Information on EC 2.7.8.38 - archaetidylserine synthase

for references in articles please use BRENDA:EC2.7.8.38
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

EC NUMBER
COMMENTARY hide
2.7.8.38
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RECOMMENDED NAME
GeneOntology No.
archaetidylserine synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-phytanyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
(2)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
archaetidylserine and archaetidylethanolamine biosynthesis
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lipid metabolism
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Glycerophospholipid metabolism
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SYSTEMATIC NAME
IUBMB Comments
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol:L-serine 2,3-bis-O-(geranylgeranyl)-sn-glycerol phosphotransferase
Requires Mn2+. Isolated from the archaeon Methanothermobacter thermautotrophicus.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CDP-1,2-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(geranylgeranyl)-sn-glycero-3-phospho-L-serine
show the reaction diagram
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91% of the activity compared to CDP-1,2-diacylglycerol with fatty acids from lecithin
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?
CDP-1,2-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(geranylgeranyl)-sn-glycero-3-phosphoserine
show the reaction diagram
CDP-1,2-bis-O-(oleoyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(oleoyl)-sn-glycero-3-phospho-L-serine
show the reaction diagram
CDP-1,2-diacylglycerol + L-serine
CMP + 1,2-diacyl-sn-glycero-3-phospho-L-serine
show the reaction diagram
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
CDP-2,3-bis-O-(oleoyl)-sn-glycerol + L-serine
CMP + 2,3-dioleoyl-sn-glycero-1-phospho-L-serine
show the reaction diagram
280% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
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?
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
CDP-2,3-dioleoyl-sn-glycerol + L-serine
CMP + 2,3-bis-O-(oleoyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
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143% of the activity compared to CDP-1,2-diacylglycerol with fatty acids from lecithin
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?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mn2+
stimulates, maximal activity in presence of 10 mM Mn2+. Mg2+ is much less effective
additional information
the enzyme does not require the addition of K+. The enzyme activity is lowered to about 70% of its maximum at 0.6 M K+, which corresponds to the intracellular concentration found in Methanothermobacter thermautotrophicus
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Triton X-100
activity is dependent on TRiton X-100
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50 - 70
50°C: about 50% of maximal activity, 70°C: about 65% of maximal activity