HOME
login
history
all enzymes
BRENDA home
History
Information on EC 2.6.1.42 - branched-chain-amino-acid transaminase
for references in articles please use BRENDA:EC2.6.1.42Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.6.1.42 branched-chain-amino-acid transaminaseIUBMB Comments
Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase.
Specify your search results
Word Map
- 2.6.1.42
-
bcats
- isoleucine
-
transamination
-
aminotransferases
- pyridoxal
- alpha-ketoisocaproate
-
ketoacids
- l-valine
- gabapentin
-
isomeroreductase
-
acetohydroxy
- nutrition
-
alpha-ketoacids
-
acetohydroxyacid
- synthesis
- analysis
- medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
bcat1, bcatm, bcatc, branched-chain aminotransferase, branched-chain amino acid aminotransferase, branched chain aminotransferase, branched-chain amino acid transaminase, bcat2, hbcatm, transaminase b, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
BCAA-AT
BCAATase
BcaT
Bcat2
BCAT7
BCATc
BCATm
branched chain amino acid: 2-oxoglutarate aminotransferase EC 2.6.1
branched chain aminotransferase
branched chain aminotransferase IlvE
branched-chain amino acid aminotransferase
branched-chain amino acid aminotransferase 1
branched-chain amino acid transaminase
branched-chain amino acid-glutamate transaminase
-
-
-
-
branched-chain amino-acid transaminase
branched-chain aminotransferase
branched-chain aminotransferase 7
EC 2.6.1.6
glutamate-branched-chain amino acid transaminase
-
-
-
-
IlvE
IlvE aminotransferase
L-branched chain amino acid aminotransferase
-
-
-
-
transaminase B
TUZN1299
branched chain amino acid: 2-oxoglutarate aminotransferase EC 2.6.1
-
formerly
branched-chain amino acid aminotransferase
-
-
-
-
branched-chain aminotransferase
-
-
-
-
transaminase B
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
branched-chain amino acid + 2-oxoglutarate = corresponding keto acid + L-glutamate, also acts on L-isoleucine and L-valine. Different from EC 2.6.1.66 valine-pyruvate transaminase
-
-
-
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
bibi ping-pong mechanism. For good 2-oxoacid substrates, release of 2-oxoglutarate is much slower than release of the product amino acid during the transamination reaction
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
KEGG
MetaCyc
L-alanine biosynthesis I, L-isoleucine biosynthesis I (from threonine), L-isoleucine biosynthesis II, L-isoleucine biosynthesis III, L-isoleucine biosynthesis IV, L-isoleucine biosynthesis V, L-isoleucine degradation I, L-isoleucine degradation II, L-leucine biosynthesis, L-leucine degradation I, L-leucine degradation III, L-leucine degradation IV (Stickland reaction), L-valine biosynthesis, L-valine degradation I, L-valine degradation II
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
branched-chain-amino-acid:2-oxoglutarate aminotransferase
Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9054-65-3
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid + L-glutamate
3-hydroxyadamantylglycine + 2-oxoglutarate
2-oxo-6-hydroxyhexanoic acid + L-glutamate
L-6-hydroxynorleucine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxobutanoate + L-glutamate
L-valine + 2-oxoglutarate
-
-
-
r
3-methyl-2-oxopentanoate + L-glutamate
L-isoleucine + 2-oxoglutarate
-
-
-
-
?
4,4-dimethyl-2-oxopentanoate + L-glutamate
L-neopentylglycine + 2-oxoglutarate
-
-
-
-
?
4-methyl-2-oxopentanoate + L-glutamate
L-leucine + 2-oxoglutarate
-
-
-
?
4-methylthio-2-oxobutanoate + L-glutamate
L-methionine + 2-oxoglutarate
-
-
-
r
DL-2-aminoadipate + 2-oxoglutarate
3-oxohexanedioic acid + L-glutamate
-
heart enzyme
-
-
r
DL-2-aminopimelate + 2-oxoglutarate
2-oxoheptanedioate + L-glutamate
-
heart enzyme
-
-
r
DL-allo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
heart enzyme
-
-
r
glycine + 2-oxoglutarate
glyoxylate + L-glutamate
-
0.4% of the activity with L-isoleucine
-
?
L-2-aminobutanoate + 4-methylthio-2-oxo-butanoate
2-oxobutanoate + L-methionine
-
-
-
-
r
L-2-aminobutyrate + 4-methyl-2-oxopentanoate
2-oxobutanoate + L-leucine
-
-
-
-
r
L-allo-isoleucine + 2-oxobutyrate
3-methyl-2-oxopentanoate + 2-aminobutyrate
-
-
-
-
r
L-allo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-allo-isoleucine + 2-oxohexanoate
3-methyl-2-oxopentanoate + 2-aminohexanoate
-
-
-
-
r
L-allo-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
-
-
-
-
r
L-allo-isoleucine + 2-oxoisopentanoate
3-methyl-2-oxopentanoate + L-valine
-
-
-
-
r
L-allo-isoleucine + 2-oxooctanoate
3-methyl-2-oxopentanoate + 2-aminooctanoate
-
-
-
-
r
L-arginine + 2-oxoglutarate
2-oxo-5-guanidinopentanoate + L-glutamate
-
-
-
-
r
L-asparagine + 2-oxoglutarate
2,4-dioxo-4-aminobutanoate + L-glutamate
-
-
-
-
r
L-glutamate + 2-oxo-3-methylpentanoate
2-oxoglutarate + L-isoleucine
-
-
-
-
r
L-glutamate + 3-methyl-2-oxopentanoate
2-oxoglutarate + L-isoleucine
-
-
-
r
L-glutamine + 2-oxoglutarate
2,5-dioxo-5-aminopentanoate + L-glutamate
-
-
-
-
r
L-histidine + 2-oxoglutarate
2-oxo-3-imidazolpropanoate + L-glutamate
-
-
-
-
r
L-homomethionine + 2-oxoglutarate
5-methylthio-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-isoleucine + 2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
-
-
-
-
r
L-isoleucine + 2-oxobutanoate
3-methyl-2-oxopentanoate + 2-aminobutanoate
-
-
-
-
r
L-isoleucine + 2-oxoisocaproate
3-methyl-2-oxopentanoate + L-leucine
-
-
-
r
L-isoleucine + 3-methyl-2-oxobutanoate
3-methyl-2-oxopentanoate + L-valine
-
-
-
-
r
L-isoleucine + 3-methylthio-2-oxobutanoate
3-methyl-2-oxopentanoate + 2-amino-3-methylthiobutanoate
-
-
-
-
r
L-isoleucine + 3-phenylpyruvate
2-oxoisohexanoate + L-phenylalanine
-
-
-
r
L-isoleucine + 4-methylthio-2-oxobutyrate
3-methyl-2-oxopentanoate + L-methionine
-
-
-
r
L-isoleucine + oxaloacetate
3-methyl-2-oxopentanoate + L-aspartate
-
brain enzyme
-
-
r
L-leucine + 2-oxo-3-methiobutyrate
2-oxoisohexanoate + L-methionine
-
-
-
-
r
L-leucine + 2-oxo-pentanoate
2-oxoisohexanoate + 2-aminopentanoate
-
-
-
-
r
L-leucine + 2-oxohexanoic acid
4-methyl-2-oxopentanoate + 2-aminohexanoic acid
-
214% of the activity with 2-oxoglutarate
-
-
?
L-leucine + 2-oxoisovaleric acid
4-methyl-2-oxopentanoate + 2-aminoisovaleric acid
-
135% of the activity with 2-oxoglutarate
-
-
?
L-leucine + 3-methyl-2-oxopentanoate
2-oxo-4-methylpentanoate + L-isoleucine
-
-
-
-
r
L-leucine + prephenate
2-oxoisohexanoate + 1-(2-amino-2-carboxyethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid
-
-
-
-
r
L-methionine + 2-oxo-isohexanoate
4-methylsulfanyl-2-oxobutanoate + L-leucine
-
-
-
-
r
L-methionine + 2-oxobutanoate
4-methylthio-2-oxobutanoate + L-2-aminobutanoate
-
-
-
-
r
L-methionine + 2-oxobutyrate
4-methylsulfanyl-2-oxobutanoate + 2-aminobutyrate
-
-
-
-
r
L-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
-
r
L-norleucine + 2-oxoisocaproate
2-oxohexanoate + L-leucine
-
-
-
r
L-norvaline + 2-oxocaproate
2-oxopentanoate + 2-aminohexanoate
-
-
-
r
L-phenylalanine + 2-oxovalerate
phenylpyruvate + L-norvaline
-
-
-
r
L-threo-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxo-3-methylpentanoate
3-methyl-2-oxobutanoate + L-isoleucine
-
-
-
-
r
L-valine + 3-methyl-2-oxopentanoate
3-methyl-2-oxobutanoate + L-isoleucine
-
-
-
-
r
L-valine + 4-methylthio-2-oxo-butanoate
2-oxoisopentanoate + L-methionine
-
-
-
-
?
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + ?
S-(1,1,2,2-tetrafluoroethyl)-2-oxo-3-thiopropanoate + ?
-
-
-
-
?
S-(1,2-dichlorovinyl)-L-cysteine + ?
S-(1,2-dichlorovinyl)-2-oxo-3-thiopropanoate + ?
-
-
-
-
?
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine + ?
S-(2-chloro-1,1,2-trifluoroethyl)-2-oxo-3-thiopropanoate + ?
-
-
-
-
?
S-methyl-L-cysteine + 2-oxoglutarate
3-(methylthio)-2-oxopropanoic acid + L-glutamate
-
heart enzyme
-
-
r
(R)-alpha-methylbenzylamine + pyruvate
alpha-methylbenzaldehyde + L-alanine
small but significant activity, the (S)-enantiomer is not a substrate
-
-
?
(R)-alpha-methylbenzylamine + pyruvate
alpha-methylbenzaldehyde + L-alanine
small but significant activity, the (S)-enantiomer is not a substrate
-
-
?
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid + L-glutamate
3-hydroxyadamantylglycine + 2-oxoglutarate
-
-
-
-
?
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid + L-glutamate
3-hydroxyadamantylglycine + 2-oxoglutarate
-
-
-
-
?
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid + L-glutamate
3-hydroxyadamantylglycine + 2-oxoglutarate
-
-
-
-
?
2-oxo-3-methylvalerate + glyoxalate
L-isoleucine + glycine
-
-
-
r
2-oxo-3-methylvalerate + glyoxalate
L-isoleucine + glycine
-
-
-
r
2-oxoglutarate + L-isoleucine
L-glutamate + 3-methyl-2-oxopentanoate
-
-
-
r
2-oxoglutarate + L-isoleucine
L-glutamate + 3-methyl-2-oxopentanoate
-
-
-
-
?
2-oxoglutarate + L-isoleucine
L-glutamate + 3-methyl-2-oxopentanoate
-
-
-
-
?
2-oxoglutarate + L-leucine
L-glutamate + 4-methyl-2-oxopentanoate
-
-
-
r
2-oxoglutarate + L-leucine
L-glutamate + 4-methyl-2-oxopentanoate
-
-
-
-
?
2-oxoglutarate + L-leucine
L-glutamate + 4-methyl-2-oxopentanoate
-
-
-
-
?
2-oxoglutarate + L-valine
L-glutamate + 3-methyl-2-oxobutanoate
-
-
-
-
?
2-oxoglutarate + L-valine
L-glutamate + 3-methyl-2-oxobutanoate
-
-
-
-
?
3-methyl-2-oxobutanoic acid + L-glutamate
L-valine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxobutanoic acid + L-glutamate
L-valine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxobutyrate + L-glutamate
L-valine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxobutyrate + L-glutamate
L-valine + 2-oxoglutarate
-
the transamination of ketoisovalerate (KIV) to valine is carried out mainly by the transaminase B enzyme, with the transaminase C enzyme playing a minor role
-
-
?
3-methyl-2-oxobutyric acid + L-glutamate
L-valine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxobutyric acid + L-glutamate
L-valine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxobutyric acid + L-glutamate
L-valine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxopentanoic acid + L-glutamate
L-isoleucine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxopentanoic acid + L-glutamate
L-isoleucine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxovaleric acid + L-glutamate
L-isoleucine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxovaleric acid + L-glutamate
L-isoleucine + 2-oxoglutarate
-
-
-
-
?
3-methyl-2-oxovaleric acid + L-glutamate
L-isoleucine + 2-oxoglutarate
-
-
-
-
?
4-methyl-2-oxopentanoic acid + L-glutamate
L-leucine + 2-oxoglutarate
-
-
-
-
?
4-methyl-2-oxopentanoic acid + L-glutamate
L-leucine + 2-oxoglutarate
-
-
-
-
?
4-methyl-2-oxovaleric acid + L-glutamate
L-leucine + 2-oxoglutarate
-
-
-
-
?
4-methyl-2-oxovaleric acid + L-glutamate
L-leucine + 2-oxoglutarate
-
-
-
-
?
4-methyl-2-oxovaleric acid + L-glutamate
L-leucine + 2-oxoglutarate
-
-
-
-
?
DL-2-aminoheptanoate + 2-oxoglutarate
2-oxoheptanoate + L-glutamate
-
-
-
r
DL-2-aminoheptanoate + 2-oxoglutarate
2-oxoheptanoate + L-glutamate
-
-
-
r
DL-2-aminooctanoate + 2-oxobutanoate
2-oxooctanoate + L-2-aminobutanoate
-
-
-
r
DL-2-aminooctanoate + 2-oxobutanoate
2-oxooctanoate + L-2-aminobutanoate
-
-
-
r
glycine + 2-oxoglutarate
L-glutamic acid + glyoxylate
-
-
-
?
L-2-aminobutanoate + phenylpyruvate
2-oxobutanoate + L-phenylalanine
-
-
-
r
L-2-aminobutanoate + phenylpyruvate
2-oxobutanoate + L-phenylalanine
-
-
-
r
L-2-aminobutyrate + 2-oxoglutarate
2-oxobutanoate + L-glutamate
-
-
-
-
r
L-2-aminobutyrate + 2-oxoglutarate
2-oxobutanoate + L-glutamate
-
heart enzyme
-
-
r
L-alanine + 4-methyl-2-oxopentanoate
pyruvate + L-leucine
no substrate: D-alanine
-
-
?
L-alanine + 4-methyl-2-oxopentanoate
pyruvate + L-leucine
no substrate: D-alanine
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
1.7% of the activity with L-isoleucine
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
1.7% of the activity with L-isoleucine
-
?
L-cysteine + 2-oxoglutarate
2-oxo-3-thiobutyrate + L-glutamate
-
-
-
r
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
-
mitochondrial enzyme
-
-
r
L-glutamate + 4-methyl-2-oxopentanoate
2-oxoglutarate + L-leucine
-
-
-
r
L-glutamate + 4-methylthio-2-oxo-butanoate
2-oxoglutarate + L-methionine
-
-
-
-
?
L-glutamate + 4-methylthio-2-oxo-butanoate
2-oxoglutarate + L-methionine
-
-
-
-
?
L-isoleucine + 2-oxo-isopentanoate
2-oxoisohexanoate + L-valine
-
-
-
r
L-isoleucine + 2-oxo-isopentanoate
2-oxoisohexanoate + L-valine
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
mitochondrial enzyme
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
lower reactivity than other origins
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of L-isoleucine
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxopentanoate
-
-
-
-
?
L-isoleucine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxopentanoate
-
-
-
-
?
L-isoleucine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxopentanoate
-
-
-
-
?
L-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
-
-
-
r
L-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
-
-
-
-
r
L-isoleucine + 2-oxoisohexanoate
3-methyl-2-oxopentanoate + L-leucine
-
-
-
-
r
L-isoleucine + 4-methylthio-2-oxo-butanoate
3-methyl-2-oxopentanoate + L-methionine
-
-
-
-
?
L-isoleucine + 4-methylthio-2-oxo-butanoate
3-methyl-2-oxopentanoate + L-methionine
-
-
-
-
?
L-isoleucine + pyruvate
2-oxoisohexanoate + L-alanine
-
-
-
?
L-isoleucine + pyruvate
2-oxoisohexanoate + L-alanine
-
-
-
?
L-leucine + 2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
-
-
-
-
r
L-leucine + 2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
-
-
-
r
L-leucine + 2-oxo-isohexanoate
2-oxoisohexanoate + L-leucine
-
-
-
r
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
last step of the synthesis or initial step of the degradation of branched chain amino acids
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of branched-chain amino acids
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
70.1% of the activity with L-isoleucine
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
70.1% of the activity with L-isoleucine
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
Q70KX9
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
82% of the activity with L-isoleucine
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of the branched-chain amino acids L-valine, L-isoleucine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of the branched-chain amino acids L-valine, L-isoleucine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of the branched-chain amino acids L-valine, L-isoleucine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
mitochondrial isoenzyme functions in the biosynthesis of L-isoleucine, L-leucine and L-valine, cytoplasmic isoenzyme functions in amino acid catabolism
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
key enzyme on the biosynthetic pathway of hydrophobic amino acids
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
first step in the metabolism of branched-chain amino acids
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
sole transaminase in fetal rat liver
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
involved in production of fusel alcohols during fermentation
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
L-glutamate + 4-methyl-2-oxopentanoate
-
-
-
-
?
L-leucine + 2-oxoglutarate
L-glutamate + 4-methyl-2-oxopentanoate
-
-
-
-
?
L-leucine + 2-oxoisohexanoate
2-oxoisohexanoate + L-leucine
-
-
-
r
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
-
-
-
-
r
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
-
-
-
-
r
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
-
-
-
-
-
L-leucine + 3-methyl-2-oxobutanoate
4-methyl-2-oxopentanoate + L-valine
-
-
-
r
L-leucine + 3-methyl-2-oxopentanoate
4-methyl-2-oxopentanoate + L-isoleucine
-
-
-
-
r
L-leucine + 3-methyl-2-oxopentanoate
4-methyl-2-oxopentanoate + L-isoleucine
-
-
-
-
r
L-leucine + 3-methyl-2-oxopentanoate
4-methyl-2-oxopentanoate + L-isoleucine
-
-
-
-
r
L-leucine + 4-methyl-2-oxopentanoate
4-methyl-2-oxopentanoate + L-leucine
-
-
-
-
r
L-leucine + 4-methyl-2-oxopentanoate
4-methyl-2-oxopentanoate + L-leucine
-
-
-
-
r
L-leucine + 4-methylthio-2-oxo-butanoate
4-methyl-2-oxopentanoate + L-methionine
-
-
-
-
?
L-leucine + 4-methylthio-2-oxo-butanoate
4-methyl-2-oxopentanoate + L-methionine
-
-
-
-
?
L-leucine + DL-2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
-
-
-
-
r
L-leucine + DL-2-oxo-3-methylpentanoate
2-oxoisohexanoate + L-isoleucine
-
-
-
-
r
L-leucine + p-hydroxyphenylpyruvate
2-oxoisohexanoate + L-tyrosine
-
-
-
-
r
L-leucine + phenylpyruvate
2-oxoisohexanoate + L-phenylalanine
-
-
-
-
r
L-leucine + phenylpyruvate
2-oxoisohexanoate + L-phenylalanine
-
2-oxo-isohexanoic acid 100%, BCATm relative rate 4%, BCATc 6%
-
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
-
2-oxoglutarate 100%, relative rate 1%
-
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
-
2-oxo-isohexanoic acid 100%, BCATm and BCATc, relative rate 6%
-
-
r
L-leucine + pyruvate
2-oxoisohexanoate + L-alanine
-
-
-
r
L-leucine + pyruvate
4-methyl-2-oxopentanoate + L-alanine
-
-
-
?
L-leucine + pyruvate
4-methyl-2-oxopentanoate + L-alanine
-
-
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
-
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
-
-
-
-
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
2.9% of the activity with L-isoleucine
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
2.9% of the activity with L-isoleucine
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
transaminated extremely poorly
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
6% of the activity with L-isoleucine
-
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
cytoplasmic isoenzyme
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
higher reactivity than other origins
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
transaminated extremely poorly
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylthio-2-oxobutanoate + L-glutamate
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylthio-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
-
-
-
-
r
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
-
brain enzyme
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
0.9% of the activity with L-isoleucine
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
0.9% of the activity with L-isoleucine
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
cytoplasmic isoenzyme
-
-
r
L-phenylalanine + 4-methylthio-2-oxo-butanoate
phenylpyruvate + L-methionine
-
-
-
-
?
L-phenylalanine + 4-methylthio-2-oxo-butanoate
phenylpyruvate + L-methionine
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
-
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
-
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
-
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
2-oxo-3-indolylpropanoate + L-glutamate
-
-
-
-
r
L-tryptophan + 2-oxoglutarate
L-glutamic acid + 3-indole-2-oxopropanoate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
L-glutamic acid + 3-indole-2-oxopropanoate
-
-
-
?
L-tryptophan + 2-oxoglutarate
L-glutamic acid + 3-indole-2-oxopropanoate
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
-
-
-
-
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
p-hydroxyphenylpyruvate + L-glutamate
-
cytoplasmic isoenzyme
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
47.9% of the activity with L-isoleucine
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
Q70KX9
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
86% of the activity with L-isoleucine
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
mitochondrial enzyme
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
biosynthesis of L-valine
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoic acid + L-glutamate
-
-
-
r
L-valine + 2-oxoglutarate
L-glutamate + 3-methyl-2-oxobutanoate
-
-
-
-
?
L-valine + 2-oxoisopentanoate
2-oxoisopentanoate + L-valine
-
-
-
r
L-valine + pyruvate
3-methyl-2-oxobutanoate + L-alanine
-
-
-
?
L-valine + pyruvate
3-methyl-2-oxobutanoate + L-alanine
-
-
-
?
trimethylpyruvate + L-glutamate
L-tert-leucine + 2-oxoglutarate
-
-
-
-
?
trimethylpyruvate + L-glutamate
L-tert-leucine + 2-oxoglutarate
-
-
-
-
?
additional information
?
-
-
enzyme may influence methionine levels and play an important role in the metabolism of the nonprotein amino acid alpha-aminobutanoate
-
-
-
additional information
?
-
-
isoform Atbcat-1 is able to initiate degradation of all branched-chain amino acids
-
-
-
additional information
?
-
-
little or no activity is detected with L-isoleucine
-
-
-
additional information
?
-
-
no activity is observed with 6-methylthio-2-oxohexanoate, 3-methyl-2-oxopentanoate, or 3-methyl-2-oxobutyrate
-
-
-
additional information
?
-
-
glycine and D-leucine are no substrates, oxaloacetate, pyruvate and glyoxylate are not amino acceptors
-
-
-
additional information
?
-
-
purified enzyme has no measurable L-aspartate-2-oxoglutarate activity
-
-
-
additional information
?
-
Escherichia coli W3110 / ATCC 27325
-
no activity towards L-aspartate
-
-
-
additional information
?
-
-
L-aspartic acid, L-arginine, L-citrulline, L-lysine, L-ornithine, L-alanine, beta-alanine and gamma-aminobutyrate are not amino donors, oxalaceteate and glyoxylate are not amino acceptors, pyruvate is a weak amino acceptor, relative activity 1%
-
-
-
additional information
?
-
-
L-citrulline and L-methionine are poor amino donors
-
-
-
additional information
?
-
-
no or very weak activity is shown toward L-methionine, L-aspartate, L-phenylalanine, glycine and the D-enantiomers of leucine, isoleucine and valine
-
-
-
additional information
?
-
no or very weak activity is shown toward L-methionine, L-aspartate, L-phenylalanine, glycine and the D-enantiomers of leucine, isoleucine and valine
-
-
-
additional information
?
-
-
no substrate: L-asparagine, L-histidine, and L-lysine, D-isoleucine, D-leucine, D-valine, as well as both enantiomers of alanine, proline, and serine
-
-
-
additional information
?
-
no substrate: L-asparagine, L-histidine, and L-lysine, D-isoleucine, D-leucine, D-valine, as well as both enantiomers of alanine, proline, and serine
-
-
-
additional information
?
-
-
no or very weak activity is shown toward L-methionine, L-aspartate, L-phenylalanine, glycine and the D-enantiomers of leucine, isoleucine and valine
-
-
-
additional information
?
-
no or very weak activity is shown toward L-methionine, L-aspartate, L-phenylalanine, glycine and the D-enantiomers of leucine, isoleucine and valine
-
-
-
additional information
?
-
-
no substrate: L-asparagine, L-histidine, and L-lysine, D-isoleucine, D-leucine, D-valine, as well as both enantiomers of alanine, proline, and serine
-
-
-
additional information
?
-
no substrate: L-asparagine, L-histidine, and L-lysine, D-isoleucine, D-leucine, D-valine, as well as both enantiomers of alanine, proline, and serine
-
-
-
additional information
?
-
-
recombinant human BCATm and BCATc have beta-lyase activity towards 3 toxic L-cysteine S-conjugates, S-(1,1,2,2-tetrafluoroethyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-cysteine and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine and toward 3-chloro-L-alanine, BCATm is also active toward benzothiazolyl-L-cysteine, pyruvate formed from beta-lyase substrates
-
-
-
additional information
?
-
-
transamination activity with oxaloacetate is too low to be evaluated, DL-aminoadipate, glycine, L-phenylalanine, L-tyrosine and L-methionine are no substrates
-
-
-
additional information
?
-
novel co-repressor for thyroid hormone nuclear receptors
-
-
-
additional information
?
-
-
no substrate: phenylalanine, tyrosine, tryptophan, aspartic acid, asparagine
-
-
-
additional information
?
-
-
with 2-oxoglutarate as acceptor L-alanine is no substrate, with L-aspartate as amino donor, oxaloacetate is no amino acceptor
-
-
-
additional information
?
-
with 2-oxoglutarate as acceptor L-alanine is no substrate, with L-aspartate as amino donor, oxaloacetate is no amino acceptor
-
-
-
additional information
?
-
-
purified mitochondrial enzyme is not active with L-phenylalanine
-
-
-
additional information
?
-
-
only little or no activity with L-tryptophan, L-phenylalanine, L-glutamine, L-alanine and L-aspartate, KIC, KIV, DL-2oxo-3-methylpentanoate, 2-oxoglutarate, 2-oxohexanoate, 2-oxopentanoate, 2-oxobutyrate, 2-oxo-3-methiobutyrate, pyruvate or phenylpyruvate are acceptors
-
-
-
additional information
?
-
-
L-leucine is the best substrate for the heart enzyme
-
-
-
additional information
?
-
-
specific for L-leucine, L-isoleucine or L-valine, no other amino acid would serve as an amino donor
-
-
-
additional information
?
-
-
activity less than 3% with glycine, L-alanine, L-lysine, L-phenylalanine, L-tryptophan, D-alloisoleucine, D-valine, D-leucine, L-threonine, L-histidine, L-arginine, L-cysteine, DL-homocyteine, beta-aminoisobutyrate, gamma-aminobutyrate, alpha-aminoisobutyrate, DL-alpha-aminocaprylate, L-serine, DL-homoserine, DL-beta-aminobutyrate, DL-N-hydroxyleucine, DL-N-hydroxyvaline, L-aspartate, L-tyrosine, L-kynurenine, L-ornithine, DL-proline, L-glutamine, L-peniclliamine, DL-methionine sulfone, DL-methionine sulfoxide and DL-beta-hydroxy-leucine
-
-
-
additional information
?
-
-
L-isoleucine is the best substrate for the heart enzyme, L-alanine, aspartic, alpha-amino-butyric acid and gamma-aminobutyric acid, epsilon-aminocaproic acid, L-ornithine, L-methionine and L-phenylalanine are no substrates, pyruvate is not a good acceptor
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-methyl-2-oxobutyrate + L-glutamate
L-valine + 2-oxoglutarate
-
the transamination of ketoisovalerate (KIV) to valine is carried out mainly by the transaminase B enzyme, with the transaminase C enzyme playing a minor role
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
-
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
Q7BPX6
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
-
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
B6RFK8
-
-
-
?
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
O97932
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
Q9GKM4
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
P47176
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of L-isoleucine
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-isoleucine + 2-oxoglutarate
3-methyl-2-oxopentanoate + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
2-oxoisohexanoate + L-glutamate
B6RFK8
-
-
-
?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
last step of the synthesis or initial step of the degradation of branched chain amino acids
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of branched-chain amino acids
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
Escherichia coli W3110 / ATCC 27325
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
Q7BPX6
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of the branched-chain amino acids L-valine, L-isoleucine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of the branched-chain amino acids L-valine, L-isoleucine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of the branched-chain amino acids L-valine, L-isoleucine and L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
mitochondrial isoenzyme functions in the biosynthesis of L-isoleucine, L-leucine and L-valine, cytoplasmic isoenzyme functions in amino acid catabolism
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
-
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
key enzyme on the biosynthetic pathway of hydrophobic amino acids
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
first step in the metabolism of branched-chain amino acids
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
sole transaminase in fetal rat liver
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
P47176
involved in production of fusel alcohols during fermentation
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
biosynthesis of L-leucine
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
Q7BPX6
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
B6RFK8
-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
P47176
-
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
biosynthesis of L-valine
-
-
r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
-
-
-
-
r
additional information
?
-
-
enzyme may influence methionine levels and play an important role in the metabolism of the nonprotein amino acid alpha-aminobutanoate
-
-
-
additional information
?
-
-
specific for L-leucine, L-isoleucine or L-valine, no other amino acid would serve as an amino donor
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
pyridoxine 5'-phosphate, pyridoxal, pyridoxamine and pyridoxine are not effective as coenzymes
-
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
covalently bound to conserved residue Lys150, crystallization data
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-((4-chloro-2,6-difluorobenzyl)amino)-7-oxo-5-propyl-4,7-dihydropyrazolo[1,5-a]-pyrimidine-3-carbonitrile
oral administration of the compound significantly raises the circulating levels of the branched-chain amino acids leucine, isoleucine, and valine. Compound demonstrates a good dose response, with leucine increasing from 473 microM (basal level) to 1.2 mM in 100 mg/kg treated mice
2-oxo-3-methylvalerate
-
measured in the forward reaction, concentrations higher than 1.0 mM inhibits the enzyme
2-oxoisovalerate
-
measured in the forward reaction, concentrations higher than 1.0 mM inhibits the enzyme
5-chloro-N'-[(2-chlorophenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
-
IC50: 0.0057 mM
5-chloro-N'-[(2-methylphenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
-
IC50: 0.00116 mM
5-chloro-N'-[(3-methylphenyl)sulfonyl]-1-benzofuran-2-carbohydrazide
-
IC50: 0.0012 mM
5-chloro-N'-[[2-(trifluoromethyl)phenyl]sulfonyl]-1-benzofuran-2-carbohydrazide
-
IC50: 0.0008 mM, potent inhibitor
benzothiazolyl-L-cysteine
-
inhibits the L-leucine-2-oxoglutarate tranamination reaction of both isoenzymes
L-cysteine
-
10 mM, inhibits activity with isoleucine and tyrosine by 22 and 34%, respectively
L-isoleucine
-
with 1 mM tyrosine as the substrate, 10 mM isoleucine inhibits activity by 94%
L-leucine
-
with 1 mM tyrosine as the substrate, 10 mM leucine inhibits activity by 93%
L-methionine
-
10 mM methionine inhibits the activity with 1 mM tyrosine and phenylalanine by 86 and 59%, respectively, but it has no effect on the isoleucine activity
L-phenylalanine
-
with 2 mM isoleucine as the substrate, 10 mM phenylalanine inhibits activity by 46%
L-valine
-
with 1 mM tyrosine as the substrate, 10 mM valine inhibits activity by 78%
N'-[(2-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.0129 mM
N'-[(2-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.0032 mM
N'-[(3-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: above 0.035 mM
N'-[(3-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.0028 mM
N'-[(4-chlorophenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.0372 mM
N'-[(4-methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
-
IC50: 0.051 mM
O-(t-butyl)hydroxylamine
-
mixed-type inhibition, acts also as growth inhibitor of organism
O-allylhydroxylamine
-
mixed-type inhibition, acts also as growth inhibitor of organism
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
rapidly inactivated by the beta-lyase substrate
S-(1,2-dichlorovinyl)-L-cysteine
-
rapidly inactivated by the beta-lyase substrate
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
rapidly inactivated by the beta-lyase substrate
2-oxoglutarate
-
5 mM 2-oxoglutarate inhibits the transamination of the 6.3-fold purified enzyme, of valine and isoleucine by about 50%, but the leucine activity is less affected. Inhibition is competitive with respect to valine
2-oxoisocaproate
-
measured in the forward reaction, concentrations higher than 1.0 mM inhibits the enzyme
carboxymethoxylamine
-
mixed-type inhibition, acts also as growth inhibitor of organism
gabapentin
-
structural analogue of leucine, competitive inhibitor of BCATc, does not inhibit BCATm
gabapentin
-
structural analogue of leucine, competitive inhibitor of BCATc, does not inhibit BCATm
O-Benzylhydroxylamine
-
mixed-type inhibition, acts also as growth inhibitor of organism
p-chloromercuribenzoate
-
isoenzyme I, complete inhibition, isoenzyme III only partially inhibited