Reference on EC 2.8.1.7 - cysteine desulfurase
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Kiyasu, T.; Asakura, A.; Nagahashi, Y.; Hoshino, T.
Contribution of cysteine desulfurase (NifS protein) to the biotin synthase reaction of Escherichia coli
J. Bacteriol.
182
2879-2885
2000
Escherichia coli, Klebsiella pneumoniae, Klebsiella pneumoniae M5a1
Mihara, H.; Esaki, N.
Bacterial cysteine desulfurases: their function and mechanisms
Appl. Microbiol. Biotechnol.
60
12-23
2002
Azotobacter vinelandii, Synechocystis sp., Saccharomyces cerevisiae, Escherichia coli, Haemophilus influenzae, Homo sapiens, Mus musculus, Pseudomonas aeruginosa, Synechocystis sp. PCC6714
Cupp-Vickery, J.R.; Urbina, H.; Vickery, L.E.
Crystal structure of IscS, a cysteine desulfurase from Escherichia coli
J. Mol. Biol.
330
1049-1059
2003
Escherichia coli
Lima, C.D.
Analysis of the E. coli NifS CsdB protein at 2.0 A reveals the structural basis for perselenide and persulfide intermediate formation
J. Mol. Biol.
315
1199-1208
2002
Escherichia coli (P77444)
Leon, S.; Touraine, B.; Briat, J.F.; Lobreaux, S.
The AtNFS2 gene from Arabidopsis thaliana encodes a NifS-like plastidial cysteine desulphurase
Biochem. J.
366
557-564
2002
Arabidopsis thaliana
Frazzon, J.; Dean, D.R.
Formation of iron-sulfur clusters in bacteria: an emerging field in bioinorganic chemistry
Curr. Opin. Chem. Biol.
7
166-173
2003
Bacteria
Kambampati, R.; Lauhon, C.T.
MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli
Biochemistry
42
1109-1117
2003
Escherichia coli (P25745), Escherichia coli
Kato, S.; Mihara, H.; Kurihara, T.; Yoshimura, T.; Esaki, N.
Gene cloning, purification, and characterization of two cyanobacterial NifS homologs driving iron-sulfur cluster formation
Biosci. Biotechnol. Biochem.
64
2412-2419
2000
Synechocystis sp.
Kispal, G.; Csere, P.; Prohl, C.; Lill, R.
The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins
EMBO J.
18
3981-3989
1999
Saccharomyces cerevisiae
Lacourciere, G.M.; Stadtman, T.C.
The NIFS protein can function as a selenide delivery protein in the biosynthesis of selenophosphate
J. Biol. Chem.
273
30921-30926
1998
Azotobacter vinelandii
Land, T.; Rouault, T.A.
Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization
Mol. Cell
2
807-815
1998
Homo sapiens
Lauhon, C.T.
Requirement for IscS in biosynthesis of all thionucleosides in Escherichia coli
J. Bacteriol.
184
6820-6829
2002
Escherichia coli
Lauhon, C.T.; Kambampati, R.
The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD
J. Biol. Chem.
275
20096-20103
2000
Escherichia coli, Escherichia coli MC1061
Loiseau, L.; Ollagnier-de-Choudens, S.; Nachin, L.; Fontecave, M.; Barras, F.
Biogenesis of Fe-S cluster by the bacterial Suf system: SufS and SufE form a new type of cysteine desulfurase
J. Biol. Chem.
278
38352-38359
2003
Escherichia coli, Dickeya chrysanthemi, Escherichia coli TG1
Mihara, H.; Fujii, T.; Kato, S.; Kurihara, T.; Hata, Y.; Esaki, N.
Structure of external aldimine of Escherichia coli CsdB, an IscS/NifS homolog: implications for its specificity toward selenocysteine
J. Biochem.
131
679-685
2002
Escherichia coli
Zheng, L.; White, R.H.; Cash, V.L.; Jack, R.F.; Dean, D.R.
Cysteine desulfurase activity indicates a role for NIFS in metallocluster biosynthesis
Proc. Natl. Acad. Sci. USA
90
2754-2758
1993
Azotobacter vinelandii
Mihara, H.; Kurihara, T.; Yoshimura, T.; Esaki, N.
Kinetic and mutational studies of three NifS homologs from Escherichia coli: mechanistic difference between L-cysteine desulfurase and L-selenocysteine lyase reactions
J. Biochem.
127
559-567
2000
Escherichia coli
Nilsson, K.; Lundgren, H.K.; Hagervall, T.G.; Bjork, G.R.
The cysteine desulfurase IscS is required for synthesis of all five thiolated nucleosides present in tRNA from Salmonella enterica serovar typhimurium
J. Bacteriol.
184
6830-6835
2002
Escherichia coli, Salmonella enterica
Outten, F.W.; Wood, M.J.; Munoz, F.M.; Storz, G.
The SufE protein and the SufBCD complex enhance SufS cysteine desulfurase activity as part of a sulfur transfer pathway for Fe-S cluster assembly in Escherichia coli
J. Biol. Chem.
278
45713-45719
2003
Escherichia coli
Yang, W.; Rogers, P.A.; Ding, H.
Repair of nitric oxide-modified ferredoxin [2Fe-2S] cluster by cysteine desulfurase (IscS)
J. Biol. Chem.
277
12868-12873
2002
Escherichia coli
Zheng, L.; White, R.H.; Cash, V.L.; Dean, D.R.
Mechanism for the desulfurization of L-cysteine catalyzed by the nifS gene product
Biochemistry
33
4714-4720
1994
Azotobacter vinelandii
Schwartz, C.J.; Djaman, O.; Imlay, J.A.; Kiley, P.J.
The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli
Proc. Natl. Acad. Sci. USA
97
9009-9014
2000
Escherichia coli
Kurihara, T.; Mihara, H.; Kato, S.; Yoshimura, T.; Esaki, N.
Assembly of iron-sulfur clusters mediated by cysteine desulfurases, IscS, CsdB and CSD, from Escherichia coli
Biochim. Biophys. Acta
1647
303-309
2003
Escherichia coli
LaGier, M.J.; Tachezy, J.; Stejskal, F.; Kutisova, K.; Keithly, J.S.
Mitochondrial-type iron-sulfur cluster biosynthesis genes (IscS and IscU) in the apicomplexan Cryptosporidium parvum
Microbiology
149
3519-3530
2003
Cryptosporidium parvum (Q8WQX4), Cryptosporidium parvum
Kirby, J.; Wright, F.; Flint, H.J.
A cysteine desulphurase gene from the cellulolytic rumen anaerobe Ruminococcus flavefaciens
Biochim. Biophys. Acta
1368
233-237
1998
Ruminococcus flavefaciens
-
Kessler, D.
Slr0077 of Synechocystis has cysteine desulfurase as well as cystine lyase activity
Biochem. Biophys. Res. Commun.
320
571-577
2004
Synechocystis sp.
Tirupati, B.; Vey, J.L.; Drennan, C.L.; Bollinger, J.M.jr.
Kinetic and structural characterization of Slr0077/SufS, the essential cysteine desulfurase from Synechocystis sp. PCC 6803
Biochemistry
43
12210-12219
2004
Synechocystis sp. (Q55793), Synechocystis sp.
Behshad, E.; Parkin, S.E.; Bollinger, J.M.jr.
Mechanism of cysteine desulfurase Slr0387 from Synechocystis sp. PCC 6803: Kinetic analysis of cleavage of the persulfide intermediate by chemical reductants
Biochemistry
43
12220-12226
2004
Synechocystis sp.
Adam, A.C.; Bornhvd, C.; Prokisch, H.; Neupert, W.; Hell, K.
the Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria
EMBO J.
25
174-183
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae Isd11-depleted
Forlani, F.; Cereda, A.; Freuer, A.; Nimtz, M.; Leimkhler, S.; Pagani, S.
The cysteine-desulfurase IscS promotes the production of the rhodanese RhdA in the persulfurated form
FEBS Lett.
579
6786-6790
2005
Escherichia coli
Nakai, Y.; Umeda, N.; Suzuki, T.; Nakai, M.; Hayashi, H.; Watanabe, K.; Kagamiyama, H.
Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs
J. Biol. Chem.
279
12363-12368
2004
Saccharomyces cerevisiae
Lauhon, C.T.; Skovran, E.; Urbina, H.D.; Downs, D.M.; Vickery, L.E.
Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo
J. Biol. Chem.
279
19551-19558
2004
Escherichia coli, Escherichia coli MC1061
Muhlenhoff, U.; Balk, J.; Richhardt, N.; Kaiser, J.T.; Sipos, K.; Kispal, G.; Lill, R.
Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae
J. Biol. Chem.
279
36906-36915
2004
Saccharomyces cerevisiae
Liew, Y.F.; Shaw, N.S.
Mitochondrial cysteine desulfurase iron-sulfur cluster S and aconitase are post-transcriptionally regulated by dietary iron in skeletal muscle of rats
J. Nutr.
135
2151-2158
2005
Rattus norvegicus (Q99P39), Rattus norvegicus
Rojas, D.M.; Vasquez, C.C.
Sensitivity to potassium tellurite of Escherichia coli cells deficient in CSD, CsdB and IscS cysteine desulfurases
Res. Microbiol.
156
465-471
2005
Escherichia coli, Escherichia coli DH5-alpha
Canal, F.; Fosset, C.; Chauveau, M.J.; Drapier, J.C.; Bouton, C.
Regulation of the cysteine desulfurase Nfs1 and the scaffold protein IscU in macrophages stimulated with interferon-gamma and lipopolysaccharide
Arch. Biochem. Biophys.
465
282-292
2007
Mus musculus
You, D.; Wang, L.; Yao, F.; Zhou, X.; Deng, Z.
A novel DNA modification by sulfur: DndA is a NifS-like cysteine desulfurase capable of assembling DndC as an iron-sulfur cluster protein in Streptomyces lividans
Biochemistry
46
6126-6133
2007
Streptomyces lividans, Streptomyces lividans (Q460H9)
Neumann, M.; Stoecklein, W.; Walburger, A.; Magalon, A.; Leimkuehler, S.
Identification of a Rhodobacter capsulatus L-cysteine desulfurase that sulfurates the molybdenum cofactor when bound to XdhC and before its insertion into xanthine dehydrogenase
Biochemistry
46
9586-9595
2007
Rhodobacter capsulatus
Zeng, J.; Zhang, Y.; Liu, Y.; Zhang, X.; Xia, L.; Liu, J.; Qiu, G.
Expression, purification and characterization of a cysteine desulfurase, IscS, from Acidithiobacillus ferrooxidans
Biotechnol. Lett.
29
1983-1990
2007
Acidithiobacillus ferrooxidans
Lundgren, H.K.; Bjoerk, G.R.
Structural alterations of the cysteine desulfurase IscS of Salmonella enterica serovar Typhimurium reveal substrate specificity of IscS in tRNA thiolation
J. Bacteriol.
188
3052-3062
2006
Salmonella enterica
Li, K.; Tong, W.H.; Hughes, R.M.; Rouault, T.A.
Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly
J. Biol. Chem.
281
12344-12351
2006
Homo sapiens
Fosset, C.; Chauveau, M.J.; Guillon, B.; Canal, F.; Drapier, J.C.; Bouton, C.
RNA silencing of mitochondrial m-Nfs1 reduces Fe-S enzyme activity both in mitochondria and cytosol of mammalian cells
J. Biol. Chem.
281
25398-25406
2006
Mus musculus (Q9Z1J3)
Ye, H.; Abdel-Ghany, S.E.; Anderson, T.D.; Pilon-Smits, E.A.; Pilon, M.
CpSufE activates the cysteine desulfurase CpNifS for chloroplastic Fe-S cluster formation
J. Biol. Chem.
281
8958-8969
2006
Arabidopsis thaliana
Layer, G.; Gaddam, S.A.; Ayala-Castro, C.N.; Ollagnier-de Choudens, S.; Lascoux, D.; Fontecave, M.; Outten, F.W.
SufE transfers sulfur from SufS to SufB for iron-sulfur cluster assembly
J. Biol. Chem.
282
13342-13350
2007
Escherichia coli
Zhao, D.; Curatti, L.; Rubio, L.M.
Evidence for nifU and nifS participation in the biosynthesis of the iron-molybdenum cofactor of nitrogenase
J. Biol. Chem.
282
37016-37025
2007
Klebsiella pneumoniae
Biederbick, A.; Stehling, O.; Roesser, R.; Niggemeyer, B.; Nakai, Y.; Elsaesser, H.P.; Lill, R.
Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation
Mol. Cell. Biol.
26
5675-5687
2006
Homo sapiens, Mus musculus
Onder, O.; Yoon, H.; Naumann, B.; Hippler, M.; Dancis, A.; Daldal, F.
Modifications of the lipoamide-containing mitochondrial subproteome in a yeast mutant defective in cysteine desulfurase
Mol. Cell. Proteomics
5
1426-1436
2006
Saccharomyces cerevisiae
Van Hoewyk, D.; Abdel-Ghany, S.E.; Cohu, C.M.; Herbert, S.K.; Kugrens, P.; Pilon, M.; Pilon-Smits, E.A.
Chloroplast iron-sulfur cluster protein maturation requires the essential cysteine desulfurase CpNifS
Proc. Natl. Acad. Sci. USA
104
5686-5691
2007
Arabidopsis thaliana
Mihara, H.; Hidese, R.; Yamane, M.; Kurihara, T.; Esaki, N.
The iscS gene deficiency affects the expression of pyrimidine metabolism genes
Biochem. Biophys. Res. Commun.
372
407-411
2008
Escherichia coli
Wu, G.; Li, P.; Wu, X.
Regulation of Escherichia coli IscS desulfurase activity by ferrous iron and cysteine
Biochem. Biophys. Res. Commun.
374
399-404
2008
Escherichia coli
Sendra, M.; Ollagnier de Choudens, S.; Lascoux, D.; Sanakis, Y.; Fontecave, M.
The SUF iron-sulfur cluster biosynthetic machinery: sulfur transfer from the SUFS-SUFE complex to SUFA
FEBS Lett.
581
1362-1368
2007
Escherichia coli
Behshad, E.; Bollinger, J.M.
Kinetic analysis of cysteine desulfurase CD0387 from Synechocystis sp. PCC 6803: formation of the persulfide intermediate
Biochemistry
48
12014-12023
2009
Synechocystis sp.
Poliak, P.; Van Hoewyk, D.; Obornik, M.; Zikova, A.; Stuart, K.D.; Tachezy, J.; Pilon, M.; Lukes, J.
Functions and cellular localization of cysteine desulfurase and selenocysteine lyase in Trypanosoma brucei
FEBS J.
277
383-393
2010
Trypanosoma brucei, Trypanosoma brucei (Q386Y7)
Zhang, W.; Urban, A.; Mihara, H.; Leimkuehler, S.; Kurihara, T.; Esaki, N.
IscS functions as a primary sulfur-donating enzyme by interacting specifically with MoeB and MoaD in the biosynthesis of molybdopterin in Escherichia coli
J. Biol. Chem.
285
2302-2308
2010
Escherichia coli
Adinolfi, S.; Iannuzzi, C.; Prischi, F.; Pastore, C.; Iametti, S.; Martin, S.R.; Bonomi, F.; Pastore, A.
Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS
Nat. Struct. Mol. Biol.
16
390-396
2009
Escherichia coli
WU, A.; ZHANG, Y.; ZHENG, C.; DAI, Y.; LIU, Y.; ZENG, J.; GU, G.; LIU, J.
Purification and enzymatic characteristics of cysteine desulfurase, IscS, in Acidithiobacillus ferrooxidans ATCC 23270
Trans. Nonferrous Met. Soc. China
18
1450-1457
2008
Acidithiobacillus ferrooxidans
-
Hidese, R.; Mihara, H.; Esaki, N.
Bacterial cysteine desulfurases: versatile key players in biosynthetic pathways of sulfur-containing biofactors
Appl. Microbiol. Biotechnol.
91
47-61
2011
Azotobacter vinelandii, Bacillus subtilis, Saccharomyces cerevisiae, Escherichia coli, Helicobacter pylori
Pandey, A.; Golla, R.; Yoon, H.; Dancis, A.; Pain, D.
Persulfide formation on mitochondrial cysteine desulfurase: enzyme activation by a eukaryote-specific interacting protein and Fe-S cluster synthesis
Biochem. J.
448
171-187
2012
Saccharomyces cerevisiae
Selbach, B.; Earles, E.; Dos Santos, P.C.
Kinetic analysis of the bisubstrate cysteine desulfurase SufS from Bacillus subtilis
Biochemistry
49
8794-8802
2010
Bacillus subtilis, Bacillus subtilis PS832
Yamanaka, Y.; Zeppieri, L.; Nicolet, Y.; Marinoni, E.N.; de Oliveira, J.S.; Odaka, M.; Dean, D.R.; Fontecilla-Camps, J.C.
Crystal structure and functional studies of an unusual L-cysteine desulfurase from Archaeoglobus fulgidus
Dalton Trans.
42
3092-3099
2013
Archaeoglobus fulgidus (O29689), Archaeoglobus fulgidus
Albrecht, A.G.; Peuckert, F.; Landmann, H.; Miethke, M.; Seubert, A.; Marahiel, M.A.
Mechanistic characterization of sulfur transfer from cysteine desulfurase SufS to the iron-sulfur scaffold SufU in Bacillus subtilis
FEBS Lett.
585
465-470
2011
Bacillus subtilis
Kim, J.H.; Frederick, R.O.; Reinen, N.M.; Troupis, A.T.; Markley, J.L.
[2Fe-2S]-Ferredoxin binds directly to cysteine desulfurase and supplies an electron for iron-sulfur cluster assembly but is displaced by the scaffold protein or bacterial frataxin
J. Am. Chem. Soc.
135
8117-8120
2013
Escherichia coli
Turowski, V.R.; Busi, M.V.; Gomez-Casati, D.F.
Structural and functional studies of the mitochondrial cysteine desulfurase from Arabidopsis thaliana
Mol. Plant
5
1001-1010
2012
Arabidopsis thaliana (O49543), Arabidopsis thaliana (Q93WX6), Arabidopsis thaliana
Chen, F.; Zhang, Z.; Lin, K.; Qian, T.; Zhang, Y.; You, D.; He, X.; Wang, Z.; Liang, J.; Deng, Z.; Wu, G.
Crystal structure of the cysteine desulfurase DndA from Streptomyces lividans which is involved in DNA phosphorothioation
PLoS ONE
7
e36635
2012
Streptomyces lividans (A7TUX7), Streptomyces lividans
Marelja, Z.; Mullick Chowdhury, M.; Dosche, C.; Hille, C.; Baumann, O.; Loehmannsroeben, H.G.; Leimkuehler, S.
The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans
PLoS ONE
8
e60869
2013
Homo sapiens
Song, J.Y.; Marszalek, J.; Craig, E.A.
Cysteine desulfurase Nfs1 and Pim1 protease control levels of Isu, the Fe-S cluster biogenesis scaffold
Proc. Natl. Acad. Sci. USA
109
10370-10375
2012
Saccharomyces cerevisiae
Kim, J.H.; Tonelli, M.; Markley, J.L.
Disordered form of the scaffold protein IscU is the substrate for iron-sulfur cluster assembly on cysteine desulfurase
Proc. Natl. Acad. Sci. USA
109
454-459
2012
Escherichia coli
Zafrilla, B.; Martinez-Espinosa, R.M.; Esclapez, J.; Perez-Pomares, F.; Bonete, M.J.
SufS protein from Haloferax volcanii involved in Fe-S cluster assembly in haloarchaea
Biochim. Biophys. Acta
1804
1476-1482
2010
Haloferax volcanii (D4GYV5), Haloferax volcanii, Haloferax volcanii DSM 3757 (D4GYV5)
Hidese, R.; Inoue, T.; Imanaka, T.; Fujiwara, S.
Cysteine desulphurase plays an important role in environmental adaptation of the hyperthermophilic archaeon Thermococcus kodakarensis
Mol. Microbiol.
93
331-345
2014
Thermococcus kodakarensis
Roret, T.; Pegeot, H.; Couturier, J.; Mulliert, G.; Rouhier, N.; Didierjean, C.
X-ray structures of Nfs2, the plastidial cysteine desulfurase from Arabidopsis thaliana
Acta Crystallogr. Sect. F
70
1180-1185
2014
Arabidopsis thaliana (Q93WX6), Arabidopsis thaliana
Terali, K.; Beavil, R.L.; Pickersgill, R.W.; van der Giezen, M.
The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1
Biochem. Biophys. Res. Commun.
440
235-240
2013
Saccharomyces cerevisiae
Rybniker, J.; Pojer, F.; Marienhagen, J.; Kolly, G.S.; Chen, J.M.; van Gumpel, E.; Hartmann, P.; Cole, S.T.
The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence
Biochem. J.
459
467-478
2014
Mycobacterium tuberculosis, Mycobacterium tuberculosis Rv3025c
Dai, Y.; Kim, D.; Dong, G.; Busenlehner, L.S.; Frantom, P.A.; Outten, F.W.
SufE D74R substitution alters active site loop dynamics to further enhance SufE interaction with the SufS cysteine desulfurase
Biochemistry
54
4824-4833
2015
Escherichia coli
Kovarova, J.; Horakova, E.; Changmai, P.; Vancova, M.; Luke?, J.
Mitochondrial and nucleolar localization of cysteine desulfurase Nfs and the scaffold protein Isu in Trypanosoma brucei
Eukaryot. Cell
13
353-362
2014
Trypanosoma brucei
Kim, S.; Park, S.
Structural changes during cysteine desulfurase CsdA and sulfur acceptor CsdE interactions provide insight into the trans-persulfuration
J. Biol. Chem.
288
27172-27180
2013
Escherichia coli (Q46925), Escherichia coli
Singh, H.; Dai, Y.; Outten, F.W.; Busenlehner, L.S.
Escherichia coli SufE sulfur transfer protein modulates the SufS cysteine desulfurase through allosteric conformational dynamics
J. Biol. Chem.
288
36189-36200
2013
Escherichia coli
Pandey, A.; Gordon, D.M.; Pain, J.; Stemmler, T.L.; Dancis, A.; Pain, D.
Frataxin directly stimulates mitochondrial cysteine desulfurase by exposing substrate-binding sites, and a mutant Fe-S cluster scaffold protein with frataxin-bypassing ability acts similarly
J. Biol. Chem.
288
36773-36786
2013
Saccharomyces cerevisiae
Bhubhanil, S.; Niamyim, P.; Sukchawalit, R.; Mongkolsuk, S.
Cysteine desulphurase-encoding gene sufS2 is required for the repressor function of RirA and oxidative resistance in Agrobacterium tumefaciens
Microbiology
160
79-90
2014
Agrobacterium tumefaciens
Grosshennig, S.; Ischebeck, T.; Gibhardt, J.; Busse, J.; Feussner, I.; Stuelke, J.
Hydrogen sulfide is a novel potential virulence factor of Mycoplasma pneumoniae: characterization of the unusual cysteine desulfurase/desulfhydrase HapE
Mol. Microbiol.
100
42-54
2016
Mycoplasma pneumoniae
Blauenburg, B.; Mielcarek, A.; Altegoer, F.; Fage, C.D.; Linne, U.; Bange, G.; Marahiel, M.A.
Crystal structure of Bacillus subtilis cysteine desulfurase SufS and its dynamic interaction with frataxin and scaffold protein SufU
PLoS ONE
11
e0158749
2016
Bacillus subtilis (O32164), Bacillus subtilis
Liu, Y.; Lei, X.Y.; Chen, L.F.; Bian, Y.B.; Yang, H.; Ibrahim, S.A.; Huang, W.
A novel cysteine desulfurase influencing organosulfur compounds in Lentinula edodes
Sci. Rep.
5
10047
2015
Lentinula edodes
Wang, Y.; Liu, Q.; Zhou, H.; Chen, X.
Expression, purification and function of cysteine desulfurase from Sulfobacillus acidophilus TPY isolated from deep-sea hydrothermal vent
3 Biotech
7
360
2017
Sulfobacillus acidophilus, Sulfobacillus acidophilus TPY
Dunkle, J.; Bruno, M.; Frantom, P.
Structural evidence for a latch mechanism regulating access to the active site of SufS-family cysteine desulfurases
Acta Crystallogr. Sect. D
76
291-301
2020
Escherichia coli (P77444), Escherichia coli
Ho, T.; Huynh, K.; Nguyen, D.; Park, H.; Jung, K.; Sur, B.; Ahn, Y.; Cha, S.; Kang, L.
Catalytic intermediate crystal structures of cysteine desulfurase from the archaeon Thermococcus onnurineus NA1
Archaea
2017
5395293
2017
Thermococcus onnurineus (B6YT87)
Banerjee, M.; Chakravarty, D.; Ballal, A.
Molecular basis of function and the unusual antioxidant activity of a cyanobacterial cysteine desulfurase
Biochem. J.
474
2435-2447
2017
Nostoc sp. PCC 7120 = FACHB-418 (Q8YU59)
Cai, K.; Tonelli, M.; Frederick, R.O.; Markley, J.L.
Human mitochondrial ferredoxin 1 (FDX1) and ferredoxin 2 (FDX2) both bind cysteine desulfurase and donate electrons for iron-sulfur cluster biosynthesis
Biochemistry
56
487-499
2017
Homo sapiens (Q9Y697), Homo sapiens
Dunkle, J.A.; Bruno, M.R.; Outten, F.W.; Frantom, P.A.
Structural evidence for dimer-interface-driven regulation of the type II cysteine desulfurase, SufS
Biochemistry
58
687-696
2019
Escherichia coli (P77444), Escherichia coli
Nakamura, R.; Hikita, M.; Ogawa, S.; Takahashi, Y.; Fujishiro, T.
Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes
FEBS J.
287
1138-1154
2020
Helicobacter pylori (O25008), Bacillus subtilis (O32164), Bacillus subtilis 168 (O32164), Helicobacter pylori ATCC 700392 (O25008)
Wang, J.; Guo, X.; Li, H.; Qi, H.; Qian, J.; Yan, S.; Shi, J.; Niu, W.
Hydrogen sulfide from cysteine desulfurase, not 3-mercaptopyruvate sulfurtransferase, contributes to sustaining cell growth and bioenergetics in E. coli under anaerobic conditions
Front. Microbiol.
10
2357
2019
Escherichia coli
Giordano, N.; Hastie, J.; Smith, A.; Foss, E.; Gutierrez-Munoz, D.; Carlson, P.J.
Cysteine desulfurase IscS2 plays a role in oxygen resistance in Clostridium difficile
Infect. Immun.
86
e00326
2018
Clostridioides difficile (Q18BE4), Clostridioides difficile, Clostridioides difficile 630 (Q18BE4)
Blahut, M.; Wise, C.E.; Bruno, M.R.; Dong, G.; Makris, T.M.; Frantom, P.A.; Dunkle, J.A.; Outten, F.W.
Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues
J. Biol. Chem.
294
12444-12458
2019
Escherichia coli (P77444), Escherichia coli
Wen, Y.; Chen, Y.; Li, L.; Xu, M.; Tan, Y.; Li, Y.; Wang, C.; Chen, Q.; Kuang, X.; Wu, Y.
Localization and characterization of a putative cysteine desulfurase in Chlamydia psittaci
J. Cell. Biochem.
120
4409-4422
2019
Chlamydia psittaci
Liu, L.; Jiang, S.; Xing, M.; Chen, C.; Lai, C.; Li, N.; Liu, G.; Wu, D.; Gao, H.; Hong, L.; Tan, P.; Chen, S.; Deng, Z.; Wu, G.; Wang, L.
Structural analysis of an L-cysteine desulfurase from an Ssp DNA phosphorothioation system
mBio
11
e00488
2020
Vibrio cyclitrophicus
Cory, S.A.; Van Vranken, J.G.; Brignole, E.J.; Patra, S.; Winge, D.R.; Drennan, C.L.; Rutter, J.; Barondeau, D.P.
Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions
Proc. Natl. Acad. Sci. USA
114
E5325-E5334
2017
Homo sapiens (Q9Y697), Homo sapiens
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