Reference on EC 2.7.8.13 - phospho-N-acetylmuramoyl-pentapeptide-transferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Struve, W.G.; Sinha, R.K.; Neuhaus, F.C.
On the initial stage in peptidoglycan synthesis. Phospho-N-acetylmuramyl-pentapeptide translocase (uridine monophosphate)
Biochemistry
5
82-93
1966
Staphylococcus aureus, Staphylococcus aureus Copenhagen
Heydanek, M.G.; Neuhaus, F.C.
The initial stage in peptidoglycan synthesis. IV. Solubilization of phospho-N-acetylmuramyl-pentapeptide translocase
Biochemistry
8
1474-1481
1969
Staphylococcus aureus, Staphylococcus aureus Copenhagen
Umbreit, J.N.; Strominger, J.L.
Complex lipid requirements for detergent-solubilized phosphoacetylmuramyl-pentapeptide translocase from Micrococcus luteus
Proc. Natl. Acad. Sci. USA
69
1972-1974
1972
Micrococcus luteus
Pless, D.D.; Neuhaus, F.C.
Initial membrane reaction in peptidoglycan synthesis. Lipid dependence of phospho-n-acetylmuramyl-pentapeptide translocase (exchange reaction)
J. Biol. Chem.
248
1568-1576
1973
Staphylococcus aureus, Staphylococcus aureus Copenhagen
Hammes, W.P.; Neuhaus, F.C.
On the specificity of phospho-N-acetylmuramyl-pentapeptide translocase. The peptide subunit of uridine diphosphate-N-actylmuramyl-pentapeptide
J. Biol. Chem.
249
3140-3150
1974
Staphylococcus aureus, Staphylococcus aureus Copenhagen
Geis, A.; Plapp, R.
Phospho-N-acetylmuramoyl-pentapeptide-transferase of Escherichia coli K12. Properties of the membrane-bound and the extracted and partially purified enzyme
Biochim. Biophys. Acta
527
414-424
1978
Escherichia coli
Weppner, W.A.; Neuhaus, F.C.
Initial membrane reaction in peptidoglycan synthesis. Interaction of lipid with phospho-N-acetylmuramyl-pentapeptide translocase
Biochim. Biophys. Acta
552
418-427
1979
Staphylococcus aureus, Staphylococcus aureus Copenhagen
Tanaka, H.; Oiwa, R.; Matsukura, S.; Inokoshi, J.; Omura, S.
Studies on bacterial cell wall inhibitors. X. Properties of phosph-N-acetylmuramoyl-pentapeptide-transferase in peptidoglycan synthesis of Bacillus megaterium and its inhibition by amphomycin
J. Antibiot.
35
1216-1221
1982
Priestia megaterium, Priestia megaterium KM / ATCC 13632
Kimura, K.; Miyata, N.; Kawanishi, G.; Kamio, Y.; Izaki, K.; Isono, K.
Liposidomycin C inhibits phospho-N-acetylmuramyl-pentapeptide transferase in peptidoglycan synthesis of Escherichia coli Y-10
Agric. Biol. Chem.
53
1811-1815
1989
Escherichia coli, Escherichia coli Y-10
-
Ikeda, M.; Wachi, M.; Jung, H.K.; Ishino, F.; Matsuhashi, M.
The Escherichia coli mraY gene encoding UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase
J. Bacteriol.
173
1021-1026
1991
Escherichia coli, Escherichia coli Y-10
Pickup, K.M.; Bushell, M.E.
Non-fragmenting variants of Streptomyces hyphae have enhanced activity of an enzyme (phospho-N-acetylmuramyl pentapeptide translocase) in peptidoglycan biosynthesis
J. Ferment. Bioeng.
79
247-251
1995
Streptomyces sp.
-
Brandish, P.E.; Burnham, M.K.; Lonsdale, J.T.; Southgate, R.; Inukai, M.; Bugg, T.D.H.
Slow binding inhibition of phospho-N-acetylmuramyl-pentapeptide-translocase (Escherichia coli) by mureidomycin A
J. Biol. Chem.
271
7609-7614
1996
Escherichia coli, Escherichia coli JM105
Bouhss, A.; Mengin-Lecreulx, D.; Le Beller, D.; Van Heijenoort, J.
Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis
Mol. Microbiol.
34
576-585
1999
Escherichia coli, Staphylococcus aureus
Azzolina, B.A.; Yuan, X.; Anderson, M.S.; El-Sherbeini, M.
The cell wall and cell division gene cluster in the Mra operon of Pseudomonas aeruginosa: Cloning, production, and purification of active enzymes
Protein Expr. Purif.
21
393-400
2001
Pseudomonas aeruginosa
Zawadzke, L.E.; Wu, P.; Cook, L.; Fan, L.; Casperson, M.; Kishnani, M.; Calambur, D.; Hofstead, S.J.; Padmanabha, R.
Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention
Anal. Biochem.
314
243-252
2003
Escherichia coli
Stachyra, T.; Dini, C.; Ferrari, P.; Bouhss, A.; Van Heijenoort, J.; Mengin-Lecreulx, D.; Blanot, D.; Biton, J.; Le Beller, D.
Fluorescence detection-based functional assay for high-throughput screening for MraY
Antimicrob. Agents Chemother.
48
897-902
2004
Escherichia coli
Lloyd, A.J.; Brandish, P.E.; Gilbey, A.M.; Bugg, T.D.H.
Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli: catalytic role of conserved aspartic acid residues
J. Bacteriol.
186
1747-1757
2004
Escherichia coli
Bouhss, A.; Crouvoisier, M.; Blanot, D.; Mengin-Lecreulx, D.
Purification and characterization of the bacterial MraY translocase catalyzing the first membrane step of peptidoglycan biosynthesis
J. Biol. Chem.
279
29974-29980
2004
Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Thermotoga maritima
Schouten, J.A.; Bagga, S.; Lloyd, A.J.; de Pascale, G.; Dowson, C.G.; Roper, D.I.; Bugg, T.D.
Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5
Mol. Biosyst.
2
484-491
2006
Escherichia coli, Escherichia coli DH5-alpha
Mohammadi, T.; Karczmarek, A.; Crouvoisier, M.; Bouhss, A.; Mengin-Lecreulx, D.; den Blaauwen, T.
The essential peptidoglycan glycosyltransferase MurG forms a complex with proteins involved in lateral envelope growth as well as with proteins involved in cell division in Escherichia coli
Mol. Microbiol.
65
1106-1121
2007
Escherichia coli, Escherichia coli LMC500
Al-Dabbagh, B.; Henry, X.; El Ghachi, M.; Auger, G.; Blanot, D.; Parquet, C.; Mengin-Lecreulx, D.; Bouhss, A.
Active site mapping of MraY, a member of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily, catalyzing the first membrane step of peptidoglycan biosynthesis
Biochemistry
47
8919-8928
2008
Bacillus subtilis (Q03521), Bacillus subtilis
Le Corre, L.; Gravier-Pelletier, C.; Le Merrer, Y.
Towards new MraY inhibitors: a serine template for uracil and 5-amino-5-deoxyribosyl scaffolding
Eur. J. Org. Chem.
2007
5386-5394
2007
Bacteria
-
Zheng, Y.; Struck, D.K.; Bernhardt, T.G.; Young, R.
Genetic analysis of MraY inhibition by the {varphi}X174 protein E
Genetics
180
1459-1466
2008
Escherichia coli, Bacillus subtilis (Q03521), Bacillus subtilis
Xu, X.H.; Trunkfield, A.E.; Bugg, T.D.; Qing, F.L.
Synthesis of gem-difluorinated nucleoside analogues of the liposidomycins and evaluation as MraY inhibitors
Org. Biomol. Chem.
6
157-161
2008
Micrococcus flavus
Kurosu, M.; Mahapatra, S.; Narayanasamy, P.; Crick, D.C.
Chemoenzymatic synthesis of Parks nucleotide: toward the development of high-throughput screening for MraY inhibitors
Tetrahedron Lett.
48
799-803
2007
Bacteria
-
Murakami, R.; Fujita, Y.; Kizuka, M.; Kagawa, T.; Muramatsu, Y.; Miyakoshi, S.; Takatsu, T.; Inukai, M.
A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity
J. Antibiot.
61
537-544
2008
Enterococcus faecalis, Staphylococcus aureus
Fujita, Y.; Murakami, R.; Muramatsu, Y.; Miyakoshi, S.; Takatsu, T.
A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation
J. Antibiot.
61
545-549
2008
Enterococcus faecalis, Staphylococcus aureus
Shapiro, A.B.; Jahic, H.; Gao, N.; Hajec, L.; Rivin, O.
A high-throughput, homogeneous, fluorescence resonance energy transfer-based assay for phospho-N-acetylmuramoyl-pentapeptide translocase (MraY)
J. Biomol. Screen.
17
662-672
2012
Escherichia coli
Moberg, A.; Zander Balderud, L.; Hansson, E.; Boyd, H.
Assessing HTS performance using bioassay ontology: screening and analysis of a bacterial phospho-N-acetylmuramoyl-pentapeptide translocase campaign
Assay Drug Dev. Technol.
12
506-513
2014
Bacillus subtilis (Q03521), Bacillus subtilis 168 (Q03521)
Al-Dabbagh, B.; Olatunji, S.; Crouvoisier, M.; El Ghachi, M.; Blanot, D.; Mengin-Lecreulx, D.; Bouhss, A.
Catalytic mechanism of MraY and WecA, two paralogues of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily
Biochimie
127
249-257
2016
Bacillus subtilis (Q03521), Bacillus subtilis, Bacillus subtilis 168 (Q03521)
Ishizaki, Y.; Hayashi, C.; Inoue, K.; Igarashi, M.; Takahashi, Y.; Pujari, V.; Crick, D.C.; Brennan, P.J.; Nomoto, A.
Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45
J. Biol. Chem.
288
30309-30319
2013
Bacillus subtilis (Q03521), Bacillus subtilis, Bacillus subtilis 168 (Q03521)
Malek Zadeh, S.; Astani, E.K.; Wang, Z.C.; Adhikari, K.; Rattinam, R.; Li, T.L.
Theoretical study of intermolecular interactions between critical residues of membrane protein MraYAA and promising antibiotic muraymycin D2
ACS Omega
5
22739-22749
2020
Aquifex aeolicus (O66465), Aquifex aeolicus
Yoo, J.; Mashalidis, E.H.; Kuk, A.C.Y.; Yamamoto, K.; Kaeser, B.; Ichikawa, S.; Lee, S.Y.
GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation
Nat. Struct. Mol. Biol.
25
217-224
2018
Enterocloster bolteae (R0BTE9), Enterocloster bolteae 90A9 (R0BTE9)
Yamamoto, K.; Sato, T.; Hikiji, Y.; Katsuyama, A.; Matsumaru, T.; Yakushiji, F.; Yokota, S.; Ichikawa, S.
Synthesis and biological evaluation of a MraY selective analogue of tunicamycins
Nucleosides Nucleotides Nucleic Acids
39
349-364
2020
Staphylococcus aureus (R0BTE9), Enterocloster bolteae (R0BTE9), Enterocloster bolteae 90A9 (R0BTE9), Staphylococcus aureus ATCC 25923 (R0BTE9)
Liu, Y.; Moura, E.C.C.M.; Doerr, J.M.; Scheidelaar, S.; Heger, M.; Egmond, M.R.; Killian, J.A.; Mohammadi, T.; Breukink, E.
Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers
PLoS ONE
13
e0206692
2018
Bacillus subtilis (Q03521), Bacillus subtilis 168 (Q03521)
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