Reference on EC 3.1.1.8 - cholinesterase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ecobichon, D.J.
Characterization of the esterases of feline serum
Can. J. Biochem.
52
1073-1078
1974
Felis catus
Reiner, E.; Simeon-Rudolf, V.; Skrinjaric-Spoljar, M.
Catalytic properties and distribution profiles of paraoxonase and cholinesterase phenotypes in human sera
Toxicol. Lett.
82/83
447-452
1995
Homo sapiens
Voigtmann, R.; Uhlenbruck, G.
Reinigung einer "Pseudo"-Cholinesterase aus der Hämolymphe von Helix pomatia
Z. Naturforsch. B
26
1374-1375
1971
Helix pomatia
Main, A.R.; Tarkan, E.; Aull, J.L.; Soucie, W.G.
Purification of horse serum cholinesterase by preparative polyacrylamide gel electrophoresis
J. Biol. Chem.
247
566-571
1972
Equus caballus
Wheeler, G.E.; Coleman, R.; Finean, J.B.
Cholinesterase activities in subcellular fractions of rat liver. Association of acetylcholinesterase with the surface membrane and other properties of the enzyme
Biochim. Biophys. Acta
255
917-930
1972
Rattus norvegicus
Riov, J.; Jaffe, M.J.
Cholinesterases from plant tissues
Plant Physiol.
51
520-528
1973
Vigna radiata var. radiata
Lee, J.C.; Harpst, J.A.
Physical properties and subunit structure of butyrylcholinesterase from horse serum
Biochemistry
12
1622-1630
1973
Equus caballus
Main, A.R.; Soucie, W.G.; Buxton, I.L.; Arinc, E.
The purification of cholinesterase from horse serum
Biochem. J.
143
733-744
1974
Equus caballus
Fluck, R.A.; Jaffe, M.J.
Cholinesterase from plant tissues. VI. Preliminary characterization of the enzyme from Solanum melongena L. and Zea mays L.
Biochim. Biophys. Acta
410
130-134
1975
Solanum melongena
Alsen, C.; Bertram, U.; Gersteuer, T.; Ohnesorge, F.K.
Studies on acetylcholinesterase and cholinesterase covalently bound to polymaleinic anhydride
Biochim. Biophys. Acta
377
297-302
1975
Equus caballus
Nagasawa, T.; Sugisaki, H.; Tani, Y.; Ogata, K.
Purification and characterization of butyrylcholine-hydrolyzing enzyme from Pseudomonas polycolor
Biochim. Biophys. Acta
429
817-827
1976
Pseudomonas aeruginosa
Lockridge, O.; La Du, B.N.
Comparison of atypical and usual human serum cholinesterase
J. Biol. Chem.
253
361-366
1978
Homo sapiens
Vigny, M.; Gisiger, V.; Massoulie, J.
Nonspecific cholinesterase and acetylcholinesterase in rat tissues: molecular forms, structural and catalytic properties, and significance of the two enzymes
Proc. Natl. Acad. Sci. USA
75
2588-2592
1978
Rattus norvegicus
Saeed, A.; De Boeck, St.; Debruyne, I.; Wouters, J.; Stockx, J.
Hen's egg yolk cholinesterase
Biochim. Biophys. Acta
614
389-399
1980
Anas platyrhynchos, Anser sp., Gallus gallus, Pavo sp., pheasant
Rush, R.S.; Main, A.R.; Miller, S.K.; Kilpatrick, B.F.
Resolution and purification of two monomeric butyrylcholinesterases from rabbit liver
J. Biol. Chem.
255
7155-7160
1980
Oryctolagus cuniculus
Brown, S.S.; Kalow, W.; Pilz, W.; Whittaker, M.; Woronick, C.L.
The plasma cholinesterase: a new perspective
Adv. Clin. Chem.
22
1-123
1981
Canis lupus familiaris, Equus caballus, Homo sapiens, Mus musculus, Pleuronectes platessa, Pseudomonas aeruginosa, Rattus norvegicus, Sus scrofa
Kovacs, K.; Szajani, B.; Boross, L.
Preparation and properties of a novel immobilized cholinesterase
J. Appl. Biochem.
4
11-18
1982
Equus caballus
-
Järv, J.; Speek, M.
Reversible inhibition of butyrylcholinesterase with aromatic hydrocarbons
Biochim. Biophys. Acta
706
174-178
1982
Equus caballus
Ralston, J.S.; Main, A.R.; Kilpatrick, B.F.; Chasson, A.L.
Use of procainamide gels in the purification of human and horse serum cholinesterases
Biochem. J.
211
243-250
1983
Equus caballus, Homo sapiens
Prody, C.A.; Zevin-Sonkin, D.; Gnatt, A.; Goldberg, O.; Soreq, H.
Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues
Proc. Natl. Acad. Sci. USA
84
3555-3559
1987
Homo sapiens
Masson, P.; Laurentie, M.
Stability of butyrylcholinesterase: thermal inactivation in water and deuterium oxide
Biochim. Biophys. Acta
957
111-121
1988
Homo sapiens
DeVos, T.; Dick, T.A.
Characterization of cholinesterases from the parasitic nematode Trichinella spiralis
Comp. Biochem. Physiol. C
103
129-134
1992
Trichinella spiralis
Chemnitius, J.M.; Chemnitius, G.C.; Haselmeyer, K.H.; Kreuzer, H.; Zech, R.
Cholinesterases of heart muscle
Biochem. Pharmacol.
43
823-829
1992
Sus scrofa
Mutero, A.; Pralavorio, M.; Simeon, V.; Fournier, D.
Catalytic properties of cholinesterase: importance of tyrosine 109 in Drosophila protein
NeuroReport
3
39-42
1992
Homo sapiens
Treskatis, S.; Ebert, C.; Layer, P.G.
Butyrylcholinesterase from chicken brain is smaller than that from serum: its purification, glycosylation, and membrane association
J. Neurochem.
58
2236-2247
1992
Gallus gallus
Khattab, A.D.; Walker, C.H.; Mackness M.I.; Saphir, P.W.
Purification and immunological characterization of pigeon serum butyrylcholinesterase
Biochem. Pharmacol.
45
991-998
1993
Alectoris rufa, Columba livia
Rao, R.V.; Balasubramanian, A.S.
The peptidase activity of human serum butyrylcholinesterase: Studies using monoclonal antibodies and characterization of the peptidase
J. Protein Chem.
12
103-110
1993
Homo sapiens
Medina, J.L.; Reinicke, K.; Simpfendörfer, R.; Roa, A.; Oliveros, H.; Bardisa, L.; Rudolph, I.
Characterization and distributation of cholinesterase activity in mouse uterine horns: changes in estrous cycle
Comp. Biochem. Physiol. C
106
473-478
1993
Mus musculus
Cokugras, A.N.; Tezcan, F.
Sheep brain pseudocholinesterase: inhibition kinetics of the partially purified enzyme by some substrate analogues
Chem. Biol. Interact.
87
259-264
1993
Ovis aries
Graham, S.G.; Crossley, A.W.A.
The characteristics of the inhibition of serum cholinesterase by metoclopramide
Eur. J. Clin. Pharmacol.
48
225-228
1995
Homo sapiens
Primo-Parmo, S.L.; Lightstone, H.; La Du, B.N.
Characterization of an unstable variant (BChE115D) of human butyrylcholinesterase
Pharmacogenetics
7
27-34
1997
Homo sapiens
McClellan, J.S.; Coblentz, W.B.; Sapp, M.; Rulewicz, G.; Gains, D.I.; Hawkins, A.; Ozment, C.; Bearden, A.; Merritt, S.; Cunningham, J.; Palmer, E.; Contractor, A.; Pezzementi, L.
cDNA cloning, in vitro expression, and biochemical characterization of cholinesterase 1 and cholinesterase 2 from amphioxus. Comparison with cholinesterase 1 and cholinesterase 2 produced in vivo
Eur. J. Biochem.
258
419-429
1998
Branchiostoma floridae
Bhanumathy, C.D.; Rao, R.V.; Balasubramanian, A.S.
Serum butyrylcholinesterase of non-human primate shows amine sensitive aryl acyl amidase and metallopeptidase activities and characteristics similar to those of the human serum enzyme
Indian J. Biochem. Biophys.
35
148-156
1998
Platyrrhini
Golicnik, M.; Sinko, G.; Simeon-Rudolf, V.; Grubic, Z.; Stojan, J.
Kinetic Model of ethopropazine Interaction with horse serum butyrylcholinesterase and its docking into the active site
Arch. Biochem. Biophys.
398
23-31
2002
Equus caballus
Weingand-Ziade, A.; Ribes, F.; Renault, F.; Masson, P.
Pressure- and heat-induced inactivation of butyrylcholinesterase: evidence for multiple intermediates and the remnant inactivation process
Biochem. J.
356
487-493
2001
Homo sapiens
Cohen, O.; Kronman, C.; Velan, B.; Shafferman, A.
Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta)
Biochem. J.
378
117-128
2004
Macaca mulatta
Wierdl, M.; Morton, C.L.; Danks, M.K.; Potter, P.M.
Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation
Biochem. Pharmacol.
59
773-781
2000
Equus caballus (Q9N1N9), Equus caballus
Boeck, A.T.; Schopfer, L.M.; Lockridge, O.
DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase
Biochem. Pharmacol.
63
2101-2110
2002
Rattus norvegicus
Bar-On, P.; Millard, C.B.; Harel, M.; Dvir, H.; Enz, A.; Sussman, J.L.; Silman, I.
Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug Rivastigmine
Biochemistry
41
3555-3564
2002
Homo sapiens
Kovarik, Z.; Radic, Z.; Berman, H.A.; Simeon-Rudolf, V.; Reiner, E.; Taylor, P.
Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates
Biochemistry
43
3222-3229
2004
Mus musculus
Masson, P.; Xie, W.; Froment, M.T.; Lockridge, O.
Effects of mutations of active site residues and amino acids interacting with the W loop on substrate activation of butyrylcholinesterase
Biochim. Biophys. Acta
1544
166-176
2001
Homo sapiens
Masson, P.; Froment, M.T.; Fort, S.; Ribes, F.; Bec, N.; Balny, C.; Schopfer, L.M.
Butyrylcholinesterase-catalyzed hydrolysis of N-methylindoxyl acetate: analysis of volume changes upon reaction and hysteretic behavior
Biochim. Biophys. Acta
1597
229-243
2002
Homo sapiens
Platteborze, P.L.; Broomfield, C.A.
Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni)
Biotechnol. Appl. Biochem.
31
225-229
2000
Homo sapiens
-
Darvesh, S.; Kumar, R.; Roberts, S.; Walsh, R.; Martin, E.
Butyrylcholinesterase-mediated enhancement of the enzymatic activity of trypsin
Cell. Mol. Neurobiol.
21
285-296
2001
Homo sapiens
Koetzner, L.; Woods, J.H.
Characterization of equine butyrylcholinesterase disposition in the mouse
Drug Metab. Dispos.
30
724-730
2002
Equus sp.
Sanchez-Hernandez, J.C.; Sanchez, B.M.
Lizard cholinesterases as biomarkers of pesticide exposure: Enzymological characterization
Environ. Toxicol. Chem.
21
2319-2325
2002
Gallotia galloti
Nachon, F.; Nicolet, Y.; Viguie, N.; Masson, P.; Fontecilla-Camps, J.C.; Lockridge, O.
Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization
Eur. J. Biochem.
269
630-637
2002
Homo sapiens
Masson, P.; Nachon, F.; Bartels, C.F.; Froment, M.T.; Ribes, F.; Matthews, C.; Lockridge, O.
High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine
Eur. J. Biochem.
270
315-324
2003
Homo sapiens
Saxena, A.; Fedorko, J.M.; Vinayaka, C.R.; Medhekar, R.; Radic, Z.; Taylor, P.; Lockridge, O.; Doctor, B.P.
Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases
Eur. J. Biochem.
270
4447-4458
2003
Equus caballus, Homo sapiens
Masson, P.; Goldstein, B.N.; Debouzy, J.C.; Froment, M.T.; Lockridge, O.; Schopfer, L.M.
Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate
Eur. J. Biochem.
271
220-234
2004
Homo sapiens
Primozic, I.; Hrenar, T.; Tomic, S.; Meic, Z.
Stereoselective hydrolysis of quaternary quinuclidinium benzoates catalyzed by butyrylcholinesterase
Eur. J. Org. Chem.
2003
295-301
2003
Equus caballus
-
Zhan, C.G.; Zheng, F.; Landry, D.W.
Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterase
J. Am. Chem. Soc.
125
2462-2474
2003
Homo sapiens
Sun, H.; El Yazal, J.; Lockridge, O.; Schopfer, L.M.; Brimijoin, S.; Pang, Y.P.
Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication
J. Biol. Chem.
276
9330-9336
2001
Homo sapiens
Nicolet, Y.; Lockridge, O.; Masson, P.; Fontecilla-Camps, J.C.; Nachon, F.
Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
J. Biol. Chem.
278
41141-41147
2003
Homo sapiens (P06276), Homo sapiens
Rozengart, E.V.; Basova, N.E.; Suvorov, A.A.; Khovanskikh, A.E.
Indophenol chromogenic substrates of cholinesterases of different origin
J. Evol. Biochem. Physiol.
38
16-23
2002
Equus sp.
-
Zhukovskii, Y.G.
On establishment of individuality of the cholinesterase enzyme in the studied preparation
J. Evol. Biochem. Physiol.
39
281-290
2003
Equus caballus
-
Altamirano, C.V.; Bartels, C.F.; Lockridge, O.
The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme
J. Neurochem.
74
869-877
2000
Homo sapiens
Cengiz, D.; Cokugras, A.N.; Tezcan, E.F.
A new perspective on thermal inactivation kinetics of human serum butyrylcholinesterase
J. Protein Chem.
21
145-149
2002
Homo sapiens
Brown, M.; Davies, I.M.; Moffat, C.F.; Redshaw, J.; Craft, J.A.
Characterization of choline esterases and their tissue and subcellular distribution in mussel (Mytilus edulis)
Mar. Environ. Res.
57
155-169
2003
Mytilus edulis
Sun, H.; Pang, Y.P.; Lockridge, O.; Brimijoin, S.
Re-engineering butyrylcholinesterase as a cocaine hydrolase
Mol. Pharmacol.
62
220-224
2002
Homo sapiens (P06276)
Giacobini, E.
Cholinesterases: New roles in brain function and in Alzheimer's disease
Neurochem. Res.
28
515-522
2003
Homo sapiens
Garcia-Ayllon, M.S.; Saez-Valero, J.; Munoz-Delgado, E.; Vidal, C.J.
Identification of hybrid cholinesterase forms consisting of acetyl- and butyrylcholinesterase subunits in human glioma
Neuroscience
107
199-208
2001
Homo sapiens
Yildiz, O.; Bodur, E.; Cokugras, A.N.; Ozer, N.
Partial purification and characterization of soluble isoform of butyrylcholinesterase from rat intestine
Protein J.
23
143-151
2004
Rattus norvegicus
Ashani, Y.; Segev, O.; Balan, A.
The effect of fluoride on the scavenging of organophosphates by human butyrylcholinesterase in buffer solutions and human plasma
Toxicol. Appl. Pharmacol.
194
90-99
2004
Homo sapiens
Dave, K.R.; Syal, A.R.; Katyare, S.S.
Tissue cholinesterases. A comparative study of their kinetic properties
Z. Naturforsch. C
55
100-108
2000
Homo sapiens, Rattus norvegicus
Bailey, D.N.; Briggs, J.R.
Studies of the inhibition of serum pseudocholinesterase activity in vitro by commonly used drugs
Am. J. Clin. Pathol.
124
226-228
2005
Homo sapiens
Kucukkilinc, T.; Ozer, I.
Inhibition of human plasma cholinesterase by malachite green and related triarylmethane dyes: mechanistic implications
Arch. Biochem. Biophys.
440
118-122
2005
Homo sapiens
Petroianu, G.A.; Nurulain, S.M.; Arafat, K.; Rajan, S.; Hasan, M.Y.
Effect of pyridostigmine, pralidoxime and their combination on survival and cholinesterase activity in rats exposed to the organophosphate paraoxon
Arch. Toxicol.
80
777-84
2006
Rattus norvegicus
Kovarik, Z.; Ciban, N.; Radic, Z.; Simeon-Rudolf, V.; Taylor, P.
Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP
Biochem. Biophys. Res. Commun.
342
973-978
2006
Mus musculus
Nachon, F.; Asojo, O.A.; Borgstahl, G.E.; Masson, P.; Lockridge, O.
Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging
Biochemistry
44
1154-1162
2005
Homo sapiens (P06276), Homo sapiens
Kamal, M.A.; Al-Jafari, A.A.; Yu, Q.S.; Greig, N.H.
Kinetic analysis of the inhibition of human butyrylcholinesterase with cymserine
Biochim. Biophys. Acta
1760
200-206
2006
Homo sapiens
Darvesh, S.; McDonald, R.S.; Penwell, A.; Conrad, S.; Darvesh, K.V.; Mataija, D.; Gomez, G.; Caines, A.; Walsh, R.; Martin, E.
Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives
Bioorg. Med. Chem.
13
211-222
2004
Homo sapiens
Zhan, C.G.; Gao, D.
Catalytic mechanism and energy barriers for butyrylcholinesterase-catalyzed hydrolysis of cocaine
Biophys. J.
89
3863-3872
2005
Equus caballus
Martinez-Moreno, P.; Nieto-Ceron, S.; Torres-Lanzas, J.; Ruiz-Espejo, F.; Tovar-Zapata, I.; Martinez-Hernandez, P.; Rodriguez-Lopez, J.N.; Vidal, C.J.; Cabezas-Herrera, J.
Cholinesterase activity of human lung tumours varies according to their histological classification
Carcinogenesis
27
429-436
2006
Homo sapiens
Saxena, A.; Sun, W.; Luo, C.; Doctor, B.P.
Human serum butyrylcholinesterase: In vitro and in vivo stability, pharmacokinetics, and safety in mice
Chem. Biol. Interact.
157-158
199-203
2005
Homo sapiens
Cerasoli, D.M.; Griffiths, E.M.; Doctor, B.P.; Saxena, A.; Fedorko, J.M.; Greig, N.H.; Yu, Q.S.; Huang, Y.; Wilgus, H.; Karatzas, C.N.; Koplovitz, I.; Lenz, D.E.
In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger
Chem. Biol. Interact.
157-158
363-365
2005
Homo sapiens
Lin, G.; Lee, Y.R.; Liu, Y.C.; Wu, Y.G.
Ortho effects for inhibition mechanisms of butyrylcholinesterase by o-substituted phenyl N-butyl carbamates and comparison with acetylcholinesterase, cholesterol esterase, and lipase
Chem. Res. Toxicol.
18
1124-1131
2005
Equus caballus
Schopfer, L.M.; Voelker, T.; Bartels, C.F.; Thompson, C.M.; Lockridge, O.
Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase
Chem. Res. Toxicol.
18
747-754
2005
Homo sapiens
Rozengart, E.V.; Basova, N.E.
Elementorganic bisonium reversible inhibitors of different cholinesterases
Dokl. Biochem. Biophys.
395
99-103
2004
Equus caballus, Berryteuthis magister
Masson, P.; Bec, N.; Froment, M.T.; Nachon, F.; Balny, C.; Lockridge, O.; Schopfer, L.M.
Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior
Eur. J. Biochem.
271
1980-1990
2004
Homo sapiens
Hrabovska, A.; Debouzy, J.C.; Froment, M.T.; Devinsky, F.; Paulikova, I.; Masson, P.
Rat butyrylcholinesterase-catalysed hydrolysis of N-alkyl homologues of benzoylcholine
FEBS J.
273
1185-1197
2006
Rattus norvegicus
Domenech, C.E.; Garrido, M.N.; Lisa, T.A.
Pseudomonas aeruginosa cholinesterase and phosphorylcholine phosphatase: two enzymes contributing to corneal infection
FEMS Microbiol. Lett.
66
131-135
1991
Pseudomonas aeruginosa
Tormos, J.R.; Wiley, K.L.; Seravalli, J.; Nachon, F.; Masson, P.; Nicolet, Y.; Quinn, D.M.
The reactant state for substrate-activated turnover of acetylthiocholine by butyrylcholinesterase is a tetrahedral intermediate
J. Am. Chem. Soc.
127
14538-14539
2005
Homo sapiens
Chiou, S.Y.; Lai, G.W.; Tsai, Y.H.; Lee, Y.R.; Lin, L.Y.; Lin, G.L.
Kinetics and mechanisms of acetylcholinesterase and butyrylcholinesterase inhibition by cardiovascular drugs and benzodiazepines
J. Chin. Chem. Soc.
52
843-848
2005
Equus caballus
-
Kovalev, N.N.; Rozengart, E.V.; Chepkasova, A.I.
Comparative study of substrate-inhibitor specificity of brain cholinesterase activity of pacific salmon fish of the Salmonidae family
J. Evol. Biochem. Physiol.
40
258-263
2004
Berryteuthis magister, Oncorhynchus gorbuscha, Oncorhynchus keta, Oncorhynchus kisutch, Oncorhynchus nerka, Salmo salar
-
Garber, N.; Nachshon, I.
Localization of cholinesterase in Pseudomonas aeruginosa strain K
J. Gen. Microbiol.
117
279-283
1980
Pseudomonas aeruginosa, Pseudomonas aeruginosa Kitasato / ATCC 25102
Luo, W.; Yu, Q.s.; Zhan, M.; Parrish, D.; Deschamps, J.R.; Kulkarni, S.S.; Holloway, H.W.; Alley, G.M.; Lahiri, D.K.; Brossi, A.; Greig, N.H.
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine
J. Med. Chem.
48
986-994
2005
Homo sapiens
Gao, D.; Zhan, C.G.
Modeling effects of oxyanion hole on the ester hydrolysis catalyzed by human cholinesterases
J. Phys. Chem. B
109
23070-23076
2005
Homo sapiens (P06276), Homo sapiens
Rodriguez-Fuentes, G.; Gold-Bouchot, G.
Characterization of cholinesterase activity from different tissues of Nile tilapia (Oreochromis niloticus)
Mar. Environ. Res.
58
505-509
2004
Oreochromis niloticus
Mehrani, H.
Simplified procedures for purification and stabilization of human plasma butyrylcholinesterase
Proc. Biochem.
39
877-882
2004
Homo sapiens
-
Suarez, D.; Field, M.J.
Molecular dynamics simulations of human butyrylcholinesterase
Proteins
59
104-117
2005
Homo sapiens
Gao, D.; Zhan, C.G.
Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase
Proteins
62
99-110
2006
Homo sapiens
Darvesh, S.; McDonald, R.S.; Darvesh, K.V.; Mataija, D.; Mothana, S.; Cook, H.; Carneiro, K.M.; Richard, N.; Walsh, R.; Martin, E.
On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases
Bioorg. Med. Chem.
14
4586-4599
2006
Homo sapiens
Ngamelue, M.N.; Homma, K.; Lockridge, O.; Asojo, O.A.
Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase
Acta Crystallogr. Sect. F
63
723-727
2007
Homo sapiens (P06276), Homo sapiens
Schallreuter, K.U.; Gibbons, N.C.; Elwary, S.M.; Parkin, S.M.; Wood, J.M.
Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates
Biochem. Biophys. Res. Commun.
355
1069-1074
2007
Homo sapiens
Walsh, R.; Martin, E.; Darvesh, S.
A versatile equation to describe reversible enzyme inhibition and activation kinetics: modeling beta-galactosidase and butyrylcholinesterase
Biochim. Biophys. Acta
1770
733-746
2007
Homo sapiens
Masson, P.; Froment, M.; Gillon, E.; Nachon, F.; Darvesh, S.; Schopfer, L.M.
Kinetic analysis of butyrylcholinesterase-catalyzed hydrolysis of acetanilides
Biochim. Biophys. Acta
1774
1139-1147
2007
Homo sapiens
Montenegro, M.F.; Moral-Naranjo, M.T.; de la Cadena, M.P.; Campoy, F.J.; Munoz-Delgado, E.; Vidal, C.J.
Human butyrylcholinesterase components differ in aryl acylamidase activity
Biol. Chem.
389
425-432
2008
Homo sapiens
Piazzi, L.; Belluti, F.; Bisi, A.; Gobbi, S.; Rizzo, S.; Bartolini, M.; Andrisano, V.; Recanatini, M.; Rampa, A.
Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones
Bioorg. Med. Chem.
15
575-585
2007
Homo sapiens
Gagnaire, B.; Geffard, O.; Xuereb, B.; Margoum, C.; Garric, J.
Cholinesterase activities as potential biomarkers: Characterization in two freshwater snails, Potamopyrgus antipodarum (Mollusca, Hydrobiidae, Smith 1889) and Valvata piscinalis (Mollusca, Valvatidae, Mueller 1774)
Chemosphere
71
553-560
2008
Potamopyrgus antipodarum, Valvata piscinalis
Boopathy, R.; Rajesh, R.V.; Darvesh, S.; Layer, P.G.
Human serum cholinesterase from liver pathological samples exhibit highly elevated aryl acylamidase activity
Clin. Chim. Acta
380
151-156
2007
Homo sapiens
Rault, M.; Mazzia, C.; Capowiez, Y.
Tissue distribution and characterization of cholinesterase activity in six earthworm species
Comp. Biochem. Physiol. B
147B
340-346
2007
Lumbricus terrestris, Lumbricus castaneus, Aporrectodea nocturna, Aporrectodea caliginosa, Aporrectodea rosea
-
Caselli, F.; Gastaldi, L.; Gambi, N.; Fabbri, E.
In vitro characterization of cholinesterases in the earthworm Eisenia andrei
Comp. Biochem. Physiol. C
143
416-421
2006
Eisenia andrei
Caselli, F.; Gastaldi, L.; Gambi, N.; Fabbri, E.
In vitro characterization of cholinesterases in the earthworm Eisenia andrei
Comp. Biochem. Physiol. C
143C
416-421
2006
Eisenia andrei
-
Bajgar, J.; Bartosova, L.; Kuca, K.; Jun, D.; Fusek, J.
Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase
Drug Chem. Toxicol.
30
351-359
2007
Equus caballus, Rattus norvegicus
Van Cong, N.; Phuong, N.T.; Bayley, M.
Sensitivity of brain cholinesterase activity to diazinon (BASUDIN 50EC) and fenobucarb (BASSA 50EC) insecticides in the air-breathing fish Channa striata (Bloch, 1793)
Environ. Toxicol. Chem.
25
1418-1425
2006
Channa striata
Aamodt, S.; Konestabo, H.S.; Sverdrup, L.E.; Gudbrandsen, M.; Reinecke, S.A.; Reinecke, A.J.; Stenersen, J.
Recovery of cholinesterase activity in the earthworm Eisenia fetida Savigny following exposure to chlorpyrifos
Environ. Toxicol. Chem.
26
1963-1967
2007
Eisenia fetida
Chiou, S.Y.; Wu, Y.G.; Lin, Y.F.; Lin, L.Y.; Lin, G.
Substrate activation of butyrylcholinesterase and substrate inhibition of acetylcholinesterase by 3,3-dimethylbutyl-N-n-butylcarbamate and 2-trimethylsilyl-ethyl-N-n-butylcarbamate
J. Biochem. Mol. Toxicol.
21
24-31
2007
Equus caballus
Rozengart, E.V.; Basova, N.E.; Suvorov, A.A.
How thionphosphonates inhibit activity of different cholinesterases
J. Evol. Biochem. Physiol.
43
164-173
2007
Equus caballus, Berryteuthis magister
-
Ko, S.O.; Kim, T.H.; Lee, H.K.; Lee, J.C.; Cho, E.S.
Temporospatial localization of acetylcholinesterase activity in the dental epithelium during mouse tooth development
Life Sci.
81
1235-1240
2007
Mus musculus
Jung, J.H.; Addison, R.F.; Shim, W.J.
Characterization of cholinesterases in marbled sole, Limanda yokohamae, and their inhibition in vitro by the fungicide iprobenfos
Mar. Environ. Res.
63
471-478
2007
Pseudopleuronectes yokohamae
Groner, E.; Ashani, Y.; Schorer-Apelbaum, D.; Sterling, J.; Herzig, Y.; Weinstock, M.
The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates
Mol. Pharmacol.
71
1610-1617
2007
Homo sapiens
Kamal, M.A.; Klein, P.; Luo, W.; Li, Y.; Holloway, H.W.; Tweedie, D.; Greig, N.H.
Kinetics of human serum butyrylcholinesterase inhibition by a novel experimental alzheimer therapeutic, dihydrobenzodioxepine cymserine
Neurochem. Res.
33
745-753
2007
Homo sapiens
Stefano, B.; Ilaria, C.; Silvano, F.
Cholinesterase activities in the scallop Pecten jacobaeus: characterization and effects of exposure to aquatic contaminants
Sci. Total Environ.
392
99-109
2008
Pecten jacobaeus
Kristoff, G.; Guerrero, N.V.; de DAngelo, A.M.; Cochon, A.C.
Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus
Toxicology
222
185-194
2006
Biomphalaria glabrata, Lumbriculus variegatus
Bartling, A.; Worek, F.; Szinicz, L.; Thiermann, H.
Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase
Toxicology
233
166-172
2007
Homo sapiens
Zdrazilova, P.; Stepankova, S.; Komersova, A.; Vranova, M.; Komers, K.; Cegan, A.
Kinetics of 13 new cholinesterase inhibitors
Z. Naturforsch. C
61
611-617
2006
Equus caballus
Chiou, S.Y.; Wu, Y.G.; Lin, G.
Activation mechanisms of butyrylcholinesterase by 2,4,6-trinitrotoluene, 3,3-dimethylbutyl-N-n-butylcarbamate, and 2-trimethylsilyl-ethyl-N-n-butylcarbamate
Appl. Biochem. Biotechnol.
150
337-344
2008
Equus caballus
Bosak, A.; Gazic, I.; Vinkovic, V.; Kovarik, Z.
Amino acid residues involved in stereoselective inhibition of cholinesterases with bambuterol
Arch. Biochem. Biophys.
471
72-76
2008
Mus musculus
Yuecel, Y.Y.; Tacal, O.; Ozer, I.
Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase
Arch. Biochem. Biophys.
478
201-205
2008
Equus caballus
Grigoryan, H.; Halebyan, G.; Lefebvre, B.; Brasme, B.; Masson, P.
Mechanism of hydrolysis of dicholine esters with long polymethylene chain by human butyrylcholinesterase
Biochim. Biophys. Acta
1784
1818-1824
2008
Homo sapiens (P06276), Homo sapiens
Bromberg, A.; Marx, S.; Frishman, G.
Kinetic study of the thermal inactivation of cholinesterase enzymes immobilized in solid matrices
Biochim. Biophys. Acta
1784
961-966
2008
Homo sapiens
Decker, M.; Kraus, B.; Heilmann, J.
Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties
Bioorg. Med. Chem.
16
4252-4261
2008
Mus musculus
Pan, L.; Tan, J.H.; Hou, J.Q.; Huang, S.L.; Gu, L.Q.; Huang, Z.S.
Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors
Bioorg. Med. Chem. Lett.
18
3790-3793
2008
Equus caballus
Sperling, L.E.; Steinert, G.; Boutter, J.; Landgraf, D.; Hescheler, J.; Pollet, D.; Layer, P.G.
Characterisation of cholinesterase expression during murine embryonic stem cell differentiation
Chem. Biol. Interact.
175
156-160
2008
Mus musculus
Masson, P.; Nachon, F.; Broomfield, C.A.; Lenz, D.E.; Verdier, L.; Schopfer, L.M.; Lockridge, O.
A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters
Chem. Biol. Interact.
175
273-280
2008
Homo sapiens
Massoulie, J.; Perrier, N.; Noureddine, H.; Liang, D.; Bon, S.
Old and new questions about cholinesterases
Chem. Biol. Interact.
175
30-44
2008
Homo sapiens
Calic, M.; Bosak, A.; Kuca, K.; Kovarik, Z.
Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases
Chem. Biol. Interact.
175
305-308
2008
Homo sapiens
Geyer, B.C.; Woods, R.R.; Mor, T.S.
Increased organophosphate scavenging in a butyrylcholinesterase mutant
Chem. Biol. Interact.
175
376-379
2008
Homo sapiens
Jun, D.; Musilova, L.; Kuca, K.; Kassa, J.; Bajgar, J.
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro
Chem. Biol. Interact.
175
421-424
2008
Homo sapiens
Li, H.; Tong, L.; Schopfer, L.M.; Masson, P.; Lockridge, O.
Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase
Chem. Biol. Interact.
175
68-72
2008
Homo sapiens
Gao, Y.; LaFleur, D.; Shah, R.; Zhao, Q.; Singh, M.; Brimijoin, S.
An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties
Chem. Biol. Interact.
175
83-87
2008
Homo sapiens
Anglister, L.; Etlin, A.; Finkel, E.; Durrant, A.R.; Lev-Tov, A.
Cholinesterases in development and disease
Chem. Biol. Interact.
175
92-100
2008
Mus musculus
Grigoryan, H.A.; Hambardzumyan, A.A.; Mkrtchyan, M.V.; Topuzyan, V.O.; Halebyan, G.P.; Asatryan, R.S.
alpha,beta -Dehydrophenylalanine choline esters, a new class of reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase
Chem. -Biol. Interact.
171
108-116
2008
Homo sapiens (P06276), Homo sapiens
Rizzo, S.; Cavalli, A.; Ceccarini, L.; Bartolini, M.; Belluti, F.; Bisi, A.; Andrisano, V.; Recanatini, M.; Rampa, A.
Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine
ChemMedChem
4
670-679
2009
Homo sapiens
Stojanov, M.D.; Jovicic, D.M.; Djuric, S.P.; Konjevic, M.M.; Todorovic, Z.M.; Prostran, M.S.
Butyrylcholinesterase activity and mortality risk in hemodialysis patients: comparison to hsCRP and albumin
Clin. Biochem.
42
22-26
2009
Homo sapiens
Loizzo, M.R.; Tundis, R.; Menichini, F.; Menichini, F.
Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update
Curr. Med. Chem.
15
1209-1228
2008
Equus caballus, Homo sapiens
Rodriguez-Fuentes, G.; Armstrong, J.; Schlenk, D.
Characterization of muscle cholinesterases from two demersal flatfish collected near a municipal wastewater outfall in Southern California
Ecotoxicol. Environ. Saf.
69
466-471
2008
Parophrys vetulus, Pleuronichthys verticalis
Belluti, F.; Piazzi, L.; Bisi, A.; Gobbi, S.; Bartolini, M.; Cavalli, A.; Valenti, P.; Rampa, A.
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors
Eur. J. Med. Chem.
44
1341-1348
2008
Homo sapiens
Jia, P.; Sheng, R.; Zhang, J.; Fang, L.; He, Q.; Yang, B.; Hu, Y.
Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors
Eur. J. Med. Chem.
44
772-784
2008
Rattus norvegicus
Liang, D.; Blouet, J.P.; Borrega, F.; Bon, S.; Massoulie, J.
Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase
FEBS J.
276
94-108
2009
Homo sapiens
Ahmad, I.; Fatima, I.
Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from Isatis tinctoria
J. Enzyme Inhib. Med. Chem.
23
313-316
2008
Equus caballus
Ahmed, M.; Batista, J.; Rocha, T.; Mazzanti, C.M.; Hassan, W.; Morsch, V.M.; Loro, V.L.; Thome, G.; Schetinger, M.R.
Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (krait) venom, human serum and rat striatum
J. Enzyme Inhib. Med. Chem.
23
912-917
2008
Homo sapiens
Al-Aboudi, A.; Odeh, H.; Khalid, A.; Naz, Q.; Choudhary, M.I.
Butyrylcholinesterase inhibitory activity of testosterone and some of its metabolites
J. Enzyme Inhib. Med. Chem.
24
553-558
2008
Equus caballus
Rozengart, E.V.; Basova, N.E.
Thiosubstrates of cholinesterases of different origin
J. Evol. Biochem. Physiol.
44
12-23
2008
Columba livia, Oryctolagus cuniculus, Drosophila melanogaster, Equus caballus, Helicoverpa armigera, Locusta migratoria migratorioides, Musca domestica, Nippostrongylus brasiliensis, no activity in Bos taurus, no activity in Zea mays, Todarodes pacificus, Triatoma infestans, Schizaphis graminum, Berryteuthis magister, Acyrthosiphon pisum, Neogale vison, Delia floralis, Delia antiqua, Coccinella septempunctata, Berryteuthis anonychus, Gonatus kamtschaticus, Eogonatus tinro, Gonatopsis borealis, no activity in Solanum melongena, no activity in Tetranychus urticae, no activity in Acheta domesticus, no activity in Triatoma infestans, no activity in Branchiostoma floridae, no activity in Electrophorus electricus, no activity in Torpedo marmorata
-
Darvesh, S.; Darvesh, K.V.; McDonald, R.S.; Mataija, D.; Walsh, R.; Mothana, S.; Lockridge, O.; Martin, E.
Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase
J. Med. Chem.
51
4200-4212
2008
Homo sapiens
Rivera-Becerril, E.; Joseph-Nathan, P.; Perez-Alvarez, V.M.; Morales-Rios, M.S.
Synthesis and biological evaluation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors
J. Med. Chem.
51
5271-5284
2008
Homo sapiens
Carolan, C.G.; Dillon, G.P.; Gaynor, J.M.; Reidy, S.; Ryder, S.A.; Khan, D.; Marquez, J.F.; Gilmer, J.F.
Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors
J. Med. Chem.
51
6400-6409
2008
Homo sapiens (P06276), Homo sapiens
Podoly, E.; Bruck, T.; Diamant, S.; Melamed-Book, N.; Weiss, A.; Huang, Y.; Livnah, O.; Langermann, S.; Wilgus, H.; Soreq, H.
Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro
Neurodegener. Dis.
5
232-236
2008
Homo sapiens
Tasker, A.; Ballard, C.G.; Joachim, C.; Warden, D.R.; Okello, E.J.; Perry, R.H.; Khan, N.; Smith, A.D.; Lehmann, D.J.; Perry, E.K.
Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients
Neurosci. Lett.
442
297-299
2008
Homo sapiens
Mikami, L.R.; Wieseler, S.; Souza, R.L.; Schopfer, L.M.; Nachon, F.; Lockridge, O.; Chautard-Freire-Maia, E.A.
Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population
Pharmacogenet. Genomics
18
213-218
2008
Homo sapiens
Saxena, A.; Luo, C.; Doctor, B.P.
Developing procedures for the large-scale purification of human serum butyrylcholinesterase
Protein Expr. Purif.
61
191-196
2008
Homo sapiens
Kolarich, D.; Weber, A.; Pabst, M.; Stadlmann, J.; Teschner, W.; Ehrlich, H.; Schwarz, H.P.; Altmann, F.
Glycoproteomic characterization of butyrylcholinesterase from human plasma
Proteomics
8
254-263
2008
Homo sapiens (P06276), Homo sapiens
Worek, F.; Aurbek, N.; Wetherell, J.; Pearce, P.; Mann, T.; Thiermann, H.
Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: Pig versus minipig acetylcholinesterase
Toxicology
244
35-41
2008
Sus scrofa
Orhan, I.; Kartal, M.; Tosun, F.; Sener, B.
Screening of various phenolic acids and flavonoid derivatives for their anticholinesterase potential
Z. Naturforsch. C
62
829-832
2008
Homo sapiens
Gholivand, K.; Alizadehgan, A.M.; Mojahed, F.; Dehghan, G.; Mohammadirad, A.; Abdollahi, M.
Some new carbacylamidophosphates as inhibitors of acetylcholinesterase and butyrylcholinesterase
Z. Naturforsch. C
63
241-250
2008
Homo sapiens
Orhan, I.; Tosun, F.; Sener, B.
Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity
Z. Naturforsch. C
63
366-370
2008
Equus caballus
Orhan, I.; Kartal, M.; Kan, Y.; Sener, B.
Activity of essential oils and individual components against acetyl- and butyrylcholinesterase
Z. Naturforsch. C
63
547-553
2008
Equus caballus
Debord, J.; Harel, M.; Verneuil, B.; Bollinger, J.; Dantoine, T.
Microcalorimetric study of the inhibition of butyrylcholinesterase by paraoxon
Anal. Biochem.
389
97-101
2009
Equus caballus
Kristoff, G.; Guerrero, N.; Cochon, A.
Inhibition of cholinesterases and carboxylesterases of two invertebrate species, Biomphalaria glabrata and Lumbriculus variegatus, by the carbamate pesticide carbaryl
Aquat. Toxicol.
96
115-123
2010
Biomphalaria glabrata, Lumbriculus variegatus
Jung, H.A.; Lee, E.J.; Kim, J.S.; Kang, S.S.; Lee, J.H.; Min, B.S.; Choi, J.S.
Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata
Arch. Pharm. Res.
32
1399-1408
2009
Equus caballus
Jung, H.A.; Jung, Y.J.; Hyun, S.K.; Min, B.S.; Kim, D.W.; Jung, J.H.; Choi, J.S.
Selective cholinesterase inhibitory activities of a new monoterpene diglycoside and other constituents from Nelumbo nucifera stamens
Biol. Pharm. Bull.
33
267-272
2010
Equus caballus
Musilek, K.; Komloova, M.; Zavadova, V.; Holas, O.; Hrabinova, M.; Pohanka, M.; Dohnal, V.; Nachon, F.; Dolezal, M.; Kuca, K.; Jung, Y.S.
Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications
Bioorg. Med. Chem. Lett.
20
1763-1766
2010
Homo sapiens
Dillon, G.P.; Gaynor, J.M.; Khan, D.; Carolan, C.G.; Ryder, S.A.; Marquez, J.F.; Reidy, S.; Gilmer, J.F.
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability
Bioorg. Med. Chem.
18
1045-1053
2010
Homo sapiens
Hofmann, J.; Keifer, M.; Furlong, C.; De Roos, A.; Farin, F.; Fenske, R.; van Belle, G.; Checkoway, H.
Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-Exposed agricultural pesticide handlers
Environ. Health Perspect.
117
1402-1408
2009
Homo sapiens
Katalinic, M.; Rusak, G.; Domacinovic Barovic, J.; Sinko, G.; Jelic, D.; Antolovic, R.; Kovarik, Z.
Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase
Eur. J. Med. Chem.
45
186-192
2010
Homo sapiens (P06276), Homo sapiens
Menichini, F.; Tundis, R.; Loizzo, M.; Bonesi, M.; Marrelli, M.; Statti, G.; Menichini, F.; Conforti, F.
Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae)
Fitoterapia
80
297-300
2009
Equus caballus
Orhan, I.; Senol, F.; Kartal, M.; Dvorska, M.; Zemlicka, M.; Smejkal, K.; Mokry, P.
Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider
Food Chem. Toxicol.
47
1747-1751
2009
Equus caballus
Suganthy, N.; Karutha Pandian, S.; Pandima Devi, K.
Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata
Neurosci. Lett.
468
216-219
2010
Oreochromis niloticus
Elsinghorst, P.W.; Haertig, W.; Goldhammer, S.; Grosche, J.; Guetschow, M.
A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques
Org. Biomol. Chem.
7
3940-3946
2009
Homo sapiens
Frasco, M.; Fournier, D.; Carvalho, F.; Guilhermino, L.
Does mercury interact with the inhibitory effect of dichlorvos on Palaemon serratus (Crustacea: Decapoda) cholinesterase?
Sci. Total Environ.
404
88-93
2008
Palaemon serratus
Shenouda, J.; Green, P.; Sultatos, L.
An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon
Toxicol. Appl. Pharmacol.
241
135-142
2009
Homo sapiens
Umar, R.; Hassan, S.; Ndukwe, O.
Butyrylcholinesterase activity in Nigerian type 2 diabetics with and without metabolic syndrome
Afr. J. Biotechnol.
9
4110-4113
2010
Homo sapiens
-
Nachon, F.; Carletti, E.; Wandhammer, M.; Nicolet, Y.; Schopfer, L.; Masson, P.; Lockridge, O.
X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger
Biochem. J.
434
73-82
2011
Homo sapiens (P06276), Homo sapiens
Chuiko, G.; Lapkina, L.; Podgornaya, V.
Substrate-inhibitory analysis of the cholinesterase in the freshwater oligochaete Lumbriculus variegatus (O.F. Mueller, 1773; Lumbriculidae, Oligochaeta)
Biochem. Syst. Ecol.
39
169-174
2011
Lumbriculus variegatus
-
Frasco, M.F.; Erzen, I.; Stojan, J.; Guilhermino, L.
Localization and properties of cholinesterases in the common prawn (Palaemon serratus): A kinetic-histochemical study
Biol. Bull.
218
1-5
2010
Palaemon serratus
Takahashi, J.; Hijikuro, I.; Kihara, T.; Murugesh, M.; Fuse, S.; Tsumura, Y.; Akaike, A.; Niidome, T.; Takahashi, T.; Sugimoto, H.
Design, synthesis and evaluation of carbamate-modified (-)-N1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors
Bioorg. Med. Chem. Lett.
20
1721-1723
2010
Mus musculus
Schulze, M.; Siol, O.; Decker, M.; Lehmann, J.
Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: Novel heterocyclic templates for butyrylcholinesterase inhibitors
Bioorg. Med. Chem. Lett.
20
2946-2949
2010
Equus caballus
Yu, L.; Cao, R.; Yi, W.; Yan, Q.; Chen, Z.; Ma, L.; Peng, W.; Song, H.
Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase
Bioorg. Med. Chem. Lett.
20
3254-3258
2010
Equus caballus
Korabecny, J.; Musilek, K.; Holas, O.; Binder, J.; Zemek, F.; Marek, J.; Pohanka, M.; Opletalova, V.; Dohnal, V.; Kuca, K.
Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease
Bioorg. Med. Chem. Lett.
20
6093-6095
2010
Homo sapiens
Huang, L.; Luo, Z.; He, F.; Lu, J.; Li, X.
Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase
Bioorg. Med. Chem.
18
4475-4484
2010
Equus caballus
Chen, X.; Tikhonova, I.G.; Decker, M.
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors
Bioorg. Med. Chem.
19
1222-1235
2011
Equus caballus
Yang, W.; Xue, L.; Fang, L.; Chen, X.; Zhan, C.
Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine
Chem. Biol. Interact.
187
148-152
2010
Homo sapiens
Moralev, S.N.; Tikhonov, D.B.
Investigation of structure-activity relationships in organophosphates-cholinesterase interaction using docking analysis
Chem. Biol. Interact.
187
153-156
2010
Equus caballus
Kovarik, Z.; Katalinic, M.; Sinko, G.; Binder, J.; Holas, O.; Jung, Y.; Musilova, L.; Jun, D.; Kuca, K.
Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase
Chem. Biol. Interact.
187
167-171
2010
Homo sapiens (P06276), Homo sapiens
Wong, K.K.; Ngo, J.C.; Liu, S.; Lin, H.Q.; Hu, C.; Shaw, P.C.; Wan, D.C.
Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis
Chem. Biol. Interact.
187
335-339
2010
Homo sapiens (P06276), Homo sapiens
Valbonesi, P.; Brunelli, F.; Mattioli, M.; Rossi, T.; Fabbri, E.
Cholinesterase activities and sensitivity to pesticides in different tissues of silver European eel, Anguilla anguilla
Comp. Biochem. Physiol. C
154
353-359
2011
Anguilla anguilla
Darvesh, S.; Reid, G.; Martin, E.
Biochemical and histochemical comparison of cholinesterases in normal and Alzheimer brain tissues
Curr. Alzheimer Res.
7
386-400
2010
Homo sapiens
Rozengart, E.; Basova, N.
Activatory effect of substrates on the cholinesterase catalysis
Dokl. Biochem. Biophys.
430
7-10
2010
Equus caballus
Wolkmer, P.; Lopes, S.T.; Franciscato, C.; da Silva, A.S.; Traesel, C.K.; Siqueira, L.C.; Pereira, M.E.; Monteiro, S.G.; Mazzanti, C.M.
Trypanosoma evansi: cholinesterase activity in acutely infected Wistar rats
Exp. Parasitol.
125
251-255
2010
Rattus norvegicus
Basova, N.; Rozengart, E.
How various substrates activate the process of enzymatic hydrolysis by different cholinesterases
J. Evol. Biochem. Physiol.
46
580-584
2010
Equus caballus, Todarodes pacificus
-
Fernandez-Gomez, F.; Munoz-Delgado, E.; Montenegro, M.; Campoy, F.; Vidal, C.; Jordan, J.
Cholinesterase activity in brain of senescence-accelerated-resistant mouse SAMR1 and its variation in brain of senescence-accelerated-prone mouse SAMP8
J. Neurosci. Res.
88
155-166
2010
Mus musculus
Xue, L.; Ko, M.; Tong, M.; Yang, W.; Hou, S.; Fang, L.; Liu, J.; Zheng, F.; Woods, J.; Tai, H.; Zhan, C.
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine
Mol. Pharmacol.
79
290-297
2011
Homo sapiens
Rodrigues, S.; Caldeira, C.; Castro, B.; Goncalves, F.; Nunes, B.; Antunes, S.
Cholinesterase (ChE) inhibition in pumpkinseed (Lepomis gibbosus) as environmental biomarker: ChE characterization and potential neurotoxic effects of xenobiotics
Pestic. Biochem. Physiol.
99
181-188
2011
no activity in Lepomis gibbosus
-
Dingova, D.; Leroy, J.; Check, A.; Garaj, V.; Krejci, E.; Hrabovska, A.
Optimal detection of cholinesterase activity in biological samples: Modifications to the standard Ellmans assay
Anal. Biochem.
462
67-75
2014
Homo sapiens, Mus musculus
Perez, J.; Monteiro, M.S.; Quintaneiro, C.; Soares, A.M.; Loureiro, S.
Characterization of cholinesterases in Chironomus riparius and the effects of three herbicides on chlorpyrifos toxicity
Aquat. Toxicol.
144-145
296-302
2013
Chironomus riparius
Nachon, F.; Carletti, E.; Ronco, C.; Trovaslet, M.; Nicolet, Y.; Jean, L.; Renard, P.Y.
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimers drugs targeting acetyl- and butyryl-cholinesterase
Biochem. J.
453
393-399
2013
Homo sapiens (P06276), Homo sapiens
Masson, P.
Time-dependent kinetic complexities in cholinesterase-catalyzed reactions
Biochemistry
77
1147-1161
2012
Homo sapiens
Yoon, Y.K.; Ali, M.A.; Wei, A.C.; Choon, T.S.; Khaw, K.Y.; Murugaiyah, V.; Osman, H.; Masand, V.H.
Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors
Bioorg. Chem.
49
33-39
2013
Homo sapiens
Trovaslet, M.; Trapp, M.; Weik, M.; Nachon, F.; Masson, P.; Tehei, M.; Peters, J.
Relation between dynamics, activity and thermal stability within the cholinesterase family
Chem. Biol. Interact.
203
14-18
2013
Homo sapiens
Stojan, J.
The significance of low substrate concentration measurements for mechanistic interpretation in cholinesterases
Chem. Biol. Interact.
203
44-50
2013
Equus caballus
Correa-Basurto, J.; Bello, M.; Rosales-Hernandez, M.C.; Hernandez-Rodriguez, M.; Nicolas-Vazquez, I.; Rojo-Dominguez, A.; Trujillo-Ferrara, J.G.; Miranda, R.; Flores-Sandoval, C.A.
QSAR, docking, dynamic simulation and quantum mechanics studies to explore the recognition properties of cholinesterase binding sites
Chem. Biol. Interact.
209
1-13
2014
Homo sapiens
Wamser, M.N.; Leite, E.F.; Ferreira, V.V.; Delwing-de Lima, D.; da Cruz, J.G.; Wyse, A.T.; Delwing-Dal Magro, D.
Effect of hypoxanthine, antioxidants and allopurinol on cholinesterase activities in rats
J. Neural Transm.
120
1359-1367
2013
Rattus norvegicus
Vinsova, J.; Kratky, M.; Komloova, M.; Dadapeer, E.; Stepankova, S.; Vorcakova, K.; Stolarikova, J.
Diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates: synthesis, antimycobacterial activity and cholinesterase inhibition
Molecules
19
7152-7168
2014
Equus caballus
Torres, J.M.; Lira, A.F.; Silva, D.R.; Guzzo, L.M.; SantAnna, C.M.; Kuemmerle, A.E.; Rumjanek, V.M.
Structural insights into cholinesterases inhibition by harmane beta-carbolinium derivatives: A kinetics-molecular modeling approach
Phytochemistry
81
24-30
2012
Equus caballus
Meirer, K.; Glatzel, D.; Kretschmer, S.; Wittmann, S.K.; Hartmann, M.; Bloecher, R.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Hofmann, B.; Fuerst, R.; Proschak, E.
Design, synthesis and cellular characterization of a dual inhibitor of 5-lipoxygenase and soluble epoxide hydrolase
Molecules
22
45
2016
Homo sapiens (P06276)
Saxena, A.; Belinskaya, T.; Schopfer, L.M.; Lockridge, O.
Characterization of butyrylcholinesterase from porcine milk
Arch. Biochem. Biophys.
652
38-49
2018
Homo sapiens (P06276), Homo sapiens, Sus scrofa (P32752), Sus scrofa
Bhakta, H.K.; Park, C.H.; Yokozawa, T.; Min, B.S.; Jung, H.A.; Choi, J.S.
Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and beta-secretase 1 inhibitors
Arch. Pharm. Res.
39
794-805
2016
Homo sapiens (P06276)
Ali, M.Y.; Seong, S.H.; Jung, H.A.; Jannat, S.; Choi, J.S.
Kinetics and molecular docking of dihydroxanthyletin-type coumarins from Angelica decursiva that inhibit cholinesterase and BACE1
Arch. Pharm. Res.
41
753-764
2018
Equus caballus (P81908)
Hagstrom, D.; Hirokawa, H.; Zhang, L.; Radic, Z.; Taylor, P.; Collins, E.S.
Planarian cholinesterase in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation
Arch. Toxicol.
91
2837-2847
2017
Dugesia japonica
Hagstrom, D.; Zhang, S.; Ho, A.; Tsai, E.S.; Radic, Z.; Jahromi, A.; Kaj, K.J.; He, Y.; Taylor, P.; Collins, E.S.
Planarian cholinesterase molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity
Arch. Toxicol.
92
1161-1176
2018
Dugesia japonica
Alkanaimsh, S.; Corbin, J.; Kailemia, M.; Karuppanan, K.; Rodriguez, R.; Lebrilla, C.; McDonald, K.; Nandi, S.
Purification and site-specific N-glycosylation analysis of human recombinant butyrylcholinesterase from Nicotiana benthamiana
Biochem. Eng. J.
142
58-67
2019
Homo sapiens (P06276)
-
Pope, C.; Uchea, C.; Flynn, N.; Poindexter, K.; Geng, L.; Brimijoin, W.S.; Hartson, S.; Ranjan, A.; Ramsey, J.D.; Liu, J.
In vitro characterization of cationic copolymer-complexed recombinant human butyrylcholinesterase
Biochem. Pharmacol.
98
531-539
2015
Homo sapiens (P06276), Homo sapiens
Fogle, E.J.; Marlier, J.F.; Stillman, A.; Gao, X.; Rao, Y.; Robins, L.I.
An investigation into the butyrylcholinesterase-catalyzed hydrolysis of formylthiocholine using heavy atom kinetic isotope effects
Bioorg. Chem.
65
57-60
2016
Equus caballus (P81908)
Sultana, N.; Sarfraz, M.; Tanoli, S.T.; Akram, M.S.; Sadiq, A.; Rashid, U.; Tariq, M.I.
Synthesis, crystal structure determination, biological screening and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases
Bioorg. Chem.
72
256-267
2017
Equus caballus (P81908)
Wieckowska, A.; Wieckowski, K.; Bajda, M.; Brus, B.; Salat, K.; Czerwinska, P.; Gobec, S.; Filipek, B.; Malawska, B.
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with beta-amyloid anti-aggregation properties and beneficial effects on memory in vivo
Bioorg. Med. Chem.
23
2445-2457
2015
Equus caballus (P81908)
Liu, Z.; Fang, L.; Zhang, H.; Gou, S.; Chen, L.
Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property
Bioorg. Med. Chem.
25
2387-2398
2017
Equus caballus (P81908)
Mohammed, A.; Sneathen, J.; Frojen, S.G.; Kuo, L.; Dupureur, C.M.
Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate
Bioorg. Med. Chem.
25
3053-3058
2017
Equus caballus (P81908), Equus caballus
Nakayama, K.; Schwans, J.P.; Sorin, E.J.; Tran, T.; Gonzalez, J.; Arteaga, E.; McCoy, S.; Alvarado, W.
Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors
Bioorg. Med. Chem.
25
3171-3181
2017
Equus caballus (P81908)
Corbin, J.M.; Kailemia, M.J.; Cadieux, C.L.; Alkanaimsh, S.; Karuppanan, K.; Rodriguez, R.L.; Lebrilla, C.B.; Cerasoli, D.M.; McDonald, K.A.; Nandi, S.
Purification, characterization, and N-glycosylation of recombinant butyrylcholinesterase from transgenic rice cell suspension cultures
Biotechnol. Bioeng.
115
1301-1310
2018
Oryza sativa
Rodriguez-Fuentes, G.; Marin-Lopez, V.; Hernandez-Marquez, E.
Cholinesterases in Gambusia yucatana biochemical characterization and its relationship with sex and total length
Bull. Environ. Contam. Toxicol.
97
776-780
2016
Gambusia yucatana
Dafferner, A.J.; Lushchekina, S.; Masson, P.; Xiao, G.; Schopfer, L.M.; Lockridge, O.
Characterization of butyrylcholinesterase in bovine serum
Chem. Biol. Interact.
266
17-27
2017
Bos taurus (P32749), Bos taurus
Kim, K.; Yao, J.; Jin, Z.; Zheng, F.; Zhan, C.G.
Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6-monoacetylmorphine
Chem. Biol. Interact.
293
107-114
2018
Homo sapiens (P06276)
Yang, S.H.; Sun, Q.; Xiong, H.; Liu, S.Y.; Moosavi, B.; Yang, W.C.; Yang, G.F.
Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy
Chem. Commun. (Camb.)
53
3952-3955
2017
Homo sapiens
Mennillo, E.; Casu, V.; Tardelli, F.; De Marchi, L.; Freitas, R.; Pretti, C.
Suitability of cholinesterase of polychaete Diopatra neapolitana as biomarker of exposure to pesticides In vitro characterization
Comp. Biochem. Physiol. C
191
152-159
2017
Diopatra neapolitana
Begum, S.; Nizami, S.S.; Mahmood, U.; Masood, S.; Iftikhar, S.; Saied, S.
In-vitro evaluation and in-silico studies applied on newly synthesized amide derivatives of N-phthaloylglycine as butyrylcholinesterase (BChE) inhibitors
Comput. Biol. Chem.
74
212-217
2018
Equus caballus (P81908)
Altaf, A.A.; Hamayun, M.; Lal, B.; Tahir, M.N.; Holder, A.A.; Badshah, A.; Crans, D.C.
Ferrocene-based anilides synthesis, structural characterization and inhibition of butyrylcholinesterase
Dalton Trans.
47
11769-11781
2018
Homo sapiens (P06276)
Albendin, G.; Arellano, J.M.; Manuel-Vez, M.P.; Sarasquete, C.; Arufe, M.I.
Characterization and in vitro sensitivity of cholinesterases of gilthead seabream (Sparus aurata) to organophosphate pesticides
Fish Physiol. Biochem.
43
455-464
2017
Sparus aurata
Larik, F.A.; Shah, M.S.; Saeed, A.; Shah, H.S.; Channar, P.A.; Bolte, M.; Iqbal, J.
New cholinesterase inhibitors for Alzheimers disease structure activity relationship, kinetics and molecular docking studies of 1-butanoyl-3-arylthiourea derivatives
Int. J. Biol. Macromol.
116
144-150
2018
Homo sapiens (P06276)
Macdonald, I.R.; Maxwell, S.P.; Reid, G.A.; Cash, M.K.; DeBay, D.R.; Darvesh, S.
Quantification of butyrylcholinesterase activity as a sensitive and specific biomarker of Alzheimers disease
J. Alzheimers Dis.
58
491-505
2017
Homo sapiens
Lockridge, O.; David, E.; Schopfer, L.M.; Masson, P.; Brazzolotto, X.; Nachon, F.
Purification of recombinant human butyrylcholinesterase on Hupresin?
J. Chromatogr. B
1102-1103
109-115
2018
Homo sapiens (P06276), Homo sapiens
Lee, J.Y.
Comparison of efficiency of purification (from human plasma) of a nerve agent adduct of butyrylcholinesterase between the affinity gel method and immunomagnetic separation
J. Chromatogr. Sci.
56
248-253
2018
Homo sapiens (P06276), Homo sapiens
Ferre, D.M.; Lentini, V.R.; Romano, R.R.; Luduena, H.R.; Jotallan, P.J.; Gorla, N.B.M.
Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos
J. Environ. Sci. Health B
53
191-198
2018
Bos taurus (P32749), Bos taurus
Terali, K.; Dalmizrak, O.; Hoti, Q.; Ozer, N.
Evaluation of the inhibitory effect of abamectin on mammalian butyrylcholinesterase enzyme kinetic and molecular docking studies
J. Environ. Sci. Health B
8
1-6
2018
Equus caballus
Rozengart, E.; Yagodina, O.; Basova, N.; Saakov, V.
Substrate-inhibitor specificity of cholinesterase and monoamine oxydase from optic ganglia of the pacific squid Todarodes pacificus and commander squid Berryteuthis magister
J. Evol. Biochem. Physiol.
53
111-122
2017
Todarodes pacificus, Berryteuthis magister
-
Zorbaz, T.; Malinak, D.; Marakovic, N.; Macek Hrvat, N.; Zandona, A.; Novotny, M.; Skarka, A.; Andrys, R.; Benkova, M.; Soukup, O.; Katalinic, M.; Kuca, K.; Kovarik, Z.; Musilek, K.
Pyridinium oximes with ortho-positioned chlorine moiety exhibit improved physicochemical properties and efficient reactivation of human acetylcholinesterase inhibited by several nerve agents
J. Med. Chem.
61
10753-10766
2018
Homo sapiens (P06276)
Kosak, U.; Brus, B.; Knez, D.; Zakelj, S.; Trontelj, J.; Pislar, A.; Sink, R.; Jukic, M.; Zivin, M.; Podkowa, A.; Nachon, F.; Brazzolotto, X.; Stojan, J.; Kos, J.; Coquelle, N.; Salat, K.; Colletier, J.P.; Gobec, S.
The magic of crystal structure-based inhibitor optimization development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity
J. Med. Chem.
61
119-139
2018
Homo sapiens (P06276), Homo sapiens, Rattus norvegicus (Q9JKC1)
Xiao, Q.; Zhou, H.; Wei, H.; Du, H.; Tan, W.; Zhan, Y.; Pistolozzi, M.
A new method to characterize the kinetics of cholinesterases inhibited by carbamates
J. Pharm. Biomed. Anal.
144
175-182
2017
Homo sapiens (P06276), Homo sapiens, Canis lupus familiaris (P32750), Canis lupus familiaris
Ali, M.Y.; Seong, S.H.; Reddy, M.R.; Seo, S.Y.; Choi, J.S.; Jung, H.A.
Kinetics and molecular docking studies of 6-formyl umbelliferone isolated from Angelica decursiva as an inhibitor of cholinesterase and BACE1
Molecules
22
1604-1616
2017
Equus caballus (P81908)
Elsebai, M.; Ghabbour, H.; Marzouk, A.; Salmas, R.; Orhan, I.; Senol, F.
Amberboin and lipidiol X-ray crystalographic data, absolute configuration and inhibition of cholinesterase
Phytochem. Lett.
27
44-48
2018
Homo sapiens (P06276)
-
Petrov, K.A.; Kharlamova, A.D.; Lenina, O.A.; Nurtdinov, A.R.; Sitdykova, M.E.; Ilyin, V.I.; Zueva, I.V.; Nikolsky, E.E.
Specific inhibition of acetylcholinesterase as an approach to decrease muscarinic side effects during myasthenia gravis treatment
Sci. Rep.
8
304
2018
Homo sapiens (P06276), Homo sapiens
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