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Information on EC 2.7.7.79 - tRNAHis guanylyltransferase

for references in articles please use BRENDA:EC2.7.7.79
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EC Tree
IUBMB Comments
In eukarya an additional guanosine residue is added post-transcriptionally to the 5'-end of tRNAHis molecules. The addition occurs opposite a universally conserved adenosine73 and is thus the result of a non-templated 3'-5' addition reaction. The additional guanosine residue is an important determinant for aminoacylation by EC 6.1.1.21, histidyl-tRNA ligase. The enzyme requires a divalent cation for activity . ATP activation is not required when the substrate contains a 5'-triphosphate (ppp-tRNAHis) .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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p-tRNAHis
+
+
+
=
pGp-tRNAHis
+
+
2
p-tRNAHis
+
=
App-tRNAHis
+
App-tRNAHis
+
=
pppGp-tRNAHis
+
Synonyms
thg1p, thg1l, histidine trna guanylyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
App-tRNAHis + GTP = pppGp-tRNAHis + AMP
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p-tRNAHis + ATP + GTP + H2O = pGp-tRNAHis + AMP + 2 diphosphate
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p-tRNAHis + ATP = App-tRNAHis + diphosphate
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pppGp-tRNAHis + H2O = pGp-tRNAHis + diphosphate
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(1c)
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-
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