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Information on EC 2.8.1.7 - cysteine desulfurase

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.1 Sulfurtransferases
                2.8.1.7 cysteine desulfurase
IUBMB Comments
A pyridoxal-phosphate protein. The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors. The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) . In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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Synonyms
nfs1p, cpnifs, l-cysteine desulfurase, cysteine desulphurase, sufs2, slr0077, lecsl, nifs4, slr0387, slr0077/sufs, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor
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L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine
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(1a)
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[enzyme]-S-sulfanylcysteine + acceptor = [enzyme]-cysteine + S-sulfanyl-acceptor
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(1b)
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