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Information on EC 3.1.1.64 - retinoid isomerohydrolase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.64 retinoid isomerohydrolase
IUBMB Comments
This enzyme, which operates in the retinal pigment epithelium (RPE), catalyses the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol, a key step in the regeneration of the visual chromophore in the vertebrate visual cycle . Interaction of the enzyme with the membrane is critical for its enzymic activity .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
13-cis isomerohydrolase, 13cIMH, all-trans-REH, all-trans-retinyl-palmitate hydrolase, esterase, all-trans-retinol palmitate, IMH, isomerohydrolase, Retinoid isomerase, retinoid isomerohydrolase, retinol hydrolase (ambiguous), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid
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PATHWAY SOURCE
PATHWAYS
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