Reference on EC 2.7.1.3 - ketohexokinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bais, R.; James, H.M.; Rofe, A.M.; Conyers, A.J.
The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol
Biochem. J.
230
53-60
1985
Homo sapiens
Cori, G.T.; Ochoa, S.; Slein, M.W.; Cori, C.F.
The metabolism of fructose in liver. Isolation of fructose-I-phosphate and inorganic pyrophosphate
Biochim. Biophys. Acta
7
304-317
1951
Rattus norvegicus
Parks, R.E.; Ben-Gershom, E.; Lardy, H.E.
Liver fructokinase
J. Biol. Chem.
227
231-242
1957
Bos taurus
Weiser, M.M.; Quill, H.
Estimation of fructokinase (ketohexokinase) in crude tissue preparations
Methods Enzymol.
41B
61-63
1975
Mammalia
-
Raushel, F.M.; Cleland, W.W.
Bovine liver fructokinase: purification and kinetic properties
Biochemistry
16
2169-2175
1977
Bos taurus
Raushel, F.M.; Cleland, W.W.
The substrate and anomeric specificity of fructokinase
J. Biol. Chem.
248
8174-8177
1973
Bos taurus, Saccharomyces cerevisiae
Phillips, M.I.; Davies, D.R.
The mechanism of guanosine triphosphate depletion in the liver after a fructose load. The role of fructokinase
Biochem. J.
228
667-671
1985
Rattus norvegicus
Hayward, B.E.; Warner, J.P.; Dunlop, N.; Fantes, J.; Intody, S.; Leek, J.; Markham, A.F.; Bonthron, D.T.
Molecular genetics of the human glucokinase regulator-fructokinase (GCKR-ketohexokinase) region of chromosome 2p23
Biochem. Soc. Trans.
25
140-145
1997
Homo sapiens
Kozak, M.; Hayward, B.; Borek, D.; Bonthron, D.T.; Jaskolski, M.
Expression, purification and preliminary crystallographic studies of human ketohexokinase
Acta Crystallogr. Sect. D
57
586-588
2001
Homo sapiens
Asipu, A.; Hayward, B.E.; O'Reilly, J.; Bonthron, D.T.
Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria
Diabetes
52
2426-2432
2003
Homo sapiens
Geigenberger, P.; Regierer, B.; Lytovchenko, A.; Leisse, A.; Schauer, N.; Springer, F.; Kossmann, J.; Fernie, A.R.
Heterologous expression of a ketohexokinase in potato plants leads to inhibited rates of photosynthesis, severe growth retardation and abnormal leaf development
Planta
218
569-578
2004
Rattus norvegicus
Giroix, M.H.; Jijakli, H.; Courtois, P.; Zhang, Y.; Sener, A.; Malaisse, W.J.
Fructokinase activity in rat liver, ileum, parotid gland, pancreas, pancreatic islet, B and non-B islet cell homogenates
Int. J. Mol. Med.
17
517-522
2006
Rattus norvegicus
Funari, V.A.; Herrera, V.L.; Freeman, D.; Tolan, D.R.
Genes required for fructose metabolism are expressed in Purkinje cells in the cerebellum
Brain Res. Mol. Brain Res.
142
115-122
2005
Homo sapiens, Mus musculus
Hwa, J.S.; Kim, H.J.; Goo, B.M.; Park, H.J.; Kim, C.W.; Chung, K.H.; Park, H.C.; Chang, S.H.; Kim, Y.W.; Kim, D.R.; Cho, G.J.; Choi, W.S.; Kang, K.R.
The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma
Proteomics
6
1077-1084
2006
Homo sapiens (P50053), Homo sapiens
Trinh, C.H.; Asipu, A.; Bonthron, D.T.; Phillips, S.E.
Structures of alternatively spliced isoforms of human ketohexokinase
Acta Crystallogr. Sect. D
65
201-211
2009
Homo sapiens (P50053), Homo sapiens
Springer, N.; Lindbloom-Hawley, S.; Schermerhorn, T.
Tissue expression of ketohexokinase in cats
Res. Vet. Sci.
87
115-117
2009
Felis catus
Maryanoff, B.; ONeill, J.; McComsey, D.; Yabut, S.; Luci, D.; Jordan Jr., A.; Masucci, J.; Jones, W.; Abad, M.; Gibbs, A.; Petrounia, I.
Inhibitors of ketohexokinase: Discovery of pyrimidinopyrimidines with specific substitution that complements the ATP-binding site
ACS Med. Chem. Lett.
2
538-543
2011
Homo sapiens
Diggle, C.; Shires, M.; McRae, C.; Crellin, D.; Fisher, J.; Carr, I.; Markham, A.; Hayward, B.; Asipu, A.; Bonthron, D.
Both isoforms of ketohexokinase are dispensable for normal growth and development
Physiol. Genomics
42 A
235-243
2010
Mus musculus
Rangaswamy, V.; Altekar, W.
Ketohexokinase (ATP:D-fructose 1-phosphotransferase) from a halophilic archaebacterium, Haloarcula vallismortis: purification and properties
J. Bacteriol.
176
5505-5512
1994
Haloarcula vallismortis, Haloarcula vallismortis ATCC 34679
Kavitha, R.; Karunagaran, S.; Chandrabose, S.S.; Lee, K.W.; Meganathan, C.
Pharmacophore modeling, virtual screening, molecular docking studies and density functional theory approaches to identify novel ketohexokinase (KHK) inhibitors
BioSystems
138
39-52
2015
Homo sapiens (P50053)
Li, X.; Qian, X.; Lu, Z.
Fructokinase A acts as a protein kinase to promote nucleotide synthesis
Cell Cycle
15
2689-2690
2016
Homo sapiens
Li, X.; Qian, X.; Peng, L.X.; Jiang, Y.; Hawke, D.H.; Zheng, Y.; Xia, Y.; Lee, J.H.; Cote, G.; Wang, H.; Wang, L.; Qian, C.N.; Lu, Z.
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinomaformation
Nat. Cell Biol.
18
561-571
2016
Homo sapiens
Le, M.; Lanaspa, M.; Cicerchi, C.; Rana, J.; Scholten, J.; Hunter, B.; Rivard, C.; Randolph, R.; Johnson, R.
Bioactivity-guided identification of botanical inhibitors of ketohexokinase
PLoS ONE
11
e0157458
2016
Homo sapiens
Gao, W.; Li, N.; Li, Z.; Xu, J.; Su, C.
Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma
Biochem. Biophys. Res. Commun.
503
1298-1306
2018
Homo sapiens (P50053), Homo sapiens
Steinhauser, C.B.; Landers, M.; Myatt, L.; Burghardt, R.C.; Vallet, J.L.; Bazer, F.W.; Johnson, G.A.
Fructose synthesis and transport at the uterine-placental interface of pigs cell-specific localization of SLC2A5, SLC2A8, and components of the polyol pathway
Biol. Reprod.
95
108
2016
Sus scrofa
Huard, K.; Ahn, K.; Amor, P.; Beebe, D.A.; Borzilleri, K.A.; Chrunyk, B.A.; Coffey, S.B.; Cong, Y.; Conn, E.L.; Culp, J.S.; Dowling, M.S.; Gorgoglione, M.F.; Gutierrez, J.A.; Knafels, J.D.; Lachapelle, E.A.; Pandit, J.; Parris, K.D.; Perez, S.; Pfefferkorn, J.A.; Price, D.A.; Raymer, B.; Ross, T.T.; Shavnya, A.
Discovery of fragment-derived small molecules for in vivo inhibition of ketohexokinase (KHK)
J. Med. Chem.
60
7835-7849
2017
Homo sapiens (P50053), Homo sapiens, Rattus norvegicus (Q02974)
Al-Jawadi, A.; Patel, C.R.; Shiarella, R.J.; Romelus, E.; Auvinen, M.; Guardia, J.; Pearce, S.C.; Kishida, K.; Yu, S.; Gao, N.; Ferraris, R.P.
Cell-type-specific, ketohexokinase-dependent induction by fructose of lipogenic gene expression in mouse small intestine
J. Nutr.
150
1722-1730
2020
Mus musculus (P97328), Mus musculus
Hayasaki, T.; Ishimoto, T.; Doke, T.; Hirayama, A.; Soga, T.; Furuhashi, K.; Kato, N.; Kosugi, T.; Tsuboi, N.; Lanaspa, M.A.; Johnson, R.J.; Maruyama, S.; Kadomatsu, K.
Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase
J. Nutr. Biochem.
71
54-62
2019
Mus musculus (P97328)
Park, T.J.; Reznick, J.; Peterson, B.L.; Blass, G.; Omerbasic, D.; Bennett, N.C.; Kuich, P.H.J.L.; Zasada, C.; Browe, B.M.; Hamann, W.; Applegate, D.T.; Radke, M.H.; Kosten, T.; Lutermann, H.; Gavaghan, V.; Eigenbrod, O.; Begay, V.; Amoroso, V.G.; Govind, V.; Minshall, R.D.; Smith, E.S.J.; Larson, J.; Gotthard, M.
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Science
356
307-311
2017
Heterocephalus glaber
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