Reference on EC 3.1.1.4 - phospholipase A2
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yang, H-C.; Mosior, M.; Ni, B.; Dennis, E.A.
Regional distribution, ontogeny, purification, and characterization of the Ca2+-independent phospholipase A2 from rat brain
J. Neurochem.
73
1278-1287
1999
Rattus norvegicus
Dessen, A.; Tang, J.; Schmidt, H.; Stahl, M.; Clark, J.D.; Seehra, J.; Somers, W.S.
Crystal structure of human cytosolic Phospholipase A2 reveals a novel topology and catalytic mechanism
Cell
97
349-360
1999
Homo sapiens
Larsson Forsell, P.K.A.; Kennedy, B.P.; Claesson, H.E.
The human calcium-independent phospholipase A2 gene
Eur. J. Biochem.
262
575-585
1999
Rattus norvegicus, Homo sapiens (O60733), Homo sapiens
Liu, X.; Pan, H.; Yang, G.; Wu, X.; Zhou, Y.
Cloning, expression and biochemical characterization of a basic-acidic hybrid phospholipase A2-II from Agkistrodon halys Pallas
Biochim. Biophys. Acta
1431
157-165
1999
Gloydius halys
Pan, F.M.; Chao, S.C.; Wu, S.H.; Chang, W.C.; Chiou, S.H.
Characterization of phospholipase A2 (PLA2) from Taiwan Cobra: Isoenzymes and their site-directed mutants
Biochem. Biophys. Res. Commun.
250
154-160
1998
Naja atra
Rice, S.Q.J.; Southan, C.; Boyd, H.F.; Terrett, J.A.; MacPhee, C.H.; Moores, K.; Gloger, I.S.; Tew, D.G.
Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor
Biochem. J.
330
1309-1315
1998
Homo sapiens
-
Han, S.K.; Yoon, E.T.; Cho, W.
Bacterial expression and characterization of human secretory class V phospholipase A2
Biochem. J.
331
353-357
1998
Homo sapiens
-
Chen, D.; Dennis, E.A.
Expression and characterization of human group V phospholipase A2
Biochim. Biophys. Acta
1394
57-64
1998
Homo sapiens, Mus musculus, Rattus norvegicus
Akiba, S.; Dodia, C.; Chen, X.; Fisher, A.B.
Characterization of acidic Ca2+-independent phospholipase A2 of bovine lung
Comp. Biochem. Physiol. B
120
393-404
1998
Bos taurus, Homo sapiens
Lamura, E.; Hillier, K.; Kinkaid, A.; Wilton, D.
Compartmentalisation and characteristics of a Ca2+-dependent phospholipase A2 in human colon mucosa
Biochem. Pharmacol.
53
1323-1332
1997
Homo sapiens
Han, S.K.; Lee, B.I.; Cho, W.
Bacterial expression and characterisation of human pancreatic phospholipase A2
Biochim. Biophys. Acta
1346
185-192
1997
Homo sapiens
Egger, D.; Wehtje, E.; Adlercreutz, P.
Characterization and optimation of phospholipase A2 catalyzed synthesis of phosphatidylcholine
Biochim. Biophys. Acta
1343
76-84
1997
Sus scrofa
Yang, H.C.; Farooqui, A.A.; Horrocks, L.A.
Characterization of plasmalogen-selective phospholipase A2 from bovine brain
Adv. Exp. Med. Biol.
416
309-313
1996
Bos taurus, Homo sapiens
Wolf, M.J.; Gross, R.W.
Expression, purification and kinetic characterization of a recombinant 80-kDa intracellular calcium-independent phospholipase A2
J. Biol. Chem.
271
30879-30885
1996
Mesocricetus auratus
Oishi, T.; Tamiya-Koizumi, K.; Kudo, I.; Iino, S.; Takagi, K.; Yoshida, Y.
Purification and characterization of nuclear alkaline phospholipase A2 in rat ascites hepatoma cells
FEBS Lett.
394
55-60
1996
Rattus norvegicus
Chiou, J.Y.; Chang, L.S.; Chen, L.N.; Chang, C.C.
Purification and characterization of a novel phospholipase A2 from King Cobra (Ophiophagus hannah) venom
J. Protein Chem.
14
451-456
1995
Ophiophagus hannah
Laing, G.D.; Kamiguti, A.S.; Wilkinson, M.C.; Lowe, G.M.; Theakston, R.D.G.
Characterisation of a phospholipase A2 from the venom of the Papuan black snake (Pseudechis papuanus)
Biochim. Biophys. Acta
1250
137-143
1995
Pseudechis papuanus
Wang, R.; Dodia, C.R.; Jain, M.K.; Fisher, A.B.
Purification and characterization of a calcium-independent acidic phospholipase A2 from rat lung
Biochem. J.
304
131-137
1994
Rattus norvegicus
Kawauchi, Y.; Takasaki, J.; Matsuura, Y.; Masuho, Y.
Preparation and characterization of human rheumatoid arthritic synovial fluid phospholipase A2 produced by recombinant baculovirus-infected cells
J. Biochem.
116
82-87
1994
Homo sapiens
-
Nakatani, Y.; Hara, S.; Murakami, M.; Kudo, I.; Inoue, K.
Characterization of cytosolic phospholipase A2 in rat mastocystoma RBL-2H3
Biol. Pharm. Bull.
17
47-50
1994
Rattus norvegicus
Kemparaju, K.; Prasad, B.N.; Gowda, V.T.
Purification of a basic phospholipase A2 from Indian Saw-Scawled Viper (Echis carinatus) venom: characterization of antigenic, catalytic and pharmacological properties
Toxicon
32
1187-1196
1994
Echis carinatus
Nok, A.J.; Esievo, K.A.N.; Ibrahim, S.; Ukoha, A.I.; Ikediobi, C.O.
Phospholipase A2 from Trypanosoma congolense: characterization and haematological properties
Cell Biochem. Funct.
11
125-130
1993
Trypanosoma congolense
Minami, T.; Tojo, H.; Shinomura, Y.; Matsuzawa, Y.; Okamoto, M.
Purification and characterization of a phospholipase A2 from human ileal mucosa
Biochim. Biophys. Acta
1170
125-130
1993
Homo sapiens
Hada, S.; Fujii, S.; Inoue, S.; Ikeda, K.; Teshima, K.
Hydrolysis of micellar diheptanoylphosphatidylcholine catalyzed by bovine pancreatic phospholipase A2: Kinetic characterization of group I and II enzymes
J. Biochem.
113
13-18
1993
Bos taurus
Paglin, S.; Roy, R.; Polgar, P.
Characterization of hormonally regulated and particulate-associated phospholipase A2 from bovine endothelial cells
J. Biol. Chem.
268
11697-11702
1993
Bos taurus
Rehfeldt, W.; Resch, K.; Goppelt-Struebe, M.
Cytosolic phospholipase A2 from human monocytic cells: characterization of substrate specificity and Ca2+-dependent membrane association
Biochem. J.
293
255-261
1993
Homo sapiens
Tojo, H.; Ying, Z.; Okamoto, M.
Purification and characterization of guinea pig gastric phospholipase A2 of the pancreatic type
Eur. J. Biochem.
215
81-90
1993
Cavia porcellus
Hanasaki, K.; Arita, H.
Purification and characterization of a high-affinity binding protein for pancreatic-type phospholipase A2
Biochim. Biophys. Acta
1127
233-241
1992
Bos taurus
Hoffmann, G.E.; Schneider, E.; Brand, K.; Kozumplik, V.; Fateh-Moghadam, S.
Characterization of a phospholipase A2 in human serum
Eur. J. Clin. Chem. Clin. Biochem.
30
111-117
1992
Homo sapiens
Franken, P.A.; van den Berg, L.; Huang, J.; Gunyuzlu, P.; Lugtigheid, R.B.; Verheij, H.M.; de Haas, G.H.
Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli
Eur. J. Biochem.
203
89-98
1992
Homo sapiens, Naja melanoleuca, Sus scrofa
Ghomashchi, F.; Yu, B.Z.; Mihelich, E.D.; Jain, M.K.; Gelb, M.H.
Kinetic characterization of phospholipase A2 modified by manoalogue
Biochemistry
30
9559-9569
1991
Apis mellifera, Naja naja, Sus scrofa
Steiner, M.
Localization and characterization of phospholipase A2 in mouse mammary gland-derived cells
Arch. Biochem. Biophys.
286
293-299
1991
Mus musculus
Takayama, K.; Kudo, I.; Kim, D.K.; Nagata, K.; Nozawa, Y.; Inoue, K.
Purification and characterization of human platelet phospholipase A2 which preferentially hydrolyzes an arachidonoyl residue
FEBS Lett.
282
326-330
1991
Homo sapiens
Siddiqi, A.R.; Zaidi, Z.H.; Jrnvall, H.
Purification and characterization of two highly different group II phospholipase A2 isoenzymes from a single viperid (Eristocophis macmahoni) venom
Eur. J. Biochem.
201
675-679
1991
Eristicophis macmahoni
Filgueiras, O.M.O.; Possmayer, F.
Purification and characterization of a phospholipase A2 associated with rabbit lung microsomes: some evidence for its mitochondrial origin
Biochim. Biophys. Acta
1046
258-266
1990
Oryctolagus cuniculus
Cao, Y.Z.; Tam, S.W.; Arthur, G.; Chen, H.; Choy, P.C.
The purification and characterization of a phospholipase A in hamster heart cytosol for the hydrolysis of phosphatidylcholine
J. Biol. Chem.
262
16927-16935
1987
Mesocricetus auratus
De Geus, P.; van den Bergh, C.J.; Kuipers, O.; Verheij, H.M.; Hockstra, W.P.M.; de Haas, G.H.
Expression of porcine pancreatic phospholipase A2. Generation of active enzyme by sequence-specific cleavage of a hybrid protein from Escherichia coli
Nucleic Acids Res.
15
3743-3759
1987
Sus scrofa (P00592), Sus scrofa
Romero, G.; Thompson, K.; Biltonen, R.L.
The activation of porcine pancreatic phospholipase A2 by dipalmitoylphosphatidylcholine large unilamellar vesicles
J. Biol. Chem.
262
13476-13482
1987
Sus scrofa
Menashe, M.
Hydrolysis of dipalmitoylphosphatidylcholine small unilamellar vesicles by porcine pancreatic phospholipase A2
J. Biol. Chem.
261
5328-5333
1986
Sus scrofa
Lichtenberg, D.; Romero, G.; Menashe, M.; Biltonen, R.L.
Hydrolysis of dipalmitoylphosphatidylcholine large unilamellar vesicles by porcine pancreatic phospholipase A2
J. Biol. Chem.
261
5334-5340
1986
Sus scrofa
Hoffman, W.J.; Vahey, M.; Hajdu, J.
Pancreatic porcine phospholipase A2 catalyzed hydrolysis of phosphatidylcholine in lecithin-bile salt mixed micelles: Kinetic studies in a lecithin-sodium cholate system
Arch. Biochem. Biophys.
221
361-370
1983
Naja naja, Sus scrofa
Donne-Op den Kelder, G.M.; de Haas, G.H.; Egmond, M.R.
Localization of the second calcium ion binding site in porcine and equine phospholipase A2
Biochemistry
22
2470-2478
1983
Bos taurus, Equus caballus, Homo sapiens, Sus scrofa
Dijkstra, B.W.; Renetseder, R.; Kalk, K.H.; Hol, W.G.J.; Drenth, J.
Structure of porcine pancreatic phospholipase A2 at 2.6 A resolution and comparison with bovine phospholipase A2
J. Mol. Biol.
168
163-179
1983
Sus scrofa
Deems, R.A.; Dennis, E.A.
Phospholipase A2 from cobra venom (Naja naja naja)
Methods Enzymol.
71
703-710
1981
Naja naja
Cottrell, R.C.
Phospholipase A2 from bee venom
Methods Enzymol.
71
698-702
1981
Apis mellifera
Zahler, P.; Kramer, R.
Isolation of phospholipase A2 from red cell membranes of sheep
Methods Enzymol.
71
690-698
1981
Ovis aries
Itoh, Y.; Iwata, T.; Izaki, K.; Takahashi, H.
Mode of action of a bacteriocin from Erwinia carotovora III. Properties of phospholipase A of Erwinia carotovora and its involvement in phospholipid degradation caused by carotovoricin
J. Gen. Appl. Microbiol.
27
239-251
1981
Pectobacterium carotovorum
-
Kondo, K.; Toda, H.; Narita, K.
Purification and characterization of phospholipase A2 from Bungarus multicinctus venom
J. Biochem.
89
29-36
1981
Bungarus multicinctus
Hendrickson, H.S.; Trygstad, W.M.; Loftness, T.L.; Sailer, S.L.
Phospholipase A2 activity on mixed lipid monolayers: Activation of phospholipase A2 from porcine pancreas and Crotalus adamanteus by anionic and neutral amphophiles
Arch. Biochem. Biophys.
212
508-514
1981
Crotalus adamanteus, Sus scrofa
Ishimaru, K.; Kihara, H.; Ohno, M.
Purification and properties of phospholipase A2 from venom of Trimeresurus flavoviridis (Habu snake)
J. Biochem.
88
443-451
1980
Protobothrops flavoviridis
Yoshida, H.; Kudo, T.; Shinkai, W.; Tamiya, N.
Phospholipase A of sea snake Laticauda semifasciata venom
J. Biochem.
85
379-388
1979
Laticauda semifasciata
Tamori, Y.; Nishijima, M.; Nojima, S.
Properties of purified detergent-resistant phospholipase A of Escherichia coli K-12
J. Biochem.
86
1129-1138
1979
Escherichia coli
Slotboom, A.J.; Jansen, E.H.J.M.; Vlijm, H.; Pattus, F.; de Araujo, P.S.; de Haas, G.H.
Ca2+ binding to porcine pancreatic phospholipase A2 and its function in enzyme-lipid interaction
Biochemistry
17
4593-4600
1978
Sus scrofa
Kondo, K.; Toda, H.; Narita, K.
Characterisation of phospholipase A activity of b 1-Bungarotoxin from Bungarus multicinctus venom
J. Biochem.
84
1291-1300
1978
Bungarus multicinctus, Crotalus adamanteus
Kondo, K.; Toda, H.; Narita, K.
Characterisation of phospholipase A activity of b 1-Bungarotoxin from Bungarus multicinctus venom
J. Biochem.
84
1301-1308
1978
Bungarus multicinctus
Sahu, S.; Lynn, W.S.
Characterization of phospholipase A from pulmonary secretions of patients with alveolar proteinosis
Biochim. Biophys. Acta
489
307-317
1977
Homo sapiens
Kihara, H.
Studies on phospholipase A in Trimeresurus flavoviridis venom. Purification and some properties pf phospholipase A inhibitor in Habu serum
J. Biochem.
80
341-349
1976
Protobothrops flavoviridis
Vignais, P.M.; Colbeau, A.; Ngo-Tri, H.; Pilarska, M.
Characterization and subcellular localization of lipase and phospholipase A activities in rat liver
Lipids
1
117-126
1976
Rattus norvegicus
-
Okawa, Y.; Yamaguchi, T.
Purification and some properties of phospholipase A from Streptomyces cinnamomeus
Agric. Biol. Chem.
40
437-438
1976
Streptomyces cinnamoneus
-
Drenth, J.; Enzing, C.M.; Kalk, K.H.; Vessies, J.C.A.
Structure of porcine pancreatic phospholipase A2
Nature
264
373-377
1976
Sus scrofa
Van Wezel, F.M.; de Haas, G.H.
Phospholipase A2 isoenzyme from porcine pancreas. Purification and some properties
Biochim. Biophys. Acta
410
299-309
1975
Sus scrofa
Pieterson W.A.; Volwerk, J.J.; de Haas, G.H.
Interaction of phospholipase A2 and its zymogen with divalent metal ions
Biochemistry
13
1439-1445
1974
Sus scrofa
Nieuwenhuizen, W.; Kunze, H.; de Haas, G.H.
Phospholipase A2 (phosphatide acylhydrolase, EC 3.1.1.4) from porcine pancreas
Methods Enzymol.
32
147-154
1974
Sus scrofa
Volwerk, J.J.; Pieterson, W.A.; de Haas, G.H.
Histidine at the active site of phospholipase A2
Biochemistry
13
1446-1454
1974
Sus scrofa
Pieterson, W.A.; Vidal, J.C.; Volwerk, J.J.; de Haas, G.H.
Zymogen-catalyzed hydrolysis of monomeric substrates and the presence of a recognition site for lipid-water interfaces in phospholipase A2
Biochemistry
13
1455-1460
1974
Sus scrofa
Rahman, Y.E.; Cerny, E.A.; Peraino, C.
Purification and some properties of rat spleen phospholipase A
Biochim. Biophys. Acta
321
526-535
1973
Rattus norvegicus, Sus scrofa
Nieuwenhuizen, W.; Steenbergh, P.; de Haas, G.H.
The isolation and properties of two phospholipases A2 from porcine pancreas
Eur. J. Biochem.
40
1-7
1973
Sus scrofa
Yamaguchi, T.; Okawa, Y.; Sakaguchi, K.
Two thermostable phospholipases A in porcine pancreas
J. Biochem.
73
187-190
1973
Sus scrofa
Hanahan, D.J.
Phospholipases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
5
71-85
1971
Crotalus adamanteus, Crotalus atrox, Rattus norvegicus, Sus scrofa
-
Segelke, B.W.; Nguyen, D.; Chee, R.; Xuong, N.H.; Dennis, E.A.
Structures of two novel crystal forms of Naja naja naja phospholipase A2 lacking Ca2+ reveal trimeric packing
J. Mol. Biol.
279
223-232
1998
Naja naja (P15445), Naja naja
Perisic, O.; Fong, S.; Lynch, D.E.; Bycroft, M.; Williams, R.L.
Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2
J. Biol. Chem.
273
1596-1604
1998
Homo sapiens
Wang, X.Q.; Yang, J.; Gui, L.L.; Lin, Z.J.; Chen, Y.C.; Zhou, Y.C.
Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution
J. Mol. Biol.
255
669-676
1996
Gloydius halys (P14418), Gloydius halys
Suzuki, A.; Matsueda, E.; Yamane, T.; Ashida, T.; Kihara, H.; Ohno, M.
Crystal structure analysis of phospholipase A2 from Trimesurus flavoviridis (Habu snake) venom at 1.5 A resolution
J. Biochem.
117
730-740
1995
Protobothrops flavoviridis
Thunissen, M.M.; Franken, P.A.; de Haas, G.H.; Drenth, J.; Kalk, K.H.; Verheij, H.M.; Dijkstra, B.W.
Crystal structure of a porcine pancreatic phospholipase A2 mutant. A large conformational change caused by the F63V mutant
J. Mol. Biol.
232
839-855
1993
Sus scrofa
Fremont, D.H.; Anderson, D.H.; Wilson, I.A.; Dennis, E.A.; Xuong, N.H.
Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association
Proc. Natl. Acad. Sci. USA
90
342-346
1993
Naja naja
Thunissen, M.M.; Franken, P.A.; de Haas, G.H.; Drenth, J.; Kalk, K.H.; Verheij, H.M.; Dijkstra, B.W.
Site-directed mutagenesis and X-ray crystallography of two phospholipase A2 mutants: Y52F and Y73F
Protein Eng.
5
597-603
1992
Sus scrofa
Xu, S.; Gu, L.; Wang, Q.; Shu, Y.; Song, S.; Lin, Z.
Structure of a king cobra phospholipase A2 determined from a hemihedrally twinned crystal
Acta Crystallogr. Sect. D
59
1574-1581
2003
Ophiophagus hannah
Lee, J.H.; Ahn, S.H.; Kim, S.H.; Choi, Y.H.; Park, K.J.; Kong, I.S.
Characterization of Vibrio mimicus phospholipase A (PhlA) and cytotoxicity on fish cell
Biochem. Biophys. Res. Commun.
298
269-276
2002
Vibrio mimicus
Fuly, A.L.; de Miranda, A.L.; Zingali, R.B.; Guimaraes, J.A.
Purification and characterization of a phospholipase A2 isoenzyme isolated from Lachesis muta snake venom
Biochem. Pharmacol.
63
1589-1597
2002
Lachesis muta
Kanashiro, M.M.; Escocard, R.d.C.M.; Petretski, J.H.; Prates, M.V.; Alves, E.W.; Machado, O.L.T.; Dias da Silva, W.; Kipnis, T.L.
Biochemical and biological properties of phospholipases A2 from Bothrops atrox snake venom
Biochem. Pharmacol.
64
1179-1186
2002
Bothrops atrox
Edwards, S.H.; Thompson, D.; Baker, S.F.; Wood, S.P.; Wilton, D.C.
The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism
Biochemistry
41
15468-15476
2002
Homo sapiens (P14555), Homo sapiens
Winstead, M.V.; Balsinde, J.; Dennis, E.A.
Calcium-independent phospholipase A2: structure and function
Biochim. Biophys. Acta
1488
28-39
2000
Homo sapiens, Mammalia, Mus musculus, Rattus norvegicus
Gao, R.; Kini, R.M.; Li, G.; Luo, R.; Selvanayagam, Z.E.; Gopalakrishnakone, P.
Purification and properties of three new phospholipase A2 isoenzymes from Micropechis ikaheka venom
Biochim. Biophys. Acta
1545
30-40
2001
Micropechis ikaheca
Andriao-Escarso, S.H.; Soares, A.M.; Rodrigues, V.M.; Angulo, Y.; Diaz, C.; Lomonte, B.; Gutierrez, J.M.; Giglio, J.R.
Myotoxic phospholipases A2 in Bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu
Biochimie
82
755-763
2000
Bothrops spp.
Valentin, E.; Lambeau, G.
What can venom phospholipases A2 tell us about the functional diversity of mammalian secreted phospholipases A2?
Biochimie
82
815-831
2000
Crotalus atrox, Mammalia, Exaiptasia diaphana, Pandinus imperator, Pseudonaja textilis, Apis mellifera (P00630)
Ketelhut, D.F.; de Mello, M.H.; Veronese, E.L.; Esmeraldino, L.E.; Murakami, M.T.; Arni, R.K.; Giglio, J.R.; Cintra, A.C.; Sampaio, S.V.
Isolation, characterization and biological activity of acidic phospholipase A2 isoforms from Bothrops jararacussu snake venom
Biochimie
85
983-991
2003
Bothrops jararacussu
Ben Salah, R.; Zouari, N.; Reinbolt, J.; Mejdoub, H.
Purification of turkey pancreatic phospholipase A2
Biosci. Biotechnol. Biochem.
67
2139-2144
2003
Meleagris gallopavo
Wickramaratna, J.C.; Fry, B.G.; Aguilar, M.I.; Kini, R.M.; Hodgson, W.C.
Isolation and pharmacological characterization of a phospholipase A2 myotoxin from the venom of the Irian Jayan death adder (Acanthophis rugosus)
Br. J. Pharmacol.
138
333-342
2003
Acanthophis rugosus
Kishimura, H.; Ojima, T.; Hayashi, K.; Nishita, K.
Bacterial expression and characterization of starfish phospholipase A2
Comp. Biochem. Physiol. B
128B
565-573
2001
Patiria pectinifera
-
Uchiyama, S.; Fujikawa, Y.; Uematsu, K.; Matsuda, H.; Aida, S.; Iijima, N.
Localization of group IB phospholipase A2 isoform in the gills of the red sea bream, Pagrus (Chrysophrys) major
Comp. Biochem. Physiol. B
132B
671-683
2002
Pagrus major
-
Hirschberg, H.J.H.B.; Simons, J.W.F.A.; Dekker, N.; Egmond, M.R.
Cloning, expression, purification and characterization of patatin, a novel phospholipase A
Eur. J. Biochem.
268
5037-5044
2001
Solanum tuberosum
Bahn, S.C.; Lee, H.Y.; Kim, H.J.; Ryu, S.B.; Shin, J.S.
Characterization of Arabidopsis secretory phospholipase A2-gamma cDNA and its enzymatic properties
FEBS Lett.
553
113-118
2003
Arabidopsis thaliana (Q9M0D7)
Tanaka, N.; Ishida, T.; Hukuda, S.; Horiike, K.
Purification of a low-molecular-weight phospholipase A2 associated with soluble high-molecular-weight acidic proteins from rabbit nucleus pulposus and its comparison with a rabbit splenic group IIa phospholipase A2
J. Biochem.
127
985-991
2000
Oryctolagus cuniculus
Matoba, Y.; Katsube, Y.; Sugiyama, M.
The crystal structure of prokaryotic phospholipase A2
J. Biol. Chem.
277
20059-20069
2002
Streptomyces violaceoruber
Shin, H.S.; Chin, M.R.; Kim, J.S.; Chung, J.H.; Ryu, C.K.; Jung, S.Y.; Kim, D.K.
Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells: its involvement in Ca2+-dependent release of arachidonic acid from mammalian red blood cells
J. Biol. Chem.
277
21086-21094
2002
Bos taurus, Homo sapiens
Stewart, A.; Ghosh, M.; Spencer, D.M.; Leslie, C.C.
Enzymatic properties of human cytosolic phospholipase A2g
J. Biol. Chem.
277
29526-29536
2002
Homo sapiens
Forsell, P.K.A.L.; Lindberg, A.; Karlsson, S.; Lindgren, J.A.; Claesson, H.E.
Purification, characterization, and cDNA sequencing of cytosolic phospholipase A2 from equine neutrophils
J. Lipid Res.
41
1222-1230
2000
Equus caballus (O77793)
Sekar, K.; Vaijayanthi Mala, S.; Yogavel, M.; Velmurugan, D.; Poi, M.J.; Vishwanath, B.S.; Gowda, T.V.; Jeyaprakash, A.A.; Tsai, M.D.
Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2
J. Mol. Biol.
333
367-376
2003
Bos taurus (P00593), Bos taurus
Zhong, X.; Liu, J.; Wu, X.; Zhou, Y.
Expression, purification and biochemical characterization of a recombinant phospholipase A2, with anticoagulant activity from Agkistrodon halys Pallas
J. Nat. Toxins
10
17-25
2001
Gloydius halys
Beghini, D.G.; Toyama, M.H.; Hyslop, S.; Sodek, L.; Novello, J.C.; Marangoni, S.
Enzymatic characterization of a novel phospholipase A2 from Crotalus durissus cascavella rattlesnake (Maracamboia) venom
J. Protein Chem.
19
603-607
2000
Crotalus durissus cascavella
Bonfim, V.L.; Toyama, M.H.; Novello, J.C.; Hyslop, S.; Oliveira, C.R.; Rodrigues-Simioni, L.; Marangoni, S.
Isolation and enzymatic characterization of a basic phospholipase A2 from Bothrops jararacussu snake venom
J. Protein Chem.
20
239-245
2001
Bothrops jararacussu
Iijima, N.; Uchiyama, S.; Fujikawa, Y.; Esaka, M.
Purification, characterization, and molecular cloning of group I phospholipases A2 from the gills of the red sea bream, Pagrus major
Lipids
35
1359-1370
2000
Pagrus major
Lee, D.; Won, J.H.; Auh, C.K.; Park, Y.M.
Purification and characterization of a cytosolic phospholipase A2 from rat liver
Mol. Cells
16
361-367
2003
Rattus norvegicus
Farooqui, A.A.; Ong, W.Y.; Horrocks, L.A.; Farooqui, T.
Brain cytosolic phospholipase A2: localization, role, and involvement in neurological diseases
Neuroscientist
6
169-180
2000
Bos taurus, Homo sapiens, Mammalia, Rattus norvegicus
-
Jung, K.M.; Kim, D.K.
Purification and characterization of a membrane-associated 48-kilodalton phospholipase A2 in leaves of broad bean
Plant Physiol.
123
1057-1067
2000
Vicia faba
Holk, A.; Rietz, S.; Zahn, M.; Quader, H.; Scherer, G.F.E.
Molecular identification of cytosolic, patatin-related phospholipases A from Arabidopsis with potential functions in plant signal transduction
Plant Physiol.
130
90-101
2002
Arabidopsis thaliana
Ward, R.J.; de Oliveira, A.H.; Bortoleto, R.K.; Rosa, J.C.; Faca, V.M.; Greene, L.J.
Refolding and purification of Bothropstoxin-I, a Lys49-phospholipase A2 homologue, expressed as inclusion bodies in Escherichia coli
Protein Expr. Purif.
21
134-140
2001
Bothrops jararacussu
Grotendorst, G.R.; Hessinger, D.A.
Enzymatic characterization of the major phospholipase A2 component of sea anemone (Aiptasia pallida) nematocyst venom
Toxicon
38
931-943
2000
Exaiptasia diaphana
Lu, Q.M.; Jin, Y.; Wei, J.F.; Li, D.S.; Zhu, S.W.; Wang, W.Y.; Xiong, Y.L.
Characterization and cloning of a novel phospholipase A2 from the venom of Trimeresurus jerdonii snake
Toxicon
40
1313-1319
2002
Protobothrops jerdonii (Q8JIY9), Protobothrops jerdonii
Sundell, I.B.; Aziz, K.A.; Zuzel, M.; Theakston, R.D.G.
The role of phospholipases A2 in the stimulation of neutrophil motility by cobra venoms
Toxicon
41
459-468
2003
Naja naja, Naja mossambica
Yang, W.L.; Peng, L.S.; Zhong, X.F.; Wei, J.W.; Jiang, X.Y.; Ye, L.T.; Zou, L.; Tu, H.B.; Wu, W.Y.; Xu, A.L.
Functional expression and characterization of a recombinant phospholipase A2 from sea snake Lapemis hardwickii as a soluble protein in E. coli
Toxicon
41
713-721
2003
Hydrophis hardwickii
Sato, H.; Feix, J.B.; Hillard, C.J.; Frank, D.W.
Characterization of phospholipase activity of the Pseudomonas aeruginosa type III cytotoxin, ExoU
J. Bacteriol.
187
1192-1195
2005
Pseudomonas aeruginosa
Phillips, R.M.; Six, D.A.; Dennis, E.A.; Ghosh, P.
In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors
J. Biol. Chem.
278
41326-41332
2003
Pseudomonas aeruginosa, Pseudomonas aeruginosa PA103
Sato, H.; Frank, D.W.
ExoU is a potent intracellular phospholipase
Mol. Microbiol.
53
1279-1290
2004
Pseudomonas aeruginosa
Rose, T.M.; Prestwich, G.D.
Fluorogenic phospholipids as head group-selective reporters of phospholipase A activity
ACS Chem. Biol.
1
83-92
2006
Streptomyces violaceoruber, Apis mellifera, Bos taurus, Homo sapiens, Naja mossambica
Jin, Q.; Yang, L.X.; Jiao, H.M.; Lu, B.; Wu, Y.Q.; Zhou, Y.C.
Purification, gene cloning and expression of an acidic phospholipase A2 from Agkistrodon shedaoensis Zhao
Acta Biochim. Biophys. Sin.
36
27-32
2004
Gloydius shedaoensis
Caramelo, J.J.; Delfino, J.M.
A subnanogram assay for phospholipase activity based on a long-chain radioiodinatable phosphatidylcholine
Anal. Biochem.
333
289-295
2004
Naja naja
Doley, R.; King, G.F.; Mukherjee, A.K.
Differential hydrolysis of erythrocyte and mitochondrial membrane phospholipids by two phospholipase A2 isoenzymes (NK-PLA2-I and NK-PLA2-II) from the venom of the Indian monocled cobra Naja kaouthia
Arch. Biochem. Biophys.
425
1-13
2004
Naja kaouthia
Seibert, C.S.; Tanaka-Azevedo, A.M.; Santoro, M.L.; Mackessy, S.P.; Soares Torquato, R.J.; Lebrun, I.; Tanaka, A.S.; Sano-Martins, I.S.
Purification of a phospholipase A2 from Lonomia obliqua caterpillar bristle extract
Biochem. Biophys. Res. Commun.
342
1027-1033
2006
Lonomia obliqua
Yamazaki, K.; Imai, M.; Suzuki, I.
Soybean lecithin hydrolysis using hog pancreas phospholipase A2 influenced by the hydrophobic character of W/O microemulsion systems
Biochem. Eng. J.
19
171-179
2004
Sus scrofa
-
Yu, B.Z.; Pan, Y.H.; Janssen, M.J.; Bahnson, B.J.; Jain, M.K.
Kinetic and structural properties of disulfide engineered phospholipase A2: insight into the role of disulfide bonding patterns
Biochemistry
44
3369-3379
2005
Sus scrofa (P00592), Sus scrofa
Song, H.; Ramanadham, S.; Bao, S.; Hsu, F.F.; Turk, J.
A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols
Biochemistry
45
1061-1073
2006
Rattus norvegicus
Damico, D.C.; Lilla, S.; de Nucci, G.; Ponce-Soto, L.A.; Winck, F.V.; Novello, J.C.; Marangoni, S.
Biochemical and enzymatic characterization of two basic Asp49 phospholipase A2 isoforms from Lachesis muta muta (Surucucu) venom
Biochim. Biophys. Acta
1726
75-86
2005
Lachesis muta muta
Ryu, S.B.; Lee, H.Y.; Doelling, J.H.; Palta, J.P.
Characterization of a cDNA encoding Arabidopsis secretory phospholipase A2-alpha, an enzyme that generates bioactive lysophospholipids and free fatty acids
Biochim. Biophys. Acta
1736
144-151
2005
Arabidopsis thaliana (Q8S8N6), Arabidopsis thaliana
Balasubramanya, R.; Chandra, V.; Kaur, P.; Singh, T.P.
Crystal structure of the complex of the secretory phospholipase A2 from Daboia russelli pulchella with an endogenic indole derivative, 2-carbamoylmethyl-5-propyl-octahydro-indol-7-yl-acetic acid at 1.8 A resolution
Biochim. Biophys. Acta
1752
177-185
2005
Daboia russelii pulchella (P59071), Daboia russelii pulchella
Satish, S.; Tejaswini, J.; Krishnakantha, T.P.; Gowda, T.V.
Purification of a Class B1 platelet aggregation inhibitor phospholipase A2 from Indian cobra (Naja Naja) venom
Biochimie
86
203-210
2004
Naja naja
Murakami, M.T.; Gabdoulkhakov, A.; Genov, N.; Cintra, A.C.; Betzel, C.; Arni, R.K.
Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states
Biochimie
88
543-549
2005
Bothrops jararacussu
Machiah, D.K.; Gowda, T.V.
Purification of a post-synaptic neurotoxic phospholipase A2 from Naja naja venom and its inhibition by a glycoprotein from Withania somnifera
Biochimie
88
701-710
2006
Naja naja
Cecchini, A.L.; Soares, A.M.; Cecchini, R.; de Oliveira, A.H.C.; Ward, R.J.; Giglio, J.R.; Arantes, E.C.
Effect of crotapotin on the biological activity of Asp49 and Lys49 phospholipases A2 from Bothrops snake venoms
Comp. Biochem. Physiol. C
138C
429-436
2004
Bothrops moojeni, Bothrops jararacussu, Bothrops pirajai
-
Radwan, F.F.; Aboul-Dahab, H.M.
Milleporin-1, a new phospholipase A2 active protein from the fire coral Millepora platyphylla nematocysts
Comp. Biochem. Physiol. C
139
267-272
2004
Millepora platyphylla
Wang, Y.M.; Peng, H.F.; Tsai, I.H.
Unusual venom phospholipases A2 of two primitive tree vipers Trimeresurus puniceus and Trimeresurus borneensis
FEBS J.
272
3015-3025
2005
Trimeresurus borneensis, Trimeresurus puniceus
Bao, Y.; Bu, P.; Jin, L.; Hongxia, W.; Yang, Q.; An, L.
Purification, characterization and gene cloning of a novel phospholipase A2 from the venom of Agkistrodon blomhoffii ussurensis
Int. J. Biochem. Cell Biol.
37
558-565
2005
Gloydius ussuriensis
Kishimura, H.; Hayashi, K.
Purification and properties of phospholipase A2 isozymes from pyloric ceca of the starfish (Asterina pectinifera)
J. Food Biochem.
28
181-194
2004
Patiria pectinifera
Istivan, T.S.; Coloe, P.J.; Fry, B.N.; Ward, P.; Smith, S.C.
Characterization of a haemolytic phospholipase A(2) activity in clinical isolates of Campylobacter concisus
J. Med. Microbiol.
53
483-493
2004
Campylobacter concisus
Qin, S.; Pande, A.H.; Nemec, K.N.; Tatulian, S.A.
The N-terminal alpha-helix of pancreatic phospholipase A2 determines productive-mode orientation of the enzyme at the membrane surface
J. Mol. Biol.
344
71-89
2004
Homo sapiens
Kolko, M.; Christoffersen, N.R.; Barreiro, S.G.; Miller, M.L.; Pizza, A.J.; Bazan, N.G.
Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain
J. Neurosci. Res.
83
874-882
2006
Rattus norvegicus
Vargas-Villarreal, J.; Mata-Cardenas, B.D.; Palacios-Corona, R.; Gonzalez-Salazar, F.; Cortes-Gutierrez, E.I.; Martinez-Rodriguez, H.G.; Said-Fernandez, S.
Trichomonas vaginalis: identification of soluble and membrane-associated phospholipase A1 and A2 activities with direct and indirect hemolytic effects
J. Parasitol.
91
5-11
2005
Trichomonas vaginalis
Singh, G.; Gourinath, S.; Sarvanan, K.; Sharma, S.; Bhanumathi, S.; Betzel, C.; Yadav, S.; Srinivasan, A.; Singh, T.P.
Crystal structure of a carbohydrate induced homodimer of phospholipase A2 from Bungarus caeruleus at 2.1A resolution
J. Struct. Biol.
149
264-272
2005
Bungarus caeruleus (Q6SLM1), Bungarus caeruleus
Fujikawa, R.; Fujikawa, Y.; Iijima, N.; Esaka, M.
Molecular cloning, expression, and characterization of secretory phospholipase A2 in tobacco
Lipids
40
901-908
2005
Nicotiana tabacum (Q5CCT8), Nicotiana tabacum
Wang, B.; Lu, D.; Gao, R.; Yang, Z.; Cao, S.; Feng, Y.
A novel phospholipase A2/esterase from hyperthermophilic archaeon Aeropyrum pernix K1
Protein Expr. Purif.
35
199-205
2004
Aeropyrum pernix
Singh, G.; Jasti, J.; Saravanan, K.; Sharma, S.; Kaur, P.; Srinivasan, A.; Singh, T.P.
Crystal structure of the complex formed between a group I phospholipase A2 and a naturally occurring fatty acid at 2.7 A resolution
Protein Sci.
14
395-400
2005
Bungarus caeruleus (Q6SLM1), Bungarus caeruleus
Singh, N.; Jabeen, T.; Pal, A.; Sharma, S.; Perbandt, M.; Betzel, C.; Singh, T.P.
Crystal structures of the complexes of a group IIA phospholipase A(2) with two natural anti-inflammatory agents, anisic acid, and atropine reveal a similar mode of binding
Proteins
64
89-100
2006
Daboia russelii pulchella
Huang, P.; Mackessy, S.P.
Biochemical characterization of phospholipase A2 (trimorphin) from the venom of the Sonoran Lyre Snake Trimorphodon biscutatus lambda (family Colubridae)
Toxicon
44
27-36
2004
Trimorphodon lambda
Santamaria, C.; Larios, S.; Angulo, Y.; Pizarro-Cerda, J.; Gorvel, J.P.; Moreno, E.; Lomonte, B.
Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region
Toxicon
45
807-815
2005
Bothrops asper
Belo, C.A.; Leite, G.B.; Toyama, M.H.; Marangoni, S.; Corrado, A.P.; Fontana, M.D.; Southan, A.; Rowan, E.G.; Hyslop, S.; Rodrigues-Simioni, L.
Pharmacological and structural characterization of a novel phospholipase A2 from Micrurus dumerilii carinicauda venom
Toxicon
46
736-750
2005
Micrurus dumerilii carinicauda
Jabeen, T.; Singh, N.; Singh, R.K.; Ethayathulla, A.S.; Sharma, S.; Srinivasan, A.; Singh, T.P.
Crystal structure of a novel phospholipase A2 from Naja naja sagittifera with a strong anticoagulant activity
Toxicon
46
865-875
2005
Naja sagittifera (Q6T179), Naja sagittifera
Shashidharamurthy, R.; Kemparaju, K.
A neurotoxic phospholipase A(2) variant: Isolation and characterization from eastern regional Indian cobra (Naja naja) venom
Toxicon
47
727-733
2006
Naja naja
Damico, D.C.; Bueno, L.G.; Rodrigues-Simioni, L.; Marangoni, S.; da Cruz-Hofling, M.A.; Novello, J.C.
Functional characterization of a basic D49 phospholipase A(2) (LmTX-I) from the venom of the snake Lachesis muta muta (bushmaster)
Toxicon
47
759-765
2006
Lachesis muta muta
Le Trong, I.; Stenkamp, R.E.
An alternate description of two crystal structures of phospholipase A2 from Bungarus caeruleus
Acta Crystallogr. Sect. D
63
548-549
2007
Bungarus caeruleus
Santos, K.F.; Murakami, M.T.; Cintra, A.C.; Toyama, M.H.; Marangoni, S.; Forrer, V.P.; Brandao Neto, J.R.; Polikarpov, I.; Arni, R.K.
Crystallization and preliminary X-ray crystallographic analysis of the heterodimeric crotoxin complex and the isolated subunits crotapotin and phospholipase A2
Acta Crystallogr. Sect. F
63
287-290
2007
Crotalus durissus terrificus
Murakami, M.T.; Kuch, U.; Mebs, D.; Arni, R.K.
Crystallization and preliminary X-ray diffraction analysis of a novel Arg49 phospholipase A2 homologue from Zhaoermia mangshanensis venom
Acta Crystallogr. Sect. F
63
605-607
2007
Protobothrops mangshanensis (P84776), Protobothrops mangshanensis
Hurley, B.P.; Williams, N.L.; McCormick, B.A.
Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration
Am. J. Physiol. Lung Cell Mol. Physiol.
290
703-709
2006
Pseudomonas aeruginosa
-
Boehl, M.; Ketscher, L.; Tietboehl, C.; Gutzeit, H.O.
Phospholipase A2 inhibition at different substrate concentrations
Anal. Biochem.
359
280-282
2006
Sus scrofa (P00592)
Pande, A.H.; Qin, S.; Nemec, K.N.; He, X.; Tatulian, S.A.
Isoform-specific membrane insertion of secretory phospholipase A2 and functional implications
Biochemistry
45
12436-12447
2006
Apis mellifera (P00630), Apis mellifera, Homo sapiens (P14555), Homo sapiens
Nemec, K.N.; Pande, A.H.; Qin, S.; Bieber Urbauer, R.J.; Tan, S.; Moe, D.; Tatulian, S.A.
Structural and functional effects of tryptophans inserted into the membrane-binding and substrate-binding sites of human group IIA phospholipase A2
Biochemistry
45
12448-12460
2006
Homo sapiens
Bacha, A.B.; Gargouri, Y.; Bezzine, S.; Mejdoub, H.
Purification and biochemical characterization of phospholipase A2 from dromedary pancreas
Biochim. Biophys. Acta
1760
1202-1209
2006
Camelus dromedarius
Gora, S.; Lambeau, G.; Bollinger, J.G.; Gelb, M.; Ninio, E.; Karabina, S.
The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2
Biochim. Biophys. Acta
1761
1093-1099
2006
Homo sapiens
Kita, Y.; Ohto, T.; Uozumi, N.; Shimizu, T.
Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s
Biochim. Biophys. Acta
1761
1317-1322
2006
Mus musculus (P47713)
Ponce-Soto, L.A.; Lomonte, B.; Gutierrez, J.M.; Rodrigues-Simioni, L.; Novello, J.C.; Marangoni, S.
Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus
Biochim. Biophys. Acta
1770
585-593
2007
Bothrops alternatus (P86453), Bothrops alternatus
Tsai, I.; Tsai, H.; Wang, Y.; Tun-P, T.; Warrell, D.A.
Venom phospholipases of Russells vipers from Myanmar and eastern India-Cloning, characterization and phylogeographic analysis
Biochim. Biophys. Acta
1774
1020-1028
2007
Daboia russelii, Daboia siamensis
Cogo, J.C.; Lilla, S.; Souza, G.H.; Hyslop, S.; de Nucci, G.
Purification, sequencing and structural analysis of two acidic phospholipases A2 from the venom of Bothrops insularis (jararaca ilhoa)
Biochimie
88
1947-1959
2006
Bothrops insularis (Q8QG87), Bothrops insularis
Hess, M.; Schulze Elfringhoff, A.; Lehr, M.
1-(5-Carboxy- and 5-carbamoylindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: bioisosteric replacement of the carboxylic acid and carboxamide moiety
Bioorg. Med. Chem.
15
2883-2891
2007
Homo sapiens
Moon, T.C.; Quan, Z.; Kim, J.; Kim, H.P.; Kudo, I.; Murakami, M.; Park, H.; Chang, H.W.
Inhibitory effect of synthetic C-C biflavones on various phospholipase A2s activity
Bioorg. Med. Chem.
15
7138-7143
2007
Homo sapiens, Homo sapiens (P47712)
Gopalsamy, A.; Yang, H.; Ellingboe, J.W.; McKew, J.C.; Tam, S.; Joseph-McCarthy, D.; Zhang, W.; Shen, M.; Clark, J.D.
1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors
Bioorg. Med. Chem. Lett.
16
2978-2981
2006
Rattus norvegicus
Bailey, R.W.; Olson, E.D.; Vu, M.P.; Brueseke, T.J.; Robertson, L.; Christensen, R.E.; Parker, K.H.; Judd, A.M.; Bell, J.D.
Relationship between membrane physical properties and secretory phospholipase A2 hydrolysis kinetics in S49 cells during ionophore-induced apoptosis
Biophys. J.
93
2350-2362
2007
Mus musculus
Saliba, A.M.; Nascimento, D.O.; Silva, M.C.A.; Assis, M.C.; Gayer, C.R.M.; Raymond, B.; Coelho, M.G.P.; Marques, E.A.; Touqui, L.; Albano, R.M.; Lopes, U.G.; Paiva, D.D.; Bozza, P.T.; Plotkowski, M.C.
Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU
Cell. Microbiol.
7
1811-1822
2005
Pseudomonas aeruginosa, Pseudomonas aeruginosa PA103
Mansfeld, J.; Ulbrich-Hofmann, R.
Secretory phospholipase A2-alpha from Arabidopsis thaliana: functional parameters and substrate preference
Chem. Phys. Lipids
150
156-166
2007
Arabidopsis thaliana
Quiros, S.; Alape-Giron, A.; Angulo, Y.; Lomonte, B.
Isolation, characterization and molecular cloning of AnMIP, a new alpha-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae)
Comp. Biochem. Physiol. B
146
60-68
2007
Bothrops asper, Oxyuranus scutellatus, Apis mellifera (P00630)
Miyabara, E.H.; Baptista, I.L.; Lomonte, B.; Selistre-de-Araujo, H.S.; Gutierrez, J.M.; Moriscot, A.S.
Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A2 myotoxins in vivo and in vitro
Comp. Biochem. Physiol. C
143
284-294
2006
Bothrops asper (P20474), Bothrops asper
Kishimura, H.; Ando, S.
Characteristics of phospholipase A2 mutant of the starfish Asterina pectinifera
Enzyme Microb. Technol.
40
461-465
2007
Patiria pectinifera (O96100)
-
Lee, V.T.; Pukatzki, S.; Sato, H.; Kikawada, E.; Kazimirova, A.A.; Huang, J.; Li, X.; Arm, J.P.; Frank, D.W.; Lory, S.
Pseudolipasin A is a specific inhibitor for phospholipase A2 activity of Pseudomonas aeruginosa cytotoxin ExoU
Infect. Immun.
75
1089-1098
2007
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAK-VL1
Davis, B.; Koster, G.; Douet, L.J.; Scigelova, M.; Woffendin, G.; Ward, J.M.; Smith, A.; Humphres, J.; Burnand, K.G.; Macphee, C.H.; Postle, A.D.
Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein
J. Biol. Chem.
283
6428-6437
2007
Homo sapiens
Maity, G.; Mandal, S.; Chatterjee, A.; Bhattacharyya, D.
Purification and characterization of a low molecular weight multifunctional cytotoxic phospholipase A2 from Russells viper venom
J. Chromatogr. B
845
232-243
2007
Daboia russelii russelii
Ben Bacha, A.; Gargouri, Y.; Bezzine, S.; Mosbah, H.; Mejdoub, H.
Ostrich pancreatic phospholipase A2: purification and biochemical characterization
J. Chromatogr. B
857
108-114
2007
Struthio camelus
Abe, A.; Hiraoka, M.; Shayman, J.A.
Positional specificity of lysosomal phospholipase A2
J. Lipid Res.
47
2268-2279
2006
Mus musculus
Touaibia, M.; Djimde, A.; Cao, F.; Boilard, E.; Bezzine, S.; Lambeau, G.; Redeuilh, C.; Lamouri, A.; Massicot, F.; Chau, F.; Dong, C.Z.; Heymans, F.
Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities
J. Med. Chem.
50
1618-1626
2007
Homo sapiens, Sus scrofa
Pan, Y.H.; Bahnson, B.J.
Structural basis for bile salt inhibition of pancreatic phospholipase A2
J. Mol. Biol.
369
439-450
2007
Sus scrofa (P00592)
Kim, J.O.; Chakrabarti, B.K.; Guha-Niyogi, A.; Louder, M.K.; Mascola, J.R.; Ganesh, L.; Nabel, G.J.
Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2
J. Virol.
81
1444-1450
2007
Homo sapiens
Zhang, F.; Wang, Y.
Cloning, expression, and purification of lipoprotein-associated phospholipase A2 in Pichia pastoris
Mol. Biotechnol.
33
29-36
2006
Homo sapiens (Q13093)
Jovel, S.R.; Kumagai, T.; Danshiitsoodol, N.; Matoba, Y.; Nishimura, M.; Sugiyama, M.
Purification and characterization of the second Streptomyces phospholipase A2 refolded from an inclusion body
Protein Expr. Purif.
50
82-88
2006
Streptomyces coelicolor, Streptomyces violaceoruber (Q6UV28), Streptomyces violaceoruber, Streptomyces coelicolor A3(2), Streptomyces violaceoruber A-2688 (Q6UV28), Streptomyces violaceoruber A-2688
Bonfim, V.L.; Ponce-Soto, L.A.; Novello, J.C.; Marangoni, S.
Cytotoxic action in myoblasts and myotubes (C2C12) and enzymatic characterization of a new phospholipase A2 isoform (Bj-V) from Bothrops jararacussu venom
Protein Pept. Lett.
13
707-713
2006
Bothrops jararacussu
dos Santos, J.I.; Marchi-Salvador, D.P.; Fernandes, C.A.; Silveira, L.B.; Soares, A.M.; Fontes, M.R.
Preliminary X-ray crystallographic studies of a Lys49-phospholipase A2 homologue from Bothrops pirajai venom complexed with p-bromo-phenacyl bromide and alpha-tocopherol inhibitors
Protein Pept. Lett.
14
698-701
2007
Bothrops pirajai (P58399), Bothrops pirajai
Kanaujia, S.P.; Sekar, K.
Structures and molecular-dynamics studies of three active-site mutants of bovine pancreatic phospholipase A2
Acta Crystallogr. Sect. D
64
1003-1011
2008
Bos taurus (P00593)
Ho, T.C.; Chen, S.L.; Yang, Y.C.; Lo, T.H.; Hsieh, J.W.; Cheng, H.C.; Tsao, Y.P.
Cytosolic phospholipase A2-alpha is an early apoptotic activator in PEDF-induced endothelial cell apoptosis
Am. J. Physiol. Cell Physiol.
296
C273-C284
2009
Homo sapiens
Wu, Y.; Feinstein, S.I.; Manevich, Y.; Chowdhury, I.; Pak, J.H.; Kazi, A.; Dodia, C.; Speicher, D.W.; Fisher, A.B.
Mitrogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity
Biochem. J.
419
669-679
2009
Homo sapiens, Rattus norvegicus
Correa, L.C.; Marchi-Salvador, D.P.; Cintra, A.C.; Sampaio, S.V.; Soares, A.M.; Fontes, M.R.
Crystal structure of a myotoxic Asp49-phospholipase A2 with low catalytic activity: Insights into Ca2+-independent catalytic mechanism
Biochim. Biophys. Acta
1784
591-599
2008
Bothrops jararacussu (P45881), Bothrops jararacussu
Grkovich, A.; Armando, A.; Quehenberger, O.; Dennis, E.A.
TLR-4 mediated group IVA phospholipase A2 activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent
Biochim. Biophys. Acta
1791
975-982
2009
Mus musculus
Perumal Samy, R.; Gopalakrishnakone, P.; Ho, B.; Chow, V.T.
Purification, characterization and bactericidal activities of basic phospholipase A2 from the venom of Agkistrodon halys (Chinese pallas)
Biochimie
90
1372-1388
2008
Gloydius halys
Bonfim, V.L.; Ponce-Soto, L.A.; Martins de Souza, D.; Souza, G.H.; Baldasso, P.A.; Eberlin, M.N.; Marangoni, S.
Structural and functional characterization of myotoxin, Cr-IV 1, a phospholipase A2 D49 from the venom of the snake Calloselasma rhodostoma
Biologicals
36
168-176
2008
Calloselasma rhodostoma
Antonopoulou, G.; Barbayianni, E.; Magrioti, V.; Cotton, N.; Stephens, D.; Constantinou-Kokotou, V.; Dennis, E.A.; Kokotos, G.
Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes
Bioorg. Med. Chem.
16
10257-10269
2008
Homo sapiens
Fritsche, A.; Elfringhoff, A.S.; Fabian, J.; Lehr, M.
1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis, biological activity, metabolic stability, and solubility
Bioorg. Med. Chem.
16
3489-3500
2008
Homo sapiens
Linderoth, L.; Andresen, T.L.; Joergensen, K.; Madsen, R.; Peters, G.H.
Molecular basis of phospholipase A2 activity toward phospholipids with sn-1 substitutions
Biophys. J.
94
14-26
2008
Agkistrodon piscivorus piscivorus
Heiner, A.L.; Gibbons, E.; Fairbourn, J.L.; Gonzalez, L.J.; McLemore, C.O.; Brueseke, T.J.; Judd, A.M.; Bell, J.D.
Effects of cholesterol on physical properties of human erythrocyte membranes: impact on susceptibility to hydrolysis by secretory phospholipase A2
Biophys. J.
94
3084-3093
2008
Agkistrodon piscivorus piscivorus
Simonsen, A.C.
Activation of phospholipase A2 by ternary model membranes
Biophys. J.
94
3966-3975
2008
Homo sapiens
Kim, C.; Kim, J.Y.; Kim, J.H.
Cytosolic phospholipase A2, lipoxygenase metabolites, and reactive oxygen species
BMB Rep.
41
555-559
2008
Homo sapiens
Bate, C.; Tayebi, M.; Williams, A.
Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation
BMC Biol.
6
8
2008
Mus musculus
Burke, J.E.; Dennis, E.A.
Phospholipase A2 biochemistry
Cardiovasc. Drugs Ther.
23
49-59
2009
Apis mellifera, Bitis gabonica, Bos taurus, Crotalus sp., Homo sapiens, Mus musculus, Naja naja, Oryza sativa, Rattus norvegicus, Sus scrofa, Protoparvovirus
Kamble, R.R.; Belgur, S.S.; Aladkatti, R.; Khazi, I.A.
Synthesis and evaluation of benzophenone oximes derivatized with sydnone as inhibitors of secretory phospholipase A2 with anti-inflammatory activity
Chem. Pharm. Bull.
57
16-21
2009
Naja naja, Daboia russelii, Trimeresurus malabaricus
Monti, M.C.; Casapullo, A.; Cavasotto, C.N.; Tosco, A.; Dal Piaz, F.; Ziemys, A.; Margarucci, L.; Riccio, R.
The binding mode of petrosaspongiolide M to the human group IIA phospholipase A2: exploring the role of covalent and noncovalent interactions in the inhibition process
Chemistry
15
1155-1163
2009
Homo sapiens (P14555), Homo sapiens
da Silva, S.L.; Calgarotto, A.K.; Maso, V.; Damico, D.C.; Baldasso, P.; Veber, C.L.; Villar, J.A.; Oliveira, A.R.; Comar, M.; Oliveira, K.M.; Marangoni, S.
Molecular modeling and inhibition of phospholipase A2 by polyhydroxy phenolic compounds
Eur. J. Med. Chem.
44
312-321
2009
Crotalus adamanteus
De Luca, D.; Minucci, A.; Zecca, E.; Piastra, M.; Pietrini, D.; Carnielli, V.P.; Zuppi, C.; Tridente, A.; Conti, G.; Capoluongo, E.D.
Bile acids cause secretory phospholipase A2 activity enhancement, revertible by exogenous surfactant administration
Intensive Care Med.
35
321-326
2009
Homo sapiens
Kiss, A.; Baliko, G.; Csorba, A.; Chuluunbaatar, T.; Medzihradszky, K.F.; Alfoeldi, L.
Cloning and characterization of the DNA region responsible for Megacin A-216 production in Bacillus megaterium 216
J. Bacteriol.
190
6448-6457
2008
Priestia megaterium (A7LGL2), Priestia megaterium 216 (A7LGL2)
Duncan, R.E.; Sarkadi-Nagy, E.; Jaworski, K.; Ahmadian, M.; Sul, H.S.
Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)
J. Biol. Chem.
283
25428-25436
2008
Rattus norvegicus
Burke, J.E.; Hsu, Y.H.; Deems, R.A.; Li, S.; Woods, V.L.; Dennis, E.A.
A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2
J. Biol. Chem.
283
31227-31236
2008
Homo sapiens (P47712)
Rigoni, M.; Paoli, M.; Milanesi, E.; Caccin, P.; Rasola, A.; Bernardi, P.; Montecucco, C.
Snake phospholipase A2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores
J. Biol. Chem.
283
34013-34020
2008
Vipera ammodytes
Tian, W.; Wijewickrama, G.T.; Kim, J.H.; Das, S.; Tun, M.P.; Gokhale, N.; Jung, J.W.; Kim, K.P.; Cho, W.
Mechanism of regulation of group IVA phospholipase A2 activity by Ser727 phosphorylation
J. Biol. Chem.
283
3960-3971
2008
Homo sapiens
Tucker, D.E.; Ghosh, M.; Ghomashchi, F.; Loper, R.; Suram, S.; St John, B.; Girotti, M.; Bollinger, J.G.; Gelb, M.H.; Leslie, C.C.
Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function
J. Biol. Chem.
284
9596-9611
2009
Homo sapiens
Hess, M.; Schulze Elfringhoff, A.; Lehr, M.
Design and synthesis of 3-pyrrol-3-yl-3H-isobenzofuran-1-ones as inhibitors of human cytosolic phospholipase A2alpha
J. Enzyme Inhib. Med. Chem.
23
946-957
2008
Homo sapiens
Cunningham, T.J.; Yao, L.; Lucena, A.
Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines unexpected therapeutic properties
J. Inflamm.
5
17
2008
Rattus norvegicus
Figueiredo, M.B.; Genta, F.A.; Garcia, E.S.; Azambuja, P.
Lipid mediators and vector infection: Trypanosoma rangeli inhibits Rhodnius prolixus hemocyte phagocytosis by modulation of phospholipase A2 and PAF-acetylhydrolase activities
J. Insect Physiol.
54
1528-1537
2008
Rhodnius prolixus
Oslund, R.C.; Cermak, N.; Gelb, M.H.
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
J. Med. Chem.
51
4708-4714
2008
Homo sapiens, Mus musculus
Baskakis, C.; Magrioti, V.; Cotton, N.; Stephens, D.; Constantinou-Kokotou, V.; Dennis, E.A.; Kokotos, G.
Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes
J. Med. Chem.
51
8027-8037
2008
Homo sapiens
Song, C.; Zhang, X.Y.; Manku, M.
Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment
J. Neurosci.
29
14-22
2009
Rattus norvegicus
Peroutka, R.J.; Elshourbagy, N.; Piech, T.; Butt, T.R.
Enhanced protein expression in mammalian cells using engineered SUMO fusions: secreted phospholipase A2
Protein Sci.
17
1586-1595
2008
Mus musculus (Q9QUL3), Mus musculus
Hu, P.; Sun, L.; Zhu, Z.Q.; Hou, X.W.; Wang, S.; Yu, S.S.; Wang, H.L.; Zhang, P.; Wang, M.; Niu, L.W.; Teng, M.K.; Ruan, D.Y.
Crystal structure of Natratoxin, a novel snake secreted phospholipaseA2 neurotoxin from Naja atra venom inhibiting A-type K+ currents
Proteins
72
673-683
2008
Naja atra
Marchi-Salvador, D.P.; Correa, L.C.; Magro, A.J.; Oliveira, C.Z.; Soares, A.M.; Fontes, M.R.
Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom
Proteins
72
883-891
2008
Crotalus durissus terrificus (P24027), Crotalus durissus terrificus
Machado Braga, M.D.; Costa Martins, A.M.; Alves, C.D.; Beserra de Menezes, D.; Martins, R.D.; Ferreira Barbosa, P.S.; Oliveira, I.M.; Toyama, M.H.; Toyama, D.O.; dos Santos Diz Filho, E.B.; Ramos Fagundes, F.H.; Fonteles, M.C.; Azul Monteiro, H.S.
Purification and renal effects of phospholipase A2 isolated from Bothrops insularis venom
Toxicon
51
181-190
2008
Bothrops insularis
Souza, A.D.; Rodrigues-Filho, E.; Souza, A.Q.; Pereira, J.O.; Calgarotto, A.K.; Maso, V.; Marangoni, S.; Da Silva, S.L.
Koninginins, phospholipase A2 inhibitors from endophytic fungus Trichoderma koningii
Toxicon
51
240-250
2008
Homo sapiens, Bothrops jararacussu
Chiou, Y.; Cheng, Y.; Kao, P.; Wang, J.; Chang, L.
Mutations on the N-terminal region abolish differentially the enzymatic activity, membrane-damaging activity and cytotoxicity of Taiwan cobra phospholipase A2
Toxicon
51
270-279
2008
Naja atra (P00598), Naja atra
Murakami, M.T.; Kuch, U.; Betzel, C.; Mebs, D.; Arni, R.K.
Crystal structure of a novel myotoxic Arg49 phospholipase A2 homolog (zhaoermiatoxin) from Zhaoermia mangshanensis snake venom: insights into Arg49 coordination and the role of Lys122 in the polarization of the C-terminus
Toxicon
51
723-735
2008
Protobothrops mangshanensis (P84776), Protobothrops mangshanensis
Shimada, A.; Ohkura, N.; Hayashi, K.; Samejima, Y.; Omori-Satoh, T.; Inoue, S.; Ikeda, K.
Subunit structure and inhibition specificity of alpha-type phospholipase A2 inhibitor from Protobothrops flavoviridis
Toxicon
51
787-796
2008
Protobothrops flavoviridis
Methot, M.; Demers, E.; Bussieres, S.; Desbat, B.; Breton, R.; Salesse, C.
Phospholipid monolayer hydrolysis by cytosolic phospholipase A2 gamma and lecithin retinol acyl transferase
Colloids Surf. A Physicochem. Eng. Asp.
321
147-150
2008
Homo sapiens
-
Ma, L.; Uchida, H.; Nagai, J.; Inoue, M.; Aoki, J.; Ueda, H.
Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain
J. Pharmacol. Exp. Ther.
333
540-546
2010
Mus musculus
Zarai, Z.; Bacha, A.B.; Horchani, H.; Bezzine, S.; Zouari, N.; Gargouri, Y.; Mejdoub, H.
A novel hepatopancreatic phospholipase A2 from Hexaplex trunculus with digestive and toxic activities
Arch. Biochem. Biophys.
494
121-129
2010
Camelus dromedarius, Hexaplex trunculus, Struthio camelus, Sus scrofa
Judson, B.L.; Brown, W.J.
Assembly of an intact Golgi complex requires phospholipase A2 (PLA2) activity, membrane tubules, and dynein-mediated microtubule transport
Biochem. Biophys. Res. Commun.
389
473-477
2009
Homo sapiens
Boittin, F.X.; Shapovalov, G.; Hirn, C.; Ruegg, U.T.
Phospholipase A2-derived lysophosphatidylcholine triggers Ca2+ entry in dystrophic skeletal muscle fibers
Biochem. Biophys. Res. Commun.
391
401-406
2010
Mus musculus
Giannattasio, G.; Lai, Y.; Granata, F.; Mounier, C.M.; Nallan, L.; Oslund, R.; Leslie, C.C.; Marone, G.; Lambeau, G.; Gelb, M.H.; Triggiani, M.
Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis
Biochim. Biophys. Acta
1791
92-102
2009
Homo sapiens (O15496), Homo sapiens
Pan, Y.H.; Bahnson, B.J.
Structure of a premicellar complex of alkyl sulfates with the interfacial binding surfaces of four subunits of phospholipase A2
Biochim. Biophys. Acta
1804
1443-1448
2010
Sus scrofa (P00592), Sus scrofa
Fernandez, J.; Gutierrez, J.M.; Angulo, Y.; Sanz, L.; Juarez, P.; Calvete, J.J.; Lomonte, B.
Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization
Biochimie
92
273-283
2010
Bothrops asper (P20474), Bothrops asper
Choi, Y.A.; Kim, D.K.; Bang, O.S.; Kang, S.S.; Jin, E.J.
Secretory phospholipase A2 promotes MMP-9-mediated cell death by degrading type I collagen via the ERK pathway at an early stage of chondrogenesis
Biol. Cell
102
107-119
2010
Gallus gallus
Chethankumar, M.; Srinivas, L.
New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L
Biol. Chem.
389
299-303
2008
Naja naja
Bovens, S.; Kaptur, M.; Elfringhoff, A.S.; Lehr, M.
1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues
Bioorg. Med. Chem. Lett.
19
2107-2111
2009
Homo sapiens
Boukli, L.; Touaibia, M.; Meddad-Belhabich, N.; Djimde, A.; Park, C.; Kim, J.; Yoon, J.; Lamouri, A.; Heymans, F.
Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4'-yl(oyl)] piperazines
Bioorg. Med. Chem.
16
1242-1253
2008
Homo sapiens, Sus scrofa
Kirincich, S.J.; Xiang, J.; Green, N.; Tam, S.; Yang, H.Y.; Shim, J.; Shen, M.W.; Clark, J.D.; McKew, J.C.
Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties
Bioorg. Med. Chem.
17
4383-4405
2009
Rattus norvegicus, synthetic construct
Barbayianni, E.; Stephens, D.; Grkovich, A.; Magrioti, V.; Hsu, Y.H.; Dolatzas, P.; Kalogiannidis, D.; Dennis, E.A.; Kokotos, G.
2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides
Bioorg. Med. Chem.
17
4833-4843
2009
Homo sapiens
Armugam, A.; Cher, C.; Lim, K.; Koh, D.; Howells, D.; Jeyaseelan, K.
A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis
BMC Neurosci.
10
120
2009
Naja sputatrix
Wang, W.Y.; Li, J.; Yang, D.; Xu, W.; Zha, R.P.; Wang, Y.P.
OxLDL stimulates lipoprotein-associated phospholipase A2 expression in THP-1 monocytes via PI3K and p38 MAPK pathways
Cardiovasc. Res.
85
845-852
2010
Homo sapiens
Chalbot, S.; Zetterberg, H.; Blennow, K.; Fladby, T.; Grundke-Iqbal, I.; Iqbal, K.
Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease
Clin. Chem.
55
2171-2179
2009
Homo sapiens, Mus musculus
Garcia-Garcia, H.M.; Serruys, P.W.
Phospholipase A2 inhibitors
Curr. Opin. Lipidol.
20
327-332
2009
Homo sapiens, Sus scrofa
Shrestha, S.; Kim, Y.
Activation of immune-associated phospholipase A2 is functionally linked to Toll/Imd signal pathways in the red flour beetle, Tribolium castaneum
Dev. Comp. Immunol.
34
530-537
2010
Tribolium castaneum
Karray, A.; Frikha, F.; Ben Bacha, A.; Ben Ali, Y.; Gargouri, Y.; Bezzine, S.
Biochemical and molecular characterization of purified chicken pancreatic phospholipase A2
FEBS J.
276
4545-4554
2009
Gallus gallus
Nirmal, N.; Praba, G.O.; Velmurugan, D.
Modeling studies on phospholipase A2-inhibitor complexes
Indian J. Biochem. Biophys.
45
256-262
2008
Bos taurus (P00593), Bos taurus, Daboia russelii (P59071), Daboia russelii
Tai, N.; Kuwabara, K.; Kobayashi, M.; Yamada, K.; Ono, T.; Seno, K.; Gahara, Y.; Ishizaki, J.; Hori, Y.
Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model
Inflamm. Res.
59
53-62
2010
Mus musculus
Dharmappa, K.K.; Mohamed, R.; Shivaprasad, H.V.; Vishwanath, B.S.
Genistein, a potent inhibitor of secretory phospholipase A2: a new insight in down regulation of inflammation
Inflammopharmacology
18
25-31
2010
Homo sapiens
Burke, J.E.; Babakhani, A.; Gorfe, A.A.; Kokotos, G.; Li, S.; Woods, V.L.; McCammon, J.A.; Dennis, E.A.
Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry
J. Am. Chem. Soc.
131
8083-8091
2009
synthetic construct
Gubern, A.; Casas, J.; Barcelo-Torns, M.; Barneda, D.; de la Rosa, X.; Masgrau, R.; Picatoste, F.; Balsinde, J.; Balboa, M.A.; Claro, E.
Group IVA phospholipase A2 is necessary for the biogenesis of lipid droplets
J. Biol. Chem.
283
27369-27382
2008
Homo sapiens
Guy, J.E.; Stahl, U.; Lindqvist, Y.
Crystal structure of a class XIB phospholipase A2 (PLA2): rice (oryza sativa) isoform-2 pla2 and an octanoate complex
J. Biol. Chem.
284
19371-19379
2009
Oryza sativa (Q9XG81), Oryza sativa
Bhattacharya, A.; Muller, F.L.; Liu, Y.; Sabia, M.; Liang, H.; Song, W.; Jang, Y.C.; Ran, Q.; Van Remmen, H.
Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria
J. Biol. Chem.
284
46-55
2009
Mus musculus
Chen, K.C.; Kao, P.H.; Lin, S.R.; Chang, L.S.
Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation
J. Cell. Biochem.
106
93-102
2009
Naja atra
Lee, C.W.; Lee, I.T.; Lin, C.C.; Lee, H.C.; Lin, W.N.; Yang, C.M.
Activation and induction of cytosolic phospholipase A2 by IL-1beta in human tracheal smooth muscle cells: role of MAPKs/p300 and NF-kappaB
J. Cell. Biochem.
109
1045-1056
2010
Homo sapiens
Chen, K.C.; Liu, W.H.; Chang, L.S.
Taiwan cobra phospholipase A2-elicited JNK activation is responsible for autocrine fas-mediated cell death and modulating Bcl-2 and Bax protein expression in human leukemia K562 cells
J. Cell. Biochem.
109
245-254
2010
Naja atra
Mouchlis, V.D.; Mavromoustakos, T.M.; Kokotos, G.
Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor
J. Comput. Aided Mol. Des.
24
107-115
2010
Homo sapiens (P14555)
Casas, J.; Meana, C.; Esquinas, E.; Valdearcos, M.; Pindado, J.; Balsinde, J.; Balboa, M.A.
Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages
J. Immunol.
183
2767-2774
2009
Homo sapiens
Ayilavarapu, S.; Kantarci, A.; Fredman, G.; Turkoglu, O.; Omori, K.; Liu, H.; Iwata, T.; Yagi, M.; Hasturk, H.; Van Dyke, T.E.
Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils
J. Immunol.
184
1507-1515
2010
Homo sapiens
Meliton, A.Y.; Munoz, N.M.; Meliton, L.N.; Binder, D.C.; Osan, C.M.; Zhu, X.; Dudek, S.M.; Leff, A.R.
Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro
J. Inflamm.
7
14
2010
Homo sapiens
Figueiredo, M.; Garcia, E.; Azambuja, P.
Blockades of phospholipase A2 and platelet-activating factor receptors reduce the hemocyte phagocytosis in Rhodnius prolixus: In vitro experiments
J. Insect Physiol.
54
344-350
2008
Rhodnius prolixus
Burke, J.; Dennis, E.
Phospholipase A2 structure/function, mechanism, and signaling
J. Lipid Res.
50 Suppl
S237-S242
2009
Apis mellifera, Homo sapiens, Mus musculus, Naja naja
Markakis, K.P.; Koropouli, M.K.; Grammenou-Savvoglou, S.; van Winden, E.C.; Dimitriou, A.A.; Demopoulos, C.A.; Tselepis, A.D.; Kotsifaki, E.E.
Implication of lipoprotein associated phospholipase A2 activity on oxidized low density lipoprotein uptake by macrophages
J. Lipid Res.
51
2191-2201
2010
Mus musculus
Dalm, D.; Palm, G.J.; Aleksandrov, A.; Simonson, T.; Hinrichs, W.
Nonantibiotic properties of tetracyclines: structural basis for inhibition of secretory phospholipase A2
J. Mol. Biol.
398
83-96
2010
Naja naja (P15445), Naja naja
Dreiseitel, A.; Korte, G.; Schreier, P.; Oehme, A.; Locher, S.; Hajak, G.; Sand, P.G.
sPhospholipase A(2) is inhibited by anthocyanidins
J. Neural Transm.
116
1071-1077
2009
Homo sapiens
Jackman, J.A.; Cho, N.J.; Duran, R.S.; Frank, C.W.
Interfacial binding dynamics of bee venom phospholipase A2 investigated by dynamic light scattering and quartz crystal microbalance
Langmuir
26
4103-4112
2010
Apis mellifera
Sharbaugh, D.M.; Talham, D.R.
Effect of phospholipase A2 hydrolysis products on calcium oxalate precipitation at lipid interfaces
Langmuir
26
4925-4932
2010
Naja mossambica
Bazaa, A.; Luis, J.; Srairi-Abid, N.; Kallech-Ziri, O.; Kessentini-Zouari, R.; Defilles, C.; Lissitzky, J.C.; El Ayeb, M.; Marrakchi, N.
MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration
Matrix Biol.
28
188-193
2009
Macrovipera lebetina transmediterranea (B5U6Z2), Macrovipera lebetina transmediterranea
Hu, F.; Hu, X.; Ma, C.; Zhao, J.; Xu, J.; Yu, X.
Molecular characterization of a novel Clonorchis sinensis secretory phospholipase A(2) and investigation of its potential contribution to hepatic fibrosis
Mol. Biochem. Parasitol.
167
127-134
2009
synthetic construct, Clonorchis sinensis (C6YBD6), Clonorchis sinensis
De-Paula, V.J.; Schaeffer, E.L.; Talib, L.L.; Gattaz, W.F.; Forlenza, O.V.
Inhibition of phospholipase A2 increases Tau phosphorylation at Ser214 in embryonic rat hippocampal neurons
Prostaglandins Leukot. Essent. Fatty Acids
82
57-60
2010
Rattus norvegicus
Korotaeva, A.A.; Samoilova, E.V.; Piksina, G.F.; Prokazova, N.V.
Oxidized phosphatidylcholine stimulates activity of secretory phospholipase A2 group IIA and abolishes sphingomyelin-induced inhibition of the enzyme
Prostaglandins Other Lipid Mediat.
91
38-41
2010
Homo sapiens
Fonseca, R.G.; Ferreira, T.L.; Ward, R.J.
Refolding and purification of the human secreted group IID phospholipase A2 expressed as inclusion bodies in Escherichia coli
Protein Expr. Purif.
67
82-87
2009
Homo sapiens
Gonzalez-Morales, L.; Diego-Garcia, E.; Segovia, L.; Gutierrez, M.d.e.l..C.; Possani, L.D.
Venom from the centipede Scolopendra viridis Say: purification, gene cloning and phylogenetic analysis of a phospholipase A2
Toxicon
54
8-15
2009
Scolopendra viridis
Osipov, A.V.; Filkin, S.Y.; Makarova, Y.V.; Tsetlin, V.I.; Utkin, Y.N.
A new type of thrombin inhibitor, noncytotoxic phospholipase A2, from the Naja haje cobra venom
Toxicon
55
186-194
2010
Naja haje, Naja kaouthia (P00596)
Wei, J.F.; Wei, X.L.; Mo, Y.Z.; He, S.H.
Induction of microvascular leakage and histamine release by promutoxin, an Arg49 phospholipase A2
Toxicon
55
888-896
2010
Protobothrops mucrosquamatus
Du, Y.R.; Xiao, Y.; Lu, Z.M.; Ding, J.; Xie, F.; Fu, H.; Wang, Y.; Strong, J.A.; Zhang, J.M.; Chen, J.
Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways
Biochem. Biophys. Res. Commun.
408
32-37
2011
Rattus norvegicus
Chandra, D.; Prasanth, G.; Singh, N.; Kumar, S.; Jithesh, O.; Sadasivan, C.; Sharma, S.; Singh, T.; Haridas, M.
Identification of a novel and potent inhibitor of phospholipase A 2 in a medicinal plant: Crystal structure at 1.93 A and Surface Plasmon Resonance analysis of phospholipase A2 complexed with berberine
Biochim. Biophys. Acta
1814
657-663
2011
Daboia russelii russelii (P59071)
Perumal Samy, R.; Gopalakrishnakone, P.; Bow, H.; Puspharaj, P.N.; Chow, V.T.
Identification and characterization of a phospholipase A2 from the venom of the Saw-scaled viper: Novel bactericidal and membrane damaging activities
Biochimie
92
1854-1866
2010
Echis carinatus
Nevalainen, T.J.
1-Cysteine peroxiredoxin: A dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities
Biochimie
92
638-644
2010
Homo sapiens
Huancahuire-Vega, S.; Ponce-Soto, L.A.; Martins-de-Souza, D.; Marangoni, S.
Biochemical and pharmacological characterization of PhTX-I a new myotoxic phospholipase A2 isolated from Porthidium hyoprora snake venom
Comp. Biochem. Physiol. C
154
108-119
2011
Bothrocophias hyoprora
Nunes, D.C.; Rodrigues, R.S.; Lucena, M.N.; Cologna, C.T.; Oliveira, A.C.; Hamaguchi, A.; Homsi-Brandeburgo, M.I.; Arantes, E.C.; Teixeira, D.N.; Ueira-Vieira, C.; Rodrigues, V.M.
Isolation and functional characterization of proinflammatory acidic phospholipase A2 from Bothrops leucurus snake venom
Comp. Biochem. Physiol. C
154
226-233
2011
Bothrops leucurus
Moin, S.; Rainer, M.; Waheed, H.; Stasyk, T.; Huber, L.; Lottspeich, F.; Bonn, G.
Purification and characterization of a phospholipase A2 and identification of a kappa bungarotoxin from Bungarus sindanus sindanus (Sindhi Krait) snake venom
Curr. Anal. Chem.
7
176-183
2011
Bungarus sindanus
-
Hariprasad, G.; Kumar, M.; Srinivasan, A.; Kaur, P.; Singh, T.P.; Jithesh, O.
Structural analysis of a group III Glu62-phospholipase A2 from the scorpion, Mesobuthus tamulus: Targeting and reversible inhibition by native peptides
Int. J. Biol. Macromol.
48
423-431
2011
Mesobuthus tamulus (Q6T178), Mesobuthus tamulus
Ghomashchi, F.; Naika, G.S.; Bollinger, J.G.; Aloulou, A.; Lehr, M.; Leslie, C.C.; Gelb, M.H.
Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms
J. Biol. Chem.
285
36100-36111
2010
Homo sapiens, Mus musculus
Escoffier, J.; Pierre, V.; Jemel, I.; Munch, L.; Boudhraa, Z.; Ray, P.; De Waard, M.; Lambeau, G.; Arnoult, C.
Group X secreted phospholipase A2 specifically decreases sperm motility in mice
J. Cell. Physiol.
226
2601-2609
2011
Mus musculus
Shrestha, S.; Kim, Y.
Biochemical characteristics of immune-associated phospholipase A2 and its inhibition by an entomopathogenic bacterium, Xenorhabdus nematophila
J. Microbiol.
47
774-782
2010
Tribolium castaneum (C0LTQ2), Tribolium castaneum
Madsen, J.J.; Linderoth, L.; Subramanian, A.K.; Andresen, T.L.; Peters, G.H.
Secretory phospholipase A2 activity toward diverse substrates
J. Phys. Chem. B
115
6853-6861
2011
Agkistrodon piscivorus piscivorus, Apis mellifera (P00630), Homo sapiens (P14555)
Bacha, A.B.; Karray, A.; Bouchaala, E.; Gargouri, Y.; Ali, Y.B.
Purification and biochemical characterization of pancreatic phospholipase A2 from the common stingray Dasyatis pastinaca
Lipids Health Dis.
10
32
2011
Dasyatis pastinaca
Santos, M.; Toyama, D.; Oliveira, S.; Cotrim, C.; Diz-Filho, E.; Fagundes, F.; Soares, V.; Aparicio, R.; Toyama, M.
Modulation of the pharmacological activities of secretory phospholipase A2 from Crotalus durissus cascavella induced by naringin
Molecules
16
738-761
2011
Crotalus durissus cascavella
de Alvarenga, E.S.; Silva, S.A.; Barosa, L.C.; Demuner, A.J.; Parreira, A.G.; Ribeiro, R.I.; Marcussi, S.; Ferreira, J.M.; Resende, R.R.; Granjeiro, P.A.; Silva, J.A.; Soares, A.M.; Marangoni, S.; Da Silva, S.L.
Synthesis and evaluation of sesquiterpene lactone inhibitors of phospholipase A2 from Bothrops jararacussu
Toxicon
57
100-108
2011
Bothrops jararacussu
Saikia, D.; Thakur, R.; Mukherjee, A.
An acidic phospholipase A2 (RVVA-PLA2-I) purified from Daboia russelli venom exerts its anticoagulant activity by enzymatic hydrolysis of plasma phospholipids and by non-enzymatic inhibition of factor Xa in a phospholipids/Ca2+ independent manner
Toxicon
57
841-850
2011
Daboia russelii
Schmidt, J.A.; Kalkofen, D.N.; Donovan, K.W.; Brown, W.J.
A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking
Traffic
11
1530-1536
2010
Homo sapiens
Stahnke, S.; Lux, K.; Uhrig, S.; Kreppel, F.; Hoesel, M.; Coutelle, O.; Ogris, M.; Hallek, M.; Buening, H.
Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles
Virology
409
77-83
2011
Adeno-associated virus (P03135), Adeno-associated virus
Zou, Z.; Zeng, F.; Zhang, L.; Niu, L.; Teng, M.; Li, X.
Purification, crystallization and preliminary X-ray diffraction analysis of an acidic phospholipase A2 with vasoconstrictor activity from Agkistrodon halys pallas venom
Acta Crystallogr. Sect. F
68
1329-1332
2012
Gloydius halys
Qiu, S.; Lai, L.
Tailoring the pH dependence of human non-pancreatic secretory phospholipase A2 by engineering surface charges
Appl. Biochem. Biotechnol.
171
1454-1464
2013
Homo sapiens
Aragao, E.A.; Vieira, D.S.; Chioato, L.; Ferreira, T.L.; Lourenzoni, M.R.; Silva, S.R.; Ward, R.J.
Characterization of suramin binding sites on the human group IIA secreted phospholipase A2 by site-directed mutagenesis and molecular dynamics simulation
Arch. Biochem. Biophys.
519
17-22
2012
Homo sapiens (P14555)
Song, H.S.; Choi, M.Y.; Ko, M.S.; Jeong, J.M.; Kim, Y.H.; Jang, B.H.; Sung, J.H.; Kim, M.G.; Whang, W.K.; Sim, S.S.
Competitive inhibition of cytosolic Ca2+-dependent phospholipase A2 by acteoside in RBL-2H3 cells
Arch. Pharm. Res.
35
905-910
2012
Rattus norvegicus
Fonseca-Maldonado, R.; Ferreira, T.L.; Ward, R.J.
The bactericidal effect of human secreted group IID phospholipase A2 results from both hydrolytic and non-hydrolytic activities
Biochimie
94
1437-1440
2012
Homo sapiens (Q9UNK4), Homo sapiens
Vieira, L.F.; Magro, A.J.; Fernandes, C.A.; de Souza, B.M.; Cavalcante, W.L.; Palma, M.S.; Rosa, J.C.; Fuly, A.L.; Fontes, M.R.; Gallacci, M.; Butzke, D.S.; Calderon, L.A.; Stabeli, R.G.; Giglio, J.R.; Soares, A.M.
Biochemical, functional, structural and phylogenetic studies on Intercro, a new isoform phospholipase A2 from Crotalus durissus terrificus snake venom
Biochimie
95
2365-2375
2013
Crotalus durissus terrificus
Mukherjee, A.K.
A major phospholipase A2 from Daboia russelii russelii venom shows potent anticoagulant action via thrombin inhibition and binding with plasma phospholipids
Biochimie
99
153-161
2014
Daboia russelii
Ben Bacha, A.; Daihan, S.K.; Moubayed, N.M.; Mejdoub, H.
Purification and characterization of a phospholipase A2-IIA from common stingray (Dasyatis pastinaca) intestine
Indian J. Biochem. Biophys.
50
186-195
2013
Dasyatis pastinaca
Zizza, P.; Iurisci, C.; Bonazzi, M.; Cossart, P.; Leslie, C.C.; Corda, D.; Mariggio, S.
Phospholipase A2IValpha regulates phagocytosis independent of its enzymatic activity
J. Biol. Chem.
287
16849-16859
2012
Mus musculus (P47713)
Morrison, K.; Witte, K.; Mayers, J.R.; Schuh, A.L.; Audhya, A.
Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform
J. Biol. Chem.
287
38824-38834
2012
Caenorhabditis elegans
Hiraoka, M.; Okamoto, K.; Ohguro, H.; Abe, A.
Role of N-glycosylation of human lysosomal phospholipase A2 for the formation of catalytically active enzyme
J. Lipid Res.
54
3098-3105
2013
Homo sapiens (Q8NCC3), Homo sapiens
Xu, S.; Pei, R.; Guo, M.; Han, Q.; Lai, J.; Wang, Y.; Wu, C.; Zhou, Y.; Lu, M.; Chen, X.
Cytosolic phospholipase A2 gamma is involved in hepatitis C virus replication and assembly
J. Virol.
86
13025-13037
2012
Homo sapiens
Verlotta, A.; Trono, D.
Expression, purification and refolding of active durum wheat (Triticum durum Desf.) secretory phospholipase A2 from inclusion bodies of Escherichia coli
Protein Expr. Purif.
101
28-36
2014
Triticum turgidum subsp. durum (M1GL46), Triticum turgidum subsp. durum
Hsu, P.Y.; Lee, K.K.; Lee, P.S.; Hu, C.C.; Lin, C.H.; Liu, P.C.
Biochemical characterization of a phospholipase A2 from Photobacterium damselae subsp. piscicida
Z. Naturforsch. C
68
471-481
2014
Photobacterium damselae (Q8RR52), Photobacterium damselae
Feng, V.; Joh, Y.; Ishikawa, K.; Ishida, H.; Ando, S.; Yamagaki, T.; Nakanishi, H.; Cao, S.; Matsui, I.; Kosugi, Y.
Thermophilic phospholipase A2 in the cytosolic fraction from the archaeon Pyrococcus horikoshii
J. Am. Oil Chem. Soc.
77
1147-1152
2000
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
-
Liu, A.; Yu, X.W.; Sha, C.; Xu, Y.
Streptomyces violaceoruber phospholipase A2 expression in Pichia pastoris, properties, and application in oil degumming
Appl. Biochem. Biotechnol.
175
3195-3206
2015
Streptomyces violaceoruber (Q6UV28), Streptomyces violaceoruber
Duvernay, M.T.; Matafonov, A.; Lindsley, C.W.; Hamm, H.E.
Platelet lipidomic profiling novel insight into cytosolic phospholipase A2alpha activity and its role in human platelet activation
Biochemistry
54
5578-5588
2015
Homo sapiens (P47712), Homo sapiens (W0FXB0)
Batchu, K.C.; Haenninen, S.; Jha, S.K.; Jeltsch, M.; Somerharju, P.
Factors regulating the substrate specificity of cytosolic phospholipase A2-alpha in vitro
Biochim. Biophys. Acta
1861
1597-1604
2016
Homo sapiens (P47712), Homo sapiens
Ng, C.Y.; Kwok, T.X.; Tan, F.C.; Low, C.M.; Lam, Y.
Fluorogenic probes to monitor cytosolic phospholipase A2 activity
Chem. Commun. (Camb.)
53
1813-1816
2017
Apis mellifera (P00630)
Arnsmann, M.; Hanekamp, W.; Elfringhoff, A.S.; Lehr, M.
Structure-activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A2. Effect of substituents at the indole 3-position on activity, solubility, and metabolic stability
Eur. J. Med. Chem.
125
1107-1114
2017
Homo sapiens (P47712)
Ye, M.; Chung, H.S.; Lee, C.; Hyun Song, J.; Shim, I.; Kim, Y.S.; Bae, H.
Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinsons disease alpha-synuclein transgenic mice
Exp. Mol. Med.
48
e244
2016
Apis mellifera (P00630), Apis mellifera
Naini, S.M.; Choukroun, G.J.; Ryan, J.R.; Hentschel, D.M.; Shah, J.V.; Bonventre, J.V.
Cytosolic phospholipase A2alpha regulates G1 progression through modulating FOXO1 activity
FASEB J.
30
1155-1170
2016
Mus musculus (P47713), Mus musculus, Danio rerio (P50392), Danio rerio
Kotani, S.; Izawa, S.; Komai, N.; Takayanagi, A.; Arioka, M.
Mitochondria-localized phospholipase A2, AoPlaA, in Aspergillus oryzae displays phosphatidylethanolamine-specific activity and is involved in the maintenance of mitochondrial phospholipid composition
Fungal Genet. Biol.
96
1-11
2016
Aspergillus oryzae (C7G4B6), Aspergillus oryzae
Zhang, A.; Veesenmeyer, J.L.; Hauser, A.R.
Phosphatidylinositol 4,5-bisphosphate-dependent oligomerization of the Pseudomonas aeruginosa cytotoxin ExoU
Infect. Immun.
86
e00402
2018
Pseudomonas aeruginosa (O34208), Pseudomonas aeruginosa
Smichi, N.; Othman, H.; Achouri, N.; Noiriel, A.; Arondel, V.; Srairi-Abid, N.; Abousalham, A.; Gargouri, Y.; Miled, N.; Fendri, A.
Functional and structural characterization of a thermostable phospholipase A2 from a Sparidae Fish (Diplodus annularis)
J. Agric. Food Chem.
65
2468-2480
2017
Diplodus annularis (A0A1L4FQZ9)
Jang, K.K.; Lee, Z.W.; Kim, B.; Jung, Y.H.; Han, H.J.; Kim, M.H.; Kim, B.S.; Choi, S.H.
Identification and characterization of Vibrio vulnificus plpA encoding a phospholipase A2 essential for pathogenesis
J. Biol. Chem.
292
17129-17143
2017
Vibrio vulnificus, Vibrio vulnificus MO6-24/O
Nakamura, H.; Wakita, S.; Yasufuku, K.; Makiyama, T.; Waraya, M.; Hashimoto, N.; Murayama, T.
Sphingomyelin regulates the activity of secretory phospholipase A2 in the plasma membrane
J. Cell. Biochem.
116
1898-1907
2015
Cricetulus griseus
El Alaoui, M.; Soulere, L.; Noiriel, A.; Popowycz, F.; Khatib, A.; Queneau, Y.; Abousalham, A.
A continuous spectrophotometric assay that distinguishes between phospholipase A1 and A2 activities
J. Lipid Res.
57
1589-1597
2016
Sus scrofa
Fisher, A.B.
The phospholipase A2 activity of peroxiredoxin 6
J. Lipid Res.
59
1132-1147
2018
Trematomus bernacchii, Xenopus tropicalis (B1WAZ6), Mus musculus (O08709), Rattus norvegicus (O35244), Bos taurus (O77834), Homo sapiens (P30041), Gallus gallus (Q5ZJF4), Arabidopsis thaliana (Q8S8N6)
Wang, H.; Klein, M.G.; Snell, G.; Lane, W.; Zou, H.; Levin, I.; Li, K.; Sang, B.C.
Structure of human GIVD cytosolic phospholipase A2 reveals insights into substrate recognition
J. Mol. Biol.
428
2769-2779
2016
Homo sapiens (Q86XP0), Homo sapiens
Chuang, D.Y.; Simonyi, A.; Kotzbauer, P.T.; Gu, Z.; Sun, G.Y.
Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway
J. Neuroinflammation
12
199
2015
Mus musculus (P0C871), Mus musculus (P47713), Mus musculus
Karkabounas, A.; Georgiadou, D.G.; Argitis, P.; Psycharis, V.; Nakos, G.; Kosmas, A.M.; Lekka, M.E.
Immobilization of lipid substrates application on phospholipase A2 determination
Lipids
50
1259-1271
2015
Sus scrofa (P00592)
Yamamoto, K.; Miki, Y.; Sato, H.; Murase, R.; Taketomi, Y.; Murakami, M.
Secreted phospholipase A2 specificity on natural membrane phospholipids
Methods Enzymol.
583
101-117
2017
Mus musculus, Mus musculus (Q9QZT4)
Dileep, K.V.; Remya, C.; Cerezo, J.; Fassihi, A.; Perez-Sanchez, H.; Sadasivan, C.
Comparative studies on the inhibitory activities of selected benzoic acid derivatives against secretory phospholipase A2, a key enzyme involved in the inflammatory pathway
Mol. Biosyst.
11
1973-1979
2015
Sus scrofa (P00592)
Movahedi Naini, S.; Sheridan, A.M.; Force, T.; Shah, J.V.; Bonventre, J.V.
Group IVA cytosolic phospholipase A2 regulates the G2-to-M transition by modulating the activity of tumor suppressor SIRT2
Mol. Cell. Biol.
35
3768-3784
2015
Homo sapiens (P47712)
Sharma, M.; Iyer, J.K.; Shih, N.; Majumder, M.; Mattaparthi, V.S.; Mukhopadhyay, R.; Doley, R.
Daboxin P, a major phospholipase A2 enzyme from the Indian Daboia russelii russelii venom targets factor X and factor Xa for its anticoagulant activity
PLoS ONE
11
e0153770
2016
Daboia russelii (C0HK16)
Seroussi, E.; Blum, S.E.; Krifucks, O.; Lavon, Y.; Leitner, G.
Application of pancreatic phospholipase A2 for treatment of bovine mastitis
PLoS ONE
13
e0203132
2018
Bos taurus (P00593), Bos taurus
Mouchlis, V.D.; Bucher, D.; McCammon, J.A.; Dennis, E.A.
Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates
Proc. Natl. Acad. Sci. USA
112
E516-E525
2015
Homo sapiens (O60733), Homo sapiens (P47712), Homo sapiens
Dias, E.H.V.; Dos Santos Paschoal, T.; da Silva, A.P.; da Cunha Pereira, D.F.; de Sousa Simamoto, B.B.; Matias, M.S.; Santiago, F.M.; Rosa, J.C.; Soares, A.; Santos-Filho, N.A.; de Oliveira, F.; Mamede, C.C.N.
BaltPLA2 A new phospholipase A2 from Bothrops alternatus snake venom with antiplatelet aggregation activity
Protein Pept. Lett.
25
943-952
2018
Bothrops alternatus
Terra, A.L.; Moreira-Dill, L.S.; Simoes-Silva, R.; Monteiro, J.R.; Cavalcante, W.L.; Gallacci, M.; Barros, N.B.; Nicolete, R.; Teles, C.B.; Medeiros, P.S.; Zanchi, F.B.; Zuliani, J.P.; Calderon, L.A.; Stabeli, R.G.; Soares, A.M.
Biological characterization of the Amazon coral Micrurus spixii snake venom Isolation of a new neurotoxic phospholipase A2
Toxicon
103
1-11
2015
Micrurus spixii
Du, Q.S.; Trabi, M.; Richards, R.S.; Mirtschin, P.; Madaras, F.; Nouwens, A.; Zhao, K.N.; de Jersey, J.; Lavin, M.F.; Guddat, L.W.; Masci, P.P.
Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom
Toxicon
111
37-49
2016
Pseudechis australis (P04056), Pseudechis australis
Almeida, J.R.; Resende, L.M.; Silva, A.G.; Ribeiro, R.I.; Stabeli, R.G.; Soares, A.M.; Calderon, L.A.; Marangoni, S.; Da Silva, S.L.
Biochemical and functional studies of ColTx-I, a new myotoxic phospholipase A2 isolated from Crotalus oreganus lutosus (Great Basin rattlesnake) snake venom
Toxicon
117
1-12
2016
Crotalus oreganus lutosus (C0HK05), Crotalus oreganus lutosus
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