Reference on EC 3.1.1.64 - retinoid isomerohydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cooper, D.A.; Olson, J.A.
Hydrolysis of cis and trans isomers of retinyl palmitate by retinyl ester hydrolase of pig liver
Arch. Biochem. Biophys.
260
705-711
1988
Sus scrofa
Blaner, W.S.; Das, S.R.; Gouras, P.; Flood, M.T.
Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells
J. Biol. Chem.
262
53-58
1987
Homo sapiens
Blaner W.S.; Prystowsky, J.H.; Smith, J.E.; Goodman, D.S.
Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities
Biochim. Biophys. Acta
794
419-427
1984
Bos taurus
Bustamante, J.J.; Ziari, S.; Ramirez, R.D.; Tsin, A.T.C.
Retinyl ester hydrolase and the visual cycle in the chicken eye
Am. J. Physiol.
269
R1346-R1350
1995
Gallus gallus
Mata, J.R.; Mata, N.L.; Tsin, A.T.C.
Substrate specificity of retinyl ester hydrolase activity in retinal pigment epithelium
J. Lipid Res.
39
604-612
1998
Bos taurus
Mata, N.L.; Mata, J.R.; Tsin, A.T.C.
Comparison of retinyl ester hydrolase activities in bovine liver and retinal pigment epithelium
J. Lipid Res.
37
1947-1952
1996
Bos taurus
Jin, M.; Li, S.; Moghrabi, W.N.; Sun, H.; Travis, G.H.
Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium
Cell
122
449-459
2005
Bos taurus
Chen, Y.; Moiseyev, G.; Takahashi, Y.; Ma, J.X.
Impacts of two point mutations of RPE65 from Lebers congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65
FEBS Lett.
580
4200-4204
2006
Homo sapiens
Takahashi, Y.; Chen, Y.; Moiseyev, G.; Ma, J.X.
Two point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity
J. Biol. Chem.
281
21820-21826
2006
Homo sapiens
Radu, R.A.; Hu, J.; Peng, J.; Bok, D.; Mata, N.L.; Travis, G.H.
Retinal pigment epithelium-retinal G protein receptor-opsin mediates light-dependent translocation of all-trans-retinyl esters for synthesis of visual chromophore in retinal pigment epithelial cells
J. Biol. Chem.
283
19730-19738
2008
Mus musculus
Guignard, T.J.; Jin, M.; Pequignot, M.O.; Li, S.; Chassigneux, Y.; Chekroud, K.; Guillou, L.; Richard, E.; Hamel, C.P.; Brabet, P.
FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and LRAT
J. Biol. Chem.
285
18759-18768
2010
Homo sapiens
Redmond, T.M.; Poliakov, E.; Kuo, S.; Chander, P.; Gentleman, S.
RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization
J. Biol. Chem.
285
1919-1927
2010
Homo sapiens
Golczak, M.; Kiser, P.D.; Lodowski, D.T.; Maeda, A.; Palczewski, K.
Importance of membrane structural integrity for RPE65 retinoid isomerization activity
J. Biol. Chem.
285
9667-9682
2010
Homo sapiens
Kiser, P.D.; Golczak, M.; Lodowski, D.T.; Chance, M.R.; Palczewski, K.
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle
Proc. Natl. Acad. Sci. USA
106
17325-17330
2009
Bos taurus (Q28175), Bos taurus
Kiser, P.D.; Palczewski, K.
Membrane-binding and enzymatic properties of RPE65
Prog. Retin. Eye Res.
29
428-442
2010
Bos taurus
Nikolaeva, O.; Takahashi, Y.; Moiseyev, G.; Ma, J.X.
Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65
Biochem. Biophys. Res. Commun.
391
1757-1761
2010
Homo sapiens
Nikolaeva, O.; Moiseyev, G.; Rodgers, K.K.; Ma, J.X.
Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity
Biochem. J.
436
591-597
2011
Gallus gallus
Gollapalli, D.R.; Maiti, P.; Rando, R.R.
RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters
Biochemistry
42
11824-11830
2003
Bos taurus
Moiseyev, G.; Crouch, R.K.; Goletz, P.; Oatis, J.; Redmond, T.M.; Ma, J.X.
Retinyl esters are the substrate for isomerohydrolase
Biochemistry
42
2229-2238
2003
Bos taurus, Mus musculus
Lyubarsky, A.L.; Savchenko, A.B.; Morocco, S.B.; Daniele, L.L.; Redmond, T.M.; Pugh, E.N.
Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye
Biochemistry
44
9880-9888
2005
Mus musculus
Maiti, P.; Kong, J.; Kim, S.R.; Sparrow, J.R.; Allikmets, R.; Rando, R.R.
Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation
Biochemistry
45
852-860
2006
Bos taurus
Poliakov, E.; Parikh, T.; Ayele, M.; Kuo, S.; Chander, P.; Gentleman, S.; Redmond, T.M.
Aromatic lipophilic spin traps effectively inhibit RPE65 isomerohydrolase activity
Biochemistry
50
6739-6741
2011
Bos taurus
Nikolaeva, O.; Takahashi, Y.; Moiseyev, G.; Ma, J.X.
Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane
FEBS J.
276
3020-3030
2009
Gallus gallus
Takahashi, Y.; Moiseyev, G.; Chen, Y.; Nikolaeva, O.; Ma, J.X.
An alternative isomerohydrolase in the retinal Mueller cells of a cone-dominant species
FEBS J.
278
2913-2926
2011
Danio rerio (A9C3R8), Danio rerio (Q6PBW5), Danio rerio
Takahashi, Y.; Moiseyev, G.; Chen, Y.; Farjo, K.; Nikolaeva, O.; Ma, J.X.
An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain
FEBS J.
278
973-987
2011
Danio rerio (A9C3R9), Danio rerio
Takahashi, Y.; Moiseyev, G.; Chen, Y.; Ma, J.X.
Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium
FEBS Lett.
579
5414-5418
2005
Homo sapiens
Lopes, V.S.; Gibbs, D.; Libby, R.T.; Aleman, T.S.; Welch, D.L.; Lillo, C.; Jacobson, S.G.; Radu, R.A.; Steel, K.P.; Williams, D.S.
The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65
Hum. Mol. Genet.
20
2560-2570
2011
Mus musculus
McBee, J.K.; Van Hooser, J.P.; Jang, G.F.; Palczewski, K.
Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo
J. Biol. Chem.
276
48483-48493
2001
Bos taurus
Mata, N.L.; Moghrabi, W.N.; Lee, J.S.; Bui, T.V.; Radu, R.A.; Horwitz, J.; Travis, G.H.
Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells
J. Biol. Chem.
279
635-643
2004
Mus musculus
Moiseyev, G.; Takahashi, Y.; Chen, Y.; Gentleman, S.; Redmond, T.M.; Crouch, R.K.; Ma, J.X.
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle
J. Biol. Chem.
281
2835-2840
2006
Bos taurus
Moiseyev, G.; Takahashi, Y.; Chen, Y.; Kim, S.; Ma, J.X.
RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species
J. Biol. Chem.
283
8110-8117
2008
Bos taurus, Gallus gallus, Homo sapiens
Takahashi, Y.; Moiseyev, G.; Ablonczy, Z.; Chen, Y.; Crouch, R.K.; Ma, J.X.
Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65
J. Biol. Chem.
284
3211-3218
2009
Bos taurus, Homo sapiens
Yuan, Q.; Kaylor, J.J.; Miu, A.; Bassilian, S.; Whitelegge, J.P.; Travis, G.H.
Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups
J. Biol. Chem.
285
988-999
2010
Gallus gallus, Bos taurus (Q28175)
Amann, P.M.; Luo, C.; Owen, R.W.; Hofmann, C.; Freudenberger, M.; Schadendorf, D.; Eichmueller, S.B.; Bazhin, A.V.
Vitamin A metabolism in benign and malignant melanocytic skin cells: importance of lecithin/retinol acyltransferase and RPE65
J. Cell. Physiol.
227
718-728
2012
Homo sapiens
Travis, G.H.; Kaylor, J.; Yuan, Q.
Analysis of the retinoid isomerase activities in the retinal pigment epithelium and retina
Methods Mol. Biol.
652
329-339
2010
Bos taurus, Gallus gallus
Redmond, T.M.; Yu, S.; Lee, E.; Bok, D.; Hamasaki, D.; Chen, N.; Goletz, P.; Ma, J.X.; Crouch, R.K.; Pfeifer, K.
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle
Nat. Genet.
20
344-351
1998
Mus musculus
Redmond, T.M.; Poliakov, E.; Yu, S.; Tsai, J.Y.; Lu, Z.; Gentleman, S.
Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle
Proc. Natl. Acad. Sci. USA
102
13658-13663
2005
Homo sapiens
Takahashi, Y.; Moiseyev, G.; Nikolaeva, O.; Ma, J.X.
Identification of the key residues determining the product specificity of isomerohydrolase
Biochemistry
51
4217-4225
2012
Danio rerio, Gallus gallus
Takahashi, Y.; Moiseyev, G.; Ma, J.X.
Identification of key residues determining isomerohydrolase activity of human RPE65
J. Biol. Chem.
289
6743-26751
2014
Homo sapiens
Poliakov, E.; Gubin, A.N.; Stearn, O.; Li, Y.; Campos, M.M.; Gentleman, S.; Rogozin, I.B.; Redmond, T.M.
Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates
PLoS ONE
7
e49975
2012
no activity in tunicata, no activity in cephalochordata, Petromyzon marinus (L0ATZ0), Petromyzon marinus
Eroglu, A.; Gentleman, S.; Poliakov, E.; Redmond, T.M.
Inhibition of RPE65 retinol isomerase activity by inhibitors of lipid metabolism
J. Biol. Chem.
291
4966-4973
2016
Homo sapiens (Q16518)
Sheridan, C.; Boyer, N.P.; Crouch, R.K.; Koutalos, Y.
RPE65 and the accumulation of retinyl esters in mouse retinal pigment epithelium
Photochem. Photobiol.
93
844-848
2017
Mus musculus (Q91ZQ5), Mus musculus
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