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Disease on EC 2.7.1.68 - 1-phosphatidylinositol-4-phosphate 5-kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Phosphatidylinositol kinase is reduced in Alzheimer's disease.
Anaphylaxis
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.
[Compartmentalization of phosphatidylinositol 4, 5-bisphosphate]
Anemia
Characterization of phosphoinositide kinases in normal and sickle anaemia red cells.
Anemia, Sickle Cell
Characterization of phosphoinositide kinases in normal and sickle anaemia red cells.
Arthritis
Neglected Two-Week-Old Unstable Fracture-Dislocation of the Hip in a 60 Years Old, Managed with Hip Preservation Surgery.
Pipkin type IV femoral head fractures: a case series and review of literature.
[Early primary total hip arthroplasty for acetabular fractures in elderly patients]
Breast Neoplasms
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer.
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Increased signal transduction activity and down-regulation in human cancer cells.
NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase ? and its implication in breast cancer cell proliferation.
Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells.
Quercetin down-regulates signal transduction in human breast carcinoma cells.
Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer.
Carcinoma
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
Increased signal transduction activity and down-regulation in human cancer cells.
Intracellular signalling: phosphatidylinositol lipid metabolism in cancer cells.
Regulation of signal transduction.
Regulation of the signal transduction program by drugs.
Signal transduction and biochemical targeting of ovarian carcinoma.
Synergistic action of tiazofurin and genistein in human ovarian carcinoma cells.
Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells.
Carcinoma, Hepatocellular
1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): a proliferation- and malignancy-linked signal transduction enzyme.
Current issues in the regulation of signal transduction.
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
Increased signal transduction activity and down-regulation in human cancer cells.
Intracellular signalling: phosphatidylinositol lipid metabolism in cancer cells.
Regulation of the signal transduction program by drugs.
Carcinoma, Non-Small-Cell Lung
Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis.
Carcinoma, Ovarian Epithelial
Increased signal transduction activity and down-regulation in human cancer cells.
Colonic Neoplasms
Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a.
Coxa Valga
Femoral Varus Osteotomy for Hip Instability after Traumatic Fracture Dislocations of the Hip Associated with Femoral Head Fractures: A Report of Two Cases.
Dehydration
A gene encoding phosphatidylinositol-4-phosphate 5-kinase is induced by water stress and abscisic acid in Arabidopsis thaliana.
Endometriosis
Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway.
Fracture Dislocation
Femoral Varus Osteotomy for Hip Instability after Traumatic Fracture Dislocations of the Hip Associated with Femoral Head Fractures: A Report of Two Cases.
Ganz Surgical Dislocation of the Hip Is a Safe Technique for Operative Treatment of Pipkin Fractures. Results of a Prospective Trial.
Posterior wall acetabulum fracture-dislocation with subsequent ipsilateral pipkin IV fracture-dislocation: How many hits can a hip take?
Surgical dislocation or the modified Heuter anterior approach for Pipkin I and II femoral head fracture dislocations.
Genetic Diseases, Inborn
Structural insights into lethal contractural syndrome type 3 (LCCS3) caused by a missense mutation of PIP5K?.
Glioma
CircRNA PIP5K1A promotes the progression of glioma through upregulation of the TCF12/PI3K/AKT pathway by sponging miR-515-5p.
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
Guillain-Barre Syndrome
Correlation Between Daam2 Expression Changes and Demyelination in Guillain-Barre Syndrome.
Hip Dislocation
A case of pathological fracture caused by vitamin D insufficiency in a young athlete and a review of the literature.
A treatment strategy to avoid iatrogenic Pipkin type III femoral head fracture-dislocations.
Bilateral irreducible asymmetrical fracture-dislocation of the hip: A case report and literature review.
Bilateral posterior hip dislocation associated with right Pipkin II fracture: A case report.
Failed reduction of posterior hip dislocation accompanied by femoral head fracture: causes and resolving strategy.
Management of Pipkin Fractures Using a Safe Surgical Hip Dislocation.
Operative versus nonoperative management of Pipkin type-II fractures associated with posterior hip dislocation.
Rotational osteoplasty and bioabsorbable polylactate pin fixation in Pipkin type 2 fracture with acute osteochondral defect: a case report.
Surgical hip dislocation vs arthroscopy for fixation of subfoveal femoral head fractures: A new technique for Pipkin type 1 fractures.
Transfer of osteochondral shell autografts to salvage femoral head impaction injuries in hip trauma patients.
Treatment of Pipkin type I fracture using safe surgical hip dislocation: A case report.
Trochanteric Flip (Ganz) Anterior Hip Dislocation for Fixation of Pipkin Fracture-Dislocations.
Usefulness of arthroscopic surgery in hip trauma cases.
Infertility
Role of phosphatidylinositol-4-phosphate 5' kinase (ppk-1) in ovulation of Caenorhabditis elegans.
Influenza, Human
A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection.
Intestinal Diseases
Eimeria maxima phosphatidylinositol 4-phosphate 5-kinase: locus sequencing, characterization, and cross-phylum comparison.
Lung Neoplasms
Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis.
Malaria
A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum.
Muscle Weakness
Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.
Neoplasm Metastasis
Cdk5-mediated phosphorylation regulates phosphatidylinositol 4-phosphate 5-kinase type I ? 90 activity and cell invasion.
Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer.
Neoplasms
1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): a proliferation- and malignancy-linked signal transduction enzyme.
A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase.
Amplification of signal transduction capacity and down-regulation by drugs.
Amplified increase in signal transduction activity in cancer cells.
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Current issues in the regulation of signal transduction.
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
Down-regulation of increased signal transduction capacity in human cancer cells.
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
Intracellular signalling: phosphatidylinositol lipid metabolism in cancer cells.
Oncogenic pathways implicated in ovarian epithelial cancer.
Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage.
Phosphatidylinositol phosphate 5-kinase I?i2 in association with Src controls anchorage-independent growth of tumor cells.
PIP5K1A: a potential target for cancers with KRAS or TP53 mutations.
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
Type I Gamma Phosphatidylinositol Phosphate 5-kinase i5 Controls the Ubiquitination and Degradation of a Tumor Suppressor Mitogen-Inducible Gene 6.
Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer.
Neuroblastoma
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling.
Oculocerebrorenal Syndrome
The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule.
Osteoarthritis
Dislocated intra-articular femoral head fracture associated with fracture-dislocation of the hip and acetabulum: report of 12 cases and technical notes on surgical intervention.
STUDY OF THE TREATMENT OF FEMORAL HEAD FRACTURES.
Usefulness of arthroscopic surgery in hip trauma cases.
Osteoarthritis, Hip
Treatment of Pipkin fractures.
[Treatment of Pipkin fractures]
Osteonecrosis
Ganz Surgical Dislocation of the Hip Is a Safe Technique for Operative Treatment of Pipkin Fractures. Results of a Prospective Trial.
Pipkin type IV femoral head fractures: a case series and review of literature.
Usefulness of arthroscopic surgery in hip trauma cases.
Pancreatic Neoplasms
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
Polycystic Kidney Diseases
Apical PtdIns(4,5)P2 is required for ciliogenesis and suppression of polycystic kidney disease.
Prostatic Neoplasms
Profiling and relative quantitation of phosphoinositides by multiple precursor ion scanning based on phosphate methylation and isotopic labeling.
Sarcoma, Avian
Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cells.
Starvation
Regulation of the signal transduction program by drugs.
Stomach Neoplasms
Type Igamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin.
Tuberculosis
Polyphosphate deficiency in Mycobacterium tuberculosis is associated with enhanced drug susceptibility and impaired growth in guinea pigs.
Whooping Cough
Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells.
Wiskott-Aldrich Syndrome
Effect of ovarian hormones on genes promoting dendritic spines in laser-captured serotonin neurons from macaques.