Reference on EC 2.8.1.2 - 3-mercaptopyruvate sulfurtransferase
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Scott, E.M.; Wright, R.C.
Identity of beta-mercaptopyruvate sulfurtransferase and rhodanese in human erythrocytes
Biochem. Biophys. Res. Commun.
97
1334-1338
1980
Homo sapiens
Wrobel, M.; Frendo, J.
Comparison of some molecular and catalytic properties of mitochondrial and cytosolic rhodanese and mercaptopyruvate sulphurtransferase from frog (Rana temporaria) liver
Bull. Pol. Acad. Sci. Biol. Sci.
32
303-313
1984
Rana temporaria
-
Van den Hamer, C.J.A.; morell, A.G.; Scheinberg, I.H.
A study of the cooper content of beta-mercaptopyruvate trans-sulfurase
J. Biol. Chem.
242
2514-2516
1967
Rattus norvegicus
Vachek, H.; Wood, J.L.
Purification and properties of mercaptopyruvate sulfur transferase of Escherichia coli
Biochim. Biophys. Acta
258
133-146
1972
Escherichia coli
Wlodek, L.; Ostrowski, W.S.
3-Mercaptopyruvate sulphurtransferase from rat erythrocytes
Acta Biochim. Pol.
29
121-133
1982
Rattus norvegicus
Kasperczyk, H.; Koj, A.; Wasylewski, Z.
Similarity of some molecular and catalytic parameters of mitochondrial and cytosolic mercaptopyruvate sulfurtransferase from rat liver
Bull. Acad. Pol. Sci. Biol. Sci.
25
7-13
1977
Rattus norvegicus
Jarabak, R.
3-Mercaptopyruvate sulfurtransferase
Methods Enzymol.
77
291-297
1981
Bos taurus
Jarabak, R.; Westley, J.
3-Mercaptopyruvate sulfurtransferase: rapid equilibrium-ordered mechanism with cyanide as the acceptor substrate
Biochemistry
19
900-904
1980
Bos taurus
Koj, A.; Frendo, J.; Wojtczak, L.
Subcellular distribution and intramitochondrial localization of three sulfurtransferases in rat liver
FEBS Lett.
57
42-46
1975
Rattus norvegicus, Rattus norvegicus Wistar
Jarabak, R.; Westley, J.
Steady-state kinetics of 3-mercaptopyruvate sulfurtransferase from bovine kidney
Arch. Biochem. Biophys.
185
458-465
1978
Bos taurus
Taniguchi, T.; Kimura, T.
Role of 3-mercaptopyruvate sulfurtransferase in the formation of the iron-sulfur chromophore of adrenal ferredoxin
Biochim. Biophys. Acta
364
284-295
1974
Bos taurus
Alphey, M.S.; Williams, R.A.; Mottram, J.C.; Coombs, G.H.; Hunter, W.N.
The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active site
J. Biol. Chem.
278
48219-48227
2003
Leishmania major
Frendo, J.; Wrobel, M.; Was, K.
3-Mercaptopyruvate sulfurtransferase and rhodanese activities in human myometrium and leiomyomas of the uterus
Nowotwory J. Oncol.
52
123-125
2002
Homo sapiens
-
Meyer, T.; Burow, M.; Bauer, M.; Papenbrock, J.
Arabidopsis sulfurtransferases: investigation of their function during senescence and in cyanide detoxification
Planta
217
1-10
2003
Arabidopsis thaliana
Nagahara, N.; Ito, T.; Kitamura, H.; Nishino, T.
Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis
Histochem. Cell Biol.
110
243-250
1998
Rattus norvegicus
Magahara, N.; Ito, T.; Minami, M.
Mercaptopyruvate sulfurtransferase as a defense against cyanide toxication: molecular properties and mode of detoxification
Histol. Histopathol.
14
1277-1286
1999
Rattus norvegicus
Magahara, N.; Nishino, T.
Role of amino acid residues in the active site of rat liver mercaptopyruvate sulfurtransferase. CDNA cloning, overexpression, and site-directed mutagenesis
J. Biol. Chem.
271
27395-27401
1996
Rattus norvegicus (P97532)
Magahara, N.; Okazaki, T.; Nishino, T.
Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-directed mutagenesis
J. Biol. Chem.
270
16230-16235
1995
Rattus norvegicus, Rattus norvegicus Wistar
Makamura, T.; Yamaguchi, Y.; Sano, H.
Plant mercaptopyruvate sulfurtransferases: molecular cloning, subcellular localization and enzymatic activities
Eur. J. Biochem.
267
5621-5630
2000
Arabidopsis thaliana (Q24JL3)
Porter, D.W.; Baskin, S.I.
Specificity studies of 3-mercaptopyruvate sulfurtransferase
J. Biochem. Toxicol.
10
287-292
1995
Bos taurus
Porter, D.W.; Baskin, S.I.
The effect of three alpha-keto acids on 3-mercaptopyruvate sulfurtransferase activity
J. Biochem. Toxicol.
11
45-50
1996
Bos taurus
Spallarossa, A.; Forlani, F.; Carpen, A.; Armirotti, A.; Pagani, S.; Bolognesi, M.; Bordo, D.
The "rhodanese" fold and catalytic mechanism of 3-mercaptopyruvate sulfurtransferases: Crystal structure of SseA from Escherichia coli
J. Mol. Biol.
335
583-593
2004
Escherichia coli (P31142)
Williams, R.A.; Kelly, S.M.; Mottram, J.C.; Coombs, G.H.
3-Mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism
J. Biol. Chem.
278
1480-1486
2003
Leishmania major (Q7K9G0), Leishmania major, Leishmania mexicana (Q8T381), Leishmania mexicana
Nagahara, N.; Sawada, N.; Nakagawa, T.
Affinity labeling of a catalytic site, cysteine(247), in rat mercaptopyruvate sulfurtransferase by chloropyruvate as an analog of a substrate
Biochimie
86
723-729
2004
Rattus norvegicus
Nagahara, N.; Katayama, A.
Post-translational regulation of mercaptopyruvate sulfurtransferase via a low redox potential cysteine-sulfenate in the maintenance of redox homeostasis
J. Biol. Chem.
280
34569-34576
2005
Rattus norvegicus
Wrobel, M.; Jurkowska, H.
Menadione effect on L-cysteine desulfuration in U373 cells
Acta Biochim. Pol.
54
407-411
2007
Homo sapiens
Iciek, M.; Marcinek, J.; Mleczko, U.; Wlodek, L.
Selective effects of diallyl disulfide, a sulfane sulfur precursor, in the liver and Ehrlich ascites tumor cells
Eur. J. Pharmacol.
569
1-7
2007
Mus musculus
Nagahara, N.; Yoshii, T.; Abe, Y.; Matsumura, T.
Thioredoxin-dependent enzymatic activation of mercaptopyruvate sulfurtransferase. An intersubunit disulfide bond serves as a redox switch for activation
J. Biol. Chem.
282
1561-1569
2007
Rattus norvegicus, Rattus norvegicus (P97532)
Billaut-Laden, I.; Rat, E.; Allorge, D.; Crunelle-Thibaut, A.; Cauffiez, C.; Chevalier, D.; Lo-Guidice, J.M.; Broly, F.
Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme
Toxicol. Lett.
165
101-111
2006
Homo sapiens
Wrobel, M.; Lewandowska, I.; Bronowicka-Adamska, P.; Paszewski, A.
The level of sulfane sulfur in the fungus Aspergillus nidulans wild type and mutant strains
Amino Acids
37
565-571
2008
Aspergillus nidulans
Shibuya, N.; Tanaka, M.; Yoshida, M.; Ogasawara, Y.; Togawa, T.; Ishii, K.; Kimura, H.
3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain
Antioxid. Redox Signal.
11
703-714
2009
Mus musculus (Q99J99)
Nagahara, N.
A novel mercaptopyruvate sulfurtransferase thioredoxin-dependent redox-sensing molecular switch: a mechanism for the maintenance of cellular redox equilibrium
Mini Rev. Med. Chem.
8
585-589
2008
Rattus norvegicus (P97532)
Shibuya, N.; Mikami, Y.; Kimura, Y.; Nagahara, N.; Kimura, H.
Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide
J. Biochem.
146
623-626
2009
Rattus norvegicus
Westrop, G.D.; Georg, I.; Coombs, G.H.
The mercaptopyruvate sulfurtransferase of Trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide
J. Biol. Chem.
284
33485-33494
2009
Trichomonas vaginalis
Jurkowska, H.; Placha, W.; Nagahara, N.; Wrobel, M.
The expression and activity of cystathionine-gamma-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines
Amino Acids
41
151-158
2011
Homo sapiens
Nagahara, N.
Regulation of mercaptopyruvate sulfurtransferase activity via intrasubunit and intersubunit redox-sensing switches
Antioxid. Redox Signal.
19
1792-1802
2013
Mus musculus, Rattus norvegicus
Mikami, Y.; Shibuya, N.; Ogasawara, Y.; Kimura, H.
Hydrogen sulfide is produced by cystathionine gamma-lyase at the steady-state low intracellular Ca2+ concentrations
Biochem. Biophys. Res. Commun.
431
131-135
2013
Rattus norvegicus
Modis, K.; Asimakopoulou, A.; Coletta, C.; Papapetropoulos, A.; Szabo, C.
Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway
Biochem. Biophys. Res. Commun.
433
401-407
2013
Mus musculus
Mikami, Y.; Shibuya, N.; Kimura, Y.; Nagahara, N.; Ogasawara, Y.; Kimura, H.
Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide
Biochem. J.
439
479-485
2011
Mus musculus
Tanizawa, K.
Production of H2S by 3-mercaptopyruvate sulphurtransferase
J. Biochem.
149
357-359
2011
Homo sapiens
Yadav, P.K.; Yamada, K.; Chiku, T.; Koutmos, M.; Banerjee, R.
Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase
J. Biol. Chem.
288
20002-20013
2013
Homo sapiens (P25325), Homo sapiens
Modis, K.; Coletta, C.; Erdelyi, K.; Papapetropoulos, A.; Szabo, C.
Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics
FASEB J.
27
601-611
2013
Mus musculus (Q99J99), Mus musculus
Singh, P.; Rao, P.; Bhattacharya, R.
Dose and time-dependent effects of cyanide on thiosulfate sulfurtransferase, 3-mercaptopyruvate sulfurtransferase, and cystathionine lambda-lyase activities
J. Biochem. Mol. Toxicol.
27
499-507
2013
Mus musculus (Q99J99)
Fraesdorf, B.; Radon, C.; Leimkuehler, S.
Characterization and interaction studies of two isoforms of the dual localized 3-mercaptopyruvate sulfurtransferase TUM1 from humans
J. Biol. Chem.
289
34543-34556
2014
Homo sapiens (P25325), Homo sapiens
Miyamoto, R.; Otsuguro, K.; Yamaguchi, S.; Ito, S.
Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons
J. Neurochem.
130
29-40
2014
Rattus norvegicus (P97532)
Nagahara, N.; Nagano, M.; Ito, T.; Suzuki, H.
Redox regulation of mammalian 3-mercaptopyruvate sulfurtransferase
Methods Enzymol.
554
229-254
2015
Rattus norvegicus (P97532)
Zhao, H.; Chan, S.J.; Ng, Y.K.; Wong, P.T.
Brain 3-mercaptopyruvate sulfurtransferase (3MST): cellular localization and downregulation after acute stroke
PLoS ONE
8
e67322
2013
Rattus norvegicus (P97532)
Nagahara, N.; Nagano, M.; Ito, T.; Shimamura, K.; Akimoto, T.; Suzuki, H.
Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria
Sci. Rep.
3
1986
2013
Mus musculus (Q99J99)
Kimura, Y.; Toyofuku, Y.; Koike, S.; Shibuya, N.; Nagahara, N.; Lefer, D.; Ogasawara, Y.; Kimura, H.
Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain
Sci. Rep.
5
14774
2015
Mus musculus (Q99J99)
Lec, J.; Boutserin, S.; Mazon, H.; Mulliert, G.; Boschi-Muller, S.; Talfournier, F.
Unraveling the mechanism of cysteine persulfide formation catalyzed by 3-mercaptopyruvate sulfurtransferases
ACS Catal.
8
2049-2059
2018
Escherichia coli, Homo sapiens (P25325), Escherichia coli DH5alpha
-
Nagahara, N.; Koike, S.; Nirasawa, T.; Kimura, H.; Ogasawara, Y.
Alternative pathway of H2S and polysulfides production from sulfurated catalytic-cysteine of reaction intermediates of 3-mercaptopyruvate sulfurtransferase
Biochem. Biophys. Res. Commun.
496
648-653
2018
Rattus norvegicus (P97532)
Panagaki, T.; Randi, E.B.; Szabo, C.
Role of 3-mercaptopyruvate sulfurtransferase in the regulation of proliferation and cellular bioenergetics in human Down syndrome fibroblasts
Biomolecules
10
653
2020
Homo sapiens (P25325), Homo sapiens
Abdollahi Govar, A.; Toero, G.; Szaniszlo, P.; Pavlidou, A.; Bibli, S.I.; Thanki, K.; Resto, V.A.; Chao, C.; Hellmich, M.R.; Szabo, C.; Papapetropoulos, A.; Modis, K.
3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics
Br. J. Pharmacol.
177
866-883
2020
Homo sapiens (P25325), Homo sapiens
Zuhra, K.; Tome, C.S.; Masi, L.; Giardina, G.; Paulini, G.; Malagrino, F.; Forte, E.; Vicente, J.B.; Giuffre, A.
N-acetylcysteine serves as substrate of 3-mercaptopyruvate sulfurtransferase and stimulates sulfide metabolism in colon cancer cells
Cells
8
828
2019
Homo sapiens (P25325), Homo sapiens
Wang, J.; Guo, X.; Li, H.; Qi, H.; Qian, J.; Yan, S.; Shi, J.; Niu, W.
Hydrogen sulfide from cysteine desulfurase, not 3-mercaptopyruvate sulfurtransferase, contributes to sustaining cell growth and bioenergetics in E. coli under anaerobic conditions
Front. Microbiol.
10
2357
2019
Escherichia coli, Escherichia coli BW25113
Bronowicka-Adamska, P.; Bentke, A.; Lasota, M.; Wrobel, M.
Effect of S-allyl-L-cysteine on MCF-7 cell line 3-mercaptopyruvate sulfurtransferase/sulfane sulfur system, viability and apoptosis
Int. J. Mol. Sci.
21
1090
2020
Homo sapiens (P25325), Homo sapiens
Yadav, P.; Vitvitsky, V.; Carballal, S.; Seravalli, J.; Banerjee, R.
Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations
J. Biol. Chem.
295
6299-6310
2020
Homo sapiens (P25325), Homo sapiens, Mus musculus (Q99J99), Mus musculus
Tomita, M.; Nagahara, N.; Ito, T.
Expression of 3-mercaptopyruvate sulfurtransferase in the mouse
Molecules
21
1707
2016
Mus musculus (Q99J99), Mus musculus
Hoefler, S.; Lorenz, C.; Busch, T.; Brinkkoetter, M.; Tohge, T.; Fernie, A.R.; Braun, H.P.; Hildebrandt, T.M.
Dealing with the sulfur part of cysteine four enzymatic steps degrade l-cysteine to pyruvate and thiosulfate in Arabidopsis mitochondria
Physiol. Plant.
157
352-366
2016
Arabidopsis thaliana (O64530)
Kimura, Y.; Koike, S.; Shibuya, N.; Lefer, D.; Ogasawara, Y.; Kimura, H.
3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S
Sci. Rep.
7
10459
2017
Mus musculus (Q99J99)
Hanaoka, K.; Sasakura, K.; Suwanai, Y.; Toma-Fukai, S.; Shimamoto, K.; Takano, Y.; Shibuya, N.; Terai, T.; Komatsu, T.; Ueno, T.; Ogasawara, Y.; Tsuchiya, Y.; Watanabe, Y.; Kimura, H.; Wang, C.; Uchiyama, M.; Kojima, H.; Okabe, T.; Urano, Y.; Shimizu, T.; Nagano, T.
Discovery and mechanistic characterization of selective inhibitors of H2S-producing enzyme 3-mercaptopyruvate sulfurtransferase (3MST) targeting active-site cysteine persulfide
Sci. Rep.
7
40227
2017
Homo sapiens (P25325)
Meza, A.; Cambui, C.; Moreno, A.; Fessel, M.; Balan, A.
Mycobacterium tuberculosis CysA2 is a dual sulfurtransferase with activity against thiosulfate and 3-mercaptopyruvate and interacts with mammalian cells
Sci. Rep.
9
16791
2019
Mycobacterium tuberculosis (P9WHF9), Mycobacterium tuberculosis H37Rv (P9WHF9)
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