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Disease on EC 2.7.7.19 - polynucleotide adenylyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
Cytokines stimulate expression of inducible nitric oxide synthase in DLD-1 human adenocarcinoma cells by activating poly(A) polymerase.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Amebiasis
Amino acid residues Leu135 and Tyr236 are required for RNA binding activity of CFIm25 in Entamoeba histolytica.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Arthritis, Rheumatoid
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Ataxia
A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.
Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.
Defective Mitochondrial mRNA Maturation Is Associated with Spastic Ataxia.
Autoimmune Diseases
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Azoospermia
The poly(A) polymerase beta gene may not be associated with azoospermia caused by Sertoli-cell-only syndrome in Japanese patients by comparing patients and normal controls.
Bone Diseases
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation.
Brain Diseases
Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.
Brain Injuries
Expression of Pancreatitis-Associated Protein after Traumatic Brain Injury: A Mechanism Potentially Contributing to Neuroprotection in Human Brain.
Breast Neoplasms
Gene expression profiles for predicting the efficacy of the anticancer drug 5-fluorouracil in breast cancer.
PAPOLA contributes to cyclin D1 mRNA alternative polyadenylation and promotes breast cancer cell proliferation.
Polyadenylate polymerase enzymatic activity in mammary tumor cytosols: A new independent prognostic marker in primary breast cancer.
Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction.
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer.
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model.
Carcinogenesis
FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer.
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer.
[Polyadenylate polymerase in the diagnosis of the early stages of chemical carcinogenesis]
Carcinoma
Early 5-fluorouracil-induced changes of poly(A) polymerase in HeLa and WISH cells.
The potential functions of FAM46C in oral squamous cell carcinoma.
Carcinoma, Ehrlich Tumor
Primer specificity of ribosome-associated poly(A) polymerase from Ehrlich ascites tumour cells.
Carcinoma, Hepatocellular
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression.
Association of newly synthesized poly(A) polymerase with four distinct polypeptides.
Association of poly(A) polymerase with U1 RNA.
Author Correction: FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Comparison of cytosolic and nuclear poly(A) polymerases from rat liver and a hepatoma: structural and immunological properties and response to NI-type protein kinases.
FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Induction of a distinct nuclear poly(A) polymerase and the production of anti-tumor poly(A) polymerase antibodies in hepatocarcinogenesis.
Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications.
Mitochondrial poly(A) polymerase from a poorly differentiated hepatoma: purification and characteristics.
NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling.
Nuclear poly(A) polymerase from rat liver and a hepatoma. Comparison of properties, molecular weights and amino acid compositions.
Phosphorylation and immunology of poly(A) polymerase.
Phosphorylation of nuclear poly(A) polymerase. Comparison of liver and hepatoma enzymes.
Polyadenylate polymerases from normal and cancer cells and their potential role in messenger RNA processing: a review.
Purification and characterization of a nuclear protein kinase from rat liver and a hepatoma that is capable of activating poly(A) polymerase.
Structural and immunological identity of rat hepatoma and fetal liver nuclear poly(A) polymerase.
Structurally and immunologically distinct poly(A) polymerases in rat liver. Occurrence of a tumor-type enzyme in normal liver.
Studies on the inhibition of poly(A) polymerase from rat liver and hepatoma 3924A by rifamycin SV derivatives.
Cardiomegaly
A Splicing-Independent Function of RBM10 Controls Specific 3' UTR Processing to Regulate Cardiac Hypertrophy.
Colorectal Neoplasms
FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity.
NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling.
Congenital Abnormalities
Exome sequencing identifies a nonsense mutation in Fam46a associated with bone abnormalities in a new mouse model for skeletal dysplasia.
Crohn Disease
Pancreatitis-Associated Protein I Suppresses NF-{kappa}B Activation through a JAK/STAT-Mediated Mechanism in Epithelial Cells.
Cystadenoma
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Diabetes, Gestational
miR-657 Promotes Macrophage Polarization toward M1 by Targeting FAM46C in Gestational Diabetes Mellitus.
Transcriptome meta-analysis of peripheral lymphomononuclear cells indicates that gestational diabetes is closer to type 1 diabetes than to type 2 diabetes mellitus.
Dyskeratosis Congenita
Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita.
Endometrial Neoplasms
TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.
Enzootic Bovine Leukosis
Poly (A) polymerase of bovine lymphosarcoma.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Glioblastoma
FAM46A expression is elevated in glioblastoma and predicts poor prognosis of patients.
Glioma
Identification of the Potential Biomarkers in Patients with Glioma: A Weighted Gene Co-Expression Network Analysis.
Hepatitis
Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications.
Hepatitis B
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA.
Host RNA quality control as a hepatitis B antiviral target.
The Dihydroquinolizinone Compound RG7834 Inhibits the Polyadenylase Function of PAPD5 and PAPD7 and Accelerates the Degradation of Matured Hepatitis B Virus Surface Protein mRNA.
Hepatitis C
Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2.
The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122.
Hepatitis, Chronic
Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications.
Infections
Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis.
Dramatic increase in poly(A) synthesis after infection of Molt-3 cells with HIV.
Non-ribosomal poly A polymerase in E. coli: effects of T 4 phage infection.
Quantitative Analysis of MicroRNAs in Vaccinia virus Infection Reveals Diversity in Their Susceptibility to Modification and Suppression.
The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
[HPV genotypes in repeated PAP II smears of group of women in Slovenia]
Infertility, Male
Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice†.
PAPOLB/TPAP regulates spermiogenesis independently of chromatoid body-associated factors.
Unusual structure of the double-stranded RNA associated with the '447' cytoplasmic male sterility in Vicia faba.
Leukemia
A simple and fast method for profiling microRNA expression from low-input total RNA by microarray.
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
Poly(A)-polymerase levels in leukemia.
Polyadenylic acid polymerase activity in chronic myelogenous leukemia.
Polyadenylic acid polymerase activity in normal and leukemic human leukocytes.
The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner.
[Polyadenylate polymerase in blood serum from hemoblastosis patients]
Leukemia, Lymphocytic, Chronic, B-Cell
Poly(A)-polymerase activity in chronic lymphocytic leukemia of the B cell type.
Polyadenylic acid polymerase activity in normal and leukemic human leukocytes.
Leukemia, Lymphoid
12-0-Tetradecanoylphorbol 13-acetate (TPA)-induced enzymatic change of human non-T, non-B lymphoid leukemia cell lines.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Polyadenylic acid polymerase activity in chronic myelogenous leukemia.
Liver Cirrhosis
Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications.
Liver Neoplasms, Experimental
Anti-poly(A) polymerase antibodies in the sera of tumor-bearing rats can inhibit specific cleavage and polyadenylation reactions.
Mitochondrial poly(A) polymerase from a poorly differentiated hepatoma: purification and characteristics.
Phosphorylation and immunology of poly(A) polymerase.
Purification and characterization of a nuclear protein kinase from rat liver and a hepatoma that is capable of activating poly(A) polymerase.
Structurally and immunologically distinct poly(A) polymerases in rat liver. Occurrence of a tumor-type enzyme in normal liver.
Lung Neoplasms
Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.
Lupus Erythematosus, Systemic
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Lymphoma
The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner.
Lymphoma, Follicular
Systematic analysis of the frequently amplified 2p15-p16.1 locus reveals PAPOLG as a potential proto-oncogene in follicular and transformed follicular lymphoma.
Molluscum Contagiosum
Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus.
Mouth Neoplasms
The potential functions of FAM46C in oral squamous cell carcinoma.
Multiple Myeloma
Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells.
FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases.
FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy.
FAM46C controls antibody production by the polyadenylation of immunoglobulin mRNAs and inhibits cell migration in multiple myeloma.
FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Loss of FAM46C Promotes Cell Survival in Myeloma.
Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.
The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma.
The potential functions of FAM46C in oral squamous cell carcinoma.
[The clinical significance of M proteins]
Muscle Spasticity
A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.
Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.
Defective Mitochondrial mRNA Maturation Is Associated with Spastic Ataxia.
Neoplasm Metastasis
Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression.
Neoplasms
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
Anti-poly(A) polymerase antibodies in the sera of tumor-bearing rats can inhibit specific cleavage and polyadenylation reactions.
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression.
Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells.
Cell-free synthesis of tumor-type poly(A) polymerase.
Early 5-fluorouracil-induced changes of poly(A) polymerase in HeLa and WISH cells.
FAM46A expression is elevated in glioblastoma and predicts poor prognosis of patients.
FAM46B inhibits cell proliferation and cell cycle progression in prostate cancer through ubiquitination of ?-catenin.
FAM46B Promotes Apoptosis and Inhibits Glycolysis of Prostate Cancer Through Inhibition of the MYC-LDHA Axis.
FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy.
FAM46C controls antibody production by the polyadenylation of immunoglobulin mRNAs and inhibits cell migration in multiple myeloma.
FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer.
FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer.
FAM46C suppresses gastric cancer by inhibition of Wnt/beta-catenin.
FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity.
Identification of FAM46D as a novel cancer/testis antigen using EST data and serological analysis.
Identification of the Potential Biomarkers in Patients with Glioma: A Weighted Gene Co-Expression Network Analysis.
Increased sensitivity and accuracy of a single-stranded DNA splint-mediated ligation assay (sPAT) reveals poly(A) tail length dynamics of developmentally regulated mRNAs.
Induction of a distinct nuclear poly(A) polymerase and the production of anti-tumor poly(A) polymerase antibodies in hepatocarcinogenesis.
Inhibition of mammalian and oncornavirus nucleic acid polymerase activities by alkoxybenzophenanthridine alkaloids.
Mitochondrial poly(A) polymerase from a poorly differentiated hepatoma: purification and characteristics.
MLH1-deficient HCT116 colon tumor cells exhibit resistance to the cytostatic and cytotoxic effect of the poly(A) polymerase inhibitor cordycepin (3'-deoxyadenosine) in vitro.
Molecular aspects of small molecules-poly(a) interaction: an approach to RNA based drug design.
Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline.
NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling.
Nuclear poly(A) polymerase from rat liver and a hepatoma. Comparison of properties, molecular weights and amino acid compositions.
Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells.
p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.
Pancreatitis-associated protein I (PAP I), an acute phase protein induced by cytokines. Identification of two functional interleukin-6 response elements in the rat PAP I promoter region.
PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.
PAPOLA contributes to cyclin D1 mRNA alternative polyadenylation and promotes breast cancer cell proliferation.
Phosphorylation and immunology of poly(A) polymerase.
Polyadenylate polymerase enzymatic activity in mammary tumor cytosols: A new independent prognostic marker in primary breast cancer.
Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction.
Primer specificity of ribosome-associated poly(A) polymerase from Ehrlich ascites tumour cells.
Purification and characterization of a nuclear protein kinase from rat liver and a hepatoma that is capable of activating poly(A) polymerase.
Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16.
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer.
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model.
Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.
Structurally and immunologically distinct poly(A) polymerases in rat liver. Occurrence of a tumor-type enzyme in normal liver.
The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.
The potential functions of FAM46C in oral squamous cell carcinoma.
Tissue and species distribution of liver type and tumor type nuclear poly(A) polymerases.
[Distribution of a polyadenylate synthetase in adult and embryonal normal tissues and in tumor tissues]
Neuroblastoma
Induction of polyadenylate polymerase and differentiation in neuroblastoma cells.
Obesity
A novel nuclear-encoded mitochondrial poly(A) polymerase PAPD1 is a potential candidate gene for the extreme obesity related phenotypes in mammals.
Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells.
Optic Atrophy
A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.
Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.
Defective Mitochondrial mRNA Maturation Is Associated with Spastic Ataxia.
Osteoarthritis
Genetic inactivation of ZCCHC6 suppresses IL-6 expression and reduces the severity of experimental osteoarthritis in mice.
Susceptibility to large-joint osteoarthritis (hip and knee) is associated with BAG6 rs3117582 SNP and the VNTR polymorphism in the second exon of the FAM46A gene on chromosome 6.
Osteogenesis Imperfecta
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation.
Osteosarcoma
Down-regulation of miR-10b represses cell vitality in osteosarcoma and is inversely associated with prognosis via interacting with FAM46C: Running title: MiR-10b/FAM46C axis modulates OS progression.
Pancreatitis
Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis.
Identification of a second rat pancreatitis-associated protein. Messenger RNA cloning, gene structure, and expression during acute pancreatitis.
p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.
Pancreatitis-associated protein I (PAP I), an acute phase protein induced by cytokines. Identification of two functional interleukin-6 response elements in the rat PAP I promoter region.
Pancreatitis-Associated Protein I Suppresses NF-{kappa}B Activation through a JAK/STAT-Mediated Mechanism in Epithelial Cells.
Pancreatitis-associated protein is upregulated in mouse pancreas during acute pancreatitis.
The pancreatitis-associated protein I promoter allows targeting to the pancreas of a foreign gene, whose expression is up-regulated during pancreatic inflammation.
Papillomavirus Infections
Detection of human papillomavirus DNA by the hybrid capture assay.
[Prevalence of human papillomavirus infection in Slovenian women with repeated Pap II smears]
Paraproteinemias
Compendium of FAM46C gene mutations in plasma cell dyscrasias.
Parkinson Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pneumonia
The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
Polycythemia Vera
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
polynucleotide adenylyltransferase deficiency
The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polyadenylic acid polymerase activity in normal and leukemic human leukocytes.
Prostatic Neoplasms
FAM46B inhibits cell proliferation and cell cycle progression in prostate cancer through ubiquitination of ?-catenin.
FAM46B Promotes Apoptosis and Inhibits Glycolysis of Prostate Cancer Through Inhibition of the MYC-LDHA Axis.
FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Retinal Diseases
Genetic analysis of FAM46A in Spanish families with autosomal recessive retinitis pigmentosa: characterisation of novel VNTRs.
Retinitis Pigmentosa
Genetic analysis of FAM46A in Spanish families with autosomal recessive retinitis pigmentosa: characterisation of novel VNTRs.
Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells.
Seizures
Expression of Pancreatitis-Associated Protein after Traumatic Brain Injury: A Mechanism Potentially Contributing to Neuroprotection in Human Brain.
Sepsis
FAM46C inhibits lipopolysaccharides-induced myocardial dysfunction via downregulating cellular adhesion molecules and inhibiting apoptosis.
Sjogren's Syndrome
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Small Cell Lung Carcinoma
Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.
Squamous Cell Carcinoma of Head and Neck
Induction of ZCCHC6 expression in peripheral blood mononuclear cells by HNSCC secretions.
The potential functions of FAM46C in oral squamous cell carcinoma.
Stomach Neoplasms
FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer.
FAM46C suppresses gastric cancer by inhibition of Wnt/beta-catenin.
Tuberculosis
Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis.
Uterine Cervical Neoplasms
Clinical audit of patients with cervical cancer in Slovenia--data analysis for the year 2003.
Vaccinia
A cellular factor is required for transcription of vaccinia viral intermediate-stage genes.
A polyadenylylation-specific RNA-contact site on the surface of the bifunctional vaccinia virus RNA modifying protein VP39 that is distinct from the mRNA 5' end-binding "cleft".
An Amsacta moorei entomopoxvirus ortholog of the poly(A) polymerase small subunit exhibits methyltransferase activity and is non-essential for virus growth.
Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein.
Characterization of a polyriboadenylate polymerase from vaccinia virions.
Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity.
Domain-level rocking motion within a polymerase that translocates on single-stranded nucleic acid.
Evidence that the RNA methylation and poly(A) polymerase stimulatory activities of vaccinia virus protein VP39 do not impinge upon one another.
Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus.
Inhibition of host protein synthesis by vaccinia virus: fate of cell mRNA and synthesis of small poly (A)-rich polyribonucleotides in the presence of actinomycin D.
Interaction between the J3R subunit of vaccinia virus poly(A) polymerase and the H4L subunit of the viral RNA polymerase.
Interplay of two uridylate-specific RNA binding sites in the translocation of poly(A) polymerase from vaccinia virus.
Methyltransferase-specific domains within VP-39, a bifunctional protein that participates in the modification of both mRNA ends.
Molecular flexibility and discontinuous translocation of a non-templated polymerase.
Mutational analysis of a multifunctional protein, with mRNA 5' cap-specific (nucleoside-2'-O-)-methyltransferase and 3'-adenylyltransferase stimulatory activities, encoded by vaccinia virus.
Path of an RNA ligand around the surface of the vaccinia VP39 subunit of its cognate VP39-VP55 protein heterodimer.
Poly(A) polymerase and a dissociable polyadenylation stimulatory factor encoded by vaccinia virus.
Poly(A) polymerase from vaccinia virus-infected cells. I. Partial purification and characterization.
Poly(A) polymerase from vaccinia virus-infected cells. II. Product and primer characterization.
Poly(riboadenylic acid) preferentially inhibits in vitro translation of cellular mRNAs compared with vaccinia virus mRNAs: possible role in vaccinia virus cytopathology.
Polyadenylate polymerase from vaccinia virions.
Saltatory forward movement of a poly(A) polymerase during poly(A) tail addition.
Specific recognition of an rU2-N15-rU motif by VP55, the vaccinia virus poly(A) polymerase catalytic subunit.
Stable chelating linkage for reversible immobilization of oligohistidine tagged proteins in the BIAcore surface plasmon resonance detector.
Stimulation of poly(A) tail elongation by the VP39 subunit of the vaccinia virus-encoded poly(A) polymerase.
Terminal riboadenylate transferase: a poly A polymerase in purified vaccinia virus.
The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends.
The positive transcription elongation factor activity of the vaccinia virus J3 protein is independent from its (nucleoside-2'-O-) methyltransferase and poly(A) polymerase stimulatory functions.
The surface region of the bifunctional vaccinia RNA modifying protein VP39 that interfaces with Poly(A) polymerase is remote from the RNA binding cleft used for its mRNA 5' cap methylation function.
The vaccinia virus bifunctional gene J3 (nucleoside-2'-O-)-methyltransferase and poly(A) polymerase stimulatory factor is implicated as a positive transcription elongation factor by two genetic approaches.
Transcription elongation activity of the vaccinia virus J3 protein in vivo is independent of poly(A) polymerase stimulation.
Transition from rapid processive to slow nonprocessive polyadenylation by vaccinia virus poly(A) polymerase catalytic subunit is regulated by the net length of the poly(A) tail.
Uridylate-containing RNA sequences determine specificity for binding and polyadenylation by the catalytic subunit of vaccinia virus poly(A) polymerase.
Use of vaccinia virus poly(A) polymerase for RNA 3'-end labeling with a chain-terminating nucleotide or a short 3' homopolymer tract.
Vaccinia virus poly(A) polymerase. Specificity for nucleotides and nucleotide analogs.
Widespread but small-scale changes in the structural and dynamic properties of vaccinia virus poly(A) polymerase upon association with its processivity factor in solution.
Vesicular Stomatitis
The L protein of vesicular stomatitis virus modulates the response of the polyadenylic acid polymerase to S-adenosylhomocysteine.
Vesicular stomatitis virus mutant with altered polyadenylic acid polymerase activity in vitro.
Wilms Tumor
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.