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Information on EC 2.7.4.22 - UMP kinase

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IUBMB Comments
This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose . This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP .
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
=
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Synonyms
umpk, uridine monophosphate kinase, uridylate kinase, ump-kinase, umpks, ssumpk, xc1936, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + UMP = ADP + UDP
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