Reference on EC 2.7.7.65 - diguanylate cyclase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ausmees, N.; Mayer, R.; Weinhouse, H.; Volman, G.; Amikam, D.; Benziman, M.; Lindberg, M.
Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity
FEMS Microbiol. Lett.
204
163-167
2001
Escherichia coli, Komagataeibacter xylinus, Rhizobium leguminosarum
Paul, R.; Weiser, S.; Amiot, N.C.; Chan, C.; Schirmer, T.; Giese, B.; Jenal, U.
Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain
Genes Dev.
18
715-727
2004
Caulobacter vibrioides
Tal, R.; Wong, H.C.; Calhoon, R.; Gelfand, D.; Fear, A.L.; Volman, G.; Mayer, R.; Ross, P.; Amikam, D.; Weinhouse, H.; Cohen, A.; Sapir, S.; Ohana, P.; Benziman, M.
Three cdg operons control cellular turnover of cyclic di-GMP in Acetobacter xylinum: genetic organization and occurrence of conserved domains in isoenzymes
J. Bacteriol.
180
4416-4425
1998
Komagataeibacter xylinus
Ryjenkov, D.A.; Tarutina, M.; Moskvin, O.V.; Gomelsky, M.
Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain
J. Bacteriol.
187
1792-1798
2005
Borreliella burgdorferi, Cereibacter sphaeroides, Cereibacter sphaeroides RSP3513
O'Shea, T.M.; Klein, A.H.; Geszvain, K.; Wolfe, A.J.; Visick, K.L.
Diguanylate cyclases control magnesium-dependent motility of Vibrio fischeri
J. Bacteriol.
188
8196-8205
2006
Aliivibrio fischeri
Kuchma, S.L.; Brothers, K.M.; Merritt, J.H.; Liberati, N.T.; Ausubel, F.M.; O'Toole, G.A.
BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14
J. Bacteriol.
189
8165-8178
2007
Pseudomonas aeruginosa
Christen, B.; Christen, M.; Paul, R.; Schmid, F.; Folcher, M.; Jenoe, P.; Meuwly, M.; Jenal, U.
Allosteric control of cyclic di-GMP signaling
J. Biol. Chem.
281
32015-32024
2006
Caulobacter vibrioides (Q9A3B9)
Mendez-Ortiz, M.M.; Hyodo, M.; Hayakawa, Y.; Membrillo-Hernandez, J.
Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3', 5'-cyclic diguanylic acid. [Erratum to document cited in CA144:426702]
J. Biol. Chem.
282
22248
2007
Escherichia coli
-
Paul, R.; Abel, S.; Wassmann, P.; Beck, A.; Heerklotz, H.; Jenal, U.
Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization
J. Biol. Chem.
282
29170-29177
2007
Caulobacter vibrioides, Caulobacter vibrioides (Q9A5I5)
Andrade, M.O.; Alegria, M.C.; Guzzo, C.R.; Docena, C.; Rosa, M.C.P.; Ramos, C.H.I.; Farah, C.S.
The HD-GYP domain of RpfG mediates a direct linkage between the Rpf quorum-sensing pathway and a subset of diguanylate cyclase proteins in the phytopathogen Xanthomonas axonopodis pv citri
Mol. Microbiol.
62
537-551
2006
Xanthomonas axonopodis
Ohana, P.; Delmer, D.P.; Carlson, R.W.; Glushka, J.; Azadi, P.; Bacic, T.; Benziman, M.
Identification of a novel triterpenoid saponin from Pisum sativum as a specific inhibitor of the diguanylate cyclase of Acetobacter xylinum
Plant Cell Physiol.
39
144-152
1998
Komagataeibacter xylinus
Ohana, P.; Delmer, D.P.; Volman, G.; Benziman, M.
Glycosylated triterpenoid saponin: a specific inhibitor of diguanylate cyclase from Acetobacter xylinum. Biological activity and distribution
Plant Cell Physiol.
39
153-159
1998
Komagataeibacter xylinus
-
Chan, C.; Paul, R.; Samoray, D.; Amiot, N.C.; Giese, B.; Jenal, U.; Schirmer, T.
Structural basis of activity and allosteric control of diguanylate cyclase
Proc. Natl. Acad. Sci. USA
101
17084-17089
2004
Caulobacter vibrioides
Wassmann, P.; Chan, C.; Paul, R.; Beck, A.; Heerklotz, H.; Jenal, U.; Schirmer, T.
Structure of BeF3--modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition
Structure
15
915-927
2007
Caulobacter vibrioides, Caulobacter vibrioides (Q9A5I5)
Neunuebel, M.R.; Golden, J.W.
The Anabaena sp. strain PCC 7120 gene all2874 encodes a diguanylate cyclase and is required for normal heterocyst development under high-light growth conditions
J. Bacteriol.
190
6829-6836
2008
Anabaena sp.
De, N.; Pirruccello, M.; Krasteva, P.V.; Bae, N.; Raghavan, R.V.; Sondermann, H.
Phosphorylation-independent regulation of the diguanylate cyclase WspR
PLoS Biol.
6
601-617
2008
Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas syringae, Pseudomonas syringae DC3000, Pseudomonas putida KT 2240, Pseudomonas fluorescens PfO-1
Rao, F.; Pasunooti, S.; Ng, Y.; Zhuo, W.; Lim, L.; Liu, A.W.; Liang, Z.X.
Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase
Anal. Biochem.
389
138-142
2009
Thermotoga maritima (Q9X2A8)
Antoniani, D.; Bocci, P.; Maciag, A.; Raffaelli, N.; Landini, P.
Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors
Appl. Microbiol. Biotechnol.
85
1095-1104
2010
Escherichia coli
Tuckerman, J.R.; Gonzalez, G.; Sousa, E.H.; Wan, X.; Saito, J.A.; Alam, M.; Gilles-Gonzalez, M.A.
An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control
Biochemistry
48
9764-9774
2009
Escherichia coli (P0AA89), Escherichia coli
Sawai, H.; Yoshioka, S.; Uchida, T.; Hyodo, M.; Hayakawa, Y.; Ishimori, K.; Aono, S.
Molecular oxygen regulates the enzymatic activity of a heme-containing diguanylate cyclase (HemDGC) for the synthesis of cyclic di-GMP
Biochim. Biophys. Acta
1804
166-172
2010
Desulfotalea psychrophila (Q6ARU5), Desulfotalea psychrophila
Lai, T.H.; Kumagai, Y.; Hyodo, M.; Hayakawa, Y.; Rikihisa, Y.
The Anaplasma phagocytophilum PleC histidine kinase and PleD diguanylate cyclase two-component system and role of cyclic Di-GMP in host cell infection
J. Bacteriol.
191
693-700
2009
Anaplasma phagocytophilum (Q2GKF8), Anaplasma phagocytophilum
De, N.; Navarro, M.V.; Raghavan, R.V.; Sondermann, H.
Determinants for the activation and autoinhibition of the diguanylate cyclase response regulator WspR
J. Mol. Biol.
393
619-633
2009
Pseudomonas syringae
Sambanthamoorthy, K.; Sloup, R.E.; Parashar, V.; Smith, J.M.; Kim, E.E.; Semmelhack, M.F.; Neiditch, M.B.; Waters, C.M.
Identification of small molecules that antagonize diguanylate cyclase enzymes to inhibit biofilm formation
Antimicrob. Agents Chemother.
56
5202-5211
2012
Pseudomonas aeruginosa, Vibrio cholerae (Q9KPJ7), Vibrio cholerae
Zaehringer, F.; Massa, C.; Schirmer, T.
Efficient enzymatic production of the bacterial second messenger c-di-GMP by the diguanylate cyclase YdeH from E. coli
Appl. Biochem. Biotechnol.
163
71-79
2011
Escherichia coli
Tran, N.T.; Den Hengst, C.D.; Gomez-Escribano, J.P.; Buttner, M.J.
Identification and characterization of CdgB, a diguanylate cyclase involved in developmental processes in Streptomyces coelicolor
J. Bacteriol.
193
3100-3108
2011
Streptomyces coelicolor
Newell, P.; Yoshioka, S.; Hvorecny, K.; Monds, R.; OToole, G.
Systematic analysis of diguanylate cyclases that promote biofilm formation by Pseudomonas fluorescens Pf0-1
J. Bacteriol.
193
4685-4698
2011
Pseudomonas fluorescens, Pseudomonas fluorescens (Q3K751), Pseudomonas fluorescens (Q3KFC4)
Korovashkina, A.; Rymko, A.; Kvach, S.; Zinchenko, A.
Enzymatic synthesis of c-di-GMP using inclusion bodies of Thermotoga maritima full-length diguanylate cyclase
J. Biotechnol.
164
276-280
2013
Thermotoga maritima
Pasunooti, S.; Surya, W.; Tan, S.; Liang, Z.
Sol-gel immobilization of a thermophilic diguanylate cyclase for enzymatic production of cyclic-di-GMP
J. Mol. Catal. B
67
98-103
2010
Thermotoga maritima
-
Spangler, C.; Kaever, V.; Seifert, R.
Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2,(3)-substituted purine and pyrimidine nucleotides
J. Pharmacol. Exp. Ther.
336
234-241
2011
Escherichia coli
Vorobiev, S.M.; Neely, H.; Yu, B.; Seetharaman, J.; Xiao, R.; Acton, T.B.; Montelione, G.T.; Hunt, J.F.
Crystal structure of a catalytically active GG(D/E)EF diguanylate cyclase domain from Marinobacter aquaeolei with bound c-di-GMP product
J. Struct. Funct. Genomics
13
177-183
2012
Marinobacter nauticus (A1U3W3)
Merritt, J.; Ha, D.; Cowles, K.; Lu, W.; Morales, D.; Rabinowitz, J.; Gitai, Z.; O'Toole, G.
Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases
mBio
1
e00183
2010
Pseudomonas aeruginosa (Q9HW69), Pseudomonas aeruginosa (Q9I4M8), Pseudomonas aeruginosa
Tagliabue, L.; Antoniani, D.; Maciag, A.; Bocci, P.; Raffaelli, N.; Landini, P.
The diguanylate cyclase YddV controls production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through regulation of the PNAG biosynthetic pgaABCD operon
Microbiology
156
2901-2911
2010
Escherichia coli
Liu, N.; Pak, T.; Boon, E.M.
Characterization of a diguanylate cyclase from Shewanella woodyi with cyclase and phosphodiesterase activities
Mol. Biosyst.
6
1561-1564
2010
Shewanella woodyi
Kostick, J.L.; Szkotnicki, L.T.; Rogers, E.A.; Bocci, P.; Raffaelli, N.; Marconi, R.T.
The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes
Mol. Microbiol.
81
219-231
2011
Borreliella burgdorferi
Tarnawski, M.; Barends, T.R.; Schlichting, I.
Structural analysis of an oxygen-regulated diguanylate cyclase
Acta Crystallogr. Sect. D
71
2158-2177
2015
Escherichia coli (P0AA89), Escherichia coli
Hunter, J.; Severin, G.; Koestler, B.; Waters, C.
The Vibrio cholerae diguanylate cyclase VCA0965 has an AGDEF active site and synthesizes cyclic di-GMP
BMC Microbiol.
14
22
2014
Vibrio cholerae serotype O1, Vibrio cholerae serotype O1 C6706str2
Aragon, I.M.; Perez-Mendoza, D.; Moscoso, J.A.; Faure, E.; Guery, B.; Gallegos, M.T.; Filloux, A.; Ramos, C.
Diguanylate cyclase DgcP is involved in plant and human Pseudomonas spp. infections
Environ. Microbiol.
17
4332-4351
2015
Pseudomonas savastanoi pv. savastanoi, Pseudomonas aeruginosa (S0JAX7), Pseudomonas aeruginosa, Pseudomonas savastanoi pv. savastanoi NCPPB 3335, Pseudomonas aeruginosa PAK (S0JAX7)
Chaudhuri, S.; Pratap, S.; Paromov, V.; Li, Z.; Mantri, C.K.; Xie, H.
Identification of a diguanylate cyclase and its role in Porphyromonas gingivalis virulence
Infect. Immun.
82
2728-2735
2014
Porphyromonas gingivalis (B2RM56), Porphyromonas gingivalis, Porphyromonas gingivalis DSM 20709 (B2RM56)
Barnhart, D.M.; Su, S.; Farrand, S.K.
A signaling pathway involving the diguanylate cyclase CelR and the response regulator DivK controls cellulose synthesis in Agrobacterium tumefaciens
J. Bacteriol.
196
1257-1274
2014
Agrobacterium tumefaciens
Petrova, O.E.; Cherny, K.E.; Sauer, K.
The Pseudomonas aeruginosa diguanylate cyclase GcbA, a homolog of P. fluorescens GcbA, promotes initial attachment to surfaces, but not biofilm formation, via regulation of motility
J. Bacteriol.
196
2827-2841
2014
Pseudomonas aeruginosa, Pseudomonas fluorescens
Enomoto, G.; Nomura, R.; Shimada, T.; Ni-Ni-Win, T.; Narikawa, R.; Ikeuchi, M.
Cyanobacteriochrome SesA is a diguanylate cyclase that induces cell aggregation in Thermosynechococcus
J. Biol. Chem.
289
24801-24809
2014
Thermosynechococcus vestitus (Q8DKD5)
Oliveira, M.C.; Teixeira, R.D.; Andrade, M.O.; Pinheiro, G.M.; Ramos, C.H.; Farah, C.S.
Cooperative substrate binding by a diguanylate cyclase
J. Mol. Biol.
427
415-432
2015
Xanthomonas citri pv. citri (Q8PPS5), Xanthomonas citri pv. citri
Huangyutitham, V.; Guevener, Z.T.; Harwood, C.S.
Subcellular clustering of the phosphorylated WspR response regulator protein stimulates its diguanylate cyclase activity
MBio
4
e00242
2013
Pseudomonas aeruginosa (Q9HXT9), Pseudomonas aeruginosa
Engl, C.; Waite, C.J.; McKenna, J.F.; Bennett, M.H.; Hamann, T.; Buck, M.
Chp8, a diguanylate cyclase from Pseudomonas syringae pv. Tomato DC3000, suppresses the pathogen-associated molecular pattern flagellin, increases extracellular polysaccharides, and promotes plant immune evasion
MBio
5
e01168
2014
Pseudomonas syringae pv. tomato, Pseudomonas syringae pv. tomato DC3000
Dahlstrom, K.M.; Giglio, K.M.; Collins, A.J.; Sondermann, H.; OToole, G.A.
Contribution of physical interactions to signaling specificity between a diguanylate cyclase and its effector
MBio
6
e01978-15
2015
Pseudomonas fluorescens (Q3K751), Pseudomonas fluorescens, Pseudomonas fluorescens Pf0-1 (Q3K751)
Kim, H.; Harshey, R.
A diguanylate cyclase acts as a cell division inhibitor in a two-step response to reductive and envelope stresses
MBio
7
e00822
2016
Escherichia coli (P46139)
-
Rotcheewaphan, S.; Belisle, J.T.; Webb, K.J.; Kim, H.J.; Spencer, J.S.; Borlee, B.R.
Diguanylate cyclase activity of the Mycobacterium leprae T cell antigen ML1419c
Microbiology
162
1651-1661
2016
Mycobacterium leprae (Q7AQ57), Mycobacterium leprae, Mycobacterium leprae TN (Q7AQ57)
Deepthi, A.; Liew, C.W.; Liang, Z.X.; Swaminathan, K.; Lescar, J.
Structure of a diguanylate cyclase from Thermotoga maritima: insights into activation, feedback inhibition and thermostability
PLoS ONE
9
e110912
2014
Thermotoga maritima (Q9X2A8), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9X2A8)
Ramirez-Mata, A.; Lopez-Lara, L.I.; Xiqui-Vazquez, M.L.; Jijon-Moreno, S.; Romero-Osorio, A.; Baca, B.E.
The cyclic-di-GMP diguanylate cyclase CdgA has a role in biofilm formation and exopolysaccharide production in Azospirillum brasilense
Res. Microbiol.
167
190-201
2016
Azospirillum brasilense (A0A0Y0RFK5), Azospirillum brasilense, Azospirillum brasilense Sp7 (A0A0Y0RFK5), Azospirillum brasilense Sp7
Wu, C.; Cheng, Y.Y.; Yin, H.; Song, X.N.; Li, W.W.; Zhou, X.X.; Zhao, L.P.; Tian, L.J.; Han, J.C.; Yu, H.Q.
Oxygen promotes biofilm formation of Shewanella putrefaciens CN32 through a diguanylate cyclase and an adhesin
Sci. Rep.
3
1945
2013
Shewanella putrefaciens, Shewanella putrefaciens CN32
Su, J.; Zou, X.; Huang, L.; Bai, T.; Liu, S.; Yuan, M.; Chou, S.H.; He, Y.W.; Wang, H.; He, J.
DgcA, a diguanylate cyclase from Xanthomonas oryzae pv. oryzae regulates bacterial pathogenicity on rice
Sci. Rep.
6
25978
2016
Xanthomonas oryzae pv. oryzae (Q5GVN1), Xanthomonas oryzae pv. oryzae, Xanthomonas oryzae pv. oryzae KXO85 (Q5GVN1)
Chen, Y.; Liu, S.; Liu, C.; Huang, Y.; Chi, K.; Su, T.; Zhu, D.; Peng, J.; Xia, Z.; He, J.; Xu, S.; Hu, W.; Gu, L.
Dcsbis (PA2771) from Pseudomonas aeruginosa is a highly active diguanylate cyclase with unique activity regulation
Sci. Rep.
6
29499
2016
Pseudomonas aeruginosa (Q9I072), Pseudomonas aeruginosa, Pseudomonas aeruginosa DSM 22644 (Q9I072)
Zaehringer, F.; Lacanna, E.; Jenal, U.; Schirmer, T.; Boehm, A.
Structure and signaling mechanism of a zinc-sensory diguanylate cyclase
Structure
21
1149-1157
2013
Escherichia coli (P31129), Escherichia coli
Dahlstrom, K.M.; O'Toole, G.A.
A symphony of cyclases specificity in diguanylate cyclase signaling
Annu. Rev. Microbiol.
71
179-195
2017
Caulobacter vibrioides, Clostridioides difficile, Pseudomonas aeruginosa, Burkholderia cenocepacia, Vibrio cholerae serotype O1, Komagataeibacter xylinus (O87374), Escherichia coli (P0AA89), Vibrio cholerae serotype O1 A1552
Poudyal, B.; Sauer, K.
The PA3177 gene encodes an active diguanylate cyclase that contributes to biofilm antimicrobial tolerance but not biofilm formation by Pseudomonas aeruginosa
Antimicrob. Agents Chemother.
62
e01049-18
2018
Pseudomonas aeruginosa (Q9HZ57), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (Q9HZ57), Pseudomonas aeruginosa 1C (Q9HZ57), Pseudomonas aeruginosa PRS 101 (Q9HZ57), Pseudomonas aeruginosa DSM 22644 (Q9HZ57), Pseudomonas aeruginosa CIP 104116 (Q9HZ57), Pseudomonas aeruginosa LMG 12228 (Q9HZ57), Pseudomonas aeruginosa JCM 14847 (Q9HZ57)
Zhu, B.; Liu, C.; Liu, S.; Cong, H.; Chen, Y.; Gu, L.; Ma, L.Z.
Membrane association of SadC enhances its diguanylate cyclase activity to control exopolysaccharides synthesis and biofilm formation in Pseudomonas aeruginosa
Environ. Microbiol.
18
3440-3452
2016
Pseudomonas aeruginosa (Q9HW69), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (Q9HW69), Pseudomonas aeruginosa 1C (Q9HW69), Pseudomonas aeruginosa PRS 101 (Q9HW69), Pseudomonas aeruginosa DSM 22644 (Q9HW69), Pseudomonas aeruginosa CIP 104116 (Q9HW69), Pseudomonas aeruginosa LMG 12228 (Q9HW69), Pseudomonas aeruginosa JCM 14847 (Q9HW69)
Xiao, Y.; Liu, H.; He, M.; Nie, L.; Nie, H.; Chen, W.; Huang, Q.
A crosstalk between c-di-GMP and cAMP in regulating transcription of GcsA, a diguanylate cyclase involved in swimming motility in Pseudomonas putida
Environ. Microbiol.
22
142-157
2020
Pseudomonas putida, Pseudomonas putida (Q88GL0), Pseudomonas putida DSM 6125, Pseudomonas putida DSM 6125 (Q88GL0), Pseudomonas putida NCIMB 11950 (Q88GL0), Pseudomonas putida ATCC 47054 (Q88GL0)
Biswas, S.; Chouhan, O.; Bandekar, D.
Diguanylate cyclases in Vibrio cholerae essential regulators of lifestyle switching
Front. Cell. Infect. Microbiol.
10
582947
2020
Vibrio cholerae, Vibrio cholerae serotype O1 (A0A0H3AFM6), Vibrio cholerae serotype O1 (Q9KKY5), Vibrio cholerae serotype O1 El Tor Inaba N16961 (Q9KKY5), Vibrio cholerae serotype O1 Classical Ogawa 395 (A0A0H3AFM6), Vibrio cholerae serotype O1 ATCC 39541 (A0A0H3AFM6), Vibrio cholerae serotype O1 O395 (A0A0H3AFM6), Vibrio cholerae serotype O1 ATCC 39315 (Q9KKY5)
Biswas, S.; Chouhan, O.; Bandekar, D.
Diguanylate cyclases in Vibrio cholerae essential regulators of lifestyle switching
Front. Cell. Infect. Microbiol.
10
582947s
2020
Vibrio cholerae
Cho, K.H.; Tryon, R.G.; Kim, J.H.
Screening for diguanylate cyclase (DGC) inhibitors mitigating bacterial biofilm formation
Front. Chem.
8
264
2020
Caulobacter vibrioides (A0A0H3CCZ8), Caulobacter vibrioides (B8GZM2), Clostridioides difficile (A0A170Y3L9), Komagataeibacter xylinus (O87374), Synechocystis sp. PCC 6803 (P73272), Salmonella enterica subsp. enterica serovar Typhimurium (Q8ZNT5), Pseudomonas aeruginosa (Q9HT84), Pseudomonas aeruginosa (Q9HXT9), Vibrio cholerae serotype O1 (Q9KKZ4), Caulobacter vibrioides CB15N (A0A0H3CCZ8), Pseudomonas aeruginosa ATCC 15692 (Q9HT84), Pseudomonas aeruginosa ATCC 15692 (Q9HXT9), Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 (Q8ZNT5), Caulobacter vibrioides NA1000 (A0A0H3CCZ8), Caulobacter vibrioides NA1000 (B8GZM2), Pseudomonas aeruginosa 1C (Q9HT84), Pseudomonas aeruginosa 1C (Q9HXT9), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (Q8ZNT5), Pseudomonas aeruginosa PRS 101 (Q9HT84), Pseudomonas aeruginosa PRS 101 (Q9HXT9), Pseudomonas aeruginosa DSM 22644 (Q9HT84), Pseudomonas aeruginosa DSM 22644 (Q9HXT9), Pseudomonas aeruginosa CIP 104116 (Q9HT84), Pseudomonas aeruginosa CIP 104116 (Q9HXT9), Pseudomonas aeruginosa LMG 12228 (Q9HT84), Pseudomonas aeruginosa LMG 12228 (Q9HXT9), Vibrio cholerae serotype O1 El Tor Inaba N16961 (Q9KKZ4), Pseudomonas aeruginosa JCM 14847 (Q9HT84), Pseudomonas aeruginosa JCM 14847 (Q9HXT9), Vibrio cholerae serotype O1 ATCC 39315 (Q9KKZ4)
Zhang, Y.; Guo, J.; Zhang, N.; Yuan, W.; Lin, Z.; Huang, W.
Characterization and analysis of a novel diguanylate cyclase PA0847 from Pseudomonas aeruginosa PAO1
Infect. Drug Resist.
12
655-665
2019
Pseudomonas aeruginosa (Q9I594), Pseudomonas aeruginosa ATCC 15692 (Q9I594), Pseudomonas aeruginosa 1C (Q9I594), Pseudomonas aeruginosa PRS 101 (Q9I594), Pseudomonas aeruginosa DSM 22644 (Q9I594), Pseudomonas aeruginosa CIP 104116 (Q9I594), Pseudomonas aeruginosa LMG 12228 (Q9I594), Pseudomonas aeruginosa JCM 14847 (Q9I594)
Fernicola, S.; Paiardini, A.; Giardina, G.; Rampioni, G.; Leoni, L.; Cutruzzolxa0, F.; Rinaldo, S.
In silico discovery and in vitro validation of catechol-containing sulfonohydrazide compounds as potent inhibitors of the diguanylate cyclase PleD
J. Bacteriol.
198
147-156
2016
Pseudomonas aeruginosa (A0A0C7ADU5), Pseudomonas aeruginosa (Q9HXT9), Caulobacter vibrioides (Q9A5I5), Caulobacter vibrioides, Pseudomonas aeruginosa ATCC 15692 (Q9HXT9), Caulobacter vibrioides ATCC 19089 (Q9A5I5), Pseudomonas aeruginosa 1C (Q9HXT9), Caulobacter vibrioides CB15 (Q9A5I5), Pseudomonas aeruginosa PRS 101 (Q9HXT9), Pseudomonas aeruginosa DSM 22644 (Q9HXT9), Pseudomonas aeruginosa CIP 104116 (Q9HXT9), Pseudomonas aeruginosa LMG 12228 (Q9HXT9), Pseudomonas aeruginosa JCM 14847 (Q9HXT9)
Dahlstrom, K.M.; Giglio, K.M.; Sondermann, H.; OToole, G.A.
The inhibitory site of a diguanylate cyclase is a necessary element for interaction and signaling with an effector protein
J. Bacteriol.
198
1595-1603
2016
Pseudomonas fluorescens (Q3K751), Pseudomonas fluorescens, Pseudomonas fluorescens Pfl01 (Q3K751)
Lacanna, E.; Bigosch, C.; Kaever, V.; Boehm, A.; Becker, A.
Evidence for Escherichia coli diguanylate cyclase DgcZ interlinking surface sensing and adhesion via multiple regulatory routes
J. Bacteriol.
198
2524-2535
2016
Escherichia coli (P31129), Escherichia coli
Lengalova, A.; Fojtikova-Proskova, V.; Vavra, J.; Martinek, V.; Stranava, M.; Shimizu, T.; Martinkova, M.
Kinetic analysis of a globin-coupled diguanylate cyclase, YddV effects of heme iron redox state, axial ligands, and heme distal mutations on catalysis
J. Inorg. Biochem.
201
110833
2019
Escherichia coli (P0AA89), Escherichia coli
da Costa Vasconcelos, F.N.; Maciel, N.K.; Favaro, D.C.; de Oliveira, L.C.; Barbosa, A.S.; Salinas, R.K.; de Souza, R.F.; Farah, C.S.; Guzzo, C.R.
Structural and enzymatic characterization of a cAMP-dependent diguanylate cyclase from pathogenic Leptospira species
J. Mol. Biol.
429
2337-2352
2017
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni Fiocruz L1-130 (Q72MQ6)
Angerer, V.; Schwenk, P.; Wallner, T.; Kaever, V.; Hiltbrunner, A.; Wilde, A.
The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2
Microbiology
163
920-930
2017
Synechocystis sp. PCC 6803 (P73272)
Yuan, X.; Tian, F.; He, C.; Severin, G.B.; Waters, C.M.; Zeng, Q.; Liu, F.; Yang, C.H.
The diguanylate cyclase GcpA inhibits the production of pectate lyases via the H-NS protein and RsmB regulatory RNA in Dickeya dadantii
Mol. Plant Pathol.
19
1873-1886
2018
Dickeya dadantii, Dickeya dadantii 3937
Valentini, M.; Laventie, B.J.; Moscoso, J.; Jenal, U.; Filloux, A.
The diguanylate cyclase HsbD intersects with the HptB regulatory cascade to control Pseudomonas aeruginosa biofilm and motility
PLoS Genet.
12
e1006354
2016
Pseudomonas aeruginosa (Q9HYQ2), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (Q9HYQ2)
Wan, X.; Saito, J.; Newhouse, J.; Hou, S.; Alam, M.
The importance of conserved amino acids in heme-based globin-coupled diguanylate cyclases
PLoS ONE
12
e0182782
2017
Escherichia coli (P0AA89), Escherichia coli, Bordetella pertussis (Q7VTL8), Bordetella pertussis, Bordetella pertussis Tohama I (Q7VTL8), Bordetella pertussis ATCC BAA-589 (Q7VTL8), Bordetella pertussis NCTC 13251 (Q7VTL8)
Kuang, S.; Yuan, Y.; Wu, Z.; Peng, R.
Expression, purification and characterization of diguanylate cyclase from Rhodococcus ruber
Protein Expr. Purif.
163
105441
2019
Rhodococcus ruber, Rhodococcus ruber SD3
Xu, M.; Wang, Y.Z.; Yang, X.A.; Jiang, T.; Xie, W.
Structural studies of the periplasmic portion of the diguanylate cyclase CdgH from Vibrio cholerae
Sci. Rep.
7
1861
2017
Vibrio cholerae serotype O1 (Q9KT38), Vibrio cholerae serotype O1 El Tor Inaba N16961 (Q9KT38), Vibrio cholerae serotype O1 ATCC 39315 (Q9KT38)
Muriel, C.; Blanco-Romero, E.; Trampari, E.; Arrebola, E.; Duran, D.; Redondo-Nieto, M.; Malone, J.G.; Martin, M.; Rivilla, R.
The diguanylate cyclase AdrA regulates flagellar biosynthesis in Pseudomonas fluorescens F113 through SadB
Sci. Rep.
9
8096
2019
Pseudomonas fluorescens, Pseudomonas fluorescens F113
html completed
