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Information on EC 2.7.8.35 - UDP-N-acetylglucosamine-decaprenyl-phosphate N-acetylglucosaminephosphotransferase

for references in articles please use BRENDA:EC2.7.8.35
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IUBMB Comments
Isolated from Mycobacterium tuberculosis and Mycobacterium smegmatis. This enzyme catalyses the synthesis of monotrans,octacis-decaprenyl-N-acetyl-alpha-D-glucosaminyl diphosphate (mycobacterial lipid I), an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. cf. EC 2.7.8.33, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase.
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The enzyme appears in viruses and cellular organisms
Synonyms
glcnac-1-phosphate transferase, msmeg_4947, rv1302, polyprenyl phosphate-glcnac-1-phosphate transferase, udp-glcnac undecaprenyl phosphate glcnac-1-phosphate transferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + trans,octacis-decaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
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