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3'-phospho-2'-deoxyribooligonucleotide + H2O
2'-deoxyribonucleoside 3'-phosphate
4-methylumbelliferyl thymidine 3'-phosphate + H2O
thymidine 3'-phosphate + 4-methylumbelliferone
-
-
-
?
4-nitrophenyl phosphate
4-nitrophenol + phosphate
5'-hydroxy oligonucleotides + H2O
nucleoside 3'-oligonucleotides + nucleoside 3'-phosphates
5-'deoxy-5'-chlorothymidine-3'-(4-nitrophenyl)phosphate + H2O
5'-deoxy-5'-chlorothymidine-3'-phosphate
-
-
-
?
bis-(4-nitrophenyl)phosphate + H2O
4-nitrophenyl phosphate + 4-nitrophenol
DNA + H2O
deoxyribonucleoside 3'-phosphate + ?
DNA + H2O
deoxyribonucleoside 3'-phosphates
mRNA + H2O
?
-
XRNA is important in the degradation of deadenylated mRNAs in trypanosomes
-
-
?
polyadenylic acid + H2O
5'-hydroxy-adenine oligonucleotides + 3'AMP
polyguanylic acid
3'-GMP
-
-
-
?
polyinosinic acid
3'-IMP
-
-
-
?
polynucleotides + H2O
3'-phosphomononucleotides
polynucleotides + H2O
phosphomononucleotides
-
the enzyme contributes to the turnover of messenger RNAs in eukaryotic cells
-
-
?
polyuridylic acid + H2O
3'-UMP
ribonucleotide 3'-alkyl esters + H2O
3'-Ribonucleotides + alkyl alcohol
RNA core + H2O
nucleoside 3'-phosphates
thymidine 3'-(2,4-dinitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 2,4-dinitrophenol
thymidine 3'-(4-nitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 4-nitrophenol
tRNA + H2O
tRNA fragments + nucleoside 3'-phosphates
[PO/Mix-PS]-d[TPOCPOTPOTPOTPOTPOTPSC] + H2O
?
-
21% degraded after 2 hours, 35% degraded after 8 hours
-
-
?
[PO/Mix-PS]-d[TPOTPOTPOTPOTPOTPOTPOTPOTPOTPOTPST] + H2O
?
-
35% degraded after 2 hours, 75% degraded after 8 hours
-
-
?
[PO/RP-PS]-d[TPOCPOTPOTPOTPOTPOTPSC] + H2O
?
-
22% degraded after 2 hours, 45% degraded after 8 hours
-
-
?
[PO/SP-PS]-d[TPOCPOTPOTPOTPOTPOTPSC] + H2O
?
-
20% degraded after 2 hours, 25% degraded after 8 hours
-
-
?
[PS]-d[A6] + H2O
?
-
-
-
-
?
[RP-PS]-d[A12] + H2O
?
-
-
-
-
?
[RP-PS]-d[T12] + H2O
?
-
25% degraded after 2 hours, 75% degraded after 8 hours
-
-
?
[S]-d[A12] + H2O
?
-
-
-
-
?
[S]-d[T12] + H2O
?
-
100% degraded after 2 hours
-
-
?
[S]-d[TCCTCTTTTTTT] + H2O
?
-
-
-
-
?
[S]-d[TCTTTTTC] + H2O
?
-
100% degraded after 2 hours
-
-
?
additional information
?
-
3'-phospho-2'-deoxyribooligonucleotide + H2O
2'-deoxyribonucleoside 3'-phosphate
-
dinucleotides
-
-
?
3'-phospho-2'-deoxyribooligonucleotide + H2O
2'-deoxyribonucleoside 3'-phosphate
-
-
-
?
3'-phospho-2'-deoxyribooligonucleotide + H2O
2'-deoxyribonucleoside 3'-phosphate
-
-
-
?
3'-phospho-2'-deoxyribooligonucleotide + H2O
2'-deoxyribonucleoside 3'-phosphate
-
average size 10-12, smallest 3
-
?
3'-phospho-2'-deoxyribooligonucleotide + H2O
2'-deoxyribonucleoside 3'-phosphate
-
methylated by dimethyl sulfate
-
?
3'-phospho-2'-deoxyribooligonucleotide + H2O
2'-deoxyribonucleoside 3'-phosphate
-
size of oligonucleotides 4-9
-
?
4-nitrophenyl phosphate
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate
4-nitrophenol + phosphate
-
-
-
?
5'-hydroxy oligonucleotides + H2O
nucleoside 3'-oligonucleotides + nucleoside 3'-phosphates
-
3',5'-diribonucleoside phosphates and analoga
-
?
5'-hydroxy oligonucleotides + H2O
nucleoside 3'-oligonucleotides + nucleoside 3'-phosphates
-
dependency on type of nucleobase
-
?
5'-hydroxy oligonucleotides + H2O
nucleoside 3'-oligonucleotides + nucleoside 3'-phosphates
-
no hydrolysis of 2'-5' and 5'-5' internucleotide bonds and CpC and CpU-linkages
-
?
5'-hydroxy oligonucleotides + H2O
nucleoside 3'-oligonucleotides + nucleoside 3'-phosphates
-
5'-hydroxy-thymidine oligonucleotides , 5'-hydroxy-adenine oligonucleotides, 5'-hydroxy-2'-deoxycytidine oligonucleotides and various other 5'-hydroxy- and 5'-hydroxy-2'deoxy oligonucleotides like ApUp, d-TpTpC
-
r
5'-hydroxy oligonucleotides + H2O
nucleoside 3'-oligonucleotides + nucleoside 3'-phosphates
-
dependency on type of nucleobase
-
?
bis-(4-nitrophenyl)phosphate + H2O
4-nitrophenyl phosphate + 4-nitrophenol
-
-
-
?
bis-(4-nitrophenyl)phosphate + H2O
4-nitrophenyl phosphate + 4-nitrophenol
-
-
-
?
DNA + H2O
deoxyribonucleoside 3'-phosphate + ?
-
-
-
?
DNA + H2O
deoxyribonucleoside 3'-phosphate + ?
-
-
-
?
DNA + H2O
deoxyribonucleoside 3'-phosphates
-
denatured only, no native or double stranded
-
?
DNA + H2O
deoxyribonucleoside 3'-phosphates
-
Ape2 preferentially removes mismatched 3'-nucleotides from DNA
-
-
?
DNA + H2O
deoxyribonucleoside 3'-phosphates
-
Trm2p displays 5' to 3' exonuclease activity on double-strand DNA, and endonuclease activity on single-strand DNA
-
-
?
DNA + H2O
deoxyribonucleoside 3'-phosphates
-
alkali-denaturated DNA, 25 times lower degradation rate with native DNA
-
?
DNA + H2O
deoxyribonucleoside 3'-phosphates
-
5'-OH and 5'-P DNA with chain length of 100-2500
-
?
Flap34endo + H2O
?
-
-
-
?
Flap34endo + H2O
?
-
-
-
?
Flap34endo + H2O
?
-
-
-
?
polyadenylic acid + H2O
5'-hydroxy-adenine oligonucleotides + 3'AMP
-
-
-
r
polyadenylic acid + H2O
5'-hydroxy-adenine oligonucleotides + 3'AMP
-
-
-
?
polynucleotides + H2O
3'-phosphomononucleotides
-
involvement in DNA repair and replication, genetic recombination, elimination of damaged nucleotides
-
?
polynucleotides + H2O
3'-phosphomononucleotides
-
involvement in DNA repair and replication, genetic recombination, elimination of damaged nucleotides
-
?
polynucleotides + H2O
3'-phosphomononucleotides
-
5' -> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites
-
-
?
polyuridylic acid + H2O
3'-UMP
-
-
-
?
polyuridylic acid + H2O
3'-UMP
-
-
-
?
ribonucleotide 3'-alkyl esters + H2O
3'-Ribonucleotides + alkyl alcohol
-
-
-
?
ribonucleotide 3'-alkyl esters + H2O
3'-Ribonucleotides + alkyl alcohol
-
-
-
r
RNA core + H2O
nucleoside 3'-phosphates
-
-
-
?
RNA core + H2O
nucleoside 3'-phosphates
-
-
-
?
RNA core + H2O
nucleoside 3'-phosphates
-
RNA core are water undializable 3'-phosphoribooligonucleotides obtained by exhaustive digestion of RNA with pancreatic ribonuclease
-
?
thymidine 3'-(2,4-dinitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 2,4-dinitrophenol
-
-
-
?
thymidine 3'-(2,4-dinitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 2,4-dinitrophenol
-
-
-
?
thymidine 3'-(2,4-dinitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 2,4-dinitrophenol
-
-
-
?
thymidine 3'-(2,4-dinitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 2,4-dinitrophenol
-
-
-
?
thymidine 3'-(4-nitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 4-nitrophenol
-
-
-
?
thymidine 3'-(4-nitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 4-nitrophenol
-
-
-
?
thymidine 3'-(4-nitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 4-nitrophenol
-
-
-
?
thymidine 3'-(4-nitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 4-nitrophenol
-
-
-
?
thymidine 3'-(4-nitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 4-nitrophenol
-
-
-
?
thymidine 3'-(4-nitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 4-nitrophenol
-
-
-
?
thymidine 3'-(4-nitrophenyl)phosphate + H2O
thymidine 3'-phosphate + 4-nitrophenol
-
very slow hydrolysis
-
?
tRNA + H2O
tRNA fragments + nucleoside 3'-phosphates
-
5'-phosphoryl terminus hydrolysed by contaminating endonucleases
-
?
tRNA + H2O
tRNA fragments + nucleoside 3'-phosphates
-
or 5'-sRNA
-
?
tRNA + H2O
tRNA fragments + nucleoside 3'-phosphates
-
phosphorylated or dephosphorylated at 5'-terminus
-
?
tRNA + H2O
tRNA fragments + nucleoside 3'-phosphates
-
-
-
?
tRNA + H2O
tRNA fragments + nucleoside 3'-phosphates
-
or 5'-sRNA
-
?
tRNA + H2O
tRNA fragments + nucleoside 3'-phosphates
-
from Escherichia coli
-
?
additional information
?
-
-
[RP-but last one-PS]-d[T12] is not hydrolyzed
-
-
?
additional information
?
-
-
NurA may function closely together with SSB in DNA transactions in archaea
-
-
?
additional information
?
-
-
NurA has ssDNA endonuclease, 5'-3' ssDNA exonuclease, and 5'-3' dsDNA exonuclease activities, overview. NurA is closely linked to Mre11 and Rad50 homologues, it interacts with single-stranded DNA-binding protein, StoSSB, from the hyperthermophilic archaeon Sulfolobus tokodaii, determination by pull-down assay using Ni-NTA agarose beads and MALDI-TOF mass spectrometry, and yeast two-hybrid and co-immunoprecipitation analysis, overview. Substrates are 34-bp dsDNA and M13mp18 ssDNA
-
-
?
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5'-Terminal phosphate
-
in tRNA
-
acetylation
-
complete inhibition by acetylation of the 2'-OH of tRNA
-
arsenite
-
weak inhibitor with RNA core as substrate
Deoxyribonucleoside 3'-phosphates
-
-
dimethyl sulfate
-
inhibition after methylation of 2'-deoxyribooligonucleotides with dimethyl sulfate
F-
-
weak inhibitor with RNA core as substrate
glycosylation
-
no activity with glycosylated oligonucleotides obtained from T4 phage DNA
-
Hg2+
-
with RNA core as substrate
KCl
FEN-1 retains up to approximately 70.0% of its endonuclease at 0-50.0 mM, between 75 and 100 mM FEN-1 displays a significant reduction in activity and at the highest salt concentrations between 125-200 mM almost a complete ablation of activity occurres
Mn2+
-
with RNA core as substrate
Pentamidine
-
endo-exonuclease inhibitor, inhibits DNase activity of CBP-Trm2p
pyridoxal 5'phosphate-6-azophenyl-2',4'-disulfonic acid
-
-
ribo- and deoxyribonucleotides
-
with 5'-phosphomonoester group
-
RNAi
-
down-regulation of expression by tetracycline-inducible RNA interference
-
single-stranded DNA-binding protein
-
i.e. StoSSB, from the hyperthermophilic archaeon Sulfolobus tokodaii, StoSSB inhibits the exonuclease activity of StoNurA on ssDNA and dsDNA
-
Zn2+
-
with RNA core as substrate
additional information
-
no inhibition up to 40 mM by lysophosphatidylcholine
-
Cu2+
-
-
EDTA
-
slight inhibition at 0.1 M
EDTA
-
slight inhibition at 0.1 M
high ionic strength
-
slightly greater inhibition of rat than of guinea-pig enzyme at sodium succinate buffer concentrations greater 0.4 M, also markedly inhibition by 6 M NaCl and 2 M ammonium sulfate
-
high ionic strength
-
slightly greater inhibition of rat than of guinea-pig enzyme at sodium succinate buffer concentrations greater 0.4 M, also markedly inhibition by 6 M NaCl and 2 M ammonium sulfate
-
Mg2+
-
with RNA core as substrate
Mg2+
-
slight inbibition at 0.1 M MgCl2
Mg2+
inhibits above 20 mM
Mg2+
-
slight inbibition at 0.1 M MgCl2
Mg2+
-
almost no degradation of tRNA at higher concentrations with 1 Mg2+ per nucleotide phosphate
NaCl
-
at 100 mM Ape2 exhibits only 20% of its exonuclease activity, in the presence of 200 mM salt almost no exonuclease activity
NaCl
FEN-1 retains up to approximately 70.0% of its endonuclease at 0-50.0 mM, between 75 and 100 mM FEN-1 displays a significant reduction in activity and at the highest salt concentrations between 125-200 mM almost a complete ablation of activity occurres
Urea
-
after 2 h incubation almost 80% of activity with 1.0 M, 40% with 2.0 M, no activity with 5.0 M
Urea
-
50% inhibition with 2.0 M
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Chondrocalcinosis
Inhibition of nucleotide pyrophosphatase/phosphodiesterase 1: implications for developing a calcium pyrophosphate deposition disease modifying drug.
Genetic Diseases, Inborn
Human FEN-1 can process the 5'-flap DNA of CTG/CAG triplet repeat derived from human genetic diseases by length and sequence dependent manner.
Genetic Diseases, Inborn
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Herpes Simplex
Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein.
Huntington Disease
Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability.
Infections
A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability.
Leukemia
Down-regulation of human FEN-1 gene expression during differentiation of promyelocytic leukemia cells.
Leukemia
Gene expression of flap endonuclease-1 during cell proliferation and differentiation.
Melanoma
Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.
Neoplasms
Cloning of the Flap Endonuclease-1 Gene in Bombyx mori and Identification of an Antiapoptotic Function.
Neoplasms
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score.
Neoplasms
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Neuroblastoma
Role of phosphodiesterase II in cross talk between cGMP and cAMP in human neuroblastoma NB-OK-1 cells.
Ovarian Neoplasms
Immunohistochemical characterization of a monoclonal antibody detecting an endometrioid ovarian cancer-associated antigen.
Prostatic Neoplasms
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score.
Sarcoma
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Virus Diseases
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Werner Syndrome
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks.
Werner Syndrome
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.
Xeroderma Pigmentosum
The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21.
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Dolapchiev, L.B.; Bakalova, A.
Simple purification and some properties of beef spleen exonuclease
Prep. Biochem.
12
121-136
1982
Bos taurus
brenda
Bernardi, A.; Bernardi, G.
Spleen acid exonuclease
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
329-336
1971
Bos taurus
-
brenda
Bernardi, G.; Bernardi, A.
Spleen exonuclease (1)
Procedures in Nucleic Acid Research (Cantoni, G. L. , Davies, D. R. , eds. )
144-153
1966
Sus scrofa
-
brenda
Philippsen, P.; Zachau, H.G.
Preparation of transfer RNA fragments by limited degradation with spleen exonuclease
Methods Enzymol.
29E
473-477
1974
Sus scrofa
brenda
Zielinski, W.S.; Niewiarowski, W.
Further studies on the substrate specificity of calf spleen phosphodiesterase [3.1.4.18]
Nucleic Acids Res.
9
235-237
1981
Bos taurus
brenda
Hawley, D.M.; Tsou, K.C.; Hodes, M.E.
Preparation, properties, and uses of two fluorogenic substrates for the detection of 5'-(venom) and 3'-(spleen) nucleotide phosphodiesterases
Anal. Biochem.
117
18-23
1981
Bos taurus
brenda
Silverman, S.; Sll, D.
A rapid method for preparation of calf spleen exonuclease
Nucleic Acids Res.
4
3511-3517
1977
Bos taurus
brenda
Flanagan, P.R.; Zbarsky, S.H.
Purification of phosphodiesterase II from rat and guinea-pig intestinal mucosa
Biochem. J.
155
607-613
1976
Cavia porcellus, Rattus norvegicus
brenda
Margison, G.P.; O'Connor, P.J.; Cornish-Bowden, A.
Role of apurinic sites in the resistance of methylated oligodeoxyribonucleotides to degradation by spleen exonuclease
Biochem. J.
151
249-256
1975
Sus scrofa
brenda
Flanagan, P.R.; Zbarsky, S.H.
Phosphodiesterase II in epithelial cells from guinea-pig and rat small intestine
Biochem. J.
142
545-553
1974
Cavia porcellus, Rattus norvegicus
brenda
Holy, A.
Substrate specificity of spleen acid exonuclease and spleen cyclic phosphodiesterase
Collect. Czech. Chem. Commun.
39
310-332
1974
Bos taurus
-
brenda
Philippsen, P.; Zachau, H.G.
Partial degradation of transfer RNAs and transfer RNA fragments by spleen phosphodiesterase as studied by disc electrophoretic methods
Biochim. Biophys. Acta
277
523-538
1972
Sus scrofa
brenda
Sicard, P.J.; Barthelemy-Clavey, V.
Hog spleen-phosphohydrolases-heterogeneity
Enzymologia
43
227-244
1972
Sus scrofa
brenda
Bernardi, A.; Cantoni, G.L.
Action of spleen exonuclease on transfer ribonucleic acid
J. Biol. Chem.
244
1468-1476
1969
Bos taurus
brenda
Gunther, J.K.; Chang, A.Y.; Clark, J.M.
Action of spleen phosphodiesterase upon soluble ribonucleic acid
Arch. Biochem. Biophys.
125
480-487
1968
Bos taurus
brenda
Bernardi, A.; Bernardi, G.
Studies on acid hydrolases. IV. Isolation and characterization of spleen exonuclease
Biochim. Biophys. Acta
155
360-370
1968
Sus scrofa
brenda
Khorana, H.G.
Phosphodiesterases
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
5
79-94
1961
Bos taurus
-
brenda
Razzell, W.E.; Khorana, H.G.
Studies on polynucleotides
J. Biol. Chem.
236
1144-1149
1961
Bos taurus
brenda
Van Dyck, HJ.M.; Wattiaux, R.
Intracellular distribution of acid exonuclease in rat liver
Eur. J. Biochem.
7
15-20
1968
Rattus norvegicus
-
brenda
Erecinska, M.; Sierakowska, H.; Shugar, D.
Intracellular localization of phosphodiesterases I and II in rat liver
Eur. J. Biochem.
11
465-471
1969
Rattus norvegicus
brenda
Heppel, L.A.; Hilmoe, R.J.
Mechanism of enzymic hydrolysis of adenosine triphosphate
Fed. Proc.
12
217
1953
Bos taurus
-
brenda
Bakalova-Ivanova, A.; Dolapchiev, L.B.
Three step procedure for purification of the exonuclease from beef spleen
Dokl. Bolg. Akad. Nauk
31
921-924
1978
Sus scrofa
-
brenda
Mitkova, A.V.; Stoynov, S.S.; Bakalova, A.T.; Dolapchiev, L.B.
Emergence of the active site of spleen exonuclease upon association of the two basic monomers of the tetrameric enzyme
Int. J. Biochem. Cell Biol.
31
1399-1407
1999
Bos taurus
brenda
Mitkova, A.V.; Bakalova, A.T.; Stoynov, S.S.; Dolapchiev, L.B.
Oligomeric protein structure of beef spleen exonuclease
Arch. Biochem. Biophys.
351
236-242
1998
Bos taurus
brenda
Kurosawa, Y.; Ogawa, T.; Hirose, S.; Okazaki, T.; Okazaki, R.
Mechanism of DNA chain groth. XV. RNA-linked nascent DNA pieces in Escherichia coli strains assayed with spleen exonuclease
J. Mol. Biol.
96
653-664
1975
Sus scrofa
brenda
Mukherjee, D.; Fritz, D.T.; Kilpatrick, W.J.; Gao, M.; Wilusz, J.
Analysis of RNA exonucleolytic activities in cellular extracts
Methods Mol. Biol.
257
193-211
2004
Homo sapiens
brenda
West, S.; Gromak, N.; Proudfoot, N.J.
Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites
Nature
432
522-525
2004
Homo sapiens
brenda
Casta, L.J.; Buguliskis, J.S.; Matsumoto, Y.; Taraschi, T.F.
Expression and biochemical characterization of the Plasmodium falciparum DNA repair enzyme, flap endonuclease-1 (PfFEN-1)
Mol. Biochem. Parasitol.
157
1-12
2008
Plasmodium yoelii (Q7RME3), Plasmodium yoelii, Plasmodium falciparum (Q9GZ01), Plasmodium falciparum, Plasmodium falciparum FCR-3/C5 (Q9GZ01)
brenda
Choudhury, S.A.; Asefa, B.; Webb, A.; Ramotar, D.; Chow, T.Y.
Functional and genetic analysis of the Saccharomyces cerevisiae RNC1/TRM2: evidences for its involvement in DNA double-strand break repair
Mol. Cell. Biochem.
300
215-226
2007
Saccharomyces cerevisiae
brenda
Burkovics, P.; Szukacsov, V.; Unk, I.; Haracska, L.
Human Ape2 protein has a 3-5 exonuclease activity that acts preferentially on mismatched base pairs
Nucleic Acids Res.
34
2508-2515
2006
Homo sapiens
brenda
Wojcik, M.; Cieslak, M.; Stec, W.J.; Goding, J.W.; Koziolkiewicz, M.
Nucleotide pyrophosphatase/phosphodiesterase 1 is responsible for degradation of antisense phosphorothioate oligonucleotides
Oligonucleotides
17
134-145
2007
Homo sapiens
brenda
Li, C.H.; Irmer, H.; Gudjonsdottir-Planck, D.; Freese, S.; Salm, H.; Haile, S.; Estevez, A.M.; Clayton, C.
Roles of a Trypanosoma brucei 5->3 exoribonuclease homolog in mRNA degradation
RNA
12
2171-2186
2006
Trypanosoma brucei
brenda
Wei, T.; Zhang, S.; Zhu, S.; Sheng, D.; Ni, J.; Shen, Y.
Physical and functional interaction between archaeal single-stranded DNA-binding protein and the 5'-3' nuclease NurA
Biochem. Biophys. Res. Commun.
367
523-529
2008
Sulfurisphaera tokodaii
brenda
Gao, H.; Liu, Y.; Rumley, M.; Yuan, H.; Mao, B.
Sequence confirmation of chemically modified RNAs using exonuclease digestion and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Rapid Commun. Mass Spectrom.
23
3423-3430
2009
Bos taurus
brenda