Reference on EC 3.1.1.23 - acylglycerol lipase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Karlsson, M.; Contreras, J.A.; Hellman, U.; Tornqvist, H.; Holm, C.
cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase
J. Biol. Chem.
272
27218-27223
1997
Mus musculus, Rattus norvegicus
Rindlisbacher, B.; Reist, M.; Zahler, P.
Diacylglycerol breakdown in plasma membranes of bovine chromaffin cells is a two-step mechanism mediated by diacylglycerol lipase and a monoacylglycerol lipase
Biochim. Biophys. Acta
905
349-357
1987
Bos taurus
Fredrikson, G.; Tornqvist, H.; Belfrage, P.
Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol
Biochim. Biophys. Acta
876
288-293
1986
Rattus norvegicus
Errasfa, M.
Characterization of several phospholipase activities and diacylglycerol/2-monoacylglycerol lipases in rat alveolar macrophages
Biochim. Biophys. Acta
1085
201-208
1991
Rattus norvegicus
Keough, D.T.; de Jersey, J.; Zerner, B.
The relationship between the carboxylesterase and monoacylglycerol lipase activities of chicken liver microsomes
Biochim. Biophys. Acta
829
164-172
1985
Gallus gallus
Farooqui, A.A.; Taylor, W.A.; Horrocks, L.A.
Separation of bovine brain mono- and diacylglycerol lipases by Heparin Sepharose affinity chromatography
Biochem. Biophys. Res. Commun.
122
1241-1246
1984
Bos taurus
Somma-Delpero, C.; Valette, A.; Lepetit-Thevenin, J.; Nobili, O.; Boyer, J.; Verine, A.
Purification and properties of a monoacylglycerol lipase in human erythrocytes
Biochem. J.
312
519-525
1995
Homo sapiens
Konrad, R.J.; Major, C.D.; Wolf, B.A.
Diacylglycerol hydrolysis to arachidonic acid is necessary for insulin secretion from isolated pancreatic islets: sequential actions of diacylglycerol and monoacylglycerol lipases
Biochemistry
33
13284-13294
1994
Rattus norvegicus
Sakurada, T.; Noma, A.
Subcellular localization and some properties of monoacylglycerol lipase in rat adipocytes
J. Biochem.
90
1413-1419
1981
Rattus norvegicus
Khoo, J.C.; Steinberg, D.
Hormone-sensitive lipase from chicken adipose tissue including the separation and purification of monoglyceride lipase
Methods Enzymol.
71
627-636
1981
Gallus gallus
Tornqvist, H.; Belfrage, P.
Monoacylglycerol lipase from rat adipose tissue
Methods Enzymol.
71
647-652
1981
Rattus norvegicus
-
De Jong, B.J.P.; Kalkman, C.; Hulsmann, W.C.
Partial purification and properties of monoacylglycerol lipase and two esterases from isolated rat small intestinal epithelial cells
Biochim. Biophys. Acta
530
56-66
1978
Rattus norvegicus
Ikeda, Y.; Okamura, K.; Fujii, S.
Purification and characterization of rat liver microsomal monoacylglycerol lipase in comparison to the other esterases
Biochim. Biophys. Acta
488
128-139
1977
Rattus norvegicus
Farooqui, A.A.; Anderson, D.K.; Horrocks, L.A.
Effect of glutamate and its analogs on diacylglycerol and monoacylglycerol lipase activities of neuron-enriched cultures
Brain Res.
604
180-184
1993
Mus musculus
Yoneda, K.; Nishimura, T.; Katunuma, N.; Imamura, S.; Nitta, K.; Tsuge, H.
Crystallization and preliminary X-ray crystallographic studies of monoacylglycerol lipase of the moderately thermophilic Bacillus sp. H-257
Acta Crystallogr. Sect. D
58
1232-1233
2002
Bacillus subtilis, Bacillus subtilis H-257
Saario, S.M.; Savinainen, J.R.; Laitinen, J.T.; Jarvinen, T.; Niemi, R.
Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes
Biochem. Pharmacol.
67
1381-1387
2004
Rattus norvegicus
Monteiro, J.B.; Nascimento, M.G.; Ninow, J.L.
Lipase-catalyzed synthesis of monoacylglycerol in a homogeneous system
Biotechnol. Lett.
25
641-644
2003
Rhizomucor miehei
Dinh, T.P.; Freund, T.F.; Piomelli, D.
A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation
Chem. Phys. Lipids
121
149-158
2002
Rattus norvegicus
Eggert, T.; Pencreac'h, G.; Douchet, I.; Verger, R.; Jaeger, K.E.
A novel extracellular esterase from Bacillus subtilis and its conversion to a monoacylglycerol hydrolase
Eur. J. Biochem.
267
6459-6469
2000
Bacillus subtilis (Q79F14), Bacillus subtilis
Imamura, S.; Kitaura, S.
Purification and characterization of a monoacylglycerol lipase from the moderately thermophilic Bacillus sp. H-257
J. Biochem.
127
419-425
2000
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) H-257
Kitaura, S.; Suzuki, K.; Imamura, S.
Monoacylglycerol lipase from moderately thermophilic Bacillus sp. strain H-257: molecular cloning, sequencing, and expression in Escherichia coli of the gene
J. Biochem.
129
397-402
2001
Bacillus sp. (in: Bacteria) (P82597), Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) H-257 (P82597)
Ito, M.; Tchoua, U.; Okamoto, M.; Tojo, H.
Purification and properties of a phospholipase A2/lipase preferring phosphatidic acid, bis(monoacylglycerol) phosphate, and monoacylglycerol from rat testis
J. Biol. Chem.
277
43674-43681
2002
Rattus norvegicus
Sakiyama, T.; Yoshimi, T.; Miyake, A.; Umeoka, M.; Tanaka, A.; Ozaki, S.; Nakanishi, K.
Purification and characterization of a monoacylglycerol lipase from Pseudomonas sp. LP7315
J. Biosci. Bioeng.
91
27-32
2001
Pseudomonas sp., Pseudomonas sp. LP7315
Sakiyama, T.; Yoshimi, T.; Tanaka, A.; Ozaki, S.; Nakanishi, K.
Analysis of monoglyceride synthetic reaction in a solvent-free two-phase system catalyzed by a monoacylglycerol lipase from Pseudomonas sp. LP7315
J. Biosci. Bioeng.
91
88-90
2001
Pseudomonas sp., Pseudomonas sp. LP7315
Dinh, T.P.; Carpenter, D.; Leslie, F.M.; Freund, T.F.; Katona, I.; Sensi, S.L.; Kathuria, S.; Piomelli, D.
Brain monoglyceride lipase participating in endocannabinoid inactivation
Proc. Natl. Acad. Sci. USA
99
10819-10824
2002
Rattus norvegicus (Q8R431)
Karlsson, M.; Tornqvist, H.; Holm, C.
Expression, purification, and characterization of histidine-tagged mouse monoglyceride lipase from baculovirus-infected insect cells
Protein Expr. Purif.
18
286-292
2000
Mus musculus
Vandevoorde, S.; Saha, B.; Mahadevan, A.; Razdan, R.K.; Pertwee, R.G.; Martin, B.R.; Fowler, C.J.
Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase
Biochem. Biophys. Res. Commun.
337
104-109
2005
Rattus norvegicus
Ghafouri, N.; Tiger, G.; Razdan, R.K.; Mahadevan, A.; Pertwee, R.G.; Martin, B.R.; Fowler, C.J.
Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol
Br. J. Pharmacol.
143
774-784
2004
Rattus norvegicus
Vandevoorde, S.; Fowler, C.J.
Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate
Br. J. Pharmacol.
145
885-893
2005
Rattus norvegicus
Saario, S.M.; Salo, O.M.; Nevalainen, T.; Poso, A.; Laitinen, J.T.; Jarvinen, T.; Niemi, R.
Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes
Chem. Biol.
12
649-656
2005
Rattus norvegicus (Q8R431)
Walter, L.; Dinh, T.; Stella, N.
ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase
J. Neurosci.
24
8068-8074
2004
Mus musculus
Dinh, T.P.; Kathuria, S.; Piomelli, D.
RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol
Mol. Pharmacol.
66
1260-1264
2004
Homo sapiens, Rattus norvegicus
Quistad, G.B.; Klintenberg, R.; Caboni, P.; Liang, S.N.; Casida, J.E.
Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice
Toxicol. Appl. Pharmacol.
211
78-83
2006
Mus musculus
Cotes, K.; Dhouib, R.; Douchet, I.; Chahinian, H.; de Caro, A.; Carriere, F.; Canaan, S.
Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids
Biochem. J.
408
417-427
2007
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Vila, A.; Rosengarth, A.; Piomelli, D.; Cravatt, B.; Marnett, L.J.
Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase
Biochemistry
46
9578-9585
2007
Rattus norvegicus
Labar, G.; Bauvois, C.; Muccioli, G.G.; Wouters, J.; Lambert, D.M.
Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling
Chembiochem
8
1293-1297
2007
Homo sapiens
Chon, S.H.; Zhou, Y.X.; Dixon, J.L.; Storch, J.
Intestinal monoacylglycerol metabolism: developmental and nutritional regulation of monoacylglycerol lipase and monoacylglycerol acyltransferase
J. Biol. Chem.
282
33346-33357
2007
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Saario, S.M.; Poso, A.; Juvonen, R.O.; Jaervinen, T.; Salo-Ahen, O.M.
Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system
J. Med. Chem.
49
4650-4656
2006
Homo sapiens, Rattus norvegicus
Hashimotodani, Y.; Ohno-Shosaku, T.; Kano, M.
Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus
J. Neurosci.
27
1211-1219
2007
Mus musculus, Mus musculus C57BL/6, Rattus norvegicus
Duncan, M.; Thomas, A.D.; Cluny, N.L.; Patel, A.; Patel, K.D.; Lutz, B.; Piomelli, D.; Alexander, S.P.; Sharkey, K.A.
Distribution and function of monoacylglycerol lipase in the gastrointestinal tract
Am. J. Physiol. Gastrointest. Liver Physiol.
295
G1255-G1265
2008
Mus musculus, Rattus norvegicus
Nomura, D.K.; Hudak, C.S.; Ward, A.M.; Burston, J.J.; Issa, R.S.; Fisher, K.J.; Abood, M.E.; Wiley, J.L.; Lichtman, A.H.; Casida, J.E.
Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels
Bioorg. Med. Chem. Lett.
18
5875-5878
2008
Mus musculus
Zvonok, N.; Pandarinathan, L.; Williams, J.; Johnston, M.; Karageorgos, I.; Janero, D.R.; Krishnan, S.C.; Makriyannis, A.
Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis
Chem. Biol.
15
854-862
2008
Homo sapiens
Muccioli, G.G.; Labar, G.; Lambert, D.M.
CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay
ChemBioChem
9
2704-2710
2008
Homo sapiens
Burston, J.J.; Sim-Selley, L.J.; Harloe, J.P.; Mahadevan, A.; Razdan, R.K.; Selley, D.E.; Wiley, J.L.
N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase
J. Pharmacol. Exp. Ther.
327
546-553
2008
Mus musculus
Zvonok, N.; Williams, J.; Johnston, M.; Pandarinathan, L.; Janero, D.R.; Li, J.; Krishnan, S.C.; Makriyannis, A.
Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification
J. Proteome Res.
7
2158-2164
2008
Rattus norvegicus (Q8R431), Homo sapiens (Q99685), Homo sapiens
Holtfrerich, A.; Makharadze, T.; Lehr, M.
High-performance liquid chromatography assay with fluorescence detection for the evaluation of inhibitors against human recombinant monoacylglycerol lipase
Anal. Biochem.
399
218-224
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Wang, Y.; Chanda, P.; Jones, P.G.; Kennedy, J.D.
A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening
Assay Drug Dev. Technol.
6
387-393
2008
Homo sapiens
Magrioti, V.; Naxakis, G.; Hadjipavlou-Litina, D.; Makriyannis, A.; Kokotos, G.
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity
Bioorg. Med. Chem. Lett.
18
5424-5427
2008
Rattus norvegicus
King, A.R.; Lodola, A.; Carmi, C.; Fu, J.; Mor, M.; Piomelli, D.
A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors
Br. J. Pharmacol.
157
974-983
2009
Rattus norvegicus
King, A.R.; Dotsey, E.Y.; Lodola, A.; Jung, K.M.; Ghomian, A.; Qiu, Y.; Fu, J.; Mor, M.; Piomelli, D.
Discovery of potent and reversible monoacylglycerol lipase inhibitors
Chem. Biol.
16
1045-1052
2009
Rattus norvegicus
Labar, G.; Bauvois, C.; Borel, F.; Ferrer, J.L.; Wouters, J.; Lambert, D.M.
Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
ChemBioChem
11
218-227
2010
Homo sapiens (Q99685), Homo sapiens
Vandevoorde, S.
Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors
Curr. Top. Med. Chem.
8
247-267
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Bowman, A.L.; Makriyannis, A.
Refined homology model of monoacylglycerol lipase: toward a selective inhibitor
J. Comput. Aided Mol. Des.
23
799-806
2009
Homo sapiens (Q99685)
Feledziak, M.; Michaux, C.; Urbach, A.; Labar, G.; Muccioli, G.G.; Lambert, D.M.; Marchand-Brynaert, J.
beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase
J. Med. Chem.
52
7054-7068
2009
Homo sapiens
Heier, C.; Taschler, U.; Rengachari, S.; Oberer, M.; Wolinski, H.; Natter, K.; Kohlwein, S.D.; Leber, R.; Zimmermann, R.
Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomyces cerevisiae
Biochim. Biophys. Acta
1801
1063-1071
2010
Saccharomyces cerevisiae
Bjoerklund, E.; Noren, E.; Nilsson, J.; Fowler, C.J.
Inhibition of monoacylglycerol lipase by troglitazone, N-arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays
Br. J. Pharmacol.
161
1512-1526
2010
Homo sapiens, Rattus norvegicus
Guindon, J.; Guijarro, A.; Piomelli, D.; Hohmann, A.G.
Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain
Br. J. Pharmacol.
163
1464-1478
2011
Rattus norvegicus
Nomura, D.K.; Long, J.Z.; Niessen, S.; Hoover, H.S.; Ng, S.W.; Cravatt, B.F.
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
Cell
140
49-61
2010
Homo sapiens
Dhouib, R.; Laval, F.; Carriere, F.; Daffe, M.; Canaan, S.
A monoacylglycerol lipase from Mycobacterium smegmatis involved in bacterial cell interaction
J. Bacteriol.
192
4776-4785
2010
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
Bertrand, T.; Auge, F.; Houtmann, J.; Rak, A.; Vallee, F.; Mikol, V.; Berne, P.; Michot, N.; Cheuret, D.; Hoornaert, C.; Mathieu, M.
Structural basis for human monoglyceride lipase inhibition
J. Mol. Biol.
396
663-673
2010
Homo sapiens
Freitas, L.; Paula, A.; dos Santos, J.; Zanin, G.; de Castro, H.
Enzymatic synthesis of monoglycerides by esterification reaction using Penicillium camembertii lipase immobilized on epoxy SiO2-PVA composite
J. Mol. Catal. B
65
87-90
2010
Penicillium camemberti
-
Keimpema, E.; Barabas, K.; Morozov, Y.M.; Tortoriello, G.; Torii, M.; Cameron, G.; Yanagawa, Y.; Watanabe, M.; Mackie, K.; Harkany, T.
Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding
J. Neurosci.
30
13992-14007
2010
Mus musculus
Karageorgos, I.; Tyukhtenko, S.; Zvonok, N.; Janero, D.R.; Sallum, C.; Makriyannis, A.
Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism
Mol. Biosyst.
6
1381-1388
2010
Homo sapiens
Chanda, P.K.; Gao, Y.; Mark, L.; Btesh, J.; Strassle, B.W.; Lu, P.; Piesla, M.J.; Zhang, M.Y.; Bingham, B.; Uveges, A.; Kowal, D.; Garbe, D.; Kouranova, E.V.; Ring, R.H.; Bates, B.; Pangalos, M.N.; Kennedy, J.D.; Whiteside, G.T.; Samad, T.A.
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
Mol. Pharmacol.
78
996-1003
2010
Mus musculus
Jermsuntiea, W.; Aki, T.; Toyoura, R.; Iwashita, K.; Kawamoto, S.; Ono, K.
Purification and characterization of intracellular lipase from the polyunsaturated fatty acid-producing fungus Mortierella alliacea
New Biotechnol.
28
158-164
2011
Mortierella alliacea, Mortierella alliacea YN-15
Schalk-Hihi, C.; Schubert, C.; Alexander, R.; Bayoumy, S.; Clemente, J.C.; Deckman, I.; DesJarlais, R.L.; Dzordzorme, K.C.; Flores, C.M.; Grasberger, B.; Kranz, J.K.; Lewandowski, F.; Liu, L.; Ma, H.; Maguire, D.; Macielag, M.J.; McDonnell, M.E.; Mezzasalma Haarlander, T.; Miller, R.; Milligan, C.; R, R.e.
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 A resolution
Protein Sci.
20
670-683
2011
Homo sapiens (Q99685), Homo sapiens
Karageorgos, I.; Wales, T.E.; Janero, D.R.; Zvonok, N.; Vemuri, V.K.; Engen, J.R.; Makriyannis, A.
Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study
Biochemistry
52
5016-5026
2013
Homo sapiens
Rengachari, S.; Bezerra, G.A.; Riegler-Berket, L.; Gruber, C.C.; Sturm, C.; Taschler, U.; Boeszoermenyi, A.; Dreveny, I.; Zimmermann, R.; Gruber, K.; Oberer, M.
The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes
Biochim. Biophys. Acta
1821
1012-1021
2012
Bacillus sp. (in: Bacteria) (P82597), Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) H-257 (P82597)
Afzal, O.; Kumar, S.; Kumar, R.; Firoz, A.; Jaggi, M.; Bawa, S.
Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors
Bioorg. Med. Chem. Lett.
24
3986-3996
2014
Homo sapiens (Q99685), Homo sapiens
Li, C.; Vilches-Flores, A.; Zhao, M.; Amiel, S.A.; Jones, P.M.; Persaud, S.J.
Expression and function of monoacylglycerol lipase in mouse beta-cells and human islets of Langerhans
Cell. Physiol. Biochem.
30
347-358
2012
Homo sapiens, Mus musculus
Cao, Z.; Mulvihill, M.M.; Mukhopadhyay, P.; Xu, H.; Erdelyi, K.; Hao, E.; Holovac, E.; Hasko, G.; Cravatt, B.F.; Nomura, D.K.; Pacher, P.
Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice
Gastroenterology
144
808-817.e15
2013
Mus musculus
Rengachari, S.; Aschauer, P.; Schittmayer, M.; Mayer, N.; Gruber, K.; Breinbauer, R.; Birner-Gruenberger, R.; Dreveny, I.; Oberer, M.
Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase
J. Biol. Chem.
288
31093-31104
2013
Bacillus sp. (in: Bacteria) (P82597), Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) H-257 (P82597)
Tsurumura, T.; Tsuge, H.
Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure
J. Struct. Funct. Genomics
15
83-89
2014
Bacillus sp. (in: Bacteria) (P82597), Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) H-257 (P82597)
Laitinen, T.; Navia-Paldanius, D.; Rytilahti, R.; Marjamaa, J.J.; Ka?izkova, J.; Parkkari, T.; Pantsar, T.; Poso, A.; Laitinen, J.T.; Savinainen, J.R.
Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency
Mol. Pharmacol.
85
510-519
2014
Homo sapiens
Savinainen, J.R.; Kansanen, E.; Pantsar, T.; Navia-Paldanius, D.; Parkkari, T.; Lehtonen, M.; Laitinen, T.; Nevalainen, T.; Poso, A.; Levonen, A.L.; Laitinen, J.T.
Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)
Mol. Pharmacol.
86
522-535
2014
Homo sapiens (Q99685), Homo sapiens
Chon, S.H.; Douglass, J.D.; Zhou, Y.X.; Malik, N.; Dixon, J.L.; Brinker, A.; Quadro, L.; Storch, J.
Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity
PLoS ONE
7
e43962
2012
Mus musculus
Chen, H.; Tian, R.; Ni, Z.; Zhang, Z.; Chen, H.; Guo, Q.; Saier, M.H.
Conformational transition pathway in the inhibitor binding process of human monoacylglycerol lipase
Protein J.
33
503-511
2014
Homo sapiens
Lauria, S.; Casati, S.; Ciuffreda, P.
Synthesis and characterization of a new fluorogenic substrate for monoacylglycerol lipase and application to inhibition studies
Anal. Bioanal. Chem.
407
8163-8167
2015
Homo sapiens (Q99685), Homo sapiens
Kim, R.; Suh, M.
The GxSxG motif of Arabidopsis monoacylglycerol lipase (MAGL6 and MAGL8) is essential for their enzyme activities
Appl. Biol. Chem.
59
833-840
2016
Arabidopsis thaliana (O49284), Arabidopsis thaliana (O80959), Arabidopsis thaliana (Q8H133), Homo sapiens (Q99685)
-
De Leo, M.; Huallpa, C.G.; Alvarado, B.; Granchi, C.; Poli, G.; De Tommasi, N.; Braca, A.
New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)
Fitoterapia
130
251-258
2018
Homo sapiens (Q99685)
Kishimoto, Y.; Cagniard, B.; Yamazaki, M.; Nakayama, J.; Sakimura, K.; Kirino, Y.; Kano, M.
Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol
Front. Behav. Neurosci.
9
134
2015
Mus musculus (O35678), Mus musculus C57BL/6N (O35678)
Tyukhtenko, S.; Karageorgos, I.; Rajarshi, G.; Zvonok, N.; Pavlopoulos, S.; Janero, D.R.; Makriyannis, A.
Specific inter-residue interactions as determinants of human monoacylglycerol lipase catalytic competency a role for global conformational chanages
J. Biol. Chem.
291
2556-2565
2016
Homo sapiens (Q99685), Homo sapiens
Xiang, W.; Shi, R.; Kang, X.; Zhang, X.; Chen, P.; Zhang, L.; Hou, A.; Wang, R.; Zhao, Y.; Zhao, K.; Liu, Y.; Ma, Y.; Luo, H.; Shang, S.; Zhang, J.; He, F.; Yu, S.; Gan, L.; Shi, C.; Li, Y.; Yang, W.; Liang, H.; Miao, H.
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
Nat. Commun.
9
2574
2018
Mus musculus (O35678), Homo sapiens (Q99685), Homo sapiens
Kim, R.J.; Kim, H.J.; Shim, D.; Suh, M.C.
Molecular and biochemical characterizations of the monoacylglycerol lipase gene family of Arabidopsis thaliana
Plant J.
85
758-771
2016
Arabidopsis thaliana, Arabidopsis thaliana (O23179), Arabidopsis thaliana (O23180), Arabidopsis thaliana (O23181), Arabidopsis thaliana (O48723), Arabidopsis thaliana (O49284), Arabidopsis thaliana (O80959), Arabidopsis thaliana (Q8H133), Arabidopsis thaliana (Q93ZQ3), Arabidopsis thaliana (Q9FIY1), Arabidopsis thaliana (Q9SV43)
Beladjila, K.A.; Berrehal, D.; De Tommasi, N.; Granchi, C.; Bononi, G.; Braca, A.; De Leo, M.
New phenylethanoid glycosides from Cistanche phelypaea and their activity as inhibitors of monoacylglycerol lipase (MAGL)
Planta Med.
84
710-715
2018
Homo sapiens (Q99685)
Berdan, C.A.; Erion, K.A.; Burritt, N.E.; Corkey, B.E.; Deeney, J.T.
Inhibition of monoacylglycerol lipase activity decreases glucose-stimulated insulin secretion in INS-1 (832/13) cells and rat islets
PLoS ONE
11
e0149008
2016
Rattus norvegicus (Q8R431), Rattus norvegicus Sprague-Dawley (Q8R431)
Aschauer, P.; Zimmermann, R.; Breinbauer, R.; Pavkov-Keller, T.; Oberer, M.
The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition
Sci. Rep.
8
8948
2018
Mycobacterium tuberculosis (O07427), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (O07427), Mycobacterium tuberculosis ATCC 25618 (O07427)
html completed
