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Disease on EC 2.7.1.127 - inositol-trisphosphate 3-kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Adenocarcinoma of Lung
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
Alzheimer Disease
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.
Microglia-Derived Extracellular Vesicles Carrying miR-711 Alleviate Neurodegeneration in a Murine Alzheimer's Disease Model by Binding to Itpkb.
Aneurysm
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.
ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
Management of Kawasaki disease.
Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease.
Arthritis
Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.
Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells.
Autoimmune Diseases
Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.
Breast Neoplasms
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer.
Relationship of ITPKA expression with the prognosis of breast cancer.
Carcinogenesis
Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma.
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203.
Carcinoma
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer.
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.
Carcinoma, Hepatocellular
ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.
Carcinoma, Squamous Cell
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.
Colorectal Neoplasms
Immune-related genes STIM1, ITPKC and PELI1 polymorphisms are associated with risk of colorectal cancer.
Common Variable Immunodeficiency
Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency.
Erythema
ITPKC and SLC11A1 Gene Polymorphisms and Gene-Gene Interactions in Korean Patients with Kawasaki Disease.
Glioma
Mining the glioma susceptibility genes in children from gene expression profiles and a methylation database.
Graft vs Host Disease
Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease.
Hirschsprung Disease
Potential association between ITPKC genetic variations and Hirschsprung disease.
Hodgkin Disease
Diagnostic utility of STAT6YE361 expression in classical Hodgkin lymphoma and related entities.
Immune System Diseases
New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B.
Influenza, Human
Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.
inositol-trisphosphate 3-kinase deficiency
Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways.
Lung Neoplasms
Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells.
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.
Lymphatic Metastasis
Relationship of ITPKA expression with the prognosis of breast cancer.
Mucocutaneous Lymph Node Syndrome
A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis.
A replication study for association of ITPKC and CASP3 two-locus analysis in IVIG unresponsiveness and coronary artery lesion in Kawasaki disease.
Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: Association With Disease Susceptibility and BCG Scar Reactivation.
ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease.
ITPKC and SLC11A1 Gene Polymorphisms and Gene-Gene Interactions in Korean Patients with Kawasaki Disease.
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer.
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.
ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children.
ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3.
Kawasaki disease: update on pathogenesis.
PPP3CC feedback regulates IP3-Ca2+ pathway through preventing ITPKC degradation.
Single-nucleotide Polymorphism rs2290692 in the 3'UTR of ITPKC Associated With Susceptibility to Kawasaki Disease in a Han Chinese Population.
Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease.
Superantigen involvement and susceptibility factors in Kawasaki disease: profiles of TCR V?2+ T cells and HLA-DRB1, TNF-? and ITPKC genes among Filipino patients.
[Association study of a functional SNP rs28493229 of ITPKC gene and Kawasaki disease in a Chinese population].
Neoplasm Metastasis
Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Relationship of ITPKA expression with the prognosis of breast cancer.
Neoplasms
DNA methylation profiling in nonfunctioning pituitary adenomas.
Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells.
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.
Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance.
ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203.
ITPKA1 Promotes Growth, Migration and Invasion of Renal Cell Carcinoma via Activation of mTOR Signaling Pathway.
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer.
Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma.
Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice.
Relationship of ITPKA expression with the prognosis of breast cancer.
TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin.
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.
Nephrolithiasis
Study of the association between ITPKC genetic polymorphisms and calcium nephrolithiasis.
Neuroblastoma
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.
Tissue- and cell-specific expression of Ins(1,4,5)P3 3-kinase isoenzymes.
Osteosarcoma
miR-140-5p attenuates chemotherapeutic drug induced cell death by regulating autophagy through IP3k2 in human osteosarcoma cells.
Ovarian Neoplasms
ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203.
Parkinson Disease
Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan.
Association of ZNF184, IL1R2, LRRK2, ITPKB, and PARK16 with sporadic Parkinson's disease in Eastern China.
ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians.
The Parkinson's disease-associated gene ITPKB protects against ?-synuclein aggregation by regulating ER-to-mitochondria calcium release.
Severe Combined Immunodeficiency
Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency.
Small Cell Lung Carcinoma
The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer.
Triple Negative Breast Neoplasms
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer.
Uterine Cervical Neoplasms
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.