Reference on EC 2.7.1.60 - N-acylmannosamine kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Van Rinsum, J.; van Dijk, W.; Hooghwinkel, G.J.M.; Ferwerda, W.
Subcellular localization and tissue distribution of sialic acid precursor-forming enzymes
Biochem. J.
210
21-28
1983
Rattus norvegicus, Rattus norvegicus Wistar
Hinderlich, S.; Stsche, R.; Zeitler, R.; Reutter, W.
A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
J. Biol. Chem.
272
24313-24318
1997
Rattus norvegicus, Rattus norvegicus Wistar
Corfield, A.P.; Rainey, J.B.; Clamp, J.R.; Wagner, S.A.
Changes in the activity of the enzymes involved in sialic acid metabolism in isolated rat colonic mucosal cells on administration of azoxymethane
Biochem. Soc. Trans.
11
766-767
1983
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
-
Hinderlich, S.; Nohring, S.; Weise, C.; Franke, P.; Stasche, R.; Reutter, W.
Purification and characterization of N-acetylglucosamine kinase from rat liver. Comparison with UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Eur. J. Biochem.
252
133-139
1998
Rattus norvegicus
Hinderlich, S.; Berger, M.; Schwarzkopf, M.; Effertz, K.; Reutter, W.
Molecular cloning and characterization of murine and human N-acetylglucosamine kinase
Eur. J. Biochem.
267
3301-3308
2000
Homo sapiens, Mus musculus
Ghosh, S.; Roseman, S.
Enzymatic phosphorylation of N-acetyl-D-mannosamine
Biochemistry
47
955-958
1961
Rattus norvegicus
Kundig, W.; Ghosh, S.; Roseman, S.
The sialic acids. VII. N-acyl-D-mannosamine kinase from rat liver
J. Biol. Chem.
241
5619-5626
1966
Rattus norvegicus
Banerjee, S.; Ghosh, S.
Purification and properties of N-acetylmannosamine kinase from Salmonella typhimurium
Eur. J. Biochem.
8
200-206
1969
Escherichia coli, Escherichia coli B / ATCC 11303, Salmonella enterica subsp. enterica serovar Typhimurium, Staphylococcus aureus
Banerjee, S.; Ghosh, S.
N-Acetylmannosamnine kinase
Methods Enzymol.
42c
53-58
1975
Salmonella enterica subsp. enterica serovar Typhimurium
-
Zeitler, R.; Giannis, A.; Danneschewski, S.; Henk, E.; Henk, T.; Bauer, C.; Reutter, W.; Sandhoff, K.
Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro
Eur. J. Biochem.
204
1165-1168
1992
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Hinderlich, S.; Sonnenschein, A.; Reutter, W.
Metal ion requirement of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase from rat liver
BioMetals
11
253-258
1998
Rattus norvegicus
Effertz, K.; Hinderlich, S.; Reutter, W.
Selective loss of either the epimerase or kinase activity of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase due to site-directed mutagenesis based on sequence alignments
J. Biol. Chem.
274
28771-28778
1999
Rattus norvegicus
Horstkorte, R.; Noehring, S.; Wiechens, N.; Schwarzkopf, M.; Danker, K.; Reutter, W.; Lucka, L.
Tissue expression and amino acid sequence of murine UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
Eur. J. Biochem.
260
923-927
1999
Mus musculus (Q91WG8), Mus musculus NMRI (Q91WG8), Rattus norvegicus, Rattus norvegicus Wistar
Lucka, L.; Krause, M.; Danker, K.; Reutter, W.; Horstkorte, R.
Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis
FEBS Lett.
454
341-344
1999
Homo sapiens (Q9Y223)
Blume, A.; Weidemann, W.; Stelzl, U.; Wanker, E.E.; Lucka, L.; Donner, P.; Reutter, W.; Horstkorte, R.; Hinderlich, S.
Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Biochem. J.
384
599-607
2004
Rattus norvegicus
Krause, S.; Hinderlich, S.; Amsili, S.; Horstkorte, R.; Wiendl, H.; Argov, Z.; Mitrani-Rosenbaum, S.; Lochmueller, H.
Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells
Exp. Cell Res.
304
365-379
2005
Homo sapiens, Mus musculus
Hinderlich, S.; Salama, I.; Eisenberg, I.; Potikha, T.; Mantey, L.R.; Yarema, K.J.; Horstkorte, R.; Argov, Z.; Sadeh, M.; Reutter, W.; Mitrani-Rosenbaum, S.
The homozygous M712T mutation of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase results in reduced enzyme activities but not in altered overall cellular sialylation in hereditary inclusion body myopathy
FEBS Lett.
566
105-109
2004
Homo sapiens (Q9Y223), Homo sapiens
Sparks, S.E.; Ciccone, C.; Lalor, M.; Orvisky, E.; Klootwijk, R.; Savelkoul, P.J.; Dalakas, M.C.; Krasnewich, D.M.; Gahl, W.A.; Huizing, M.
Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy
Glycobiology
15
1102-1110
2005
Homo sapiens
Noguchi, S.; Keira, Y.; Murayama, K.; Ogawa, M.; Fujita, M.; Kawahara, G.; Oya, Y.; Imazawa, M.; Goto, Y.I.; Hayashi, Y.K.; Nonaka, I.; Nishino, I.
Reduction of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase activity and sialylation in distal myopathy with rimmed vacuoles
J. Biol. Chem.
279
11402-11407
2004
Homo sapiens
Blume, A.; Ghaderi, D.; Liebich, V.; Hinderlich, S.; Donner, P.; Reutter, W.; Lucka, L.
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, functionally expressed in and purified from Escherichia coli, yeast, and insect cells
Protein Expr. Purif.
35
387-396
2004
Rattus norvegicus
Penner, J.; Mantey, L.R.; Elgavish, S.; Ghaderi, D.; Cirak, S.; Berger, M.; Krause, S.; Lucka, L.; Voit, T.; Mitrani-Rosenbaum, S.; Hinderlich, S.
Influence of UDP-GlcNAc 2-epimerase/ManNAc kinase mutant proteins on hereditary inclusion body myopathy
Biochemistry
45
2968-2977
2006
Homo sapiens
Weidemann, W.; Stelzl, U.; Lisewski, U.; Bork, K.; Wanker, E.E.; Hinderlich, S.; Horstkorte, R.
The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis
FEBS Lett.
580
6649-6654
2006
Rattus norvegicus
Reinke, S.O.; Hinderlich, S.
Prediction of three different isoforms of the human UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
FEBS Lett.
581
3327-3331
2007
Homo sapiens (Q9Y223)
Bork, K.; Reutter, W.; Weidemann, W.; Horstkorte, R.
Enhanced sialylation of EPO by overexpression of UDP-GlcNAc 2-epimerase/ManAc kinase containing a sialuria mutation in CHO cells
FEBS Lett.
581
4195-4198
2007
Rattus norvegicus
Gagiannis, D.; Orthmann, A.; Danssmann, I.; Schwarzkopf, M.; Weidemann, W.; Horstkorte, R.
Reduced sialylation status in UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE)-deficient mice
Glycoconj. J.
24
125-130
2007
Mus musculus
Wang, Z.; Sun, Z.; Li, A.V.; Yarema, K.J.
Roles for UDP-GlcNAc 2-epimerase/ManNAc 6-kinase outside of sialic acid biosynthesis: modulation of sialyltransferase and BiP expression, GM3 and GD3 biosynthesis, proliferation, and apoptosis, and ERK1/2 phosphorylation
J. Biol. Chem.
281
27016-27028
2006
Homo sapiens
Ghaderi, D.; Strauss, H.M.; Reinke, S.; Cirak, S.; Reutter, W.; Lucka, L.; Hinderlich, S.
Evidence for dynamic interplay of different oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods
J. Mol. Biol.
369
746-758
2007
Rattus norvegicus
Amsili, S.; Zer, H.; Hinderlich, S.; Krause, S.; Becker-Cohen, M.; MacArthur, D.G.; North, K.N.; Mitrani-Rosenbaum, S.
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle?
PLoS ONE
3
e2477
2008
Homo sapiens (Q9Y223)
Ishihara, S.; Tomimitsu, H.; Fujigasaki, H.; Saito, F.; Mizusawa, H.
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase in nuclei and rimmed vacuoles of muscle fibers in DMRV (distal myopathy with rimmed vacuoles)
J. Med. Dent. Sci.
55
181-187
2008
Homo sapiens (Q9Y223)
Tong, Y.; Tempel, W.; Nedyalkova, L.; Mackenzie, F.; Park, H.W.
Crystal structure of the N-acetylmannosamine kinase domain of GNE
PLoS ONE
4
e7165
2009
Homo sapiens (Q9Y223), Homo sapiens
Moeller, H.; Boehrsch, V.; Lucka, L.; Hackenberger, C.P.; Hinderlich, S.
Efficient metabolic oligosaccharide engineering of glycoproteins by UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) knock-down
Mol. Biosyst.
7
2245-2251
2011
Homo sapiens
Yardeni, T.; Choekyi, T.; Jacobs, K.; Ciccone, C.; Patzel, K.; Anikster, Y.; Gahl, W.A.; Kurochkina, N.; Huizing, M.
Identification, tissue distribution, and molecular modeling of novel human isoforms of the key enzyme in sialic acid synthesis, UDP-GlcNAc 2-epimerase/ManNAc kinase
Biochemistry
50
8914-8925
2011
Homo sapiens (Q9Y223)
Kemmner, W.; Kessel, P.; Sanchez-Ruderisch, H.; Moeller, H.; Hinderlich, S.; Schlag, P.M.; Detjen, K.
Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells
FASEB J.
26
938-946
2012
Homo sapiens (Q9Y223), Homo sapiens
Yardeni, T.; Jacobs, K.; Niethamer, T.K.; Ciccone, C.; Anikster, Y.; Kurochkina, N.; Gahl, W.A.; Huizing, M.
Murine isoforms of UDP-GlcNAc 2-epimerase/ManNAc kinase: secondary structures, expression profiles, and response to ManNAc therapy
Glycoconj. J.
30
609-618
2013
Mus musculus (Q91WG8)
Martinez, J.; Nguyen, L.; Hinderlich, S.; Zimmer, R.; Tauberger, E.; Reutter, W.; Saenger, W.; Fan, H.; Moniot, S.
Crystal structures of N-acetylmannosamine kinase provide insights into enzyme activity and inhibition
J. Biol. Chem.
287
13656-13665
2012
Homo sapiens (Q9Y223), Homo sapiens
Mori-Yoshimura, M.; Monma, K.; Suzuki, N.; Aoki, M.; Kumamoto, T.; Tanaka, K.; Tomimitsu, H.; Nakano, S.; Sonoo, M.; Shimizu, J.; Sugie, K.; Nakamura, H.; Oya, Y.; Hayashi, Y.K.; Malicdan, M.C.; Noguchi, S.; Murata, M.; Nishino, I.
Heterozygous UDP-GlcNAc 2-epimerase and N-acetylmannosamine kinase domain mutations in the GNE gene result in a less severe GNE myopathy phenotype compared to homozygous N-acetylmannosamine kinase domain mutations
J. Neurol. Sci.
318
100-105
2012
Homo sapiens (Q9Y223)
Grover, S.; Arya, R.
Role of UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) in beta1-integrin-mediated cell adhesion
Mol. Neurobiol.
50
257-273
2014
Homo sapiens (Q9Y223)
North, R.A.; Seizova, S.; Stampfli, A.; Kessans, S.A.; Suzuki, H.; Griffin, M.D.; Kvansakul, M.; Dobson, R.C.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine kinase from methicillin-resistant Staphylococcus aureus
Acta Crystallogr. Sect. F
70
643-649
2014
Staphylococcus aureus, Staphylococcus aureus USA300
Harazi, A.; Becker-Cohen, M.; Zer, H.; Moshel, O.; Hinderlich, S.; Mitrani-Rosenbaum, S.
The interaction of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and alpha-actinin 2 is altered in GNE myopathy M743T mutant
Mol. Neurobiol.
54
2928-2938
2017
Homo sapiens (Q9Y223)
Liu, N.; Wang, Z.K.; Wang, H.X.; Li, Y.; Niu, Z.H.; Yu, X.F.
Muscle biopsy and UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene mutation analysis in two Chinese patients with distal myopathy with rimmed vacuoles
NeuroReport
26
598-601
2015
Homo sapiens (Q9Y223)
Hinderlich, S.; Weidemann, W.; Yardeni, T.; Horstkorte, R.; Huizing, M.
UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE): A master regulator of sialic acid synthesis
Top. Curr. Chem.
366
97-138
2015
Homo sapiens (Q9Y223)
-
Caing-Carlsson, R.; Goyal, P.; Sharma, A.; Ghosh, S.; Setty, T.G.; North, R.A.; Friemann, R.; Ramaswamy, S.
Crystal structure of N-acetylmannosamine kinase from Fusobacterium nucleatum
Acta Crystallogr. Sect. F
73
356-362
2017
Fusobacterium nucleatum subsp. nucleatum (Q8RDN7), Fusobacterium nucleatum subsp. nucleatum DSM 15643 (Q8RDN7)
Aretz, J.; Wratil, P.; Wamhoff, E.; Nguyen, H.; Reutter, W.; Rademacher, C.
Fragment screening of N-acetylmannosamine kinase reveals noncarbohydrate inhibitors
Can. J. Chem.
94
920-926
2016
Homo sapiens
-
Hinderlich, S.; Neuenschwander, M.; Wratil, P.R.; Oder, A.; Lisurek, M.; Nguyen, L.D.; von Kries, J.P.; Hackenberger, C.P.R.
Small molecules targeting human N-acetylmannosamine kinase
ChemBioChem
18
1279-1285
2017
Homo sapiens
Coombes, D.; Davies, J.S.; Newton-Vesty, M.C.; Horne, C.R.; Setty, T.G.; Subramanian, R.; Moir, J.W.B.; Friemann, R.; Panjikar, S.; Griffin, M.D.W.; North, R.A.; Dobson, R.C.J.
The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus
J. Biol. Chem.
295
3301-3315
2020
Staphylococcus aureus (Q2G159), Staphylococcus aureus, Staphylococcus aureus PS 47 (Q2G159)
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