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Information on EC 2.7.7.72 - CCA tRNA nucleotidyltransferase

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IUBMB Comments
The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
hide(3 overall reactions are displayed. Show all (4)>>)
a tRNA precursor
+
=
a tRNA with a 3' cytidine end
+
a tRNA with a 3' cytidine
+
=
a tRNA with a 3' CC end
+
a tRNA with a 3' CC end
+
=
a tRNA with a 3' CCA end
+
Synonyms
cca-adding enzyme, trnt1, cca enzyme, atp(ctp):trna nucleotidyltransferase, class i cca-adding enzyme, trna-nt, ccase, afcca, class ii cca-adding enzyme, ntsfii, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate
show the reaction diagram
a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate
show the reaction diagram
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a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate
show the reaction diagram
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a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate
show the reaction diagram
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