Reference on EC 3.1.1.29 - aminoacyl-tRNA hydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Paulin, D.; Yot, P.; Chapeville, F.
Enzymatic hydrolysis of N-substituted aminoacyl-tRNA
FEBS Lett.
1
163-165
1968
Escherichia coli, Escherichia coli MRE 600
Jost, J.P.; Bock, R.M.
Enzymatic hydrolysis of N-substituted aminoacyl transfer ribonucleic acid in yeast
J. Biol. Chem.
244
5866-5873
1969
Saccharomyces cerevisiae
Vogel, Z.; Vogel, T.; Zamir, A.; Elson, D.
The protection by 70 S ribosomes of N-acyl-aminoacyl-tRNA against cleavage by peptidyl-tRNA hydrolase and its use to assay ribosomal association
Eur. J. Biochem.
21
582-592
1971
Escherichia coli
Neth, R.; Dunlop, N.; Heller-Schch, G.; Winkler, K.
Hydrolase activity for N-substituted aminoacyl-tRNA in ribosomes and supernatant fractions from human tissues and tumors
Hoppe-Seyler's Z. Physiol. Chem.
353
117-121
1972
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
de Pereda, J.M.; Waas, W.F.; Jan, Y.; Ruoslathi, E.; Schimmel, P.; Pascual, J.
Crystral structure of a human peptidyl-tRNA hydrolase eveals a new fold and suggests basis for a bifunctional activity
J. Biol. Chem.
279
8111-8115
2003
Escherichia coli, Homo sapiens (Q9Y3E5), Homo sapiens, Saccharolobus solfataricus
Miralles, J.; Sebastian, J.; Heredia, C.F.
Independent temporal expression of two N-substituted aminoacyl-tRNA hydrolases during the development of Artemia salina
Biochim. Biophys. Acta
518
326-333
1978
Artemia salina
Fromant, M.; Ferri-Fioni, M.L.; Plateau, P.; Blanquet, S.
Peptidyl-tRNA hydrolase from Sulfolobus solfataricus
Nucleic Acids Res.
31
3227-3235
2003
Saccharomyces cerevisiae, Escherichia coli, Saccharolobus solfataricus
Gallego, M.E.; Heredia, C.F.
Purification and properties of an inducible aminoacyl-tRNA hydrolase from Artemia larvae
Biochim. Biophys. Acta
696
57-65
1982
Artemia sp.
-
Ferreiro, C.; Heredia, C.F.
Purification and characterization of an aminoacyl-tRNA hydrolase from the filamentous fungus Fusarium culmorum
Biochim. Biophys. Acta
882
410-418
1986
Fusarium culmorum
-
Refugio Garcia-Villegas, M.; De La Vega, F.; Galindo, J.M.; Segura, M.; Buckingham, R.H.; Guarneros, G.
Peptidyl-tRNA hydrolase is involved in lambda inhibition of host protein synthesis
EMBO J.
10
3549-3555
1991
Escherichia coli
Rosas-Sandoval, G.; Amrogelly, A.; Rinehart, J.; Wei, D.; Cruz-Vera, L.R.; Graham, D.E.; Stetter, K.O.; Guarneros, G.; Soell, D.
Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast
Proc. Natl. Acad. Sci. USA
99
16707-16712
2002
Methanocaldococcus jannaschii
Dutka, S.; Meinnel, T.; Lazennec, C.; Mechulam, Y.; Blanquet, S.
Role of the 1-72 base pair in tRNAs for the activity of Escherichia coli peptidyl-tRNA hydrolase
Nucleic Acids Res.
21
4025-4030
1993
Escherichia coli
Schmitt, E.; Mechulam, Y.; Fromant, M.; Plateau, P.; Blanquet, S.
Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase
EMBO J.
16
4760-4769
1997
Escherichia coli (P0A7D1), Escherichia coli
Schmitt, E.; Fromant, M.; Plateau, P.; Mechulam, Y.; Blanquet, S.
Crystallization and preliminary X-ray analysis of Escherichia coli peptidyl-tRNA hydrolase
Proteins Struct. Funct. Genet.
28
135-136
1997
Escherichia coli
Goodall, J.J.; Chen, G.J.; Page, M.G.
Essential role of histidine 20 in the catalytic mechanism of Escherichia coli peptidyl-tRNA hydrolase
Biochemistry
43
4583-4591
2004
Escherichia coli
Menez, J.; Remy, E.; Buckingham, R.H.
Suppression of thermosensitive peptidyl-tRNA hydrolase mutation in Escherichia coli by gene duplication
Microbiology
147
1581-1589
2001
Escherichia coli
Menez, J.; Buckingham, R.H.; de Zamaroczy, M.; Campelli, C.K.
Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable
Mol. Microbiol.
45
123-129
2002
Bacillus subtilis, Saccharomyces cerevisiae
Bonin, P.D.; Choi, G.H.; Trepod, C.M.; Mott, J.E.; Lyle, S.B.; Cialdella, J.I.; Sarver, R.W.; Marshall, V.P.; Erickson, L.A.
Expression, purification, and characterization of peptidyl-tRNA hydrolase from Staphylococcus aureus
Protein Expr. Purif.
24
123-130
2002
Staphylococcus aureus (Q6YP15), Staphylococcus aureus
Fromant, M.; Scvhmitt, E.; Mechulam, Y.; Lazennec, C.; Plateau, P.; Blanquet, S.
Crystal structure at 1.8 A resolution and identification of active site residues of Sulfolobus solfataricus peptidyl-tRNA hydrolase
Biochemistry
44
4292-4301
2005
Saccharolobus solfataricus
-
Singh, N.S.; Varshney, U.
A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli
Nucleic Acids REs.
32
6028-2037
2004
Escherichia coli
Powers, R.; Mirkovic, N.; et.al
Solution structure of Archaeglobus fulgidis peptidyl-tRNA hydrolase (Pth2) provides evidence for an extensive conserved family of Pth2 enzymes in archea, bacteria, and eukaryotes
Protein SCi.
14
2849-2861
2005
Archaeoglobus fulgidus (O28185)
Selvaraj, M.; Singh, N.S.; Roy, S.; Sangeetha, R.; Varshney, U.; Vijayan, M.
Cloning, expression, purification, crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
62
913-915
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Fromant, M.; Schmitt, E.; Mechulam, Y.; Lazennec, C.; Plateau, P.; Blanquet, S.
Crystal structure at 1.8 A resolution and identification of active site residues of Sulfolobus solfataricus peptidyl-tRNA hydrolase
Biochemistry
44
4294-4301
2005
Saccharolobus solfataricus (Q980V1), Saccharolobus solfataricus
Bal, N.C.; Agrawal, H.; Meher, A.K.; Arora, A.
Characterization of peptidyl-tRNA hydrolase encoded by open reading frame Rv1014c of Mycobacterium tuberculosis H37Rv
Biol. Chem.
388
467-479
2007
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Selvaraj, M.; Roy, S.; Singh, N.S.; Sangeetha, R.; Varshney, U.; Vijayan, M.
Structural plasticity and enzyme action: crystal structures of Mycobacterium tuberculosis peptidyl-tRNA hydrolase
J. Mol. Biol.
372
186-193
2007
Mycobacterium tuberculosis (P9WHN7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WHN7)
Das, G.; Varshney, U.
Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis
Microbiology
152
2191-2195
2006
Escherichia coli
Vivanco-Dominguez, S.; Cruz-Vera, L.R.; Guarneros, G.
Excess of charged tRNALys maintains low levels of peptidyl-tRNA hydrolase in pth(Ts) mutants at a non-permissive temperature
Nucleic Acids Res.
34
1564-1570
2006
Escherichia coli
Shimizu, K.; Kuroishi, C.; Sugahara, M.; Kunishima, N.
Structure of peptidyl-tRNA hydrolase 2 from Pyrococcus horikoshii OT3: insight into the functional role of its dimeric state
Acta Crystallogr. Sect. D
64
444-453
2008
Pyrococcus horikoshii (O74017), Pyrococcus horikoshii OT-3 (O74017)
Pulavarti, S.V.; Jain, A.; Pathak, P.P.; Mahmood, A.; Arora, A.
Solution structure and dynamics of peptidyl-tRNA hydrolase from Mycobacterium tuberculosis H37Rv
J. Mol. Biol.
378
165-177
2008
Mycobacterium tuberculosis (P9WHN7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WHN7), Mycobacterium tuberculosis H37Rv
Richter, R.; Rorbach, J.; Pajak, A.; Smith, P.M.; Wessels, H.J.; Huynen, M.A.; Smeitink, J.A.; Lightowlers, R.N.; Chrzanowska-Lightowlers, Z.M.
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome
EMBO J.
29
1116-1125
2010
Homo sapiens (Q14197), Homo sapiens
Singarapu, K.; Xiao, R.; Acton, T.; Rost, B.; Montelione, G.; Szyperski, T.
NMR structure of the peptidyl-tRNA hydrolase domain from Pseudomonas syringae expands the structural coverage of the hydrolysis domains of class 1 peptide chain release factors
Proteins Struct. Funct. Genet.
71
1027-1031
2008
Pseudomonas syringae pv. tomato (Q885L4)
Giorgi, L.; Plateau, P.; O'Mahony, G.; Aubard, C.; Fromant, M.; Thureau, A.; Grotli, M.; Blanquet, S.; Bontems, F.
NMR-based substrate analog docking to Escherichia coli peptidyl-tRNA hydrolase
J. Mol. Biol.
412
619-633
2011
Escherichia coli (P0A7D1), Escherichia coli
Fukunaga, R.; Yokoyama, S.
Structure of the AlaX-M trans-editing enzyme from Pyrococcus horikoshii
Acta Crystallogr. Sect. D
63
390-400
2007
Pyrococcus horikoshii (O57848), Pyrococcus horikoshii
Selvaraj, M.; Ahmad, R.; Varshney, U.; Vijayan, M.
Structures of new crystal forms of Mycobacterium tuberculosis peptidyl-tRNA hydrolase and functionally important plasticity of the molecule
Acta Crystallogr. Sect. F
68
124-128
2012
Mycobacterium tuberculosis (P9WHN7), Mycobacterium tuberculosis
Matsumoto, A.; Shimizu, Y.; Takemoto, C.; Ueda, T.; Uchiumi, T.; Ito, K.
Crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Thermus thermophilus HB8
Acta Crystallogr. Sect. F
69
332-335
2013
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Vandavasi, V.; Taylor-Creel, K.; McFeeters, R.L.; Coates, L.; McFeeters, H.
Recombinant production, crystallization and X-ray crystallographic structure determination of peptidyl-tRNA hydrolase from Salmonella typhimurium
Acta Crystallogr. Sect. F
70
872-877
2014
Salmonella enterica subsp. enterica serovar Typhimurium (A0A0F6B281), Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium 14028s (A0A0F6B281)
Goedeke, J.; Pustelny, C.; Haeussler, S.
Recycling of peptidyl-tRNAs by peptidyl-tRNA hydrolase counteracts azithromycin-mediated effects on Pseudomonas aeruginosa
Antimicrob. Agents Chemother.
57
1617-1624
2013
Pseudomonas aeruginosa
Singh, A.; Kumar, A.; Gautam, L.; Sharma, P.; Sinha, M.; Bhushan, A.; Kaur, P.; Sharma, S.; Arora, A.; Singh, T.P.
Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure based inhibitor design against peptidyl-tRNA hydrolase
Biochem. J.
463
329-337
2014
Pseudomonas aeruginosa (Q9HVC3), Pseudomonas aeruginosa
Sharma, S.; Kaushik, S.; Sinha, M.; Kushwaha, G.S.; Singh, A.; Sikarwar, J.; Chaudhary, A.; Gupta, A.; Kaur, P.; Singh, T.P.
Structural and functional insights into peptidyl-tRNA hydrolase
Biochim. Biophys. Acta
1844
1279-1288
2014
Acinetobacter baumannii, Escherichia coli, Francisella tularensis, Mycobacterium tuberculosis, Mycolicibacterium smegmatis, Pseudomonas aeruginosa, Saccharolobus solfataricus, Pyrococcus horikoshii (O74017), Methanocaldococcus jannaschii (Q60363), Saccharolobus solfataricus P2, Pyrococcus horikoshii OT-3 (O74017)
Kumar, A.; Singh, N.; Yadav, R.; Kumar, R.P.; Sharma, S.; Arora, A.; Singh, T.P.
Crystal structure of peptidyl-tRNA hydrolase from Mycobacterium smegmatis reveals novel features related to enzyme dynamics
Int. J. Biochem. Mol. Biol.
3
58-69
2012
Mycolicibacterium smegmatis
Dujeancourt, L.; Richter, R.; Chrzanowska-Lightowlers, Z.M.; Bonnefoy, N.; Herbert, C.J.
Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria
Mitochondrion
13
871-880
2013
Schizosaccharomyces pombe
McFeeters, H.; Gilbert, M.J.; Thompson, R.M.; Setzer, W.N.; Cruz-Vera, L.R.; McFeeters, R.L.
Inhibition of essential bacterial peptidyl-tRNA hydrolase activity by tropical plant extracts
Nat. Prod. Commun.
7
1107-1110
2012
Escherichia coli
Ito, K.; Murakami, R.; Mochizuki, M.; Qi, H.; Shimizu, Y.; Miura, K.; Ueda, T.; Uchiumi, T.
Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase
Nucleic Acids Res.
40
10521-10531
2012
Escherichia coli (P0A7D1), Escherichia coli
Kaushik, S.; Singh, N.; Yamini, S.; Singh, A.; Sinha, M.; Arora, A.; Kaur, P.; Sharma, S.; Singh, T.P.
The mode of inhibitor binding to peptidyl-tRNA hydrolase: binding studies and structure determination of unbound and bound peptidyl-tRNA hydrolase from Acinetobacter baumannii
PLoS ONE
8
e67547
2013
Acinetobacter baumannii (D0C9L6), Acinetobacter baumannii
Taylor-Creel, K.; Hames, M.C.; Holloway, W.B.; McFeeters, H.; McFeeters, R.L.
Expression, purification, and solubility optimization of peptidyl-tRNA hydrolase 1 from Bacillus cereus
Protein Expr. Purif.
95
259-264
2014
Bacillus cereus, Bacillus cereus ATCC 14579
Zhang, F.; Song, Y.; Niu, L.; Teng, M.; Li, X.
Crystal structure of Staphylococcus aureus peptidyl-tRNA hydrolase at a 2.25 A resolution
Acta Biochim. Biophys. Sin. (Shanghai)
47
1005-1010
2015
Staphylococcus aureus (Q2G0R9), Staphylococcus aureus, Staphylococcus aureus NCTC 8325 (Q2G0R9)
Kaushik, S.; Iqbal, N.; Singh, N.; Sikarwar, J.S.; Singh, P.K.; Sharma, P.; Kaur, P.; Sharma, S.; Owais, M.; Singh, T.P.
Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase structural, binding and antibacterial studies
Biochem. J.
475
547-560
2018
Acinetobacter baumannii (B7GYR0), Acinetobacter baumannii AB307-0294 (B7GYR0)
Kabra, A.; Fatma, F.; Shahid, S.; Pathak, P.P.; Yadav, R.; Pulavarti, S.V.; Tripathi, S.; Jain, A.; Arora, A.
Structural characterization of peptidyl-tRNA hydrolase from Mycobacterium smegmatis by NMR spectroscopy
Biochim. Biophys. Acta
1864
1304-1314
2016
Mycolicibacterium smegmatis (A0R3D3), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084 (A0R3D3), Mycolicibacterium smegmatis mc(2)155 (A0R3D3)
Shahid, S.; Kabra, A.; Mundra, S.; Pal, R.K.; Tripathi, S.; Jain, A.; Arora, A.
Role of methionine 71 in substrate recognition and structural integrity of bacterial peptidyl-tRNA hydrolase
Biochim. Biophys. Acta
1866
865-874
2018
Vibrio cholerae serotype O1 (Q9KQ21), Vibrio cholerae serotype O1 El Tor Inaba N16961 (Q9KQ21), Vibrio cholerae serotype O1 ATCC 39315 (Q9KQ21)
Verma, R.; Reichermeier, K.M.; Burroughs, A.M.; Oania, R.S.; Reitsma, J.M.; Aravind, L.; Deshaies, R.J.
Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes
Nature
557
446-451
2018
Saccharomyces cerevisiae (Q04311), Saccharomyces cerevisiae, Homo sapiens (Q9H8Y5), Saccharomyces cerevisiae ATCC 204508 (Q04311)
Burks, G.L.; McFeeters, H.; McFeeters, R.L.
Expression, purification, and buffer solubility optimization of the putative human peptidyl-tRNA hydrolase PTRHD1
Protein Expr. Purif.
126
49-54
2016
Homo sapiens (Q6GMV3), Homo sapiens
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