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ATP + alpha-D-glucose 1-phosphate
diphosphate + ADP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
ATP + alpha-D-glucose 1-phosphate
diphosphate + ADP-glucose
-
13.7% of the activity with UTP
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-galactose
UTP + alpha-D-galactose 1-phosphate
-
-
-
r
diphosphate + UDP-glucose
diphosphate + UDP-glucose
diphosphate + UDP-glucose
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-mannose
UTP + D-mannose 1-phosphate
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
farnesyl triphosphate + UDP-glucose
farnesyl-tetraphosphouridine + alpha-D-glucose + diphosphate
-
-
-
-
?
geranyl triphosphate + UDP-glucose
geranyl-tetraphosphouridine + alpha-D-glucose + diphosphate
-
-
-
-
?
GTP + alpha-D-glucose 1-phosphate
diphosphate + GDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
isopentenyl triphosphate + UDP-glucose
isopentenyl-tetraphosphouridine + alpha-D-glucose + diphosphate
-
-
-
-
?
methylenebisphosphonate + UDP-glucose
uridine 5'-(beta,gamma-methylenetriphosphate) + alpha-D-glucose + diphosphate
-
-
-
-
?
monothiodiphosphate + UDP-glucose
UTPbeta,gammaS + alpha-D-glucose 1-phosphate
-
poor substrate, 4.8% of Vmax with diphosphate
UTPbeta,gammaS is chemically unstable and undergoes hydrolysis to UDPbetaS and phosphate, which renders the otherwise reversible reaction irreversible, t1/2 at 25°C: 0.5 min
ir
TTP + alpha-D-glucose 1-phosphate
diphosphate + alpha-TDP-glucose
TTP + alpha-D-glucose 1-phosphate
TDP-glucose + diphosphate
UDP-glucose + adenosine 5'-tetraphosphate
D-glucose-1-phosphate + adenosyl-5'-pentaphospho-5'-uridine
-
-
-
-
?
UDP-glucose + ATP
D-glucose-1-phosphate + adenosyl-5'-tetraphospho-5'-uridine
-
-
-
-
?
UDP-glucose + CTP
D-glucose-1-phosphate + cytidinyl-5'-tetraphospho-5'-uridine
-
-
-
-
?
UDP-glucose + GTP
D-glucose-1-phosphate + guanosyl-5'-tetraphospho-5'-uridine
-
-
-
-
?
UDP-glucose + guanosine 5'-tetraphosphate
D-glucose-1-phosphate + guanosyl-5'-pentaphospho-5'-uridine
-
-
-
-
?
UDP-glucose + tetrapolyphosphate
uridine-5'-pentaphosphate + D-glucose-1-phosphate
-
-
-
-
?
UDP-glucose + tripolyphosphate
uridine-5'-tetraphosphate + D-glucose-1-phosphate
-
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + alpha-UDP-galactose
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-alpha-D-galactose
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
UTP + alpha-D-glucose 1-phosphate
UTP + alpha-D-glucose 1-phosphate
UTP + D-glucose-1-phosphate
diphosphate + UDP-glucose
-
-
-
-
?
UTP + D-glucose-1-phosphate
UDP-glucose + diphosphate
UTP + glucose-1-phosphate
UDP-glucose + diphosphate
-
-
-
-
?
additional information
?
-
diphosphate + CDP-glucose

CTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
calf and human liver, poor substrate
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
calf and human liver, poor substrate
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
very low activity, wild-type and mutant W218
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
18.5% of the activity with UTP
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + GDP-glucose

GTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
-
calf and human liver, poor substrate
-
-
r
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
-
calf and human liver, poor substrate
-
-
r
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
-
14.3% of the activity with UTP
-
r
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + TDP-glucose

TTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
calf and human liver
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
calf and human liver
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
very low activity, wild-type and mutant W218
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
-
-
-
?
diphosphate + UDP-glucose

diphosphate + UDP-glucose
-
-
-
r
diphosphate + UDP-glucose
diphosphate + UDP-glucose
-
-
-
r
diphosphate + UDP-glucose

UTP + alpha-D-glucose 1-phosphate
-
-
-
r
diphosphate + UDP-glucose
UTP + alpha-D-glucose 1-phosphate
-
-
-
r
diphosphate + UDP-glucose
UTP + alpha-D-glucose 1-phosphate
-
-
-
?
diphosphate + UDP-glucose
UTP + alpha-D-glucose 1-phosphate
-
-
-
r
diphosphate + UDP-glucose
UTP + alpha-D-glucose 1-phosphate
-
-
-
?
diphosphate + UDP-mannose

UTP + D-mannose 1-phosphate
-
calf and human liver, poor substrate
-
-
r
diphosphate + UDP-mannose
UTP + D-mannose 1-phosphate
-
calf and human liver, poor substrate
-
-
r
diphosphate + UDP-xylose

UTP + D-xylose 1-phosphate
-
reaction at 10% the rate of UDP-glucose or UDP-galactose pyrophosphorolysis
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
poor substrate
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
calf and human liver
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
-
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
poor substrate
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
calf and human liver
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
poor substrate
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
calf and human liver
-
-
r
dTTP + alpha-D-glucose 1-phosphate

diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
TTP + alpha-D-glucose 1-phosphate

diphosphate + alpha-TDP-glucose
-
-
-
?
TTP + alpha-D-glucose 1-phosphate
diphosphate + alpha-TDP-glucose
-
-
-
?
TTP + alpha-D-glucose 1-phosphate

TDP-glucose + diphosphate
-
-
-
r
TTP + alpha-D-glucose 1-phosphate
TDP-glucose + diphosphate
-
-
-
r
UTP + alpha-D-galactose 1-phosphate

diphosphate + alpha-UDP-galactose
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + alpha-UDP-galactose
-
-
-
?
UTP + alpha-D-galactose 1-phosphate

diphosphate + UDP-alpha-D-galactose
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-alpha-D-galactose
-
-
-
?
UTP + alpha-D-galactose 1-phosphate

diphosphate + UDP-galactose
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
at the same rate as UDP-glucose
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
about 15% of the activity with UDP-glucose
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
reverse reaction: calf and human liver
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
no activity
-
-
-
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
reaction at 5% the rate of UDP-glucose synthesis
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
reverse reaction: calf and human liver
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
1-12% of the activity with UDP-glucose
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
low activity
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
no activity
-
-
-
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
equilibrium dialysis: 8 mol UDP-galactose bound per mol enzyme
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
3.5% of the activity with UDP-glucose
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate

diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
UGP-1 is specifically active toward UTP with alpha-D-glucose 1-phosphate, but displays very low or no activity toward other nucleotides, with either alpha-D-glucose 1-phosphate or alpha-D-mannose 1-phosphate
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
enzyme is highly specific for UTP and glucose 1-phosphate
-
?
UTP + alpha-D-glucose 1-phosphate

diphosphate + UDP-glucose
-
highly specific for UTP
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction: highly specific for UDP-glucose
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is induced during amoeba encystment
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
highly specific for UTP
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction: highly specific for UDP-glucose
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is induced during amoeba encystment
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Acetabularia sp.
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reaction at the same rate as UDP-galactose
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
specific for alpha-D-glucose 1-phosphate
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
central reaction in galactose and trehalose metabolism
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
the soluble enzyme shows an apparent higher affinity for and a 2fold higher activity with alpha-D-glucose 1-phosphate than UTP
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reaction critical to mono- and polysaccharide biosynthesis
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
specific for alpha-D-glucose 1-phosphate
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
highly specific for UTP
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
key enzyme in biosynthesis of sucrose, cellulose, and other saccharides
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
cumulative feedback regulation in vivo, modulates the flow of carbon into pathways leading to cell wall polysaccharide synthesis
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
specific for alpha-D-glucose 1-phosphate
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
equilibrium dialysis: 8 mol UDP-glucose bound per mol enzyme
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction: highly specific for UDP-glucose
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
highly specific for UTP
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is essential for cell viability
-
-
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Saccharomyces fragilis
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
highly specific for UTP
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction: highly specific for UDP-glucose
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is specific for UTP
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is specific for UTP
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in exopolysaccharide biosynthesis
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in exopolysaccharide biosynthesis
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
the multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 2.7.7.24, glucose-1-phosphate thymidylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase), dTTP + N-acetylglucosamine 1-phosphate (N-acetylglucosamine 1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
the multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 2.7.7.24, glucose-1-phosphate thymidylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase), dTTP + N-acetylglucosamine 1-phosphate (N-acetylglucosamine 1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate

UDP-glucose + diphosphate
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
-
14.2% activity with galactose-1-phosphate
-
-
?
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
in the presence of a divalent metal cation (mainly Mg2+)
-
-
r
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
in the presence of a divalent metal cation (mainly Mg2+)
-
-
r
UTP + alpha-D-glucose 1-phosphate

UTP + alpha-D-glucose 1-phosphate
enzyme is highly specific for both UTP and glucose 1-phosphate
-
-
r
UTP + alpha-D-glucose 1-phosphate
UTP + alpha-D-glucose 1-phosphate
enzyme is highly specific for both UTP and glucose 1-phosphate
-
-
r
UTP + D-glucose-1-phosphate

UDP-glucose + diphosphate
-
-
-
-
?
UTP + D-glucose-1-phosphate
UDP-glucose + diphosphate
-
-
-
-
?
UTP + D-glucose-1-phosphate
UDP-glucose + diphosphate
-
-
-
-
r
UTP + D-glucose-1-phosphate
UDP-glucose + diphosphate
-
-
-
-
?
additional information

?
-
-
no activity with ADP-glucose
-
-
-
additional information
?
-
-
no activity with ATP, CTP, and GTP
-
-
-
additional information
?
-
-
no activity with ADP-glucose
-
-
-
additional information
?
-
-
no activity with ATP, CTP, and GTP
-
-
-
additional information
?
-
-
regulation
-
-
-
additional information
?
-
-
UDP-glucose and UDP-galactose pyrophosphorolysis activity in Bifidobacterium bifidum are catalyzed by a single enzyme protein
-
-
-
additional information
?
-
-
UDP-glucose and UDP-galactose pyrophosphorolysis activity in Bifidobacterium bifidum are catalyzed by a single enzyme protein
-
-
-
additional information
?
-
the activity of UgpA toward glucose 1-phosphate is about 33fold higher than that toward galactose 1-phosphate
-
-
-
additional information
?
-
the activity of UgpA toward glucose 1-phosphate is about 33fold higher than that toward galactose 1-phosphate
-
-
-
additional information
?
-
no substrate: alpha-D-glalctose 1-phosphate
-
-
-
additional information
?
-
-
TTP is a poor substrate
-
-
-
additional information
?
-
-
involved in synthesis of hemagglutinin, sulfated proteoglycans, and glycogen in cartilage
-
-
-
additional information
?
-
no substrates: ATP, GTP, nor CTP
-
-
-
additional information
?
-
-
no substrates: ATP, GTP, nor CTP
-
-
-
additional information
?
-
no substrates: ATP, GTP, nor CTP
-
-
-
additional information
?
-
-
the enzyme catalyses a freely reversible reaction and is specific for alpha-D-glucose 1-phosphate
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
-
molecular geometry at position 4 of glucose is responsible for substrate specificity. The gamma-phosphate group of UTP is essential for binding and for induction of the open conformation, which then allows entry of glucose 1-phosphate
-
-
-
additional information
?
-
molecular geometry at position 4 of glucose is responsible for substrate specificity. The gamma-phosphate group of UTP is essential for binding and for induction of the open conformation, which then allows entry of glucose 1-phosphate
-
-
-
additional information
?
-
no substrates: ATP, GTP, CTP, dTTP
-
-
-
additional information
?
-
no substrates: ATP, GTP, CTP, dTTP
-
-
-
additional information
?
-
isoform Ugp1 is required for callose deposition during pollen mother cell meiosis and bridges the apoplastic unloading pathway and pollen development
-
-
-
additional information
?
-
-
no utilization of the nucleotide diphosphate sugars UDP-Gal, UDP-GlnA, UDP-Man, UDP-Xyl, ADP-Glc, CDP-Glc and TDP-Glc
-
-
-
additional information
?
-
-
UDP-galactose is not a UMP-donor and ADP not a UMP-acceptor
-
-
-
additional information
?
-
-
the bisphosphonates alendronate, pamidronate, clodronate and etidronate are not acceptors of UMP. But UDP-glucose serves as uridylyl donor to triphosphate derivatives of the mevalonate pathway, farnesyl triphosphate, geranyl triphosphate, and isopentenyl triphosphate, with formation of farnesyl-tetraphosphouridine, geranyl-tetraphosphouridine, and isopentenyl-tetraphosphouridine, overview. No activity with farnesyl-, geranyl-, or isopentenyl-diphosphates or with dimethylallyl pyrophosphate
-
-
-
additional information
?
-
-
no activity with ADP-glucose
-
-
-
additional information
?
-
-
no activity with ADP-glucose
-
-
-
additional information
?
-
-
no activity with ATP, CTP, and GTP
-
-
-
additional information
?
-
-
no activity with ADP-glucose
-
-
-
additional information
?
-
-
no activity with ATP, CTP, and GTP
-
-
-
additional information
?
-
-
no activity with TPP
-
-
-
additional information
?
-
no substrates: dTTP, CTP, ATP, and GTP, Glc-1P, GlcNAc-1P, Gal-1P, and Man-1P
-
-
-
additional information
?
-
-
no substrates: dTTP, CTP, ATP, and GTP, Glc-1P, GlcNAc-1P, Gal-1P, and Man-1P
-
-
-
additional information
?
-
the enzyme is specific for alpha-D-glucose 1-phosphate, no activity with N-acetylgalactosamine 1-phosphate, N-acetylglucosamine 1-phosphate, or galactosamine 1-phosphate
-
-
-
additional information
?
-
-
the enzyme is specific for alpha-D-glucose 1-phosphate, no activity with N-acetylgalactosamine 1-phosphate, N-acetylglucosamine 1-phosphate, or galactosamine 1-phosphate
-
-
-
additional information
?
-
the enzyme is specific for alpha-D-glucose 1-phosphate, no activity with N-acetylgalactosamine 1-phosphate, N-acetylglucosamine 1-phosphate, or galactosamine 1-phosphate
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
additional information
?
-
UTP + alpha-D-glucose 1-phosphate

diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate

diphosphate + UDP-glucose
-
enzyme is induced during amoeba encystment
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is induced during amoeba encystment
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Acetabularia sp.
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
central reaction in galactose and trehalose metabolism
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reaction critical to mono- and polysaccharide biosynthesis
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
key enzyme in biosynthesis of sucrose, cellulose, and other saccharides
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
cumulative feedback regulation in vivo, modulates the flow of carbon into pathways leading to cell wall polysaccharide synthesis
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is essential for cell viability
-
-
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in exopolysaccharide biosynthesis
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in exopolysaccharide biosynthesis
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
additional information

?
-
-
regulation
-
-
-
additional information
?
-
-
involved in synthesis of hemagglutinin, sulfated proteoglycans, and glycogen in cartilage
-
-
-
additional information
?
-
isoform Ugp1 is required for callose deposition during pollen mother cell meiosis and bridges the apoplastic unloading pathway and pollen development
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.09 - 10
alpha-D-galactose 1-phosphate
0.01 - 3.28
alpha-D-glucose 1-phosphate
0.19 - 0.83
D-glucose-1-phosphate
0.02422
dTTP
pH 7.5, 25°C
0.32
farnesyl triphosphate
-
pH 8.0, 30°C
0.21
geranyl triphosphate
-
pH 8.0, 30°C
0.51
isopentenyl triphosphate
-
pH 8.0, 30°C
1.1
methylenebisphosphonate
-
pH 8.0, 30°C
0.33 - 0.56
Mg-diphosphate
0.22
Mg-UTP
-
UDP-glucose synthesis
0.56
MgUTP
-
recombinant wild-type enzyme, pH 8.0, 25°C
4.5
tripolyphosphate
-
30°C, pH 8.0
0.26 - 0.42
UDP-galactose
additional information
additional information
-
0.09
alpha-D-galactose 1-phosphate

cosubstrate UTP, S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
10
alpha-D-galactose 1-phosphate
-
pH 7.5, temperature not specified in the publication
0.01
alpha-D-glucose 1-phosphate

-
pH 7.8, 37°C
0.03 - 0.048
alpha-D-glucose 1-phosphate
-
pH 7.5, 30°C
0.03 - 0.048
alpha-D-glucose 1-phosphate
-
-
0.03 - 0.048
alpha-D-glucose 1-phosphate
-
pH 7.8
0.03 - 0.048
alpha-D-glucose 1-phosphate
-
pH 8.5, 37°C
0.031
alpha-D-glucose 1-phosphate
pH 7.5, temperature not specified in the publication
0.03224
alpha-D-glucose 1-phosphate
cosubstrate: UTP, pH 7.5, 25°C
0.033
alpha-D-glucose 1-phosphate
-
pH 7.5, temperature not specified in the publication
0.0364
alpha-D-glucose 1-phosphate
pH 7.5, 37°C
0.04455
alpha-D-glucose 1-phosphate
-
0.04988
alpha-D-glucose 1-phosphate
cosubstrate: dTTP, pH 7.5, 25°C
0.055 - 0.08
alpha-D-glucose 1-phosphate
-
-
0.055 - 0.08
alpha-D-glucose 1-phosphate
-
pH 7.8
0.055 - 0.08
alpha-D-glucose 1-phosphate
-
at physiological substrate concentration, pH 8.5, 37°C
0.06
alpha-D-glucose 1-phosphate
-
0.067
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant E412K
0.074
alpha-D-glucose 1-phosphate
-
pH 8.35,25°C
0.07765
alpha-D-glucose 1-phosphate
cosubstrate: UTP, pH 7.5, 25°C
0.085
alpha-D-glucose 1-phosphate
wild-type, pH 7.5, 37°C
0.088
alpha-D-glucose 1-phosphate
mutant A8G, pH 7.5, 37°C
0.095
alpha-D-glucose 1-phosphate
-
-
0.095
alpha-D-glucose 1-phosphate
-
pH 7.8
0.122
alpha-D-glucose 1-phosphate
pH 7.2, temperature not specified in the publication, recombinant enzyme
0.13
alpha-D-glucose 1-phosphate
cosubstrate UTP, S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
0.14 - 0.18
alpha-D-glucose 1-phosphate
-
pH 8.0, 30°C
0.14 - 0.18
alpha-D-glucose 1-phosphate
-
-
0.14
alpha-D-glucose 1-phosphate
-
UDP-glucose synthesis
0.151
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant K410S
0.155
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant E412Q
0.183
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant enzyme
0.192
alpha-D-glucose 1-phosphate
pH 7.8, 25°C
0.198
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant N491P/L492E
0.202
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant P414G/T415P
0.205
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant E412D
0.217
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant V416N
0.219
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant T406K/M407L
0.235
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant S309N/S311R
0.24
alpha-D-glucose 1-phosphate
pH 7.5, 30°C
0.24
alpha-D-glucose 1-phosphate
-
-
0.253
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant enzyme
0.316
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant enzyme
0.36
alpha-D-glucose 1-phosphate
-
UDP-glucose synthesis
0.36
alpha-D-glucose 1-phosphate
cosubstrate TTP, S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
0.46
alpha-D-glucose 1-phosphate
-
-
0.68 - 1
alpha-D-glucose 1-phosphate
-
pH 7.2, 30°C
0.68 - 1
alpha-D-glucose 1-phosphate
-
at substrate concentrations above 2 mM, pH 8.5, 37°C
0.68 - 1
alpha-D-glucose 1-phosphate
-
pH 8.0, 37°C
0.68 - 1
alpha-D-glucose 1-phosphate
-
recombinant wild-type enzyme, pH 8.0, 25°C
0.715
alpha-D-glucose 1-phosphate
-
pH 7.5, 37°C, recombinant enzyme
0.742
alpha-D-glucose 1-phosphate
pH 7.5, 37°C
0.83
alpha-D-glucose 1-phosphate
-
UDP-glucose synthesis
0.83
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant enzyme
1.23
alpha-D-glucose 1-phosphate
-
wild-type enzyme, pH 7.5, 80°C
1.74
alpha-D-glucose 1-phosphate
-
mutant enzyme Y97M, pH 7.5, 80°C
2.5 - 3
alpha-D-glucose 1-phosphate
-
mutant enzyme Y97N, pH 7.5, 80°C
3.28
alpha-D-glucose 1-phosphate
-
mutant enzyme Y97V, pH 7.5, 80°C
0.19
D-glucose-1-phosphate

-
-
0.83
D-glucose-1-phosphate
-
-
0.027
diphosphate

-
Y192A mutant protein
0.03
diphosphate
-
pyrophosphorolysis
0.03
diphosphate
-
Ccut-8 mutant protein; K183A mutant protein
0.034
diphosphate
recombinant wild-type, pH 7.6, 25°C
0.039
diphosphate
-
wild-type protein
0.04
diphosphate
-
K332A mutant protein
0.054
diphosphate
-
pH 8.5, 37°C
0.07
diphosphate
-
pyrophosphorolysis
0.084
diphosphate
-
pH 7.8
0.09
diphosphate
-
Ncut-21 mutant protein
0.11 - 0.13
diphosphate
-
pH 8.0, 30°C
0.11 - 0.13
diphosphate
-
at physiological substrate concentration, pH 8.5, 37°C
0.17
diphosphate
-
pH 8.35, 25°C
0.18
diphosphate
-
non-galactosemic phenotype, pH 7.8, 37°C
0.2
diphosphate
-
galactosemic phenotype, pH 7.8, 37°C
0.2
diphosphate
pH 7.8, 25°C
0.21
diphosphate
-
pH 7.8
0.24
diphosphate
-
K405A mutant protein
0.376
diphosphate
pH 7.5, 37°C
0.407
diphosphate
recombinant mutant C99S, pH 7.6, 25°C
0.9
diphosphate
-
Ncut-37 mutant protein
2.4
diphosphate
-
pH 7.6, 37°C
4.9
diphosphate
-
K260A mutant protein
6.4
diphosphate
-
Ccut-32 mutant protein
9.8
diphosphate
-
Ccut-67 mutant protein
29.4
diphosphate
-
Delta 1-4 mutant protein
33.3
diphosphate
-
Ccut-101 mutant protein
60
diphosphate
-
Delta 1-8 mutant protein
0.33
Mg-diphosphate

-
pH 7.2, 30°C
0.56
Mg-diphosphate
-
pyrophosphorolysis
0.58
Mg2+

pyrophosphorolysis direction
0.35
TTP

-
0.9
TTP
S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
0.26
UDP-galactose

pH 7.5, 30°C
0.42
UDP-galactose
-
pH 7.8
0.00167
UDP-glucose

pH 7.5, temperature not specified in the publication
0.00433
UDP-glucose
pH 7.5, temperature not specified in the publication
0.03
UDP-glucose
-
Ccut-8 mutant protein; K183A mutant protein; K332A mutant protein
0.031
UDP-glucose
-
Y192A mutant protein
0.034
UDP-glucose
-
wild-type protein
0.035
UDP-glucose
-
30°C, pH 8.0
0.04
UDP-glucose
-
pyrophosphorolysis
0.04
UDP-glucose
-
K405A mutant protein
0.05 - 0.066
UDP-glucose
-
-
0.05 - 0.066
UDP-glucose
-
-
0.05 - 0.066
UDP-glucose
-
pH 7.8
0.05 - 0.066
UDP-glucose
-
-
0.05 - 0.066
UDP-glucose
-
pH 7.6, 37°C
0.06
UDP-glucose
-
pyrophosphorolysis
0.065
UDP-glucose
recombinant wild-type, pH 7.6, 25°C
0.074
UDP-glucose
-
K260A mutant protein
0.101
UDP-glucose
recombinant mutant C99S, pH 7.6, 25°C
0.105
UDP-glucose
pH 7.8, 25°C
0.11
UDP-glucose
pH 7.5, 30°C
0.118
UDP-glucose
-
Ccut-101 mutant protein
0.12 - 0.18
UDP-glucose
-
pH 8.0, 30°C
0.12 - 0.18
UDP-glucose
-
at physiological substrate concentrations, pH 8.5, 37°C
0.14
UDP-glucose
-
non-galactosemic phenotype, pH 7.8, 37°C
0.18
UDP-glucose
-
galactosemic phenotype, pH 7.8, 37°C
0.19
UDP-glucose
-
pH 8.35, 25°C
0.31
UDP-glucose
-
Ccut-32 mutant protein
0.362
UDP-glucose
-
Ccut-67 mutant protein
0.503
UDP-glucose
-
Delta 1-8 mutant protein
0.555
UDP-glucose
-
Delta 1-4 mutant protein
0.68
UDP-glucose
-
pyrophosphorolysis
0.774
UDP-glucose
pH 7.5, temperature not specified in the publication
1.1
UDP-glucose
-
Ncut-21 mutant protein
3.04
UDP-glucose
pH 7.5, 37°C
57
UDP-glucose
-
Ncut-37 mutant protein
0.0075
UTP

-
isoenzyme UgpG, 30°C, pH 7.8
0.025
UTP
-
pH 7.5, temperature not specified in the publication
0.053
UTP
pH 7.2, temperature not specified in the publication, recombinant enzyme
0.058 - 0.07
UTP
-
pH 7.8, 37°C
0.058 - 0.07
UTP
-
pH 8.0, 37°C
0.08
UTP
-
UDP-glucose synthesis
0.08
UTP
cosubstrate alpha-D-galactose 1-phosphate, S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
0.093
UTP
-
pH 8.35, 25°C
0.1 - 0.2
UTP
-
pH 7.5, 30°C
0.1 - 0.2
UTP
-
pH 8.0, 30°C
0.1 - 0.2
UTP
-
at physiological substrate concentrations, pH 8.5, 37°C
0.14
UTP
S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
0.17
UTP
-
UDP-glucose synthesis
0.18
UTP
wild-type, pH 7.5, 37°C
0.229
UTP
-
isoenzyme RmlA, 30°C, pH 7.8
0.35
UTP
mutant A8G, pH 7.5, 37°C
0.53
UTP
-
at substrate concentrations above 2 mM, pH 8.5, 37°C
additional information
additional information

-
kinetics
-
additional information
additional information
-
two-substrate kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetics
-
additional information
additional information
Michaelis-Menten kinetics, overview
-
additional information
additional information
-
Michaelis-Menten kinetics, overview
-
additional information
additional information
-
kinetics, overview
-
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