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Information on EC 2.8.2.22 - aryl-sulfate sulfotransferase

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.22 aryl-sulfate sulfotransferase
IUBMB Comments
The enzyme, characterized from bacteria that colonize the human and mouse intestine, catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compounds. Activity is enhanced by Mg2+ and Mn2+ . Unlike EC 2.8.2.9, tyrosine-ester sulfotransferase and EC 2.8.2.1, aryl sulfotransferase, the enzyme does not act on 3'-phosphoadenylyl sulfate or adenosine 3',5'-bisphosphate .The level of sulfation of polyphenols depends on the positions of the hydroxyl groups [3-5]. Hydroxy groups of tyrosine residues in peptides such as angiotensin can also act as acceptors . The reaction proceeds according to a ping pong bi bi mechanism .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
arylsulfate sulfotransferase, arylsulfate-phenol sulfotransferase, arylsulfate:phenol sulfotransferase, arylsulfotransferase, ASST, AST, Cpz4, sulfotransferase, arylsulfate, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
an aryl sulfate + a phenol = a phenol + an aryl sulfate
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