Disease on EC 3.1.1.23 - acylglycerol lipase
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Acute Lung Injury
Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice.
Acute Lung Injury
The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats.
acylglycerol lipase deficiency
Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice.
acylglycerol lipase deficiency
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
acylglycerol lipase deficiency
Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
acylglycerol lipase deficiency
Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic ?-opioid receptor sensitivity.
acylglycerol lipase deficiency
Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.
Adenocarcinoma of Lung
Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma.
Adenoma
Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression.
Alzheimer Disease
Alleviation of Neuropathology by Inhibition of Monoacylglycerol Lipase in APP Transgenic Mice Lacking CB2 Receptors.
Alzheimer Disease
Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease.
Alzheimer Disease
Molecular reorganization of endocannabinoid signalling in Alzheimer's disease.
Arthralgia
Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis.
Arthritis
Monoacylglycerol Lipase Inhibition Using JZL184 Attenuates Paw Inflammation and Functional Deficits in a Mouse Model of Inflammatory Arthritis.
Arthritis
Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats.
Atherosclerosis
Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner.
Brain Injuries
Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats.
Breast Neoplasms
Comparative Proteome Analysis of Breast Cancer Tissues Highlights the Importance of Glycerol-3-phosphate Dehydrogenase 1 and Monoacylglycerol Lipase in Breast Cancer Metabolism.
Breast Neoplasms
Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-?B) signaling in cancer cells.
Breast Neoplasms
Identification of genes with altered expression in medullary breast cancer vs. ductal breast cancer and normal breast epithelia.
Carcinogenesis
Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer.
Carcinoma, Hepatocellular
Circulating prostaglandin E2: a novel potential prognostic biomarker in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
KLF4 suppresses the migration of hepatocellular carcinoma by transcriptionally upregulating monoglyceride lipase.
Carcinoma, Hepatocellular
Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-?B-mediated epithelial-mesenchymal transition.
Carcinoma, Hepatocellular
Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
The ménage à trois of autophagy, lipid droplets and liver disease.
Carcinoma, Hepatocellular
[Monoacylglycerol lipase high expression as an independent indicator of survival for patients with hepatocellular carcinoma].
Carcinoma, Non-Small-Cell Lung
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
Cerebral Cortical Thinning
Brain structural changes in cannabis dependence: association with MAGL.
Cholangitis, Sclerosing
Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis.
Colitis
Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation.
Colitis
The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats.
Colonic Neoplasms
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression.
Colonic Neoplasms
Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression.
Colorectal Neoplasms
Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer.
Colorectal Neoplasms
Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells.
Colorectal Neoplasms
Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer.
Colorectal Neoplasms
Targeting triglyceride metabolism for colorectal cancer prevention and therapy.
Congenital Abnormalities
Anticholinesterase insecticide action at the murine male reproductive system.
Cystitis, Interstitial
Monoacylglycerol lipase inhibition as potential treatment for interstitial cystitis.
Demyelinating Diseases
Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo.
Down Syndrome
Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome.
Encephalomyelitis
2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination.
Endometrial Neoplasms
Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer.
Endometrial Neoplasms
The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma.
Epilepsy
Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice.
Epilepsy, Temporal Lobe
Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice.
Fatty Liver
?/? Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate.
Fatty Liver
Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
Glaucoma
Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment.
Glioma
Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro.
Head Injuries, Closed
Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury.
Heart Arrest
Monoacylglycerol Lipase Inactivation by Using URB602 Mitigates Myocardial Damage in a Rat Model of Cardiac Arrest.
Heart Arrest
Monoacylglycerol Lipase Inactivation by Using URB602 Mitigates Myocardial Damage in a Rat Model of Cardiac Arrest: Erratum.
Hepatitis
Endogenous and postheparin monoglyceride hydrolase in plasma of patients with acute virus hepatitis.
Hepatitis C
Profiling of MicroRNA Targets Using Activity-Based Protein Profiling: Linking Enzyme Activity to MicroRNA-185 Function.
Hyperalgesia
Endogenous opioid and cannabinoid systems modulate the muscle pain: A pharmacological study into the peripheral site.
Hyperalgesia
Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice Through Distinct Cannabinoid Receptor Mechanisms.
Hyperalgesia
Monoacylglycerol lipase inhibitors reverse paclitaxel-induced nociceptive behavior and proinflammatory markers in a mouse model of chemotherapy-induced neuropathy.
Hyperalgesia
The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model.
Hyperalgesia
Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain.
Hyperlipidemias
Post-heparin plasma hepatic triglyceride lipase and monoglyceride hydrolase activities in hyperlipemia induced by a sucrose rich diet.
Hyperlipidemias
[Post-heparin lipolytic activity. (III). Lipoprotein lipase and monoglyceride hydrolase activities on hyperlipemia and the organs responsible for their biosynthesis]
Hyperlipoproteinemias
[Activity of endogenous monoglyceride hydrolase in healthy subjects and patients with type IV Fredricksoln's hyperlipoproteinemia]
Hypertension
Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats.
Hypertriglyceridemia
Effects of tiadenol and clofibrate on plasma post heparin lipolytic hepatic, extrahepatic and monoglyceride hydrolase activities in rats with hypertriglyceridemia induced by a sucrose rich diet.
Infarction, Middle Cerebral Artery
Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke.
Infections
Effects of the monoacylglycerol lipase inhibitor JZL184 on chickens infected with avian pathogenic Escherichia coli O78: A preliminary pharmacokinetic and infection study.
Infections
Hemolytic phospholipase Rv0183 of Mycobacterium tuberculosis induces inflammatory response and apoptosis in alveolar macrophage RAW264.7 cells.
Liver Diseases
Inhibition of monoacylglycerol lipase for the treatment of liver disease: tempting but still playing with fire.
Liver Diseases
Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease.
Liver Diseases
[Clinical experience with a new method for the determination of monoglyceride lipase (author's transl)]
Liver Neoplasms
[Effect of monoacylglycerol lipase with proliferation of MHCC97H human liver cancer cells in vivo].
Lung Neoplasms
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
Lung Neoplasms
The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB1 Cannabinoid Receptor.
Melanoma
Expression of monoacylglycerol lipase as a marker of tumour invasion and progression in malignant melanoma.
Migraine Disorders
Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine.
Migraine Disorders
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice.
Migraine Disorders
Inhibition of monoacylglycerol lipase: Another signalling pathway for potential therapeutic targets in migraine?
Migraine Disorders
P007. Inhibition of monoacylglycerol lipase activity modulates the activation of brain structures relevant for migraine pathogenesis.
Multiple Myeloma
JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice.
Multiple Sclerosis
A reversible and selective inhibitor of monoacylglycerol lipase ameliorates multiple sclerosis.
Myocardial Infarction
2-arachidonoylglycerol mobilizes myeloid cells and worsens heart function after acute myocardial infarction.
Nasopharyngeal Carcinoma
Monoacylglycerol lipase promotes metastases in nasopharyngeal carcinoma.
Neoplasm Metastasis
Expression of monoacylglycerol lipase as a marker of tumour invasion and progression in malignant melanoma.
Neoplasm Metastasis
Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma.
Neoplasm Metastasis
Monoacylglycerol lipase promotes metastases in nasopharyngeal carcinoma.
Neoplasm Metastasis
The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB1 Cannabinoid Receptor.
Neoplasms
?-Quinazolinonylalkyl aryl ureas as reversible inhibitors of monoacylglycerol lipase.
Neoplasms
Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons.
Neoplasms
Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids.
Neoplasms
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.
Neoplasms
Development of thiazole-5-carboxylate derivatives as selective inhibition of monoacylglycerol lipase as a target in Cancer.
Neoplasms
Expression of monoacylglycerol lipase as a marker of tumour invasion and progression in malignant melanoma.
Neoplasms
Identification of genes with altered expression in medullary breast cancer vs. ductal breast cancer and normal breast epithelia.
Neoplasms
JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice.
Neoplasms
Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer.
Neoplasms
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
Neoplasms
Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders.
Neoplasms
Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma.
Neoplasms
Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-?B-mediated epithelial-mesenchymal transition.
Neoplasms
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.
Neoplasms
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression.
Neoplasms
Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma.
Neoplasms
Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein.
Neoplasms
Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer.
Neoplasms
Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.
Neoplasms
The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain.
Nervous System Diseases
Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders.
Nervous System Diseases
Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.
Neuralgia
Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice.
Neuralgia
Inhibition of 2-arachydonoylgycerol degradation attenuates orofacial neuropathic pain in trigeminal nerve-injured mice.
Neuralgia
Systematic review and meta-analysis of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators tested for antinociceptive effects in animal models of injury-related or pathological persistent pain.
Neuralgia
The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.
Neuralgia
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
Neuroblastoma
Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells.
Neurodegenerative Diseases
Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders.
Neurodegenerative Diseases
CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition.
Neurodegenerative Diseases
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.
Neurodegenerative Diseases
Design, Synthesis and Evaluation of 18F-labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes.
Neurodegenerative Diseases
Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease.
Neuroinflammatory Diseases
2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination.
Neuroinflammatory Diseases
A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography.
Neuroinflammatory Diseases
Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation.
Neuroinflammatory Diseases
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
Neuroinflammatory Diseases
Endocannabinoids: A Promising Impact for Traumatic Brain Injury.
Neuroinflammatory Diseases
Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
Neuroinflammatory Diseases
Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2.
Neuroinflammatory Diseases
Monoacylglycerol lipase promotes Fc? receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines.
Non-alcoholic Fatty Liver Disease
The ménage à trois of autophagy, lipid droplets and liver disease.
Obesity
?/? Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate.
Obesity
Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer.
Obesity
Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice.
Obesity
Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity.
Osteoarthritis
Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis.
Osteoarthritis
Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain.
Osteolysis
JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice.
Osteosarcoma
JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice.
Parkinson Disease
Cannabinoid CB1 and CB2 Receptors, and Monoacylglycerol Lipase Gene Expression Alterations in the Basal Ganglia of Patients with Parkinson's Disease.
Parkinson Disease
Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease.
Peripheral Nervous System Diseases
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.
Prostatic Neoplasms
FABP5 coordinates lipid signaling that promotes prostate cancer metastasis.
Prostatic Neoplasms
JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice.
Prostatic Neoplasms
Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer.
Prostatic Neoplasms
The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells.
Reperfusion Injury
Effects of monoacylglycerol lipase inhibitor URB602 on lung ischemia-reperfusion injury in mice.
Seizures
Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase - Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology.
Seizures
Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice.
Seizures
Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
Sepsis
Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis.
Status Epilepticus
Inflammation and reactive oxygen species in status epilepticus: Biomarkers and implications for therapy.
Status Epilepticus
Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
Stroke
Monoacylglycerol Lipase Inhibitor is Safe when Combined with Delayed r-tPA Administration in Treatment of Stroke.
Stroke
Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke.
Tics
Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study.
Tourette Syndrome
Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study.
Tuberculosis
A monoacylglycerol lipase from Mycobacterium smegmatis Involved in bacterial cell interaction.
Tuberculosis
Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids.
Tuberculosis
Enantioselective inhibition of microbial lipolytic enzymes by nonracemic monocyclic enolphosphonate analogues of cyclophostin.
Tuberculosis
Hemolytic phospholipase Rv0183 of Mycobacterium tuberculosis induces inflammatory response and apoptosis in alveolar macrophage RAW264.7 cells.
Tuberculosis
IL-6 release of Rv0183 antigen-stimulated whole blood is a potential biomarker for active tuberculosis patients.
Tuberculosis
Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis.
Tuberculosis
Potential Selective Inhibitors against Rv0183 of Mycobacterium tuberculosis Targeting Host Lipid Metabolism.
Tuberculosis
The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition.
Whooping Cough
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
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