Reference on EC 2.7.1.71 - shikimate kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bode, R.; Birnbaum, D.
Aggregation und Trennbarkeit der Enzyme des Shikimat-Pathway bei Hefen
Z. Allg. Mikrobiol.
21
417-422
1981
Saccharomyces cerevisiae, Meyerozyma guilliermondii, Wickerhamomyces anomalus, Cyberlindnera jadinii, Cyberlindnera fabianii, Ogataea henricii, Lodderomyces elongisporus, Neurospora crassa, Rhodotorula sphaerocarpa, Rhodotorula toruloides, Rhodotorula mucilaginosa, Saccharomycopsis lipolytica
Lumsden, J.; Coggins, J.R.
The subunit structure of the arom multienzyme complex of Neurospora crassa. A possible pentafunctional polypeptide chain
Biochem. J.
161
599-607
1977
Neurospora crassa
Oliveira, J.S.; Pinto, C.A.; Basso, L.A.; Santos, D.S.
Cloning and Overexpression in Soluble Form of Functional Shikimate Kinase and 5-Enolpyruvylshikimate 3-Phosphate Synthase Enzymes from Mycobacterium tuberculosis
Protein Expr. Purif.
22
430-435
2001
Mycobacterium tuberculosis
Morell, H.; Sprinson, D.B.
Shikimate kinase isoenzymes in Salmonella typhimurium
J. Biol. Chem.
243
676-682
1968
Salmonella enterica subsp. enterica serovar Typhimurium
Koshiba, T.
Alicyclic acid metabolism in plants. 12. Partial purification and some properties of shikimate kinase from Phaseolus mungo seedlings
Plant Cell Physiol.
20
803-809
1979
Vigna mungo
-
de Feyter, R.
Shikimate kinases from Escherichia coli K12
Methods Enzymol.
142
355-361
1987
Escherichia coli
Bode, R.; Kunze, G.
Purification and isolation of the arom aggregates of Schizosaccharomyces pombe
Z. Allg. Mikrobiol.
23
289-296
1983
Schizosaccharomyces pombe
Cerasoli, E.; Kelly, S.M.; Coggins, J.R.; Lapthorn, A.J.; Clarke, D.T.; Price, N.C.
Effects of salts on the function and conformational stability of shikimate kinase
Biochim. Biophys. Acta
1648
43-54
2003
Dickeya chrysanthemi
Kempner, E.S.; Cole, K.W.; Gaertner, F.H.
The functional unit of the arom conjugate in Neurospora
J. Biol. Chem.
257
8919-8921
1982
Neurospora crassa
Bowen, J.R.; Kosuge, T.
In vivo activity, purification, and characterization of shikimate kinase from Sorghum
Plant Physiol.
64
382-386
1979
Sorghum bicolor
DeFeyter, R.C.; Pittard, J.
Purification and properties of shikimate kinase II from Escherichia coli K-12
J. Bacteriol.
165
331-333
1986
Escherichia coli
Schmidt, C.L.; Daneel, H.J.; Schultz, G.; Buchanan, B.B.
Shikimate kinase from spinach chloroplasts. Purification, characterization and regulatory function in aromatic amino acid biosynthesis
Plant Physiol.
93
758-766
1990
Spinacia oleracea
Duncan, K.; Edwards, R.M.; Coggins, J.R.
The pentafunctional arom enzyme of Saccharomyces cerevisiae is a mosaic of monofunctional domains
Biochem. J.
246
375-386
1987
Saccharomyces cerevisiae
Lobner-Olesen, A.; Marinus, M.G.
Identification of the gene (aroK) encoding shikimic acid kinase I of Escherichia coli
J. Bacteriol.
174
525-529
1992
Escherichia coli
Romanowski, M.J.; Burley, S.K.
Crystal structure of the Escherichia coli shikimate kinase I (AroK) that confers sensitivity to mecillinam
Proteins Struct. Funct. Genet.
47
558-562
2002
Escherichia coli
Gu, Y.; Reshetnikova, L.; Li, Y.; Wu, Y.; Yan, H.; Singh, S.; Ji, X.
Crystal structure of shikimate kinase from Mycobacterium tuberculosis reveals the dynamic role of the LID domain in catalysis
J. Mol. Biol.
319
779-789
2002
Mycobacterium tuberculosis (P9WPY3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPY3)
Krell, T.; Coyle, J.E.; Horsburgh, M.J.; Coggins, J.R.; Lapthorn, A.J.
Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase from Erwinia chrysanthemi
Acta Crystallogr. Sect. D
53
612-614
1997
Dickeya chrysanthemi
Krell, T.; Coggins, J.R.; Lapthorn, A.J.
The three-dimensional structure of shikimate kinase
J. Mol. Biol.
278
983-997
1998
Dickeya chrysanthemi
Daugherty, M.; Vonstein, V.; Overbeek, R.; Osterman, A.
Archaeal shikimate kinase, a new member of the GHMP-kinase family
J. Bacteriol.
183
292-300
2001
Methanocaldococcus jannaschii
Cerasoli, E.; Kelly, S.M.; Coggins, J.R.; Boam, D.J.; Clarke, D.T.; Price, N.C.
The refolding of type II shikimate kinase from Erwinia chrysanthemi after denaturation in urea
Eur. J. Biochem.
269
2124-2132
2002
Dickeya chrysanthemi
Whipp, M.J.; Pittard, A.J.
A reassessment of the relationship between aroK- and aroL-encoded shikimate kinase enzymes of Escherichia coli
J. Bacteriol.
177
1627-1629
1995
Escherichia coli
Krell, T.; Maclean, J.; Boam, D.J.; Cooper, A.; Resmini, M.; Brocklehurst, K.; Kelly, S.M.; Price, N.C.; Lapthorn, A.J.; Coggins, J.R.
Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine
Protein Sci.
10
1137-1149
2001
Dickeya chrysanthemi
Idziak, C.; Price, N.C.; Kelly, S.M.; Krell, T.; Boam, D.J.; Lapthorn, A.J.; Coggins, J.R.
The interaction of shikimate kinase from Erwinia chrysanthemi with substrates
Biochem. Soc. Trans.
25
S627
1997
Dickeya chrysanthemi
Pereira, J.H.; de Oliveira, J.S.; Canduri, F.; Dias, M.V.; Palma, M.S.; Basso, L.A.; Santos, D.S.; de Azevedo, W.F., Jr.
Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid
Acta Crystallogr. Sect. D
60
2310-2319
2004
Mycobacterium tuberculosis
Pereira, J.H.; de Oliveira, J.S.; Canduri, F.; Dias, M.V.; Palma, M.S.; Basso, L.A.; de Azevedo, W.F., Jr.; Santos, D.S.
Interaction of shikimic acid with shikimate kinase
Biochem. Biophys. Res. Commun.
325
10-17
2004
Mycobacterium tuberculosis (P9WPY3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPY3)
Dhaliwal, B.; Nichols, C.E.; Ren, J.; Lockyer, M.; Charles, I.; Hawkins, A.R.; Stammers, D.K.
Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase
FEBS Lett.
574
49-54
2004
Mycobacterium tuberculosis
Cheng, W.C.; Chang, Y.N.; Wang, W.C.
Structural basis for shikimate-binding specificity of Helicobacter pylori shikimate kinase
J. Bacteriol.
187
8156-8163
2005
Helicobacter pylori (P56073), Helicobacter pylori
Kasai, K.; Kanno, T.; Akita, M.; Ikejiri-Kanno, Y.; Wakasa, K.; Tozawa, Y.
Identification of three shikimate kinase genes in rice: characterization of their differential expression during panicle development and of the enzymatic activities of the encoded proteins
Planta
222
438-447
2005
Oryza sativa (Q5NTH3), Oryza sativa (Q5NTH4), Oryza sativa (Q7X7H9), Oryza sativa
Dias, M.V.; Faim, L.M.; Vasconcelos, I.B.; Simoes de Oliveira, J.; Basso, L.A.; Santos, D.S.; Filgueira de Azevedo, W.J.
Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
F63
1-6
2007
Mycobacterium tuberculosis (P9WPY3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPY3)
Gan, J.; Gu, Y.; Li, Y.; Yan, H.; Ji, X.
Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with shikimic acid and an ATP analogue
Biochemistry
45
8539-8545
2006
Mycobacterium tuberculosis (P9WPY3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPY3)
Han, C.; Zhang, J.; Chen, L.; Chen, K.; Shen, X.; Jiang, H.
Discovery of Helicobacter pylori shikimate kinase inhibitors: bioassay and molecular modeling
Bioorg. Med. Chem.
15
656-662
2007
Helicobacter pylori, Helicobacter pylori SS1
Pereira, J.H.; Vasconcelos, I.B.; Oliveira, J.S.; Caceres, R.A.; de Azevedo, W.F.; Basso, L.A.; Santos, D.S.
Shikimate kinase: a potential target for development of novel antitubercular agents
Curr. Drug Targets
8
459-468
2007
Dickeya chrysanthemi, Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Pauli, I.; Caceres, R.A.; de Azevedo, W.F.
Molecular modeling and dynamics studies of shikimate kinase from Bacillus anthracis
Bioorg. Med. Chem.
16
8098-8108
2008
Bacillus anthracis
Segura-Cabrera, A.; Rodriguez-Perez, M.A.
Structure-based prediction of Mycobacterium tuberculosis shikimate kinase inhibitors by high-throughput virtual screening
Bioorg. Med. Chem. Lett.
18
3152-3157
2008
Mycobacterium tuberculosis (P9WPY3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPY3)
Fucile, G.; Falconer, S.; Christendat, D.
Evolutionary diversification of plant shikimate kinase gene duplicates
PLoS Genet.
4
e1000292
2008
Arabidopsis thaliana
Chen, K.; Dou, J.; Tang, S.; Yang, Y.; Wang, H.; Fang, H.; Zhou, C.
Deletion of the aroK gene is essential for high shikimic acid accumulation through the shikimate pathway in E. coli
Biores. Technol.
119
141-147
2012
Escherichia coli, Escherichia coli DHPYA-T7
Kenyon, C.P.; Roth, R.L.
The role of the C8 proton of ATP in the catalysis of shikimate kinase and adenylate kinase
BMC Biochem.
13
15
2012
Mycobacterium tuberculosis
Kumar, M.; Verma, S.; Sharma, S.; Srinivasan, A.; Singh, T.P.; Kaur, P.
Structure-based in silico design of a high-affinity dipeptide inhibitor for novel protein drug target shikimate kinase of Mycobacterium tuberculosis
Chem. Biol. Drug Des.
76
277-284
2010
Mycobacterium tuberculosis
Saidemberg, D.M.; Passarelli, A.W.; Rodrigues, A.V.; Basso, L.A.; Santos, D.S.; Palma, M.S.
Shikimate kinase (EC 2.7.1.71) from Mycobacterium tuberculosis: kinetics and structural dynamics of a potential molecular target for drug development
Curr. Med. Chem.
18
1299-1310
2011
Mycobacterium tuberculosis
Arora, N.; Banerjee, A.K.; Murty, U.S.
In silico characterization of shikimate kinase of Shigella flexneri: a potential drug target
Interdiscip. Sci.
2
280-290
2010
Shigella flexneri, Shigella flexneri 8401
Vianna, C.P.; de Azevedo, W.F.
Identification of new potential Mycobacterium tuberculosis shikimate kinase inhibitors through molecular docking simulations
J. Mol. Model.
18
755-764
2012
Mycobacterium tuberculosis
Cheng, W.C.; Chen, Y.F.; Wang, H.J.; Hsu, K.C.; Lin, S.C.; Chen, T.J.; Yang, J.M.; Wang, W.C.
Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism
PLoS ONE
7
e33481
2012
Helicobacter pylori (P56073), Helicobacter pylori
Fucile, G.; Garcia, C.; Carlsson, J.; Sunnerhagen, M.; Christendat, D.
Structural and biochemical investigation of two Arabidopsis shikimate kinases: the heat-inducible isoform is thermostable
Protein Sci.
20
1125-1136
2011
Arabidopsis thaliana (Q8GY88), Arabidopsis thaliana
Sutton, K.A.; Breen, J.; MacDonald, U.; Beanan, J.M.; Olson, R.; Russo, T.A.; Schultz, L.W.; Umland, T.C.
Structure of shikimate kinase, an in vivo essential metabolic enzyme in the nosocomial pathogen Acinetobacter baumannii, in complex with shikimate
Acta Crystallogr. Sect. D
71
1736-1744
2015
Acinetobacter baumannii (A0A0M3KL09), Acinetobacter baumannii, Acinetobacter baumannii 307-0294 (A0A0M3KL09)
Liu, Z.; Zhu, Q.; Li, Y.; Yu, J.; Wang, W.; Tan, R.; Zhou, J.; Liao, H.
Isolation and in silico characterization of a shikimate kinase from Cassia obtusifolia
Acta Physiol. Plant.
37
85
2015
Senna obtusifolia (A0A0F6PN71)
-
Simithy, J.; Gill, G.; Wang, Y.; Goodwin, D.C.; Calderon, A.I.
Development of an ESI-LC-MS-based assay for kinetic evaluation of Mycobacterium tuberculosis shikimate kinase activity and inhibition
Anal. Chem.
87
2129-2136
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Rajput, V.S.; Mehra, R.; Kumar, S.; Nargotra, A.; Singh, P.P.; Khan, I.A.
Screening of antitubercular compound library identifies novel shikimate kinase inhibitors of Mycobacterium tuberculosis
Appl. Microbiol. Biotechnol.
100
5415-5426
2016
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Prado, V.; Lence, E.; Vallejo, J.A.; Beceiro, A.; Thompson, P.; Hawkins, A.R.; Gonzalez-Bello, C.
Study of the phosphoryl-transfer mechanism of shikimate kinase by NMR spectroscopy
Chemistry
22
2758-2768
2016
Helicobacter pylori (P56073), Helicobacter pylori, Mycobacterium tuberculosis (P9WPY3), Mycobacterium tuberculosis
Blanco, B.; Prado, V.; Lence, E.; Otero, J.M.; Garcia-Doval, C.; van Raaij, M.J.; Llamas-Saiz, A.L.; Lamb, H.; Hawkins, A.R.; Gonzalez-Bello, C.
Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover
J. Am. Chem. Soc.
135
12366-12376
2013
Mycobacterium tuberculosis (P9WPY3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPY3)
Prado, V.; Lence, E.; Maneiro, M.; Vazquez-Ucha, J.C.; Beceiro, A.; Thompson, P.; Hawkins, A.R.; Gonzalez-Bello, C.
Targeting the motion of shikimate kinase: development of competitive inhibitors that stabilize an inactive open conformation of the enzyme
J. Med. Chem.
59
5471-5487
2016
Helicobacter pylori (P56073), Helicobacter pylori, Mycobacterium tuberculosis (P9WPY3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPY3)
Hsu, K.C.; Cheng, W.C.; Chen, Y.F.; Wang, W.C.; Yang, J.M.
Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways
PLoS Comput. Biol.
9
e1003127
2013
Helicobacter pylori (P56073), Helicobacter pylori
Rosado, L.A.; Vasconcelos, I.B.; Palma, M.S.; Frappier, V.; Najmanovich, R.J.; Santos, D.S.; Basso, L.A.
The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses
PLoS ONE
8
e61918
2013
Mycobacterium tuberculosis
Liu, X.; Lin, J.; Hu, H.; Zhou, B.; Zhu, B.
Metabolic engineering of Escherichia coli to enhance shikimic acid production from sorbitol
World J. Microbiol. Biotechnol.
30
2543-2550
2014
Escherichia coli, Escherichia coli JW0379-1
Simithy, J.; Fuanta, N.R.; Alturki, M.; Hobrath, J.V.; Wahba, A.E.; Pina, I.; Rath, J.; Hamann, M.T.; DeRuiter, J.; Goodwin, D.C.; Calderon, A.I.
Slow-binding inhibition of Mycobacterium tuberculosis shikimate kinase by manzamine alkaloids
Biochemistry
57
4923-4933
2018
Mycobacterium tuberculosis
Rahul Reddy, M.B.; Krishnasamy, S.K.; Kathiravan, M.K.
Identification of novel scaffold using ligand and structure based approach targeting shikimate kinase
Bioorg. Chem.
102
104083
2020
Mycobacterium tuberculosis
Prado, V.; Lence, E.; Thompson, P.; Hawkins, A.R.; Gonzalez-Bello, C.
Freezing the dynamic gap for selectivity motion-based design of inhibitors of the shikimate kinase enzyme
Chemistry
22
17988-18000
2016
Helicobacter pylori, Mycobacterium tuberculosis
Yao, J.; Wang, X.; Luo, H.; Gu, P.
Understanding the catalytic mechanism and the nature of the transition state of an attractive drug-target enzyme (shikimate kinase) by quantum mechanical/molecular mechanical (QM/MM) studies
Chemistry
23
16380-16387
2017
Helicobacter pylori (P56073), Helicobacter pylori
Gonzalez-Bello, C.
Inhibition of shikimate kinase and type II dehydroquinase for antibiotic discovery Structure-based design and simulation studies
Curr. Top. Med. Chem.
16
960-977
2016
Mycobacterium tuberculosis
Xu, H.; Zhang, L.; Li, R.; Wang, X.; Liu, S.; Liu, X.; Jing, Y.; Xiao, J.
SKL1 is essential for chloroplast development in Arabidopsis
Front. Plant Sci.
9
179
2018
Arabidopsis thaliana
Ahmad, S.; Baseer, S.; Navid, A.; Ahmad, F.; Azam, S.
An integrated computational hierarchy for identification of potent inhibitors against shikimate kinase enzyme from Shigella sonnei, a major cause of global dysentery
Gene Rep.
11
283-293
2018
Shigella sonnei
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Nugroho, W.S.; Kim, D.W.; Han, J.C.; Hur, Y.B.; Nam, S.W.; Kim, H.J.
Cloning, expression, and characterization of a cold-adapted shikimate kinase from the psychrophilic bacterium Colwellia psychrerythraea 34H
J. Microbiol. Biotechnol.
26
2087-2097
2016
Colwellia psychrerythraea, Escherichia coli (P0A6D7)
Favela-Candia, A.; Tellez-Valencia, A.; Campos-Almazan, M.; Sierra-Campos, E.; Valdez-Solana, M.; Oria-Hernandez, J.; Castillo-Villanueva, A.; Najera, H.; Avitia-Dominguez, C.
Biochemical, kinetic, and computational structural characterization of shikimate kinase from methicillin-resistant Staphylococcus aureus
Mol. Biotechnol.
61
274-285
2019
Staphylococcus aureus (Q6GGG1), Staphylococcus aureus, Staphylococcus aureus MRSA252 (Q6GGG1), Staphylococcus aureus ATCC BAA1720 (Q6GGG1)
Pernas, M.; Blanco, B.; Lence, E.; Thompson, P.; Hawkins, A.; Gonzlez-Bello, C.
Synthesis of rigidified shikimic acid derivatives by ring-closing metathesis to imprint inhibitor efficacy against shikimate kinase enzyme
Org. Chem. Front.
6
2514-2528
2019
Helicobacter pylori, Mycobacterium tuberculosis (P9WPY3), Mycobacterium tuberculosis H37Rv (P9WPY3)
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