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Information on EC 2.8.3.25 - bile acid CoA-transferase

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.3 CoA-transferases
                2.8.3.25 bile acid CoA-transferase
IUBMB Comments
The enzyme, characterized from the gut bacterium Clostridium scindens, catalyses the last step in bile acid 7alpha-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. Clostridium scindens possesses two forms of the enzyme, encoded by the baiF and baiK genes. While the enzymes have a broad acceptor specificity and can use allocholate, ursodeoxycholate, and beta-muricholate, the donor specificity is more strict. BaiF acts on lithocholoyl-CoA and deoxycholoyl-CoA, and BaiK acts only on the latter.
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The expected taxonomic range for this enzyme is: Clostridium scindens
Synonyms
baiF, baiK, bile acid coenzyme A transferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA
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(2)
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lithocholoyl-CoA + cholate = lithocholate + choloyl-CoA
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(1)
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PATHWAY SOURCE
PATHWAYS
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