolic acetoacetate for biosynthesis
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
acetoacetate + CoA
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acetoacetyl-CoA + H2O
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liver ketogenesis
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acetoacetyl-CoA + H2O
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cytoplasmic fatty acid synthesis
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acetoacetyl-CoA + H2O
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provision of cytosolic acetoacetate for biosynthesis
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?
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2-mercaptoethanol
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stimulation
alpha-thioglycerol
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stimulation
beta-mercaptoethylamine
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stimulation
dithiothreitol
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stimulation
thioglycolate
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stimulation
cysteine
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stimulation
glutathione
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stimulation
glutathione
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stimulation
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0.0052 - 0.025
acetoacetyl-CoA
0.0052
acetoacetyl-CoA
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brain mitochondria
0.021
acetoacetyl-CoA
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liver cytosol, absence of glutathione
0.025
acetoacetyl-CoA
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liver cytosol, presence of glutathione
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0.039
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brain mitochondria
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domestic pigeon
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chicken
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rainbow trout
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Wistar strain
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cow
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brenda
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Wistar strain
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brenda
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ACOT8_HUMAN
319
0
35914
Swiss-Prot
other Location (Reliability: 2)
ACOT8_MOUSE
320
0
35827
Swiss-Prot
other Location (Reliability: 1)
ACOT8_RAT
320
0
36003
Swiss-Prot
other Location (Reliability: 1)
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50
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pH 7.0, 20 min, 79% decrease of specific acitvity
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Aragon, J.J.; Lowenstein, J.M.
A survey of enzymes which generate or use acetoacetyl thioesters in rat liver
J. Biol. Chem.
258
4725-4733
1983
Rattus norvegicus
brenda
Burch, R.E.; Triantafillou, D.
Acetoacetyl coenzyme A deacylase activity in liver mitochondria from fed and fasted rats
Biochemistry
7
1009-1013
1968
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Drummond, G.I.; Stern, J.R.
Enzymes of ketone body metabolism. II. Properties of an acetoacetate-synthesizing enzyme prepared from ox liver
J. Biol. Chem.
235
318-325
1960
Bos taurus
brenda
Patel, T.B.; Clark, J.B.
Rat brain acetoacetyl-coenzyme A deacylase [proceedings
Biochem. Soc. Trans.
6
126-128
1978
Rattus norvegicus
brenda
Zammit, V.A.; Beis, A.; Newsholme, E.A.
The role of 3-oxo acid-CoA transferase in the regulation of ketogenesis in the liver
FEBS Lett.
103
212-215
1979
Gallus gallus, Columba livia, Oryctolagus cuniculus, Mus musculus, Oncorhynchus mykiss, Rattus norvegicus
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Patel, T.B.; Clark, J.B.
Acetoacetate metabolism in rat brain. Development of acetoacetyl-coenzyme A deacylase and 3-hydroxy-3-methylglutaryl-coenzyme A synthase
Biochem. J.
176
951-958
1978
Rattus norvegicus
brenda
Rous, S.
On the occurrence of enzymes of ketone-body metabolism in human adipose tissue
Biochem. Biophys. Res. Commun.
69
74-78
1976
Homo sapiens
brenda
Baird, G.D.; Hibbitt, K.G.; Lee, J.
Enzymes involved in acetoacetate formation in various bovine tissues
Biochem. J.
117
703-709
1970
Bos taurus
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Baird, G.D.; Hibbitt, K.G.
Acetoacetate formation in bovine tissues
Biochem. J.
115
49
1969
Bos taurus
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brenda
Williamson, D.H.; Bates, M.W.; Krebs, H.A.
Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver
Biochem. J.
108
353-361
1968
Rattus norvegicus
brenda
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