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EC Tree
IUBMB Comments The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein.
Word Map
2.7.11.28
neurotrophic
brain-derived
trka
ngf
neuroprotective
larotrectinib
antidepressant
p75ntr
bdnf-trkb
maze
prefrontal
pan-trk
neurotrophin-3
neurite
fusion-positive
entrectinib
probdnf
neuroplasticity
ngf-induced
etv6-ntrk3
bdnf-induced
antidepressant-like
7,8-dihydroxyflavone
mbdnf
The enzyme appears in viruses and cellular organisms
Synonyms
tropomyosin receptor kinase, tropomyosin kinase, tropomyosin kinase b,
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EC 2.7.1.132
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formerly
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tropomyosin kinase (phosphorylating)
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tropomyosin receptor kinase
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ATP + tropomyosin = ADP + O-phosphotropomyosin
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phospho group transfer
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ATP:tropomyosin O-phosphotransferase
The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein.
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alphaalpha-tropomyosin + ATP
?
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?
ATP + alpha-tropomyosin
ADP + O-phosphotropomyosin
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involved in phosphorylation of embryonal skeletal muscle proteins
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ATP + alpha-tropomyosin[264-284]
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?
ATP + beta-tropomyosin[264-284]
?
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?
ATP + casein
ADP + phosphocasein
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?
ATP + His-276-beta-tropomyosin[264-284]
?
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?
ATP + histone II-A
ADP + phosphohistone II-A
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?
ATP + Ile-284-beta-tropomyosin[264-284]
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?
ATP + KLKYKAISEELDHALNDITS(P)L
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peptide beta[264-284]
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?
ATP + KLKYKAISEELDHALNDMTS(P)I
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peptide alpha[264-284]
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?
ATP + KLKYKAISEELDNALNDITS(P)I
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peptide Ile-284-beta[264-284]
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?
ATP + KLKYKAISEELDNALNDITS(P)L
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peptide His-276-beta[264-284]
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?
ATP + KLKYKAISEELDNALNDMTS(P)L
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peptide Met-281-beta[264-284]
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?
ATP + Met-281-beta-tropomyosin[264-284]
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?
ATP + phosphorylase b
ADP + phosphophosphorylase b
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?
ATP + phosvitin
ADP + phosphophosvitin
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?
ATP + tropomyosin
ADP + O-phosphotropomyosin
ATP + troponin complex
ADP + phosphotroponin complex
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from rabbit skeletal muscle
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betabeta-tropomyosin + ATP
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?
additional information
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ATP + tropomyosin
ADP + O-phosphotropomyosin
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?
ATP + tropomyosin
ADP + O-phosphotropomyosin
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beta-tropomyosin from turkey gizzard
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?
ATP + tropomyosin
ADP + O-phosphotropomyosin
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other poor substrates are beta-tropomyosin from chicken leg muscle, rabbit skeletal muscle
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?
ATP + tropomyosin
ADP + O-phosphotropomyosin
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the phosphorylation site is a single serine-residue close to COOH-terminus, i.e Ser-283
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?
ATP + tropomyosin
ADP + O-phosphotropomyosin
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alpha-tropomyosin subunit preferred over beta-tropomyosin subunit
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?
ATP + tropomyosin
ADP + O-phosphotropomyosin
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alpha-tropomyosin subunit preferred over beta-tropomyosin subunit
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?
ATP + tropomyosin
ADP + O-phosphotropomyosin
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additional information
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no substrates are smooth muscle myosin light chain from turkey gizzard, tropomyosin from platelet and erythrocyte from chicken gizzard and smooth muscle
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additional information
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no substrates are smooth muscle myosin light chain from turkey gizzard, tropomyosin from platelet and erythrocyte from chicken gizzard and smooth muscle
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additional information
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no substrates are gamma- or beta-tropomyosin from smooth muscle from chicken gizzard
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?
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ATP + alpha-tropomyosin
ADP + O-phosphotropomyosin
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involved in phosphorylation of embryonal skeletal muscle proteins
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?
ATP + tropomyosin
ADP + O-phosphotropomyosin
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?
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additional information
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no activation by cAMP or calmodulin
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additional information
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no activation by cAMP or calmodulin
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additional information
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no activation by Ca2+
additional information
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no activation by Ca2+
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KCl
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high concentrations
pegcantratinib
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previously CT327
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additional information
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no inhibition by heparin
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additional information
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not inhibited by 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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0.05
alpha-tropomyosin
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37°C, pH 7.5, skeletal alpha-tropomyosin
0.5
alpha-tropomyosin[264-284]
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37°C, pH 7.5
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0.047
alphaalpha-tropomyosin
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37°C, pH 7.5
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0.66
beta-tropomyosin[264-284]
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37°C, pH 7.5
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0.264
betabeta-tropomyosin
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37°C, pH 7.5
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1.48
His-276-beta-tropomyosin[264-284]
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37°C, pH 7.5
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1.36
Ile-284-beta-tropomyosin[264-284]
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37°C, pH 7.5
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0.33
Met-281-beta-tropomyosin[264-284]
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37°C, pH 7.5
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6.2 - 9.5
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about half-maximal activity at pH 6.2 and 9.5
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22 - 40
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about 10% of maximal activity at 22°C and about 60% of maximal activity at 40°C
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brenda
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brenda
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brenda
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brenda
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brenda
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thigh and leg
brenda
additional information
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not in adult chicken or adult rabbit skeletal muscle
brenda
additional information
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not in adult chicken or adult rabbit skeletal muscle
brenda
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physiological function
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transiently inhibiting tropomyosin kinase B-phospholipase-C-gamma-1 signaling by treatment for two days following an isolated seizure inhibits progression of epilepsy
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A0A7D7PT03_MARVT
147
0
16733
TrEMBL
other Location (Reliability: 1 )
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F616A
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the mutant enzyme is susceptible to inhibition with 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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highly purified enzyme is very unstable upon further purification
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4°C, in 10% sucrose at least 2 weeks
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deBelle, I.; Mak, A.S.
Isolation and characterization of tropomyosin kinase from chicken embryo
Biochim. Biophys. Acta
925
17-26
1987
Gallus gallus, Oryctolagus cuniculus
brenda
Montgomery, K.; Mak, A.S.
In vitro phosphorylation of tropomyosin by a kinase from chicken embryo
J. Biol. Chem.
259
5555-5560
1984
Gallus gallus
brenda
Watson, M.H.; Taneja, A.K.; Hodges, R.S.; Mak, A.S.
Phosphorylation of alphaalpha- and betabeta-tropomyosin and synthetic peptide analogues
Biochemistry
27
4506-4512
1988
Gallus gallus
brenda
Krishnamurthy, K.; Huang, Y.Z.; Harward, S.C.; Sharma, K.K.; Tamayo, D.L.; McNamara, J.O.
Regression of epileptogenesis by inhibiting tropomyosin kinase B signaling following a seizure
Ann. Neurol.
86
939-950
2019
Mus musculus
brenda
Cranston, A.; Stocken, D.D.; Stamp, E.; Roblin, D.; Hamlin, J.; Langtry, J.; Plummer, R.; Ashworth, A.; Burn, J.; Rajan, N.
Tropomyosin receptor antagonism in cylindromatosis (TRAC), an early phase trial of a topical tropomyosin kinase inhibitor as a treatment for inherited CYLD defective skin tumours study protocol for a randomised controlled trial
Trials
18
111
2017
Homo sapiens
brenda
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2.7.11.28 tropomyosin kinase
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