Reference on EC 2.7.1.35 - pyridoxal kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takeuchi, F.; Tsubouchi, R.; Shibata, Y.
Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro
Biochem. J.
227
537-544
1985
Rattus norvegicus
McCormick, D.B.; Gregory, M.E.; Snell, E.E.
Pyridoxal phosphokinases. I. Assay, distribution, purification, and properties
J. Biol. Chem.
236
2076-2084
1961
Bos taurus, Saccharomyces cerevisiae, Oryctolagus cuniculus, Enterococcus faecalis, Homo sapiens, Lactobacillus delbrueckii subsp. bulgaricus, Lacticaseibacillus casei, Meleagris gallopavo, Mus musculus, Neurospora crassa, Rattus norvegicus
McCormick, D.B.; Snell, E.E.
Pyridoxal phosphokinase. II. Effects of inhibitors
J. Biol. Chem.
236
2085-2088
1961
Bos taurus, Enterococcus faecalis, Lacticaseibacillus casei, Rattus norvegicus, Saccharomyces pastorianus
Hirakawa-Sakurai, T.; Ohkawa, K.; Matsuda, M.
Purification and properties of pyridoxal kinase from bovine brain
Mol. Cell. Biochem.
119
203-207
1993
Bos taurus
Kerry, J.A.; Kwok, F.
Purification and characterization of pyridoxal kinase from human erythrocytes
Prep. Biochem.
16
199-216
1986
Homo sapiens
Solomon, L.R.; Hillman, R.S.
Pyridoxine kinase activity in human erythrocytes and leukocytes: assay and properties
Biochem. Med.
16
223-233
1976
Homo sapiens
Chern, C.J.; Beutler, E.
Purification and characterization of human erythrocyte pyridoxine kinase
Clin. Chim. Acta
61
353-365
1975
Homo sapiens
Gaeng, V.; von Collins, E.N.
Inhibition of pyridoxal kinase from rat liver in vitro by aromatic and aliphatic amines
Int. J. Vitam. Nutr. Res.
43
318-323
1973
Rattus norvegicus
Arone, A.; Rogers, P.; Scholz, G.; Kwok, F.
Crystallization and preliminary X-ray studies of pyridoxal kinase from sheep brain
J. Biol. Chem.
264
4322-4323
1989
Ovis aries
Abercrombie, D.M.; Martin, D.L.
Inhibition of pyridoxal kinase by the pyridoxal-gamma-aminobutyrate imine
J. Biol. Chem.
255
79-84
1980
Bos taurus
Karawya, E.; Mostafa, M.H.; Osman, N.
The kinetic mechanism of inhibition of liver pyridoxal kinase with tryptophan metabolites
Biochim. Biophys. Acta
657
153-158
1981
Ovis aries
Kwok, F.; Kerry, J.A.; Churchich, J.E.
Sheep brain pyridoxal kinase: fluorescence spectroscopy of the dimeric enzyme
Biochim. Biophys. Acta
874
167-173
1986
Ovis aries
Neary, J.T.; Meneely, R.L.; Grever, M.R.; Diven, W.F.
The interactions between biogenic amines and pyridoxal, pyridoxal phosphate, and pyridoxal kinase
Arch. Biochem. Biophys.
151
42-47
1972
Bos taurus
Chern, C.J.; Beutler, E.
Assay for human erythrocyte pyridoxine kinase
Anal. Biochem.
67
97-109
1975
Homo sapiens
Kerry, J.A.; Rohde, M.; Kwok, F.
Brain pyridoxal kinase. Purification and characterization
Eur. J. Biochem.
158
581-585
1986
Ovis aries
Kwok, F.; Churchich, J.E.
Brain pyridoxal kinase. Purification, substrate specificities, and sensitized photodestruction of an essential histidine
J. Biol. Chem.
254
6489-6495
1979
Sus scrofa
Karawya, E.; Fonda, M.L.
Physical and kinetic properties of sheep liver pyridoxine kinase
Arch. Biochem. Biophys.
216
170-177
1982
Ovis aries
Li, M.H.; Kwok, F.; An, X.M.; Chang, W.R.; Lau, C.K.; Zhang, J.P.; Liu, S.Q.; Leung, Y.C.; Jiang, T.; Liang, D.C.
Crystallization and preliminary crystallographic studies of pyridoxal kinase from sheep brain
Acta Crystallogr. Sect. D
58
1479-1481
2002
Ovis aries
Maras, B.; Valiante, S.; Orru, S.; Simmaco, M.; Barra, D.; Churchich, J.E.
Structure of pyridoxal kinase from sheep brain and role of the tryptophanyl residues
J. Protein Chem.
18
259-268
1999
Ovis aries
Shi, H.; Zhu, J.K.
SOS4, a pyridoxal kinase gene, is required for root hair development in Arabidopsis
Plant Physiol.
129
585-593
2002
Arabidopsis sp.
Yang, Y.; Tsui, H.C.; Man, T.K.; Winkler, M.E.
Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12
J. Bacteriol.
180
1814-1821
1998
Escherichia coli
Laine-Cessac, P.; Cailleux, A.; Allain, P.
Mechanisms of the inhibition of human erythrocyte pyridoxal kinase by drugs
Biochem. Pharmacol.
54
863-870
1997
Homo sapiens
Lee, H.S.; Moon, B.J.; Choi, S.Y.; Kwon, O.S.
Human pyridoxal kinase: overexpression and properties of the recombinant enzyme
Mol. Cells
10
452-459
2000
Homo sapiens
Scott, T.C.; Phillips, M.A.
Characterization of Trypanosoma brucei pyridoxal kinase: purification, gene isolation and expression in Escherichia coli
Mol. Biochem. Parasitol.
88
1-11
1997
Trypanosoma brucei
Cho, J.J.; Kim, S.K.; Kim, Y.T.
Catalytic and structural properties of pyridoxal kinase
J. Biochem. Mol. Biol.
30
125-131
1997
Ovis aries
-
Laine-Cessac, P.; Allain, P.
Kinetic studies of the effects of K+, Na+, and Li+ on the catalytic activity of human erythrocyte pyridoxal kinase
Enzyme Protein
49
291-304
1997
Homo sapiens
Fong, C.C.; Lai, W.P.; Leung, Y.C.; Lo, S.C.; Wong, M.S.; Yang, M.
Study of substrate-enzyme interaction between immobilized pyridoxamine and recombinant porcine pyridoxal kinase using surface plasmon resonance biosensor
Biochim. Biophys. Acta
1596
95-107
2002
Sus scrofa
Park, J.H.; Burns, K.; Kinsland, C.; Begley, T.P.
Characterization of two kinases involved in thiamine pyrophosphate and pyridoxal phosphate biosynthesis in Bacillus subtilis: 4-amino-5-hydroxymethyl-2methylpyrimidine kinase and pyridoxal kinase
J. Bacteriol.
186
1571-1573
2004
Bacillus subtilis
Cheung, P.Y.; Fong, C.C.; Ng, K.T.; Lam, W.C.; Leung, Y.C.; Tsang, C.W.; Yang, M.; Wong, M.S.
Interaction between pyridoxal kinase and pyridoxal-5-phosphate-dependent enzymes
J. Biochem.
134
731-738
2003
Sus scrofa
Li, M.H.; Kwok, F.; Chang, W.R.; Liu, S.Q.; Lo, S.C.; Zhang, J.P.; Jiang, T.; Liang, D.C.
Conformational changes in the reaction of pyridoxal kinase
J. Biol. Chem.
279
17459-17465
2004
Ovis aries
Tang, L.; Li, M.H.; Cao, P.; Wang, F.; Chang, W.R.; Bach, S.; Reinhardt, J.; Ferandin, Y.; Galons, H.; Wan, Y.; Gray, N.; Meijer, L.; Jiang, T.; Liang, D.C.
Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives
J. Biol. Chem.
280
31220-31229
2005
Ovis aries (P82197)
Wrenger, C.; Eschbach, M.L.; Muller, I.B.; Warnecke, D.; Walter, R.D.
Analysis of the vitamin B6 biosynthesis pathway in the human malaria parasite Plasmodium falciparum
J. Biol. Chem.
280
5242-5248
2005
Plasmodium falciparum
Hwang, I.K.; Yoo, K.Y.; Kim, D.S.; Eum, W.S.; Park, J.K.; Park, J.; Kwon, O.S.; Kang, T.C.; Choi, S.Y.; Won, M.H.
Changes of pyridoxal kinase expression and activity in the gerbil hippocampus following transient forebrain ischemia
Neuroscience
128
511-518
2004
Meriones unguiculatus
di Salvo, M.L.; Hunt, S.; Schirch, V.
Expression, purification, and kinetic constants for human and Escherichia coli pyridoxal kinases
Protein Expr. Purif.
36
300-306
2004
Escherichia coli, Homo sapiens (O00764), Homo sapiens
Newman, J.A.; Das, S.K.; Sedelnikova, S.E.; Rice, D.W.
Cloning, purification and preliminary crystallographic analysis of a putative pyridoxal kinase from Bacillus subtilis
Acta Crystallogr. Sect. F
F62
1006-1009
2006
Bacillus subtilis
Kim, D.W.; Kim, C.K.; Choi, S.H.; Choi, H.S.; Kim, S.Y.; An, J.J.; Lee, S.R.; Lee, S.H.; Kwon, O.S.; Kang, T.C.; Won, M.H.; Cho, Y.J.; Cho, S.W.; Kang, J.H.; Kim, T.Y.; Lee, K.S.; Park, J.; Eum, W.S.; Choi, S.Y.
Tat-mediated protein transduction of human brain pyridoxal kinase into PC12 cells
Biochimie
87
481-487
2005
Homo sapiens
Kaestner, U.; Hallmen, C.; Wiese, M.; Leistner, E.; Drewke, C.
The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba
FEBS J.
274
1036-1045
2007
Homo sapiens (O00764), Homo sapiens
Flanagan, J.M.; Beutler, E.
The genetic basis of human erythrocyte pyridoxal kinase activity variation
Haematologica
91
801-804
2006
Homo sapiens
Safo, M.K.; Musayev, F.N.; di Salvo, M.L.; Hunt, S.; Claude, J.B.; Schirch, V.
Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases
J. Bacteriol.
188
4542-4552
2006
Escherichia coli (P40191), Escherichia coli
Bach, S.; Knockaert, M.; Reinhardt, J.; Lozach, O.; Schmitt, S.; Baratte, B.; Koken, M.; Coburn, S.P.; Tang, L.; Jiang, T.; Liang, D.C.; Galons, H.; Dierick, J.F.; Pinna, L.A.; Meggio, F.; Totzke, F.; Schaechtele, C.; Lerman, A.S.; Carnero, A.; Wan, Y.; Gray, N.; Meijer, L.
Roscovitine targets, protein kinases and pyridoxal kinase
J. Biol. Chem.
280
31208-31219
2005
Ovis aries, Homo sapiens
Newman, J.A.; Das, S.K.; Sedelnikova, S.E.; Rice, D.W.
The crystal structure of an ADP complex of Bacillus subtilis pyridoxal kinase provides evidence for the parallel emergence of enzyme activity during evolution
J. Mol. Biol.
363
520-530
2006
Bacillus subtilis
Cao, P.; Gong, Y.; Tang, L.; Leung, Y.C.; Jiang, T.
Crystal structure of human pyridoxal kinase
J. Struct. Biol.
154
327-332
2006
Homo sapiens (O00764), Homo sapiens
Musayev, F.N.; Di Salvo, M.L.; Ko, T.P.; Gandhi, A.K.; Goswami, A.; Schirch, V.; Safo, M.K.
Crystal Structure of human pyridoxal kinase: Structural basis of M+ and M2+ activation
Protein Sci.
16
2184-2194
2007
Homo sapiens (O00764), Homo sapiens
Kwak, S.E.; Kim, J.E.; Kim, D.W.; Kwon, O.S.; Choi, S.Y.; Kang, T.C.
Pyridoxine 5-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus
Hippocampus
19
45-56
2009
Rattus norvegicus
Shi, R.; Zhang, J.; Jiang, C.; Huang, L.
Bombyx mori pyridoxal kinase cDNA cloning and enzymatic characterization
J. Genet. Genomics
34
683-690
2007
Bombyx mori (Q1PCB1), Bombyx mori
Gonzalez, E.; Danehower, D.; Daub, M.E.
Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathway
Plant Physiol.
145
985-996
2007
Arabidopsis thaliana (Q8W1X2)
Yu, S.; Luo, L.
Expression analysis of a novel pyridoxal kinase messenger RNA splice variant, PKL, in oil rape suffering abiotic stress and phytohormones
Acta Biochim. Biophys. Sin. (Shanghai)
40
1005-1014
2008
Brassica napus (A4K866), Brassica napus (A4K867), Brassica napus
Gandhi, A.K.; Ghatge, M.S.; Musayev, F.N.; Sease, A.; Aboagye, S.O.; di Salvo, M.L.; Schirch, V.; Safo, M.K.
Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase
Biochem. Biophys. Res. Commun.
381
12-15
2009
Homo sapiens (O00764), Homo sapiens
Kwak, S.E.; Kim, J.E.; Kim, D.W.; Kwon, O.S.; Choi, S.Y.; Kang, T.C.
Enhanced pyridoxal 5-phosphate synthetic enzyme immunoreactivities do not contribute to GABAergic inhibition in the rat hippocampus following pilocarpine-induced status epilepticus
Neuroscience
159
1108-1118
2009
Rattus norvegicus (O35331)
Mueller, I.B.; Wu, F.; Bergmann, B.; Knoeckel, J.; Walter, R.D.; Gehring, H.; Wrenger, C.
Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum
PLoS ONE
4
e4406
2009
Plasmodium falciparum
Huang, S.; Ma, W.; Zhang, P.; Zhang, J.; Xie, Y.; Huang, L.
Recombinant expression, purification and characterization of Bombyx mori (Lepidoptera: Bombycidae) pyridoxal kinase
Eur. J. Entomol.
108
25-34
2011
Bombyx mori (Q1PCB1)
-
Jones, D.C.; Alphey, M.S.; Wyllie, S.; Fairlamb, A.H.
Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome
Mol. Microbiol.
86
51-64
2012
Trypanosoma brucei
Rueschhoff, E.E.; Gillikin, J.W.; Sederoff, H.W.; Daub, M.E.
The SOS4 pyridoxal kinase is required for maintenance of vitamin B6-mediated processes in chloroplasts
Plant Physiol. Biochem.
63
281-291
2013
Arabidopsis thaliana
Gandhi, A.K.; Desai, J.V.; Ghatge, M.S.; di Salvo, M.L.; Di Biase, S.; Danso-Danquah, R.; Musayev, F.N.; Contestabile, R.; Schirch, V.; Safo, M.K.
Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition
PLoS ONE
7
e40954
2012
Homo sapiens (O00764), Homo sapiens
Kronenberger, T.; Lunev, S.; Wrenger, C.; Groves, M.R.
Purification, crystallization and preliminary X-ray diffraction analysis of pyridoxal kinase from Plasmodium falciparum (PfPdxK)
Acta Crystallogr. Sect. F
70
1550-1555
2014
Plasmodium falciparum (A0A1C3KUB4), Plasmodium falciparum
Kim, M.I.; Hong, M.
Crystal structure and catalytic mechanism of pyridoxal kinase from Pseudomonas aeruginosa
Biochem. Biophys. Res. Commun.
478
300-306
2016
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO
di Salvo, M.L.; Nogues, I.; Parroni, A.; Tramonti, A.; Milano, T.; Pascarella, S.; Contestabile, R.
On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5-phosphate
Biochim. Biophys. Acta
1854
1160-1166
2015
Escherichia coli, Escherichia coli BW25113
Navarro, F.; Ramirez-Sarmiento, C.A.; Guixe, V.
Catalytic and regulatory roles of species involved in metal-nucleotide equilibriums in human pyridoxal kinase
Biometals
26
805-812
2013
Homo sapiens
Castro-Fernandez, V.; Bravo-Moraga, F.; Ramirez-Sarmiento, C.A.; Guixe, V.
Emergence of pyridoxal phosphorylation through a promiscuous ancestor during the evolution of hydroxymethyl pyrimidine kinases
FEBS Lett.
588
3068-3073
2014
Escherichia coli (P40191)
Kimura, T.; Shirakawa, R.; Yaoita, N.; Hayashi, T.; Nagano, K.; Horiuchi, H.
The antimalarial drugs chloroquine and primaquine inhibit pyridoxal kinase, an essential enzyme for vitamin B6 production
FEBS Lett.
588
3673-3676
2014
Homo sapiens, Plasmodium vivax (A5K1Z8), Trypanosoma cruzi (Q4D946), Plasmodium vivax Salvador I (A5K1Z8), Trypanosoma cruzi CL Brener (Q4D946)
Nodwell, M.B.; Koch, M.F.; Alte, F.; Schneider, S.; Sieber, S.A.
A subfamily of bacterial ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage
J. Am. Chem. Soc.
136
4992-4999
2014
Staphylococcus aureus (A0A0H3JTP0), Staphylococcus aureus, Staphylococcus aureus ATCC 700699 (A0A0H3JTP0)
Ramos, R.J.; Albersen, M.; Vringer, E.; Bosma, M.; Zwakenberg, S.; Zwartkruis, F.; Jans, J.J.M.; Verhoeven-Duif, N.M.
Discovery of pyridoxal reductase activity as part of human vitamin B6 metabolism
Biochim. Biophys. Acta
1863
1088-1097
2019
Homo sapiens (O00764), Homo sapiens
Gao, K.; Wang, W.; Kronenberger, T.; Wrenger, C.; Groves, M.
The crystal structure of the Plasmodium falciparum PdxK provides an experimental model for pro-drug activation
Crystals
9
534
2019
Plasmodium falciparum (C6KT01)
-
Kim, J.H.; Kim, J.; Kim, H.J.; Sathiyanarayanan, G.; Bhatia, S.K.; Song, H.S.; Choi, Y.K.; Kim, Y.G.; Park, K.; Yang, Y.H.
Biotransformation of pyridoxal 5-phosphate from pyridoxal by pyridoxal kinase (pdxY) to support cadaverine production in Escherichia coli
Enzyme Microb. Technol.
104
9-15
2017
Escherichia coli (P77150), Escherichia coli
Deka, G.; Kalyani, J.N.; Jahangir, F.B.; Sabharwal, P.; Savithri, H.S.; Murthy, M.R.N.
Structural and functional studies on Salmonella typhimurium pyridoxal kinase the first structural evidence for the formation of Schiff base with the substrate
FEBS J.
286
3684-3700
2019
Salmonella enterica subsp. enterica serovar Typhimurium (A0A0F7J8S0)
Kumar, V.; Sharma, M.; Rakesh, B.R.; Malik, C.K.; Neelagiri, S.; Neerupudi, K.B.; Garg, P.; Singh, S.
Pyridoxal kinase a vitamin B6 salvage pathway enzyme from Leishmania donovani
Int. J. Biol. Macromol.
119
320-334
2018
Leishmania donovani (A0A0G2YFI9), Leishmania donovani, Leishmania donovani MHOM/80/IN/Dd8 (A0A0G2YFI9)
Are, S.; Gatreddi, S.; Jakkula, P.; Qureshi, I.A.
Structural attributes and substrate specificity of pyridoxal kinase from Leishmania donovani
Int. J. Biol. Macromol.
152
812-827
2020
Leishmania donovani (A0A0G2YFI9), Leishmania donovani, Leishmania donovani MHOM/80/IN/Dd8 (A0A0G2YFI9)
Mascolo, E.; Barile, A.; Mecarelli, L.S.; Amoroso, N.; Merigliano, C.; Massimi, A.; Saggio, I.; Hansen, T.; Tramonti, A.; Di Salvo, M.L.; Barbetti, F.; Contestabile, R.; Verni, F.
The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity
Sci. Rep.
9
14188
2019
Homo sapiens (O00764), Homo sapiens, Drosophila melanogaster (Q7KUC2)
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